Navigation Links
Better housing conditions for zebrafish could improve research results
Date:5/3/2012

Changing the conditions that zebrafish are kept in could have an impact on their behaviour in animal studies and the reliability of results, according to scientists from Queen Mary, University of London.

Zebrafish, like rats and mice, are often used by neuroscientists to explore mechanisms controlling behaviour and in the search for new compounds to treat behavioural disease such as addiction, attention deficit disorders or autism.

It is known that housing and handling affects the results of behavioural studies done in rats and mice, but until now there have been few studies of how the environment the fish are kept in before they are tested can impact on the results.

Writing in the journal PLoS ONE, Dr Caroline Brennan from Queen Mary's School of Biological and Chemical Sciences explains: "Practical considerations make zebrafish a very useful species in which to explore mechanisms controlling behaviour. Their small size (less than 2 cm) and prolific breeding (approx. 300 eggs per pairing) makes it easy and cheap to keep large numbers of zebrafish in a small space. It is also relatively easy to change the zebrafish genome to explore how changes in different genes affect behaviour.

"As fish have many proteins and brain circuits in common with humans, factors that affect the fish behaviour can tell us about things that may affect human behaviour."

One of the most commonly used zebrafish behavioural tests is the 'tank diving' test that is considered a measure of the fish's stress level. When a zebrafish is placed in a new tank it shows a characteristic 'diving' response where the fish will dive to the bottom of the tank and remain there more or less stationary for a brief period of time before rising to shallower depths. The interpretation is that the longer it takes the fish to rise, the more stressed it is. This test has been suggested as a means of screening for new compounds to treat stress disorders.


'/>"/>
Contact: Bridget Dempsey
b.dempsey@qmul.ac.uk
44-207-882-7927
Queen Mary, University of London
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Bigger gorillas better at attracting mates and raising young
2. Modern hybrid corn makes better use of nitrogen, study shows
3. Intensive kidney dialysis indicates better survival rates than conventional dialysis
4. Fish larvae find the reef by orienting: The earlier the better
5. Improved loblolly pines better for the environment, study finds
6. Giant squids giant eyes: The better to see hungry whales with
7. UNH researchers find African farmers need better climate change data to improve farming practices
8. Breakthroughs in Chikungunya research from A*STAR spell new hope for better treatment and protection
9. New methods for better purification of wastewater
10. Iowa State, Ames Lab chemists aid study of mutated plants that may be better for biofuels
11. Sandia seeks better neural control of prosthetics for amputees
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... modeling study suggests that fish consumption advisories for ... to long-lived contaminants like persistent organic pollutants (POPs). ... of researchers including University of Toronto Scarborough PhD ... at how different levels of environmental contamination, a ... chemicals in the body influenced exposure in her ...
(Date:4/17/2014)... in German . ... they also provide us with a continuous stream of information ... or sit still in a car the world glides ... retinas. Seemingly without effort, our brain calculates self-motion from this ... and a steady gaze during our own movements. Together with ...
(Date:4/17/2014)... professor Rajendra Singh Thursday as a "Champion of ... solar deployment in the residential, commercial and industrial ... of Electrical and Computer Engineering and director of ... local hero leading the charge across the country ... power and driving policy changes at the local ...
Breaking Biology News(10 mins):Fish consumption advisories fail to cover all types of contaminants 2How vision makes sure that little fish do not get carried away 2How vision makes sure that little fish do not get carried away 3How vision makes sure that little fish do not get carried away 4White House honors Clemson professor as 'Champion of Change' for solar deployment 2
... applauds the US Court of Appeals for the District of ... against the use of public funds for embryonic stem cell ... cell research and the nation,s scientific community. Most importantly, ... suffering from incurable diseases," says Susan L. Solomon, CEO of ...
... a groundbreaking new videojournal to complement the ... & Advanced Surgical Techniques has been ... ( http://www.liebertpub.com ). Videoscopy ( http://www.liebertpub.com/products/product.aspx?pid=390 ) ... of the latest techniques and technologies used ...
... ground to plant trees may be an excellent gateway to ... University of Maryland study, based on work with New York ... in environmental stewardship, the more s/he engages with other types ... Together ", which the researchers released to coincide with Arbor ...
Cached Biology News:Groundbreaking minimally invasive surgical videojournal launched by Mary Ann Liebert Inc. 2Digging in dirt, Arbor Day planting, may help build citizenship: UMD study 2
(Date:1/15/2014)... The Pittcon Organizing Committee is pleased to ... Tech , an e-Journal and producer of Food ... second year for the co-location of Food Labs Conference to ... that the registration fee to attend the two-day Food Lab ...
(Date:1/15/2014)... 15, 2014 Look inside the new ... for the lab, from fluid handling to instruments to ... ship when you order. , Preferred Solutions features ... from the L/S® model for precise flow control and ...
(Date:1/15/2014)... and SAN JOSE, California , ... biotechnology company developing antibody-drug conjugates for cancer, today announced the ... of Directors. Dr Reynolds has over 20 years, development experience ... Officer at Seattle Genetics. "I am delighted to ...
(Date:1/15/2014)... This webinar will focus on EMA and ... in biosimilars. , Regulatory frameworks are evolving many countries ... the complex nature of biopharmaceuticals makes the demonstration of ... challenging. Based on the specific aspects of biosimilar drug ...
Breaking Biology Technology:Pittcon Announces Second Year Partnership With Food Safety Tech 2Pittcon Announces Second Year Partnership With Food Safety Tech 3Cole-Parmer Begins 2014 with the Release of Preferred Solutions 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 3Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2
... Mylan Inc. (Nasdaq: MYL ) today ... company,s credit ratings, including the "Corporate Family Rating," to ... is stable.  According to Moody,s: "Mylan,s ... in the global generic pharmaceutical industry, its strong geographic ...
... a molecular diagnostics company, announced today the publication of ... which may influence the amount of fetal DNA found ... Kypros Nicolaides, MD, of Harris Birthright Research Centre for ... Kingdom. (Logo: http://photos.prnewswire.com/prnh/20120326/NY75864LOGO ) ...
... a metal surface at the scale of atoms and ... computer chips or the reflective silver in optical components ... may seem high-tech and precise, the technique has been ... physics. In a new study, Brown University engineers modeled ...
Cached Biology Technology:Moody's Upgrades Mylan 2Ariosa Diagnostics Announces Publication of Study on Influential Factors Affecting Fetal DNA Concentration in Blood of Pregnant Women 2How ion bombardment reshapes metal surfaces 2How ion bombardment reshapes metal surfaces 3
... Alsevers solution is an isotonic, balanced salt ... preservative, which permits the storage of whole blood ... usage, an equal volume of blood is collected ... but thoroughly, mixed. The solution is placed in ...
... OligoMix or individual RNA sequences from high throughput ... small RNAs from LC Sciences. These products provide ... millions) of DESIGNED sequences delivered in a microtube ... containing a single verified RNA sequence. This is ...
... GCMS-QP2010s Gas Chromatograph/Mass Spectrometer, utilizing many ... GCMS-QP2010 Plus, offers high throughput and ... excellent performance-to-cost ratio. Like the GCMS-QP2010 ... linear velocity for optimum separation, 20 ...
... Assay Kit contains all reagents necessary to ... lineage, as determined by staining for mineralization. ... necessary reagents and a protocol for quantifying ... product is useful for studying the effects ...
Biology Products: