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Better estrogen-testing methods needed to improve patient care
Date:3/5/2013

ies often cannot be compared because measurements and standards were not uniform.

Although a "gold standard" estradiol testing method using mass spectrometry exists, its cost and complexity have discouraged many clinical and research laboratories from implementing this approach.

"The Endocrine Society calls for physicians, members of the research community, government agencies, patient advocates and insurers to collaborate to make accurate testing more accessible," Rosner said.

Recommendations in the statement include:

  • The development of a universally recognized estradiol standard to which all measurements can be traced;
  • The development of estradiol reference ranges specific for age, gender and stage of reproductive development, including puberty/adolescence, menstrual cycle and menopause;
  • A wider recognition among physicians, laboratory staff and researchers that low estradiol values in men, children and menopausal women obtained using current clinical testing methods are likely to be untrustworthy; and
  • The creation of new methods capable of accurately and precisely measuring small concentrations of estradiol in routine clinical specimens. Until such methods are available, a system needs to be implemented to continuously evaluate existing testing and facilitate the improvement of estradiol measurements.

Other authors of the statement include: Susan Hankinson of the University of Massachusetts, Amherst; Patrick Sluss of Massachusetts General Hospital; Hubert Vesper of the U.S. Centers for Disease Control and Prevention; and Margaret Wierman of the University of Colorado School of Medicine.

The statement, "Challenges to the Measurement of Estradiol: An Endocrine Society Position Statement," appears in the April 2013 issue of the Journal of Clinical Endocrinology and Metabolism.


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Contact: Jenni Glenn Gingery
jgingery@endo-society.org
301-941-0240
The Endocrine Society
Source:Eurekalert

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