Navigation Links
Better estrogen-testing methods needed to improve patient care
Date:3/5/2013

Chevy Chase, MDIn a Position Statement unveiled today, The Endocrine Society advocates that all methods for measuring estrogens, which play a crucial role in human biology, be made traceable to a common standard.

In addition to the well-known role of estrogens in sexual development, these hormones, particularly estradiol, have a significant impact on the health of the skin, blood vessels, bones, muscle, kidney, liver, digestive system, brain, lung and pancreas. Studies have linked changes in estradiol levels to coronary artery disease, stroke and breast cancer.

"Estradiol levels need to be accurately, precisely and consistently measured to provide the proper care for patients from the cradle to the grave," said the statement's lead author, William Rosner, MD, of Columbia University. "Health care providers rely on estradiol testing to diagnose and help treat a variety of conditions, including infertility, osteoporosis and breast cancer. Current testing methods need to evolve to meet patients' needs."

The statement identifies a number of issues with the current testing methods used for a typical patient's care. Most of the tests used in the clinical setting cannot detect the low estradiol concentrations found in men, children, menopausal women and breast cancer patients taking drugs that decrease estradiol levels. In addition, other compounds in the body can interfere with the testing, leading to results that can be 10 times the true estradiol level. Quality assessments have found large variations in measurements performed by different laboratories or with different pieces of equipment. Accurate results are needed so that diagnoses are not missed, and patients and health care providers can make informed decisions about treatment options.

In addition, current testing methods limit the ability to generalize results from any given study to the population at large. Furthermore, in the current environment, data from different studies often cannot be compared because measurements and standards were not uniform.

Although a "gold standard" estradiol testing method using mass spectrometry exists, its cost and complexity have discouraged many clinical and research laboratories from implementing this approach.

"The Endocrine Society calls for physicians, members of the research community, government agencies, patient advocates and insurers to collaborate to make accurate testing more accessible," Rosner said.

Recommendations in the statement include:

  • The development of a universally recognized estradiol standard to which all measurements can be traced;
  • The development of estradiol reference ranges specific for age, gender and stage of reproductive development, including puberty/adolescence, menstrual cycle and menopause;
  • A wider recognition among physicians, laboratory staff and researchers that low estradiol values in men, children and menopausal women obtained using current clinical testing methods are likely to be untrustworthy; and
  • The creation of new methods capable of accurately and precisely measuring small concentrations of estradiol in routine clinical specimens. Until such methods are available, a system needs to be implemented to continuously evaluate existing testing and facilitate the improvement of estradiol measurements.

Other authors of the statement include: Susan Hankinson of the University of Massachusetts, Amherst; Patrick Sluss of Massachusetts General Hospital; Hubert Vesper of the U.S. Centers for Disease Control and Prevention; and Margaret Wierman of the University of Colorado School of Medicine.

The statement, "Challenges to the Measurement of Estradiol: An Endocrine Society Position Statement," appears in the April 2013 issue of the Journal of Clinical Endocrinology and Metabolism.


'/>"/>

Contact: Jenni Glenn Gingery
jgingery@endo-society.org
301-941-0240
The Endocrine Society
Source:Eurekalert

Related biology news :

1. New methods for better purification of wastewater
2. Breakthroughs in Chikungunya research from A*STAR spell new hope for better treatment and protection
3. UNH researchers find African farmers need better climate change data to improve farming practices
4. Giant squids giant eyes: The better to see hungry whales with
5. Improved loblolly pines better for the environment, study finds
6. Fish larvae find the reef by orienting: The earlier the better
7. Intensive kidney dialysis indicates better survival rates than conventional dialysis
8. Modern hybrid corn makes better use of nitrogen, study shows
9. Bigger gorillas better at attracting mates and raising young
10. Better housing conditions for zebrafish could improve research results
11. Better plants for biofuels
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2016)... 2016 "Increase in mobile transactions is driving ... biometrics market is expected to grow from USD 4.03 ... at a CAGR of 29.3% between 2016 and 2022. ... growing demand for smart devices, government initiatives, and increasing ... component is expected to grow at a high rate ...
(Date:12/8/2016)... Research Future published a half cooked research report on Mobile Biometric ... Market is expected to grow over the CAGR of ~35% during ... ... Mobile Biometric Security and Service Market is increasing at a ... security from unwanted cyber threats. The increasing use of mobile device ...
(Date:12/7/2016)... India , December 7, 2016 According to a ... Machine Learning), Software Tool (Facial Expression, Voice Recognition), Service, Application Area, End User, ... is estimated to grow from USD 6.72 Billion in 2016 to USD 36.07 ... Continue Reading ... ...
Breaking Biology News(10 mins):
(Date:1/12/2017)... Linda, Ca (PRWEB) , ... ... ... for low-cost, disposable devices with short response times capable of performing routine ... food fields, disposable screen-printed electrodes provide fast, sensitive detection and quantification of ...
(Date:1/12/2017)... ... January 12, 2017 , ... After her ... Rosendahl’s doctors gave her only a few months to live. Now a paper ... has stabilized Rosendahl’s disease and increased both the quantity and quality of her ...
(Date:1/12/2017)... 2017   Protein Sciences Corporation , a ... Flublok Influenza Vaccine ®, announced today that its ... safety results and induced strong neutralizing antibodies against ... is expected to advance into human clinical trials ... Institute of Technology in Immunobiologicals of the Oswaldo ...
(Date:1/12/2017)... The report "Direct-Fed Microbials Market by Type (Lactic Acid Bacteria and Bacillus), Livestock (Pork/Swine, ... Forecast to 2022", published by MarketsandMarkets, the global market is estimated to be ... Million by 2022, at a CAGR of 6.96% from 2016. ... ... Logo ...
Breaking Biology Technology: