Navigation Links
Berkeley Lab scientists help develop promising therapy for Huntington's disease
Date:11/1/2012

There's new hope in the fight against Huntington's disease. A group of researchers that includes scientists from the U.S. Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) have designed a compound that suppresses symptoms of the devastating disease in mice.

The compound is a synthetic antioxidant that targets mitochondria, an organelle within cells that serves as a cell's power plant. Oxidative damage to mitochondria is implicated in many neurodegenerative diseases including Alzheimer's, Parkinson's, and Huntington's.

The scientists administered the synthetic antioxidant, called XJB-5-131, to mice that have a genetic mutation that triggers Huntington's disease. The compound improved mitochondrial function and enhanced the survival of neurons. It also inhibited weight loss and stopped the decline of motor skills, among other benefits. In short, the Huntington's mice looked and behaved like normal mice.

Based on their findings, the scientists believe that XJB-5-131 is a promising therapeutic compound that deserves further investigation as a way to fight neurodegenerative diseases.

They report their research in a paper that appears online Nov. 1 in the journal Cell Reports.

"The compound was very successful. More research is needed, but it has the real potential to make an impact in treating neurodegenerative disorders," says Cynthia McMurray of Berkeley Lab's Life Sciences Division. She conducted the research with other Berkeley Lab researchers, including Zhiyin Xun, and scientists from the University of Pittsburgh.

Huntington's disease is a genetic disorder in which neurons in certain parts of the brain waste away. Symptoms of the disease typically appear in mid-life. These include loss of muscle coordination and cognitive decline. There is no cure. Currently, patients are prescribed antidepressants or compounds that reduce the loss of motor coordination, neither of which
'/>"/>

Contact: Dan Krotz
dakrotz@lbl.gov
510-486-4019
DOE/Lawrence Berkeley National Laboratory
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Berkeley Lab scientists generate electricity from viruses
2. Berkeley Lab scientists help define the healthy human microbiome
3. Waves of Berkeley Lab responders deploy omics to track Deepwater Horizon cleanup microbes
4. UC Berkeley chemists installing first carbon dioxide sensor network in Oakland
5. UC Berkeley survey shows college campuses can make good bird havens
6. Stanford scientists develop gene therapy approach to grow blood vessels in ischemic limbs
7. Queens scientists seek vaccine for Pseudomonas infection
8. Scientists produce eye structures from human blood-derived stem cells
9. American Society of Plant Biologists honors early career women scientists
10. Brandeis scientists win prestigious prize for circadian rhythms research
11. Scientists discover new method of proton transfer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Berkeley Lab scientists help develop promising therapy for Huntington's disease
(Date:12/19/2014)... Markets ( http://www.researchandmarkets.com/research/8kmfcn/iphone_5s ) has announced the ... Apple/AuthenTec TMDR92 & Sapphire - Technology Report" report ... Following the acquisition of AuthenTec in ... the iPhone 5S. It is currently the only device ...
(Date:12/17/2014)... 2014 The Defense Logistics Agency is insourcing its ... counterfeit microcircuits from entering into its supply chain. ... anti-counterfeit initiative dubbed DNA marking. The capability will validate ... throughout the supply chain. The new quality control measures ...
(Date:12/15/2014)... Dec. 12, 2014 Research and Markets ( ... "Global Facial Recognition Market 2015-2019" report to their ... Facial recognition is a technology used for the ... facial feature of a person such as nose, jaw ...
Breaking Biology News(10 mins):iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3
... discovered in Arizona suggests dinosaurs did not spread throughout ... advantage of a natural catastrophe that wiped out their ... was studied by an international team of scientists, including ... the University of Toronto Mississauga, Tim Rowe, professor of ...
... 2,700 researchers from 80 countries, the world,s scientists as well ... Marine Life, which provides the first in-depth look at the ... Census of Marine Life initiative, started in 2000, is the result ... result of more than 540 expeditions and 9,000 days at sea, ...
... the ever-evolving landscape of our planet and the elemental forces ... exchange network being led by The University of Nottingham. ... in the University,s School of Geography, is a two-year project ... It will focus on technology that can be used ...
Cached Biology News:New fossil suggests dinosaurs not so fierce after all 2San Diego Supercomputer Center participates in first 'Census of Marine Life' 2Keeping a watch on the world 2Keeping a watch on the world 3
(Date:1/22/2015)... Jan. 22, 2015  Transwestern | RBJ today announces the firm ... space for Shire a leading biopharmaceutical company, at Two Ledgemont ... RBJ,s Robert Richards , president, and Brian Cohen ... the entire five-floor building at 95 Hayden Ave. ...
(Date:1/22/2015)... Pipette.com has added the Eppendorf ... portfolio of Eppendorf products. , The Eppendorf Centrifuge 5424/5424 ... 5424/5424 R and receive the following:, , ... or Eppendorf Reference 2 ,     3 Free ...
(Date:1/22/2015)... 2015 Diagenode, Inc., a leading ... Bioruptor® and complete solutions for epigenetics research, recently ... alleviating the need for manual processing. The new ... ChIP of histones or transcription factors and a ...
(Date:1/22/2015)... Jan. 22, 2015  Derma Sciences, Inc. (Nasdaq: ... on advanced wound care, announces that AMNIOEXCEL® and ... been added to the Premier, Inc. Regenerative Skin ... for the AMNIOEXCEL® and AMNIOMATRIX® product lines, which ...
Breaking Biology Technology:Transwestern?RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Eppendorf Announces Promotional Bundle Which Includes: Eppendorf Centrifuge 5424, 3-Pack of Pipettes, and Tips - Available Now at Pipette.com 2Diagenode Launches Unique Semi-Automated Solution for Chromatin Immunoprecipitation 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 3Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 5
... frequency identification (RFID) becomes increasingly widespread - moving out ... previously used it for their own purposes to become ... highly fragmented industry with pockets of development virtually everywhere, ... Consortium at the University of Wisconsin-Madison . ...
... a special section devoted to radio frequency identification (RFID) ... only now beginning to make a real impact on ... this series of articles on RFID, articles written by ... and academia. , ,In Wisconsin, businesses and organizations are ...
... has filed suit against three companies, seeking rulings regarding ... Tuesday. The suits were filed in federal court in Madison. ... Corp., seeking a court ruling supporting Third Wave's right ... Tuesday, Third Wave filed suit against Chiron Corp. , ...
Cached Biology Technology:RFID technology is opportunity for Wisconsin companies 2RFID technology is opportunity for Wisconsin companies 3RFID technology is opportunity for Wisconsin companies 4RFID technology is opportunity for Wisconsin companies 5RFID technology is opportunity for Wisconsin companies 6RFID technology is opportunity for Wisconsin companies 7RFID technology is opportunity for Wisconsin companies 8RFID starting to make real impact on business 2RFID starting to make real impact on business 3Third Wave files patent suits against Digene, Chiron and Bayer 2
... GELase™ Agarose Gel-Digesting Preparation contains a ... for simple, quantitative recovery of intact DNA ... agarose gels following electrophoresis in TAE, TBE, ... be digested directly in the TAE, TBE, ...
... GELase™ Agarose Gel-Digesting Preparation contains a ... for simple, quantitative recovery of intact DNA ... agarose gels following electrophoresis in TAE, TBE, ... be digested directly in the TAE, TBE, ...
... Perhaps sheer in-house demand is causing shortages ... precious antibody. This can cause unwanted distractions, problems ... royalties for your hard work and endeavour! Bring ... up and market it internationally. We work under ...
... Perhaps sheer in-house demand is causing shortages ... your precious antibody. This can cause unwanted ... • Receive royalties for your hard work ... let us build it up and market ...
Biology Products: