Navigation Links
Baumann lab identifies elusive telomere RNA subunit in single cell model
Date:12/27/2007

The Stowers Institutes Baumann Lab has identified the long-sought telomerase RNA gene in a single-cell research model. Their findings have been posted to the Web site of the journal Nature Structural & Molecular Biology and will appear in a future print edition.

Chromosomes shorten with every cell division. In stem cells and in cancer cells, this shortening is compensated by telomerase, an enzyme that adds short repeat sequences to the ends of chromosomes to replenish lost DNA. As telomerase is required for the continued growth of most cancer cells, the enzyme is considered a promising target for new anti-cancer drugs. A correlation between telomere length and a variety of diseases has further intensified interest in understanding telomerase and its regulation.

The RNA subunit of telomerase is of particular interest as it represents one of the two core components of telomerase and provides the template for the short repeats that are added to the ends of chromosomes. The Baumann Lab is working to understand how telomerase is assembled, how it is recruited to chromosome ends, and how its activity is regulated. These efforts may shed light on the sometimes surprising correlations between telomere shortening and stress, smoking, obesity, and a variety of diseases including cancer and coronary heart disease.

Telomerase RNA has been studied in a variety of simple model organisms, but telomere maintenance turned out to be quite different in these species compared to human cells. Recently, the Baumann Lab used a biochemical approach to identify and clone the RNA subunit of telomerase in Schizosaccharomyces pombe, or fission yeast.

The identification of the fission yeast equivalent of the telomerase RNA gene provides us with a critical tool to study telomerase in a genetically tractable, single-cell organism with a telomere maintenance machinery that shares many features with human cells, explained Peter Baumann, Ph.D., Assistant
'/>"/>

Contact: Marie Jennings
mfj@stowers-institute.org
816-926-4015
Stowers Institute for Medical Research
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study identifies warning signs of pregnancy danger
2. Study identifies genetic risk factor for rheumatoid arthritis, lupus
3. Study by Pittsburgh researchers identifies possible vaccine target for chlamydia
4. Breakthrough research identifies how cells from pigs may cure diabetes
5. Smithsonian identifies invasive crab species in Panama Canal expansion area
6. Smithsonian identifies invasive crab species in Panama Canal expansion area
7. New technology identifies warped fingerprints at warp speed
8. Study identifies pathway required for normal reproductive development
9. St. Jude identifies the specific cell that causes eye cancer, disproving long-held theory
10. Stowers Institutes Hawley Lab identifies factors responsible for restart of meiotic cycle
11. Understanding hypertension in African Americans proves elusive
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2015)... 2015  Marken is starting its 35 th ... a new marketing campaign to solidify its place as ... campaign focuses on First as a primary ... The first headline in the series, ... its client,s priorities. Marken recognizes the need to protect ...
(Date:2/5/2015)... , Jan. 28, 2015 NXT-ID, Inc. (NASDAQ: ... "Company"), a biometric authentication company focused on the growing ... upcoming RedChip Global Online CEO Conference on January 29 ... Gino Pereira , CEO of NXT-ID will present ... product, the Wocket smart wallet and its full suite ...
(Date:1/22/2015)... Jan. 9, 2015 Valid S.A. ("Company") (BM&FBOVESPA: VLID3 ON), ... general the State of Washington,s Department ... new enrollment and central issuance system for driver,s licenses and ... The project planning and development will start in January 2015, ...
Breaking Biology News(10 mins):Marken Launches New Patient-Centric Campaign 2CEO of NXT-ID, Inc. to Discuss Company's Biometric Technologies at RedChip Online Conference January 29th 2CEO of NXT-ID, Inc. to Discuss Company's Biometric Technologies at RedChip Online Conference January 29th 3Valid USA Signs Contract For Washington Driver's License Issuance 2
... Society for Microbiology (ASM) Abbott Laboratories Award in ... A. Rosenberg, Chief of Surgery, National Cancer Institute, ... Health Sciences, and Professor of Surgery, George Washington ... by Abbott Laboratories Diagnostics Division, this award recognizes ...
... American Society for Microbiology (ASM) Scherago-Rubin Award is ... Laboratory Supervisor, Walter Reed Army Medical Center, Washington, ... microbiologist. Ms. Van Brakle has worked in ... the past 16 years, the past 5 of ...
... in German . The sense of ... is to fish or even mammals. This is the main ... for Ornithology) and her colleagues. The sense of smell in ... Recent behavioural studies have shown that some bird species use ...
Cached Biology News:American Society for Microbiology honors Steven A. Rosenberg 2American Society for Microbiology honors Regina S. Van Brakle 2Do birds have a good sense of smell? 2
(Date:3/4/2015)... N.Y. , March 4, 2015  Brooklyn residents ... their acute and chronic pain and injuries. Nunzio ... announce the grand opening of his NJS Physical Medicine ... on Thursday, March 5, 2015. Health Plus ... facility, which is located at 1178 Flatbush Avenue. This ...
(Date:3/4/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/nqxxt3/biomarkers ) ... report "Biomarkers - Technologies, Markets and Companies" ... report follows the broad definition of a biomarker ... and evaluated as an indicator of normal biological ... to a therapeutic intervention. Tests based on biomarkers ...
(Date:3/4/2015)... 4, 2015 /CNW/ - Resverlogix Corp. (TSX:RVX) (the ... a collaborative research program with Emerald Logic, ... Collective Evolution Technology (FACET), Emerald Logic analyzed ... obtained from each of 798 patients who ... trials ASSERT, SUSTAIN and ASSURE. The objective ...
(Date:3/4/2015)... Irvine, CA (PRWEB) March 04, 2015 ... research leader in Personalized Medicine, is excited to ... “Incorporating Genetic Testing to Optimize the Management of ... be available at Medscape.com for the next year. ... medical professionals how to recognize inadequate pain treatments, ...
Breaking Biology Technology:NJS Physical Medicine & Rehabilitation Opening on Flatbush Avenue, Brooklyn, NY 2Global Biomarkers Report 2014-2024 - Technologies, Markets and Companies 2Global Biomarkers Report 2014-2024 - Technologies, Markets and Companies 3Resverlogix Collaborates with Emerald Logic to Identify Factors Driving Drug Response and Efficacy in Phase 2 Program 2Resverlogix Collaborates with Emerald Logic to Identify Factors Driving Drug Response and Efficacy in Phase 2 Program 3Resverlogix Collaborates with Emerald Logic to Identify Factors Driving Drug Response and Efficacy in Phase 2 Program 4Proove Biosciences Launches CME Accredited Program with Medscape 2Proove Biosciences Launches CME Accredited Program with Medscape 3
... Mass., Sept. 15 Cequent Pharmaceuticals, a,pioneer in ... to prevent and treat human disease, announced that ... agreement with the Novartis Option Fund,and will move ... for inflammatory,bowel disease (IBD) using Cequent,s proprietary TransKingdom ...
... 15 Varian, Inc.,(NasdaqGS: VARI) today announced that ... Vice President and Controller, to a new position, ... Wirtjes,assumes the Treasurer position from G. Edward McClammy, ... Chief Financial Officer., The Board of Directors ...
... SAN MARINO, Calif., Sept. 15 Epeius Biotechnologies,Corporation ... development,for metastatic cancer, has been highlighted in a ... National Cancer Institute (JNCI, Sept. 9,2008). The article, ... approaches in genetic medicine that may succeed where ...
Cached Biology Technology:Cequent Pharmaceuticals Meets Novartis Option Fund Milestone; Continues to Next Phase to Validate Inflammatory Bowel Disease Targets in Vivo 2Varian, Inc. Board of Directors Makes Officer Changes 2Epeius Biotechnologies' Lead Product, Rexin-G for Metastatic Cancer, Aptly Highlighted by National Cancer Institute Journal 2
... thermal cycler with 96 x 0.2 ml ... amplification (PCR) applications. It is equipped with ... samples) that is compatible with optical modules ... and control by algorithm, block, or in-sample ...
... MULTI-FUN Incubator is a compact benchtop ... a microprocessor controller with a large ... and agitation speed. Air circulation inside ... incubator. Temperature can be easily calibrated ...
Anti Autotaxin /ENPP2 , - (Rabbit)...
Mouse polyclonal antibody to TNPO2 - transportin 2 (importin 3, karyopherin beta 2b)...
Biology Products: