Navigation Links
Baumann lab identifies elusive telomere RNA subunit in single cell model
Date:12/27/2007

The Stowers Institutes Baumann Lab has identified the long-sought telomerase RNA gene in a single-cell research model. Their findings have been posted to the Web site of the journal Nature Structural & Molecular Biology and will appear in a future print edition.

Chromosomes shorten with every cell division. In stem cells and in cancer cells, this shortening is compensated by telomerase, an enzyme that adds short repeat sequences to the ends of chromosomes to replenish lost DNA. As telomerase is required for the continued growth of most cancer cells, the enzyme is considered a promising target for new anti-cancer drugs. A correlation between telomere length and a variety of diseases has further intensified interest in understanding telomerase and its regulation.

The RNA subunit of telomerase is of particular interest as it represents one of the two core components of telomerase and provides the template for the short repeats that are added to the ends of chromosomes. The Baumann Lab is working to understand how telomerase is assembled, how it is recruited to chromosome ends, and how its activity is regulated. These efforts may shed light on the sometimes surprising correlations between telomere shortening and stress, smoking, obesity, and a variety of diseases including cancer and coronary heart disease.

Telomerase RNA has been studied in a variety of simple model organisms, but telomere maintenance turned out to be quite different in these species compared to human cells. Recently, the Baumann Lab used a biochemical approach to identify and clone the RNA subunit of telomerase in Schizosaccharomyces pombe, or fission yeast.

The identification of the fission yeast equivalent of the telomerase RNA gene provides us with a critical tool to study telomerase in a genetically tractable, single-cell organism with a telomere maintenance machinery that shares many features with human cells, explained Peter Baumann, Ph.D., Assistant
'/>"/>

Contact: Marie Jennings
mfj@stowers-institute.org
816-926-4015
Stowers Institute for Medical Research
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study identifies warning signs of pregnancy danger
2. Study identifies genetic risk factor for rheumatoid arthritis, lupus
3. Study by Pittsburgh researchers identifies possible vaccine target for chlamydia
4. Breakthrough research identifies how cells from pigs may cure diabetes
5. Smithsonian identifies invasive crab species in Panama Canal expansion area
6. Smithsonian identifies invasive crab species in Panama Canal expansion area
7. New technology identifies warped fingerprints at warp speed
8. Study identifies pathway required for normal reproductive development
9. St. Jude identifies the specific cell that causes eye cancer, disproving long-held theory
10. Stowers Institutes Hawley Lab identifies factors responsible for restart of meiotic cycle
11. Understanding hypertension in African Americans proves elusive
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... , Nov. 19, 2014  Earlier this year ... New York College, and one of the most prolific ... signals that are transmitted from Smartphones to third party ... Smartphones and has one of the earliest known patents ... its usage in the military, child care, elder care ...
(Date:11/21/2014)... , Nov. 20, 2014   Atmel® Corporation ... in microcontroller (MCU) and touch technology solutions, today launched ... sensors with the widest V cc range ... temperature accuracy and faster I 2 C bus communication ... serial EEPROM memory making them ideal for consumer, industrial, ...
(Date:11/18/2014)... -- The Parenteral Drug Association (PDA) today confirmed that seven ... at least seven more will participate in the upcoming 2014 ... in Washington D.C. , Dec. 2-4. ... from the regulatory agencies in the United States ... effort to help advance the use of metrics in the ...
Breaking Biology News(10 mins):Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 2Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 4Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 4FDA's Janet Woodcock, EMA's Emer Cooke Headline PDA Quality Metrics Conference 2
... new mother counts her newborn's fingers and toes, she ... for baby's complete set of 20 digits. , ... fatty substance responsible for clogging arteries, Vanderbilt University Medical ... to an important developmental protein controls the development of ...
... study, the presence of caspase-12, which appears to modulate ... "vulnerability to bacterial infection and septic shock" while a ... suggests that caspase-12 antagonists could be a potentially useful ... immune disorders. , The study was published in ...
... household gelling agent in making jams and jellies, but ... instance, and may have a role in important biological ... disease. , Despite the importance of pectin as a ... have known relatively little about how this family of ...
Cached Biology News:Cholesterol gets 'thumbs up' for role in digit development 2Cholesterol gets 'thumbs up' for role in digit development 3Lack of a key enzyme dramatically increases resistance to sepsis 2Lack of a key enzyme dramatically increases resistance to sepsis 3Discovery of new molecular tools for biosynthesis could lead to advances in use of pectin 2Discovery of new molecular tools for biosynthesis could lead to advances in use of pectin 3
(Date:11/26/2014)... 25 novembre 2014 /PRNewswrie/ -- Theravalues Corporation annuncia con ... europeo in occasione di Hi Europe 2014 (dal 2 ... Si tratta della curcumina con la maggiore biodisponibilità ... cristalli) e ingredienti approvati dalle norme europee. ... della pianta curcumina ( Curcuma longa ) che è ...
(Date:11/24/2014)... Nov. 24, 2014 VolitionRx Limited (OTCQB: ... for cancer and other conditions, today announced that data from ... Science for Business BioWin Day 2014, being held November 26, ... come from VolitionRx,s lung cancer pilot study, the samples for ... Hospitalier Universitaire (CHU) de Liege in Belgium ...
(Date:11/24/2014)... November 24, 2014 2014 Deep ... Industry is a professional and in-depth research report ... Dihydrazide information, like its definition, classification, application, and ... This report covers the international market analysis, including ... as the US, Europe, Asia, China, Japan etc. ...
(Date:11/22/2014)... November 21, 2014 Two new educational webinars ... comes next for ALS research and how the pharmaceutical industry ... the Ice Bucket Challenge: Where Does the ALS Money Go? ... 2 December 2014, Time: 1:30pm ET, Register to ... speaker Dr. Merit Cudkowicz, Julianne Dorn Professor of Neurology at ...
Breaking Biology Technology:La curcumina con la maggiore biodisponibilità di sempre farà il suo debutto in Europa 2La curcumina con la maggiore biodisponibilità di sempre farà il suo debutto in Europa 3VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 2VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 3VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 4VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 5VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 6Adipic Dihydrazide Industry 2019 Research Forecasts on Worldwide, China Regions Now Available at ReportsnReports.com 2Adipic Dihydrazide Industry 2019 Research Forecasts on Worldwide, China Regions Now Available at ReportsnReports.com 3DrugDev Webinars in December to Explore What Comes Next for ALS Research and How We Can Make Life Easier for Clinical Sites 2
... J. Samskog, H. Wadensten, and J. Flensburg , ... , ... brain tissue. The trypsin-digested tissue was separated by strong cation exchange ... detection was performed by mass spectrometry using neutral loss of phosphoric ...
... , ... for potential targets is a major requirement in drug development ... activation, particularly G-protein coupled receptors (GPCRs) (1). , ... orphan GPCRs of potential therapeutic value requiring identification of natural ...
... , ... CypHer ™ 5, a pH sensitive ... CypHer5 has been used to obtain dose-response and rank-order potency ... expressing cells (2). For live-cell receptor internalization studies, an enhanced ...
Cached Biology Technology:Sensitive identification of phosphopeptides in brain tissue using Ettan MDLC and Finnigan LTQ 2Sensitive identification of phosphopeptides in brain tissue using Ettan MDLC and Finnigan LTQ 3Sensitive identification of phosphopeptides in brain tissue using Ettan MDLC and Finnigan LTQ 4Screening for β2-adrenergic receptor agonists using the pH-sensitive dye,CypHer5, and the IN Cell Analyzer 3000 2Screening for β2-adrenergic receptor agonists using the pH-sensitive dye,CypHer5, and the IN Cell Analyzer 3000 3Screening for β2-adrenergic receptor agonists using the pH-sensitive dye,CypHer5, and the IN Cell Analyzer 3000 4Screening for β2-adrenergic receptor agonists using the pH-sensitive dye,CypHer5, and the IN Cell Analyzer 3000 5Screening for β2-adrenergic receptor agonists using the pH-sensitive dye,CypHer5, and the IN Cell Analyzer 3000 6Screening for potential beta 2-adrenergic receptor antagonists using CypHer5E and IN Cell Analyzer 1000 2Screening for potential beta 2-adrenergic receptor antagonists using CypHer5E and IN Cell Analyzer 1000 3Screening for potential beta 2-adrenergic receptor antagonists using CypHer5E and IN Cell Analyzer 1000 4Screening for potential beta 2-adrenergic receptor antagonists using CypHer5E and IN Cell Analyzer 1000 5Screening for potential beta 2-adrenergic receptor antagonists using CypHer5E and IN Cell Analyzer 1000 6