Navigation Links
Bacterial toxins cause deadly heart disease
Date:8/19/2013

University of Iowa researchers have discovered what causes the lethal effects of staphylococcal infective endocarditis - a serious bacterial infection of heart valves that kills approximately 20,000 Americans each year.

According to the UI study, the culprits are superantigens -- toxins produced in large quantities by Staphylococcus aureus (staph) bacteria - which disrupt the immune system, turning it from friend to foe.

"The function of a superantigen is to 'mess' with the immune system," says Patrick Schlievert, Ph.D., UI professor and chair of microbiology at the UI Carver College of Medicine. "Our study shows that in endocarditis, a superantigen is over-activating the immune system, and the excessive immune response is actually contributing very significantly to the destructive aspects of the disease, including capillary leakage, low blood pressure, shock, fever, destruction of the heart valves, and strokes that may occur in half of patients."

Other superantigens include toxic shock syndrome toxin-1, which Schlievert identified in 1981 as the cause of toxic shock syndrome.

Staph bacteria is the most significant cause of serious infectious diseases in the United States, according to the Centers for Disease Control and Prevention (CDC), and infective endocarditis is the most serious complication of staph bloodstream infection. This dangerous condition affects approximately 40,000 people annually and has a death rate of about 50 percent. Among patients who survive the infection, approximately half will have a stroke due to the damage from the aggressive infection of the heart valves.

Despite the serious nature of this disease, little progress has been made over the past several decades in treating the deadly condition.

The new study, led Schlievert, and published Aug. 20 in the online open-access journal mBio, suggests that blocking the action of superantigens might provide a new approach f
'/>"/>

Contact: Jennifer Brown
jennifer-l-brown@uiowa.edu
319-356-7124
University of Iowa Health Care
Source:Eurekalert

Page: 1 2

Related biology news :

1. UC Davis researchers discover molecular target for the bacterial infection brucellosis
2. Newly discovered bacterial partnership changes ocean chemistry
3. Bacterial blockade
4. Study finds depletion of alveolar macrophages linked to bacterial super-infections
5. New methods to visualize bacterial cell-to-cell communication
6. UT study: Chemical in antibacterial soaps may harm nursing babies
7. Spinning up antibacterial silver on glass
8. Bacterial DNA may integrate into human genome more readily in tumor tissue
9. HIV-derived antibacterial shows promise against drug-resistant bacteria
10. Metabolic model of E. coli reveals how bacterial growth responds to temperature change
11. Bacterial security agents go rogue
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... 15, 2014  HITLAB SM announced today ... audit to confirm its adherence to current U.S. ... enables HITLAB to conduct regulated smart device and ... for patient safety and research quality. ... quality, and delivery with innovative technology," said ...
(Date:12/11/2014)... Dec. 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/twhjll/biometrics_market ) has announced the ... APAC Region 2015-2019"  report to their offering. ... market is advances in technology. With continuous advances ... solutions to the latest standard that meets the ...
(Date:12/10/2014)... -- Valencell, a leader in performance biometric data sensor technology, ... its licensees for highly accurate, clinically validated biometric technology. ... from fitness and health sectors, but first responders/military and ... only as useful as the biometric data it delivers. ... long-term mass consumer adoption of wearable products," said Dr. ...
Breaking Biology News(10 mins):HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2Wearable Technology Products Demand Highly Accurate Biometric Technology 2
... Access to Research Careers) Program has announced the travel ... Advanced Course in Immunology at The University of Minnesota ... These awards are meant to promote the entry ... mainstream of the basic science community and to encourage ...
... A deep-sea mystery has been solved with the discovery that ... cod and mackerel, use the same buoyancy control as whales. ... Oceanography , researchers from British Antarctic Survey describe how Southern ... ,hibernates, in the deep ocean during winter when seas are ...
... out of a comic book or a science fiction movie ... two investigators at the Wellman Center for Photomedicine at Massachusetts ... appear in the journal Nature Photonics and is ... Seok Hyun Yun, PhD, describe how a single cell genetically ...
Cached Biology News:Single GFP-expressing cell is basis of living laser device 2Single GFP-expressing cell is basis of living laser device 3
(Date:12/19/2014)... 18, 2014 Relmada Therapeutics, Inc. (OTCQB: RLMD), ... of chronic pain, announced the results of its annual ... was a transformational year in Relmada,s history and it ... company," said Sergio Traversa , chief executive officer ... on key financial, human resource and clinical development objectives ...
(Date:12/17/2014)... December 16, 2014 “Never say, ... Philipps- Universität Marburg’s Department of Physics, advises young ... the newly released SPIE Women in Optics ... too shy to ask questions.” , In the ... and mathematics) occupations ranging from university professor and ...
(Date:12/17/2014)... Long Beach, CA (PRWEB) December 17, 2014 ... Technology, Inc. to provide a larger packaged waste water ... district in King Abdullah Economic City (KAEC). Two years ... for EMAAR’s Jeddah Gate Development, serving two residential towers ... plant capacity is over a quarter million gallons per ...
(Date:12/17/2014)... Gene synthesis and bioengineering company ... into a technology access and services agreement with ... proprietary protein engineering technology, known as “ProteinGPS®” to ... extremely excited that the global leader ADM has ... bioengineering technology has now been validated through many ...
Breaking Biology Technology:Relmada Therapeutics Announces Results of Annual Shareholders Meeting 2Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 2Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 3ADM and DNA2.0 Enter Into Protein Engineering Technology Access and Service Agreement 2
... System (RTLS) Market, ORLANDO, Fla., Feb. 25 ... in precision ultra wideband (UWB),real- time location systems ... (PLUS) product line at the HIMSS08,healthcare conference and ... patented UWB technology, enables RTLS solutions to move ...
... Strativa,Pharmaceuticals, the proprietary products division of a wholly ... PRX ) today,announced that its development partner, Immtech ... discontinue the development program for,pafuramidine maleate, an investigative ... that it had received additional,reports of adverse events ...
... at the upcoming World ... Congress of Anesthesiologists Meeting, IRVINE, Calif., ... Measure-Through Motion and Low Perfusion pulse,oximetry, announced that it ... hemoglobin (SpHb(TM)) and oxygen content,(SpOC(TM)) monitoring at the World ...
Cached Biology Technology:Time Domain Showcases Precision Location Capability of Ultra Wideband PLUS Product Line at HIMSS 2008 2Time Domain Showcases Precision Location Capability of Ultra Wideband PLUS Product Line at HIMSS 2008 3Strativa Pharmaceuticals, a Division of Par Pharmaceutical, Announces the Discontinuation of the Development Program for Pafuramidine 2Strativa Pharmaceuticals, a Division of Par Pharmaceutical, Announces the Discontinuation of the Development Program for Pafuramidine 3Masimo Announces Continuous Noninvasive Total Hemoglobin 2Masimo Announces Continuous Noninvasive Total Hemoglobin 3Masimo Announces Continuous Noninvasive Total Hemoglobin 4