Navigation Links
Bacterial toxins cause deadly heart disease
Date:8/19/2013

University of Iowa researchers have discovered what causes the lethal effects of staphylococcal infective endocarditis - a serious bacterial infection of heart valves that kills approximately 20,000 Americans each year.

According to the UI study, the culprits are superantigens -- toxins produced in large quantities by Staphylococcus aureus (staph) bacteria - which disrupt the immune system, turning it from friend to foe.

"The function of a superantigen is to 'mess' with the immune system," says Patrick Schlievert, Ph.D., UI professor and chair of microbiology at the UI Carver College of Medicine. "Our study shows that in endocarditis, a superantigen is over-activating the immune system, and the excessive immune response is actually contributing very significantly to the destructive aspects of the disease, including capillary leakage, low blood pressure, shock, fever, destruction of the heart valves, and strokes that may occur in half of patients."

Other superantigens include toxic shock syndrome toxin-1, which Schlievert identified in 1981 as the cause of toxic shock syndrome.

Staph bacteria is the most significant cause of serious infectious diseases in the United States, according to the Centers for Disease Control and Prevention (CDC), and infective endocarditis is the most serious complication of staph bloodstream infection. This dangerous condition affects approximately 40,000 people annually and has a death rate of about 50 percent. Among patients who survive the infection, approximately half will have a stroke due to the damage from the aggressive infection of the heart valves.

Despite the serious nature of this disease, little progress has been made over the past several decades in treating the deadly condition.

The new study, led Schlievert, and published Aug. 20 in the online open-access journal mBio, suggests that blocking the action of superantigens might provide a new approach f
'/>"/>

Contact: Jennifer Brown
jennifer-l-brown@uiowa.edu
319-356-7124
University of Iowa Health Care
Source:Eurekalert

Page: 1 2

Related biology news :

1. UC Davis researchers discover molecular target for the bacterial infection brucellosis
2. Newly discovered bacterial partnership changes ocean chemistry
3. Bacterial blockade
4. Study finds depletion of alveolar macrophages linked to bacterial super-infections
5. New methods to visualize bacterial cell-to-cell communication
6. UT study: Chemical in antibacterial soaps may harm nursing babies
7. Spinning up antibacterial silver on glass
8. Bacterial DNA may integrate into human genome more readily in tumor tissue
9. HIV-derived antibacterial shows promise against drug-resistant bacteria
10. Metabolic model of E. coli reveals how bacterial growth responds to temperature change
11. Bacterial security agents go rogue
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2015)... 12, 2015 NXT-ID, Inc. (NASDAQ: ... biometric authentication company focused on the growing mobile commerce ... 62/113114 for DISTRIBUTED METHOD AND SYSTEM TO ... patent further establishes NXT-ID,s position in the emerging "Internet ... the ability for multiple devices to collaborate with one ...
(Date:2/9/2015)... , Feb. 9, 2015  Lintec of America recently ... for carbon nanotube (CNT) macrostructures, including sheets, yarns and ... (UTD). Leveraging the vast industrial resources of ... Japan , Lintec of America is forming the ... TX , focusing on scaling up the manufacturing ...
(Date:2/5/2015)... 26, 2015   Epic Sciences , a precision diagnostics ... that Murali Prahalad , Ph.D., president and CEO, is ... (PMWC) 2015: Silicon Valley, which is taking place at ... on January 26-28, 2015. Dr. ... as Biomarkers." Last year, Epic Sciences was a finalist in ...
Breaking Biology News(10 mins):NXT-ID Patents Collaborative Services to Enable the "Internet of Things" 2NXT-ID Patents Collaborative Services to Enable the "Internet of Things" 3Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 2Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 3Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 4Epic Sciences to Present at Personalized Medicine World Conference 2015 on the Use of Circulating Tumor Cells as Cancer Biomarkers 2
... methods, such like mitochondrial DNA analysis, to differentiate ... a flashy symbol of modern science cleverly exploited ... by laboratory scientists to draw attention of government ... picture painted by these methods may be false, ...
... Scientist Jiř Friml from VIB and Ghent University, both ... Krber European Science Award, worth 750 000 euro. The ... particularly innovative research projects. Friml gets the prize for ... "Friml,s work on the genetic, molecular and cellular ...
... in protecting against cancer given that it prevents cancer-causing ... to the proliferation of tumour cells. UAB lecturer Ignasi ... research team, the study served to discover that this ... activated during the formation process of ova and spermatozoids. ...
Cached Biology News:Molecular methods are not sufficient in systematics and evolution 2Molecular methods are not sufficient in systematics and evolution 3VIB-UGent scientist Jiri Friml receives Koerber European Science Award 2010 2New function discovered in cancer prevention protein 2
(Date:3/4/2015)... 2015 The UPMC Center for Health Security ... the Emerging Leaders in Biosecurity Initiative (ELBI). As part ... field of biosecurity, UPMC has selected 28 US and ... of backgrounds, including biological science, medicine, policy, the military, ... "With the vision and support of the Defense Threat ...
(Date:3/4/2015)... , Mar. 04, 2015 Research and Markets ... addition of the "Global Biologics and Biosimilars ... , The Global Biologics and ... in-depth study on the current state of the ... provides a basic overview of the industry including ...
(Date:3/4/2015)... , March 4, 2015 AcelRx Pharmaceuticals, ... pharmaceutical company focused on the development and commercialization ... and breakthrough pain, today announced that it will ... after market close on Monday, March 9th, 2015. ... at 4:30 p.m. Eastern Time (1:30 p.m. Pacific ...
(Date:3/4/2015)... , March 4, 2015 ... Paris in December 2011, ... of yttrium-90 resin microspheres versus sorafenib in advanced hepatocellular ... expected late 2016.   SARAH, a large ... cancer (hepatocellular carcinoma, or HCC) has completed patient enrolment, ...
Breaking Biology Technology:UPMC Center for Health Security Announces 2015 Emerging Leaders in Biosecurity 2UPMC Center for Health Security Announces 2015 Emerging Leaders in Biosecurity 3Global Biologics and Biosimilars Industry Report 2015-2020 2AcelRx Pharmaceuticals to Hold Annual 2014 Financial Results Conference Call and Webcast on Monday, March 9th, 2015 2AcelRx Pharmaceuticals to Hold Annual 2014 Financial Results Conference Call and Webcast on Monday, March 9th, 2015 3Treatment of Primary Liver Cancer: SARAH Study Completes Enrolment, Results Expected Late 2016 2Treatment of Primary Liver Cancer: SARAH Study Completes Enrolment, Results Expected Late 2016 3Treatment of Primary Liver Cancer: SARAH Study Completes Enrolment, Results Expected Late 2016 4Treatment of Primary Liver Cancer: SARAH Study Completes Enrolment, Results Expected Late 2016 5
... Epeius Biotechnologies,Corporation announced today the issue of ... in vivo. This patent provides additional,intellectual property ... embodied in the company,s leading anti-cancer agent,Rexin-G. ... Epeius,tumor-targeted gene delivery system enables Rexin-G to ...
... physicists have shown that in graphene the intrinsic limit ... material conducts electricity, is higher than any other known ... graphite, is a new material which combines aspects of ... the journal Nature Nanotechnology, indicate that graphene holds great ...
... March 24 Bio Career Center,( http://www.BioCareerCenter.com ), ... life-science professionals, has created a new tool to ... "Bio Skills Select" will allow companies to ... prospective candidates to answer. These,questions will range from ...
Cached Biology Technology:Epeius Biotechnologies Awarded U.S. Patent for Targeted Injectable Gene Delivery In Vivo 2UM physicists show electrons can travel over 100 times faster in graphene than in silicon 2UM physicists show electrons can travel over 100 times faster in graphene than in silicon 3Bio Career Center Develops New Tool to Assist in Employer/Candidate Match 2
... cDNA Labeling System - dCTP with ... For the generation and purification of ... packaged together for complete cDNA labeling ... be used for performing labeling reactions ...
... Post-Labeling Reactive Dye Pack, 12 x ... specifically optimized for microarray labeling.Higher reactivity ... reactive dye per vial, at > ... individually dispensed, and packed in foil ...
... with CyScribe GFX Purification Kit, 24 ... of Cy3- and Cy5-labeled cDNA.Optimized reagents ... labeling and purification.Flexible and optimized protocols ... reactions with either Cy3- or Cy5-labeled ...
... ISO 9001:2000 Certified USDA Research Registered ... SOP's Training AALAS Certified Technicians ... Procedures GLP Documentation Upon Request Focus ... point for all your custom immunology service ...
Biology Products: