Navigation Links
Bacterial reporters that get the scoop
Date:3/17/2014

It's a jungle in there. In the tightly woven ecosystem of the human gut, trillions of bacteria compete with each other on a daily basis while they sense and react to signals from the immune system, ingested food, and other bacteria.

Problems arise when bad gut bugs overtake friendly ones, or when the immune system is thrown off balance, as in Crohn's disease, celiac disease, and colorectal cancer. Doctors have struggled to diagnose these conditions early and accurately. But now a new engineered strain of E. coli bacteria could deliver status updates from this complex landscape to help keep gastrointestinal diseases at bay.

The new strain non-destructively detected and recorded an environmental signal in the mouse gut, and remembered what it "saw." The advance, reported in the Proceedings of the National Academy of Sciences, could lead to a radically new screening tool for human gut health.

The key to turning E. coli into gut reporters was to insert a well-known genetic switch that flips when it senses a specific environmental cue. This switch confers on the cells the ability to "remember" what they sense for up to a week long enough for scientists to recover fecal samples and test whether the switch has flipped.

"This achievement paves the way toward living monitors programmed using synthetic gene circuits," said Wyss Institute Core Faculty member Pamela Silver, Ph.D., senior author on the study who is also the Elliott T. and Onie H. Adams Professor of Biochemistry and Systems Biology at Harvard Medical School (HMS). Silver's team included James Collins, Ph.D., who is also a Wyss Core Faculty member and professor of bioengineering at Boston University, as well as other collaborators from the Wyss Institute, Harvard Medical School and Boston University. "It could lead to new diagnostics for all sorts of complex environments."

The approach Silver's team took runs counter to the prevai
'/>"/>

Contact: Kristen Kusek
kristen.kusek@wyss.harvard.edu
617-432-8266
Wyss Institute for Biologically Inspired Engineering at Harvard
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Spread of antibiotic resistance understood by unravelling bacterial secretion system
2. Bacterial fibers critical to human and avian infection
3. £4 million to tackle spread of bacterial infections
4. Puzzling question in bacterial immune system answered
5. Little but lethal -- small RNAs coordinate bacterial attack on epithelial cells
6. Gut microbes affect MicroRNA response to bacterial infection
7. In surprise finding, blood clots absorb bacterial toxin
8. New method of DNA editing allows synthetic biologists to unlock secrets of a bacterial genome
9. Structure of bacterial nanowire protein hints at secrets of conduction
10. Evidence of 3.5 billion-year-old bacterial ecosystems found in Australia
11. Changing the conversation -- polymers disrupt bacterial communication
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Bacterial reporters that get the scoop
(Date:10/17/2014)... University of Copenhagen have shown for the first time ... Cystic fibrosis patients, giving them the opportunity to get ... infections. , The study also discovered the bacterial growth ... was halted or slowed down by the immune cells. ... oxygen and helped "suffocate" the bacteria, forcing the bacteria ...
(Date:10/16/2014)... synthesis of recent research findings to inform their management ... states. , The Ecology and Management of Moist ... of the Relevant Biophysical Science and Implications for Future ... U.S. Forest Service,s Pacific Northwest Research Station, is a ... synthesis of the large body of scientific information on ...
(Date:10/16/2014)... – Post-menopausal women experienced improvements in vaginal atrophy, ... genital bleeding, after 12 weeks of daily 10 ... germ-based nutritional supplement previously shown to help relieve ... pilot study reported in a poster at the ... , "These data documented improved vaginal epithelium, ...
Breaking Biology News(10 mins):Scientists opens black box on bacterial growth in cystic fibrosis lung infection 2New report synthesizes best available science on management of moist mixed-conifer forests 2S-equol supplements associated with improved measures of reproductive health in postmenopausal women 2
... Feb. 29 /Xinhua-PRNewswire/ -- Futronic Technology Company,Limited, ... hardware products,today announced that the latest version ... and Windows 2008 Server., FinLogon is ... using proprietary fingerprint recognition technology. By a,finger ...
... of impact strata on Mars, Holden Crater; Eocene-Oligocene ... that liquid water is not responsible for recent ... Cretaceous early Albian greenhouse conditions and implications for ... Earth,s copper supply; discovery of large nitrate pools ...
... biochemistry, has received the National Science Foundation,s prestigious ... competitive funding award, designed to support the integrated ... their careers, is bestowed on those scientists and ... leaders of the 21st century. Fewer than 20 ...
Cached Biology News:Futronic Announces Microsoft Vista and Windows 2008 Server Support for Its Fingerprint Logon Software 2March GEOLOGY and GSA TODAY media highlights 2March GEOLOGY and GSA TODAY media highlights 3March GEOLOGY and GSA TODAY media highlights 4March GEOLOGY and GSA TODAY media highlights 5March GEOLOGY and GSA TODAY media highlights 6March GEOLOGY and GSA TODAY media highlights 7March GEOLOGY and GSA TODAY media highlights 8March GEOLOGY and GSA TODAY media highlights 9March GEOLOGY and GSA TODAY media highlights 10March GEOLOGY and GSA TODAY media highlights 11March GEOLOGY and GSA TODAY media highlights 12March GEOLOGY and GSA TODAY media highlights 13March GEOLOGY and GSA TODAY media highlights 14March GEOLOGY and GSA TODAY media highlights 15UD's Bobev receives NSF Early Career Award for research on novel compounds of rare Earth metals 2UD's Bobev receives NSF Early Career Award for research on novel compounds of rare Earth metals 3
(Date:10/22/2014)... 2014 Research and Markets ... DNA Diagnostics Market (Product types, Application, Technology, End ... Company Profiles, Demand, Insights, Analysis, Research, Report, Opportunities, ... to their offering. This new ... end users and Geography) Global Size, Industry Analysis, ...
(Date:10/22/2014)... 2014 The Americas Inorganic Refrigerants ... market in Americas with analysis and forecast of ... Americas Inorganic Refrigerants Market report, to get an ... provides a glimpse of the segmentation in the ... various tables and figures. , http://www.micromarketmonitor.com/market/americas-inorganic-refrigerants-4191654241.html ...
(Date:10/22/2014)... October 21, 2014 Shimadzu Scientific Instruments ... data tool for the pain management and clinical markets. ... processing and review by allowing users to highlight and ... , QuantAnalytics allows analysts to filter results by ... data processing by eliminating the need to sift through ...
(Date:10/22/2014)... 22, 2014 WriteResult, LLC – ... has been working with a team of researchers from ... Farms Community Farming Collaborative to provide electronic questionnaire data ... The study, which started in May, aims to evaluate ... participants weekly exposure to and participation in urban agriculture ...
Breaking Biology Technology:Global DNA Diagnostics Market (Product types, Application, Technology, End User and Geography) - Forecast to 2020 2Global DNA Diagnostics Market (Product types, Application, Technology, End User and Geography) - Forecast to 2020 3The Americas Inorganic Refrigerants Market is estimated to grow to $71.6 million by 2018 - New Report by MicroMarket Monitor 2The Americas Inorganic Refrigerants Market is estimated to grow to $71.6 million by 2018 - New Report by MicroMarket Monitor 3Shimadzu Releases QuantAnalytics Open Access LCMS Software Package for Clinical Applications 2myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 2myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 3
... and Mayo Foundation,for Medical Education and Research announced ... systems biology (CSB(TM)) profiling to,breast cancer patient stratification. ... profile test to improve diagnosis and treatment for ... an exciting research and development,program with Mayo, a ...
... E. Nedwin, Ph.D., MBA to Join Genencor,s Senior ... Genencor, a division of Danisco,A/S, today announced that ... as,Executive Vice President - Technical Enzymes, effective Oct. ... Management Team, Dr. Nedwin will head the,division,s activities ...
... MUNICH, Germany, October 1 - New Product ... - Approval Requested in 28 European Countries DAIICHI ... for,approval of a new antihypertensive medication. It is a ... (ARB),Olmesartan and the calcium antagonist Amlodipin. When approved, ...
Cached Biology Technology:Genencor Appoints New Executive Vice President - Technical Enzymes 2DAIICHI SANKYO EUROPE is Applying for Approval of its New Combination Product of Olmesartan and Amlodipin 2