Navigation Links
BUSM study shows potential of differentiated iPS cells in cell therapy without immune rejection
Date:1/25/2013

BUSM researchers evaluated this matter by taking adult cells from an experimental model and deriving iPS cells from them. They then differentiated the iPS cells into three cell types: neuronal (nerve); hepatocytes (liver); and endothelial (blood vessel lining) cells. These three cell types represent each of the three germ layers present during embryonic development mesoderm, ectoderm and endoderm. Cells from these layers differentiate and ultimately develop into the body's tissue and organ systems. Using experiments to mirror the potential clinical use of patient-specific iPS cells in cell therapy, the team transplanted each of the differentiated cells into a genetically identical experimental model and found no signs of an elevated immune response or indications of rejection.

The study results suggest that using patient-specific iPS cells should overcome issues of immune rejection in transplantation, which will be a significant problem for potential embryonic stem cell-derived therapies. Immune rejection in transplantation is treated clinically by immunosuppressive drugs but they can have serious side-effects, including the risk of developing cancer.

"If the use of immunosuppressive drugs can be avoided, as may be the case for patient-specific iPS cell based therapies, it would be preferable. Our results are very promising and future work should be directed at assessing whether tissues derived from human iPS cells will similarly lack immunogenicity," said Boyd.


'/>"/>

Contact: Jenny Eriksen Leary
jenny.eriksen@bmc.org
617-638-6841
Boston University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. Law that regulates shark fishery is too liberal: UBC study
3. New study will help protect vulnerable birds from impacts of climate change
4. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
5. BYU study: Using a gun in bear encounters doesnt make you safer
6. 15-year study: When it comes to creating wetlands, Mother Nature is in charge
7. Pycnogenol (French maritime pine bark extract) shown to improve menopause symptoms in new study
8. Crystal structure of archael chromatin clarified in new study
9. EU-funded study underlines importance of Congo Basin for global climate and biodiversity
10. University of Houston study shows BP oil spill hurt marshes, but recovery possible
11. Study demonstrates cells can acquire new functions through transcriptional regulatory network
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... 15, 2014  HITLAB SM announced today its completion ... its adherence to current U.S. Food and Drug Administration ... smart device and smart phone application trials utilizing the ... "HITLAB is determined to improve global healthcare access, ...
(Date:12/17/2014)... , Dec. 16, 2014 Research and Markets ... the "Global Chemical Sensor Market 2015-2019" report ... One major trend upcoming in this ... biomedical applications. Chemical sensors help in recording of patient ...
(Date:12/15/2014)... and Markets ( http://www.researchandmarkets.com/research/87pph8/global_facial ) has announced ... 2015-2019" report to their offering. ... a technology used for the identification of individuals. Facial ... person such as nose, jaw edges, mouth, and the ...
Breaking Biology News(10 mins):HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3
... A new study demonstrates that mechanical forces affect ... regeneration and wound healing. The forces diminish or enhance ... they are applied during the healing process. The ... site immediately after healing began disrupted vascular growth into ...
... Salts Emerging as New Recreational Drugs, (#1120069, Wednesday, ... bath salts as recreational drugs has greatly escalated in ... Sciences Center in Oklahoma City, Oklahoma describe an incident ... who also exhibited violent behavior upon his emergency department ...
... MA Exposure in the womb to bisphenol A ... and other consumer goods is associated with behavior ... study led by researchers at Harvard School of Public ... Simon Fraser University in Vancouver, British Columbia. ...
Cached Biology News:Mechanical stress can help or hinder wound healing depending on time of application 2Mechanical stress can help or hinder wound healing depending on time of application 3CHEST 2011: Embargoed studies highlight new lung health research 2CHEST 2011: Embargoed studies highlight new lung health research 3CHEST 2011: Embargoed studies highlight new lung health research 4CHEST 2011: Embargoed studies highlight new lung health research 5CHEST 2011: Embargoed studies highlight new lung health research 6Exposure to chemical BPA before birth linked to behavioral, emotional difficulties in girls 2
(Date:1/22/2015)... Jan. 22, 2015  Transwestern | RBJ today announces the firm ... space for Shire a leading biopharmaceutical company, at Two Ledgemont ... RBJ,s Robert Richards , president, and Brian Cohen ... the entire five-floor building at 95 Hayden Ave. ...
(Date:1/22/2015)... 22, 2015 Protocol Networks brings independent ... team of brand-neutral, independent consultants, Protocol Networks has recently ... that over the years, his company has attracted several ... of Plainfield, as well as others. With the success ...
(Date:1/22/2015)... January 22, 2015 Controlled Substance Compliance ... which helps companies check the legal requirements around using ... to China. , As their international operations expand ... adopting software solutions built as a result of the ...
(Date:1/22/2015)... Calif. , Jan. 22. 2015  Varian Medical Systems (NYSE: ... software, has been honored for its commitment to sustainability with ... companies. Varian is the highest ranked healthcare equipment company among ... today during the World Economic Forum at Davos, ...
Breaking Biology Technology:Transwestern | RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Protocol Networks Brings Independent Technology Consulting to the Constitution State 2Global Compliance Service for Controlled Substances to Expand to China 2Varian Honored Among World's 100 Most Sustainable Corporations 2
... PARIS, September 22, 2011 ,   ... - Presentation of services offered by the ALTEN Group ... acquisition of Calsoft Labs in April 2011. The integration is a ... be presented at the "Broadband World Forum 2011" exhibition at CNIT ...
... New hybrid carbon material, which combines both graphene ... Nanotubes (GNR@SWNTs) have been discovered by researchers from ... nanotubes and graphene materials have attracted enormous interest ... came up with the idea to create a ...
... has closed the nominations for the 2011 Life Science ... 2011, hundreds of scientists on The Science Advisory Board® ... the ballot to determine the recipients of the prestigious ... survey, will be available to fill out between September ...
Cached Biology Technology:ALTEN and Calsoft Labs at the BWF 2011 Exhibition 2New hybrid carbon material discovered 2BioInformatics LLC Announces the Nominees for the 2011 Life Science Industry Awards® 2BioInformatics LLC Announces the Nominees for the 2011 Life Science Industry Awards® 3BioInformatics LLC Announces the Nominees for the 2011 Life Science Industry Awards® 4
...
...
Collected from 8-12 week-old New Zealand or Californian rabbits....
Antibody specific for phosphorylattion of histone H3 that occurs during mitosis. Rabbit polyclonal serum. Antigen: Synthetic peptides derived from histone H3, phosphorylated at serines 10 or 28...
Biology Products: