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BUSM researchers identify molecule that could aid lung cancer detection, treatment
Date:10/25/2013

development of the normal airway cells and suppress lung cancer cell growth. This suggests that miR-4423 plays a major regulatory role in cell fate decisions made by airway epithelial cells during maturation and low levels of miR-4423 contributes to lung cancer development. Interestingly, throughout the body, miR-4423 seems only to be present in high levels in the airway epithelium, suggesting this could be a very specific process occurring only in the lungs.

"Our findings open up the option to study whether returning miR-4423 levels to normal in the airway could help stop cancer growth and potentially be a way to treat lung cancer," said Catalina Perdomo, PhD, a researcher in the division of computational biomedicine at BUSM who is the paper's lead author.

"Interestingly, when we examined the genomes of other species for microRNAs that might function like miR-4423, we did not find anything in non-primates," said Marc Lenburg, PhD, an associate professor in computational medicine and bioinformatics at BUSM who is one the study's senior authors. "It makes us wonder what it is different about lung development in primates and excited that this could be a very specific process to target for lung cancer treatment."


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Contact: Jenny Eriksen Leary
jenny.eriksen@bmc.org
617-638-6841
Boston University Medical Center
Source:Eurekalert

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