Navigation Links
BRG1 mutations confer resistance to hormones in lung cancer
Date:3/15/2012

Retinoic acid (vitamin A) and steroids are hormones found in our body that protect against oxidative stress, reduce inflammation and are involved in cellular differentiation processes. One of the characteristics of tumours is that their cells have lost the ability to differentiate; therefore these hormones have useful properties to prevent cancer. Currently, retinoic acid and steroids are being used to treat some types of leukaemia.

A study led by the research group on Genes and Cancer of the Bellvitge Biomedical Research Institute (IDIBELL) has shown that the loss of BRG1 gene implies a lack of response of cells to these hormones, and therefore the tumour may continue growing. Study results have been published in the journal EMBO Molecular Medicine.

BRG1 gene

The IDIBELL research group on Genes and Cancer led by Montse Sanchez-Cespedes discovered some years ago that the BRG1 gene, a tumour suppressor, is inactivated in non-small cell lung cancer by genetic mutations. "The BRG1 protein is part of a chromatin remodelling complex that regulates the expression of several genes", explains the researcher, "and it is related to the differentiation of lung cells, allowing cells response to certain hormones and environment vitamins like vitamin A or steroids."

When BRG1 is mutated and therefore inactive, tumour cells do not respond to the presence of these hormones and they continue growing and spreading. For this reason, these types of tumours are refractory to the treatment with these substances.

Clinic Application

"At the moment", says Montse Sanchez-Cespedes, "we are not able to restore the functionality of a tumour suppressor gene as BRG1 in patients. Therefore, we are still far from a therapeutic application but this discovery enables us to understand better the biology of tumours. What we will try to do in the immediate future is to look for agents that specifically destroy the cells with
'/>"/>

Contact: Arantxa Mena
comunicacio@idibell.cat
IDIBELL-Bellvitge Biomedical Research Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers discover gene mutations that cause childhood brain cancer
2. Penn biologists discover how silent mutations influence protein production
3. Rapid approach to identify influenza A virus mutations and drug resistance developed
4. Further gene mutations linked to autism risk
5. DNA mutations linked to diabetes
6. Species diversity helps ASU researchers refine analyses of human gene mutations
7. Study of huge numbers of genetic mutations point to oxidative stress as underlying cause
8. Penn biologists explain how organisms can tolerate mutations, yet adapt to environmental change
9. Mutations in different cells cooperate to set the stage for cancer
10. Supplement blocks the initiation of breast cell mutations by estrogens
11. Scripps Research scientists reveal how genetic mutations may cause type 1 diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2015)... PALM BEACH GARDENS, Fla. , March 24, ... of biometric identity management solutions, today announced that ... enabling premium clothing accessory retailer Goorin Bros ... login. The Crossmatch biometrics-based solution secures access to ... customers from the increased risk of data breaches. ...
(Date:3/23/2015)... , March 23, 2015   HOYOS Labs ... management company, today announced that the Company will demonstrate ... both enterprise and consumers at Connect:ID on March 23 ... HOYOS Labs will highlight the IEEE Biometric Open ... ; and enterprise access control system. BOPS was ...
(Date:3/23/2015)... OXFORD, Conn. , Mar. 23, 2015 NXT-ID, Inc. ... authentication company focused on the growing mobile commerce market, announces ... a new advertising campaign on CNBC television starting March 30 ... ads will commence airing in New York ... Executive Officer said: "We are excited about our new ad ...
Breaking Biology News(10 mins):Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 3NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 2NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 3
... much as one-third of global energy consumption. However, unconventional ... CO2 emissions. ETH Zurich Professor for Sociology, Dirk Helbing, ... that could improve vehicular traffic flow by up to ... the ETH Zurich Chair of Sociology, a specialist in ...
... in girls has been found to negatively affect these ... abuse, adolescent pregnancy, and cancers of the reproductive system. ... certain adolescents are at increased risk for early puberty ... strategies for high-risk youths., New research shows that greater ...
... U.S. Department of Homeland,Security (DHS) announced today that in ... a success and accomplished its intended,goals. In its first ... prosecuted 90 of those migrants, and helped reduce the ... waters between Puerto Rico,and the Dominican Republic. "The ...
Cached Biology News:Traffic control systems 2Traffic control systems 3Traffic control systems 4Family conditions may affect when girls experience puberty 2Biometrics Help Identify, Apprehend and Deter Illegal Migrants 2
(Date:4/30/2015)... DIEGO , April 30, 2015  Pfenex ... engaged in the development of biosimilar therapeutics including ... announced the closing of its previously announced underwritten ... stock at a public offering price of $15.50 ... by the underwriters of their option to purchase ...
(Date:4/30/2015)... FRANCE (PRWEB) April 30, 2015 ... and at http://www.lespausa.com , Fleur’s ... multi-action product combining the benefits of makeup, skin ... This subtly tinted cream is designed with specific ... for an even complexion and a healthy glow. ...
(Date:4/30/2015)... Kent, WA (PRWEB) April 30, 2015 ... recently developed ultrafiltration membranes, the PX, PY, ... test coupons, sheets, and disks. Designed to ... applications, these new membranes can fill critical process ... effluent hinder downstream processes. , “New regulations on ...
(Date:4/29/2015)... --  Doximity , the leading online medical network with ... announced a new, instant method for physicians to apply ... click, all US physicians can quickly submit their verified ... open job opportunity, and a recruiter will reach out ... of physicians are open to new jobs, and yet ...
Breaking Biology Technology:Pfenex Inc. Announces Closing of Public Offering of Common Stock and Full Exercise of Underwriters' Option to Purchase Additional Shares 2Fleur’s Introduces CC CRÈME Perfect Skin Solution 2Fleur’s Introduces CC CRÈME Perfect Skin Solution 3Sterlitech Offers New Ultrafiltration Membranes 2Doximity Offering Hospitals Easy, Efficient Physician Application Tool 2
... Wis . - Did the state of Wisconsin improperly apply ... by Menasha Corp. ? , ,The Wisconsin Supreme ... to hear the case, and there is an estimated $350 ... Menasha Corp. , ,At issue is the definition of modified ...
... . - For reasons that may be as innocent as ... that would trade Wisconsin's city-by-city regulation of the cable television ... jobs, help many consumers and speed new technologies to the ... earlier this spring. Since then, however, it has been gathering ...
... Accounting Oversight Board (PCAOB) will place a greater ... numerous studies, including our own, that show IT change ... the investment to fix your change management process because ... compliance program. , ,PCAOB Release number 2006-007, a ...
Cached Biology Technology:In a fast-paced economy, lawmakers must pick up speed 2In a fast-paced economy, lawmakers must pick up speed 3Why IT change management is more important than ever 2Why IT change management is more important than ever 3Why IT change management is more important than ever 4
Human Cystatin A MAb (Clone 224705)...
...
Microlite 2+ Plate, round bottom; an irradiated, high binding surface with enhanced dynamic range, extra high reflectivity and minimal cross talk for low signal luminescent reactions....
... HERAfreeze ultra low temperature freezers ... for safe storage of biological samples ... plus five separate inner doors ensure ... energy costs. ,Application oriented accessories ...
Biology Products: