Navigation Links
BGI reports study results on frequent mutation of genes encoding UMPP components in kidney cancer
Date:12/4/2011

nalyzed ten primary tumors with matched morphologically normal renal tissues utilizing the whole exome sequencing approach on BGI's sequencing platform. The mutation prevalence was estimated by screen of ~1,100 genes with somatic mutations or that have been causally implicated in cancers in 88 additional ccRCCs for prevalence screen.

There were 23 significantly mutated genes identified in the 98 ccRCCs, including the five well-known renal cancer genes such as VHL and TP53, and genes involved in chromatin modification such as PBRM1, JARID1C and SETD2. "We have identified 12 genes which were previously unknown to be involved in ccRCC, including two tumor suppressor genes, BAP1 and TSC1. Integration of previous studies and our findings suggest that some of the genes may play important roles in ccRCC genesis," said Guo.

In addition to the attempt to identify all mutated genes associated with ccRCC, researchers also focused on specific genes, pathways and mechanisms that potentially play a key role in ccRCC tumorgenesis and warrant exploration as potential targets for treatments. One of the targets was mutations in VHL gene that were commonly suggested to be involved in ccRCC genesis in many previous genetic studies with reported prevalence ranging between 50% and 80%. Interestingly, researchers have found a much lower prevalence of 27% in this study. VHL promoter hypermethylation was only found in 6% of the tumors relative to their matched normal samples, also suggesting a lower prevalence of epigenetic VHL alternation, according to the researchers.

Although the alteration of VHL gene is widely known for its association with kidney cancer, researchers also revealed the frequent mutation of UMPP linked to ccRCC in this study and have sequenced all 135 genes in UMPP in the prevalence screen. A significantly high mutation frequency of UMPP was found in the 98 carcinoma samples. The pathway analysis suggested that alternation of UMPP could potent
'/>"/>

Contact: Jia Liu
liujia@genomics.cn
BGI Shenzhen
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Genetic Engineering & Biotechnology News reports on growing role of molecular diagnostics
2. GEN reports on novel tools for deciphering biological networks
3. Synaptics Reports Record Results for First Quarter of Fiscal 2009
4. Communication Intelligence Corporation Reports Third Quarter 2008 Financial Results
5. Orchid Cellmark Reports Third Quarter 2008 Financial Results
6. Genetic Engineering & Biotechnology News reports on the trend toward predictive toxicogenomics
7. GEN reports growing focus on PI3-kinase pathway in cancer research
8. Cytori reports benefit of adipose-derived regenerative cells in spinal disc model
9. GEN reports on growing reliance on microfluidics technology
10. GEN reports on strategies to overcome blood-brain barrier
11. Aware, Inc. Reports Fourth Quarter and 2008 Financial Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... Reportlinker.com announces that a new market ... Law Enforcement Biometrics Market in North America ... About Biometrics Biometrics is a technology that ... their physical or behavioral patterns. It involves the ... as fingerprints, face recognition, DNA, palm print, hand ...
(Date:8/27/2014)... new skill is easier when it is related to ... pianist might learn a new melody more easily than ... engineers from the Center for the Neural Basis of ... and Carnegie Mellon Universityhave discovered a fundamental constraint in ... as the cover story in the Aug. 28, 2014, ...
(Date:8/27/2014)... risk to Europe based upon a proxy for impact ... a ,big data, approach to scientific research. , The ... Health ranked the top 100 pathogens affecting humans and ... which, they believe, will help governments across the continent ... diseases, including as a result of climate change, and ...
Breaking Biology News(10 mins):Law Enforcement Biometrics Market in North America 2014-2018 2Law Enforcement Biometrics Market in North America 2014-2018 3Law Enforcement Biometrics Market in North America 2014-2018 4Law Enforcement Biometrics Market in North America 2014-2018 5Pitt and Carnegie Mellon engineers discover why learning can be difficult 2Pitt and Carnegie Mellon engineers discover why learning can be difficult 3Big data approach identifies Europe's most dangerous human and domestic animal pathogens 2
... researchers in Switzerland has published a study appearing in the ... that shows how the cornea uses stem cells to ... everyday wear and tear on the cornea is repaired from ... serious repair jobs require the involvement of other stem cells ...
... (NorthShore) and Northwestern University have discovered that fiber optic ... blood levels in the colonic lining (mucosa) in humans, ... cancer. The study appears in the October ... of the American Gastroenterological Association (AGA) Institute. ...
... is a primary concern for agricultural producers in the United ... effort to maintain a profitable crop output. , ... while it is known that using nitrogen fertilizers can increase ... following cash crops have been unknown. Researchers found ...
Cached Biology News:The role of stem cells in renewing the cornea 2Breakthrough optical technology to assess colon cancer risk, accuracy 2Breakthrough optical technology to assess colon cancer risk, accuracy 3Nitrogen applied 2
(Date:8/27/2014)...   MSC , a healthcare performance improvement company ... appointment of Mary Beth Loesch to President ... experience preparing companies for rapid growth and market expansion, ... of Corporate Development and Healthcare. In that role, she ... well as corporate strategy and marketing. Previously, Loesch served ...
(Date:8/27/2014)... , Aug. 27, 2014  Lisa Kulik saw ... this July 4 holiday, thanks to a groundbreaking retinal ... an internationally renowned clinician-researcher at the University of Southern ... 55-year-old Peoria, Ariz. resident who ... its victims of sight. On June 2, she became ...
(Date:8/27/2014)... Flagship Biosciences LLC, a leading provider of ... medical device industries, has announced a laboratory and office ... consolidated its histology and tissue analysis operations from separate ... north of Denver. The new addresses are: , ... 100, Westminster, CO 80021 , Tissue Image Analysis Lab, ...
(Date:8/27/2014)... Beach County, Florida (PRWEB) August 27, 2014 ... Company Inc. (SCI) is announcing the creation of ... priority is to take the SCI’s philosophy of ... the company’s research and development actions are based ... , This new Scientific Advisory Board provides a ...
Breaking Biology Technology:MSC names Mary Beth Loesch President and CEO 2USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 2USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 3USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 4USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 5Flagship Biosciences Announces Relocation and Expansion 2New Sancilio & Company, Inc. Scientific Board 2New Sancilio & Company, Inc. Scientific Board 3
... HARBIN, China , May 27 ... One Medical" or "the Company") (Nasdaq: CSKI ... drugs in, the People,s Republic of China ... ("Tian Long") subsidiary successfully obtained renewal,of its Good ...
... May 27 Pfizer Inc. (NYSE: PFE ) ... early on the recommendations of the trial,s independent Executive Steering Committee ... Data Safety Monitoring Committee (DSMC) of the EMPHASIS-HF trial confirming the ... protocol pre-defined stopping rules. , ...
... D. Seidel, assistant professor of aerospace engineering in the ... Ralph E. Powe Junior Faculty Enhancement Award to support ... monitoring sensors to improve the resiliency of huge wind ... research at Oak Ridge Associated Universities (ORAU) member institutions. ...
Cached Biology Technology:China Sky One Medical Receives GMP Re-Certification 2China Sky One Medical Receives GMP Re-Certification 3Pfizer Announces EMPHASIS-HF Trial to Halt Recruitment due to Significant Benefit Observed in Patients Treated With Inspra® (Eplerenone) 2Pfizer Announces EMPHASIS-HF Trial to Halt Recruitment due to Significant Benefit Observed in Patients Treated With Inspra® (Eplerenone) 3Pfizer Announces EMPHASIS-HF Trial to Halt Recruitment due to Significant Benefit Observed in Patients Treated With Inspra® (Eplerenone) 4Pfizer Announces EMPHASIS-HF Trial to Halt Recruitment due to Significant Benefit Observed in Patients Treated With Inspra® (Eplerenone) 5Powe Award supports development of nanocomposites to monitor wind turbine blade structure 2
Contains L-glutamine...
... Anti-PRK2 MW 140kDa ... Immunogen Peptide spanning amino acids 926-941 ... immunoaffinity purified Quality Assurance ... lysates from HeLa cells. Stability ...
...
Replacement Parts for Electrophoresis Apparatus...
Biology Products: