Navigation Links
BGI reports study results on frequent mutation of genes encoding UMPP components in kidney cancer
Date:12/4/2011

December 4th, 2011, Cambridge, MA and Shenzhen, China BGI, the world's largest genomics organization, announced that a study on frequent mutation of genes encoding ubiquitin-mediated proteolysis pathway (UMPP) components in clear cell renal cell carcinoma (ccRCC) is published online today in Nature Genetics. In addition to BGI, co-leaders of the study included Peking University Shenzhen Hospital, Shenzhen Second People's Hospital, among others. The study reveals that alteration of UMPP may contribute to ccRCC by activation of the hypoxia regulatory network, providing new clues to trace the key molecular mechanisms and pathways that underlie the tumorigenesis and progression of ccRCC.

Clear cell renal cell carcinoma (ccRCC) is the most common and aggressive type of kidney cancer, with 102,000 deaths worldwide each year. It is characterized by high metastatic potential and poor prognosis. Up to 40% of patients have disease recurrence after nephrectomy. In this study, the research team specifically looked at alterations in ubiquitin-mediated proteolysis pathway and studied its potential impacts linked to ccRCC tumorigenesis. The UMPP has been reported to be associated with many diseases including cancer and plays a critical role in the protein metabolism as a major pathway for protein degradation in cells.

"Adding to the previous research effort of transitional cell carcinoma in bladder cancer published in Nature Genetics earlier this year, we and our partners continued our study of strongly aggressive ccRCC tumors to identify the mutated genes associated with the process of tumorigenesis," said Guangwu Guo, one of the co-leading authors of the study and PI of this project at BGI. "The new discoveries in this study led us to a remarkable step in our understanding of the genetic landscape of ccRCCs and toward potential treatment against this aggressive tumor."

To gain a deep insight into the genetic basis of ccRCC, researchers a
'/>"/>

Contact: Jia Liu
liujia@genomics.cn
BGI Shenzhen
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Genetic Engineering & Biotechnology News reports on growing role of molecular diagnostics
2. GEN reports on novel tools for deciphering biological networks
3. Synaptics Reports Record Results for First Quarter of Fiscal 2009
4. Communication Intelligence Corporation Reports Third Quarter 2008 Financial Results
5. Orchid Cellmark Reports Third Quarter 2008 Financial Results
6. Genetic Engineering & Biotechnology News reports on the trend toward predictive toxicogenomics
7. GEN reports growing focus on PI3-kinase pathway in cancer research
8. Cytori reports benefit of adipose-derived regenerative cells in spinal disc model
9. GEN reports on growing reliance on microfluidics technology
10. GEN reports on strategies to overcome blood-brain barrier
11. Aware, Inc. Reports Fourth Quarter and 2008 Financial Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/22/2014)... University of Massachusetts Amherst and the Instituto Nacional de ... they have discovered a new genus and species of ... in the Amazonia State of Brazil. , Professor Cristina ... Jos Antnio Alves-Gomes of INPA, describe the new bluntnose ... Proceedings of the Natural Sciences of Philadelphia . ...
(Date:4/22/2014)... Biology (FASEB) has released updated factsheets for ... National Institutes of Health (NIH) benefits each of the ... to make these factsheets available to help citizens and ... said FASEB President, Margaret K. Offermann, MD, PhD. NIH ... funding, investing $29.2 billion in FY 2013 in medical ...
(Date:4/22/2014)... crystal structure as a mineral first found in the ... charts faster than almost anything researchers have seen beforeand ... of using sunlight to generate electricity may be in ... National Renewable Energy Laboratory (NREL) are analyzing the new ... broad spectrum of expertise to uncover the secrets and ...
Breaking Biology News(10 mins):New electric fish genus and species discovered in Brazil's Rio Negro 2NREL unlocking secrets of new solar material 2NREL unlocking secrets of new solar material 3NREL unlocking secrets of new solar material 4NREL unlocking secrets of new solar material 5NREL unlocking secrets of new solar material 6
... , , NEW YORK, Sept. ... available in its catalogue. , , ... http://www.reportlinker.com/p0119500/World-Dynamic-Signature-Verification-Market.html , , This report ... The market for Dynamic signature verification (DSV) is analyzed - 1) ...
... , REDWOOD CITY, Calif., Sept. 15 DigitalPersona, ... that NCR Corporation is now offering DigitalPersona,s U.are.U 4500HD ... point-of-sale (POS) workstation, the NCR RealPOS 70XRT . , ... the top of the NCR RealPOS 70 XRT touchscreen, enables ...
... CHICAGO The Field Museum announced today that it has ... Albert II of Monaco Foundation for a three-year project: Establishing ... of rapid biological inventories by The Field Museum,s Environment, Culture, ... 12 vast landscapes in Ecuador, Peru, and Bolivia. Eight of ...
Cached Biology News:Reportlinker Adds World Dynamic Signature Verification Market Report 2Reportlinker Adds World Dynamic Signature Verification Market Report 3Reportlinker Adds World Dynamic Signature Verification Market Report 4Reportlinker Adds World Dynamic Signature Verification Market Report 5Reportlinker Adds World Dynamic Signature Verification Market Report 6Reportlinker Adds World Dynamic Signature Verification Market Report 7Reportlinker Adds World Dynamic Signature Verification Market Report 8Reportlinker Adds World Dynamic Signature Verification Market Report 9NCR Embeds DigitalPersona U.are.U(R) 4500HD Fingerprint Sensor in New NCR RealPOS(TM) 70XRT Point-of-Sale Workstations 2Prince Albert II of Monaco Foundation helps fund Field Museum conservation efforts in Peru 2
(Date:1/15/2014)... California , January 15, 2014 Oxford ... today announced the appointment of Thomas C Reynolds MD, PhD ... years, development experience gained in the biotechnology industry, most recently ... am delighted to welcome Tom at this transformative time for ...
(Date:1/15/2014)... 2014 Two champions of science, technology, ... of an annual competition for middle and high school ... innovative STEM study. The competition presents students with real-world ... Engineering Aptitude, Mathematics, and Sciences is a program ...
(Date:1/15/2014)... AudioNotch is the internet's leading provider of Notched ... tinnitus. Patients listen to sound therapy that is tailor-made ... weeks to months, their tinnitus volume decreases. , AudioNotch has ... and Notched White Noise. Now, AudioNotch is pleased to announce ...
(Date:1/14/2014)... a leading provider of strategic communications services to corporations and organizations ... the United States and Europe ... is returning to the firm,s Washington, D.C. ... than two years of service as Associate Commissioner for the Office ...
Breaking Biology Technology:Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5Former FDA Associate Commissioner Returns To 3D Communications 2
... LONDON, May 4 The Healthcare Group at ... announce its 2009 Quarterly Analyst Briefing Presentation on ... be held on Wednesday, 6th May 2009, at ... traditionally dominated by small molecule drugs, is currently ...
... the first three DFG Research Centres will again be ... decision was made by the Joint Committee of the ... session in Bonn. As a result, the Research Centres ... Bremen, "The Center for Functional Nanostructures" in Karlsruhe, and ...
... May 1 Fincor (Pink Sheets: FINC) ... PRPG) , a leading company in the field of water ... Dengue fever treatment. Fincor also acquired the WETTECH and Advanced ... Inc., which combines several natural drugs to fight Malaria and ...
Cached Biology Technology:The Global Active Pharmaceutical Ingredients (API) Market: A Frost & Sullivan Briefing on Changing Dynamics 2The Global Active Pharmaceutical Ingredients (API) Market: A Frost & Sullivan Briefing on Changing Dynamics 3The first DFG research centers to be funded for another 4 years 2The first DFG research centers to be funded for another 4 years 3The first DFG research centers to be funded for another 4 years 4Fincor (FINC) Makes a Share Transfer and Enters the Market With ACTRx a New Malaria and Dengue Fever Treatment 2
Human peripheral blood PBMCs, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood PBMC and T Cells...
Cord blood endothelial progenitor cells, For immunohistochemistry (IHC) Cell Chip with Human Umbilical Cord Blood Progenitor Cells...
Human plasmacytoid dendritic cells, BDCA-4+, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Dendritic Cells and EPCs...
Umbilical cord blood CD19+ B cells, For immunohistochemistry (IHC) Cell Chip with Human Umbilical Cord Blood Monocytes, B Cells and NK Cells...
Biology Products: