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BGI reports pig parasite's genomic sequence provides new clues for parasitic diseases research
Date:10/28/2011

itic and free-living roundworms to understand the parasitism-related genetic factors of A. suum and its closely related species A. lumbricoides which causes human infections. In particular, many molecules and proteins identified have seemed to be involved in the invasion of host tissue and regulation with the host immune system. They predicted the secretome of A. suum to comprise 775 proteins with diverse functions and found the A. suum secretome (about 750 molecules) is rich in peptidases linked to the penetration and degradation of host tissues. Some members of the A. suum secretome may play an important role in host-tissue degradation and others are predicted to direct or evade immune responses.

"We also identified a number of potential drug targets. Notably, in the A. suum gene set, we found a homologue (acr-23) of the C. elegans monepantel receptor, suggesting that this drug may kill A. suum. By sequencing A. suum genome, we identified abundant key information to better understand the molecular biology of A. suum and the exquisite complexities of the hostparasite interactions on an immunobiological level. We believe our work will pave the way for the future Parasitic Diseases Research." said Liu.

"Each year, ascariasis affects billions of people and animals worldwide, so it is now crucial to understand its pathogenic mechanism by genomic and post-genomic approaches. In this study, we have more interesting findings, which can provide new hope for the discovery of intervention strategies, with major implications for improving global health." said Bo Li, the co-leading author of the study and Leader of Comparative Genomics Group.


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Contact: Jia Liu
liujia@genomics.cn
BGI Shenzhen
Source:Eurekalert

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