Navigation Links
Avian flu becoming more resistant to antiviral drugs, says University of Colorado study
Date:1/7/2009

A new University of Colorado at Boulder study shows the resistance of the avian flu virus to a major class of antiviral drugs is increasing through positive evolutionary selection, with researchers documenting the trend in more than 30 percent of the samples tested.

The avian flu, an Influenza A subtype dubbed H5N1, is evolving a resistance to a group of antiviral drugs known as adamantanes, one of two classes of antiviral drugs used to prevent and treat flu symptoms, said CU-Boulder doctoral student Andrew Hill, lead study author. The rise of resistance to adamantanes -- which include the nonprescription drugs amantadine and rimantadane -- appears to be linked to Chinese farmers adding the drugs to chicken feed as a flu preventative, according to a 2008 paper by researchers from China Agricultural University, said Hill.

In contrast, resistance of the avian flu virus to the second, newer class of antiviral drugs that includes oseltamivir -- a prescription drug marketed under the brand name Tamiflu -- is present, but is not yet prevalent or under positive genetic selection, said Hill of CU-Boulder's ecology and evolutionary biology department. The CU findings should help health administrators around the world plan for the possibility of an avian flu pandemic.

The CU-Boulder study is the first to show H5N1 drug resistance to adamantanes arose through novel genetic mutations rather than an exchange of RNA segments within cells, a process known as re-assortment, said Hill. The research on the mutations, combined with molecular evolution tests and a geographic visualization technique using Google Earth, "provides a framework for analysis of globally distributed data to monitor the evolution of drug resistance," said Hill.

The CU-Boulder-led study appears online in the journal Infection, Genetics and Evolution. Co-authors included CU-Boulder Associate Professor Robert Guralnick, recent CU-Boulder graduate Meredith Wilson, Farhat Habib of Kansas State University and Daniel Janies of Ohio State University.

"As these adamantanes have gotten into nonhuman vectors like birds, the positive selection for resistance to avian flu is rising," said Hill. "If Tamiflu is ever used in the manner of adamantanes, we could conceivably see a similar resistance developing through positive selection."

The research team used an interactive "supermap" using Google Earth technology that portrays the individual gene mutations and spread of the avian flu around the globe, said Guralnick of CU-Boulder's ecology and evolutionary biology department. By projecting genetic and geographic information onto the interactive globe, users can "fly" around the planet to see where resistant H5N1 strains are occurring, said Guralnick, also Hill's doctoral adviser.

For the study, the researchers analyzed 676 whole genomes of Influenza A/H5N1 from National Institutes of Health databases of viruses isolated between 1996 and 2007. The team is comparing how often amino acid sequence changes in genes lead to mutations that affect drug resistance in the H5N1 virus and how often such changes evolve into random mutations that don't affect resistance, Hill said.

The next step is to analyze 2008 data, he said.

First detected in China in 1996, the avian flu has spread throughout Asia and to India, Russia, Pakistan, the Middle East, Africa and Europe by various carriers, including poultry and migratory waterfowl, Hill said. While H5N1 is not highly communicable to humans from birds or between humans, experts are concerned future evolution of this subtype or other subtypes, or genetic re-assortment between subtypes, could make an avian influenza strain more contagious with the potential to cause a pandemic.

"Even if H5N1 is not the flu subtype that develops into the next pandemic, this technique can help us understand the properties of flu viruses and we can use these methods to track mutations in other viruses," said Guralnick. "We can harvest genetic influenza data and monitor it in near real-time, which should give this project some traction to help governments make decisions on managing potential pandemics."

Like the legend of a road map, colors and symbols on the supermap indicate which types of hosts carry the virus or the distribution of genotypes of interest, said Hill. A click by users on viral "isolates" generates computer windows revealing H5N1 mutations linked to positive genetic selection resulting from the spread and use of adamantanes.


'/>"/>

Contact: Andrew Hill
andrew.hill@colorado.edu
303-735-0441
University of Colorado at Boulder
Source:Eurekalert  

Related biology news :

1. Protein tubules free avian flu virus from immune recognition
2. Genetic evidence for avian influenza movement from Asia to North America via wild birds
3. Avian flu threat: New approach needed
4. New research refutes myth of pure Scandinavian race
5. Solving an avian scourge could also provide benefits to human health
6. Avian origins: new analysis confirms ancient beginnings
7. MIT finds key to avian flu in humans
8. Smiths Detection to launch a portable diagnostic system for foot-and-mouth disease and avian flu
9. New field-deployable biosensor detects avian influenza virus in minutes instead of days
10. Scientists demonstrate feasibility of preventing malaria parasite from becoming sexually mature
11. Mountain summits in the Alps becoming increasingly similar
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Avian flu becoming more resistant to antiviral drugs, says University of Colorado study
(Date:3/21/2016)... , March 22, 2016 ... recognition with passcodes for superior security   ... a leading provider of secure digital communications services, today ... biometric technology and offer enterprise customers, particularly those in ... facial recognition and voice authentication within a mobile app, ...
(Date:3/17/2016)... LONDON , March 17, 2016 ... market intelligence, forecasts the global biometrics market will ... an impressive 118% increase from 2015. Consumer electronics, ... with embedded fingerprint sensors anticipated to reach two ... Dimitrios Pavlakis , Research Analyst ...
(Date:3/15/2016)... Yissum Research Development Company of the ... the Hebrew University, announced today the formation of ... various human biological indicators. Neteera Technologies has completed its ... investors. ... electromagnetic emissions from sweat ducts, enables reliable and speedy ...
Breaking Biology News(10 mins):
(Date:5/31/2016)... ... May 31, 2016 , ... Cubresa Inc. , ... that their compact PET scanner called NuPET™ for simultaneous preclinical PET ... University of Arizona (UA). , PET and MRI are complementary imaging methods for ...
(Date:5/27/2016)... ... May 27, 2016 , ... NeuMedics Inc. is pleased to announce that ... Innovation Northwest on June 2, 2016. The session begins at 1:10 PM and Iain ... can be successfully used as a topical agent and a treatment for ophthalmic complications ...
(Date:5/27/2016)... ... 27, 2016 , ... PBI-Gordon Corporation is pleased to announce Dave Loecke has ... 15-year career with PBI-Gordon, Dave has served in a wide variety of roles. His ... development and launch of many of PBI-Gordon’s most successful products. , “Dave has been ...
(Date:5/27/2016)... ISELIN, New Jersey and ... 2016 Indegene ( ... kommerziellen und marketingorientierten Lösungen für die Life-Science-Branche, ... ), ein bekannter weltweiter Anbieter von innovativen ... im Zuge des Starts von IntraScience heute ...
Breaking Biology Technology: