Navigation Links
Avian flu becoming more resistant to antiviral drugs, says University of Colorado study
Date:1/7/2009

A new University of Colorado at Boulder study shows the resistance of the avian flu virus to a major class of antiviral drugs is increasing through positive evolutionary selection, with researchers documenting the trend in more than 30 percent of the samples tested.

The avian flu, an Influenza A subtype dubbed H5N1, is evolving a resistance to a group of antiviral drugs known as adamantanes, one of two classes of antiviral drugs used to prevent and treat flu symptoms, said CU-Boulder doctoral student Andrew Hill, lead study author. The rise of resistance to adamantanes -- which include the nonprescription drugs amantadine and rimantadane -- appears to be linked to Chinese farmers adding the drugs to chicken feed as a flu preventative, according to a 2008 paper by researchers from China Agricultural University, said Hill.

In contrast, resistance of the avian flu virus to the second, newer class of antiviral drugs that includes oseltamivir -- a prescription drug marketed under the brand name Tamiflu -- is present, but is not yet prevalent or under positive genetic selection, said Hill of CU-Boulder's ecology and evolutionary biology department. The CU findings should help health administrators around the world plan for the possibility of an avian flu pandemic.

The CU-Boulder study is the first to show H5N1 drug resistance to adamantanes arose through novel genetic mutations rather than an exchange of RNA segments within cells, a process known as re-assortment, said Hill. The research on the mutations, combined with molecular evolution tests and a geographic visualization technique using Google Earth, "provides a framework for analysis of globally distributed data to monitor the evolution of drug resistance," said Hill.

The CU-Boulder-led study appears online in the journal Infection, Genetics and Evolution. Co-authors included CU-Boulder Associate Professor Robert Guralnick, recent CU-Boulder graduate Meredith Wils
'/>"/>

Contact: Andrew Hill
andrew.hill@colorado.edu
303-735-0441
University of Colorado at Boulder
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Protein tubules free avian flu virus from immune recognition
2. Genetic evidence for avian influenza movement from Asia to North America via wild birds
3. Avian flu threat: New approach needed
4. New research refutes myth of pure Scandinavian race
5. Solving an avian scourge could also provide benefits to human health
6. Avian origins: new analysis confirms ancient beginnings
7. MIT finds key to avian flu in humans
8. Smiths Detection to launch a portable diagnostic system for foot-and-mouth disease and avian flu
9. New field-deployable biosensor detects avian influenza virus in minutes instead of days
10. Scientists demonstrate feasibility of preventing malaria parasite from becoming sexually mature
11. Mountain summits in the Alps becoming increasingly similar
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Avian flu becoming more resistant to antiviral drugs, says University of Colorado study
(Date:8/4/2015)... 04, 2015 ... announced the addition of the "Digital ... Service), Sub-Segment (Computer Forensics, Network Forensics, Mobile ... Service, Vertical and Region - Global Forecast ... By Component (Hardware, Software, and ...
(Date:7/31/2015)... , 31 de julho de 2015 ... www.icg-10.org ) será realizada pela BGI de 22-25 de ... . A conferência está celebrando seu 10 ... 2006, a ICG se tornou uma das reuniões mais ... dos encontros científicos mais dinâmicos, entusiastas e prazerosos. ...
(Date:7/31/2015)... The 10 th International Conference on Genomics ... 22-25, 2015, in Shenzhen , ... 10 th anniversary this year. Since its inauguration in ... annual meetings in the ,omics, fields, and is one of ... ICG-10 focuses on recent breakthroughs and advances in ,omics, ...
Breaking Biology News(10 mins):Digital Forensics Market - The Market Represents a Compound Annual Growth Rate (CAGR) of 11.3% From 2015 to 2020 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 3The 10th International Conference on Genomics (ICG-10) to Open in October 2
... A team of biologists from UC San Diego, the Salk ... the genes that enable plants to undergo bursts of rhythmic ... leaves are shaded by other plants. The researchers report ... that these genes control the complex interplay of plant ...
... as a biofuels source has a much longer growing ... secret of its success. Their findings offer a promising ... significantly boost per-acre yields. The new study, from ... Plant Physiology Preview . Miscanthus x giganteus ...
... of glowing red. Research published today in BMC ... red light. Due to absorption of ,red, wavelengths ... normal conditions appear grey or black at depths below ... biologists that red colours are of no importance to ...
Cached Biology News:Biologists identify genes controlling rhythmic plant growth 2Biologists identify genes controlling rhythmic plant growth 3Biologists identify genes controlling rhythmic plant growth 4Giant grass offers clues to growing corn in cooler climes, researchers report 2
(Date:8/27/2015)... MENLO PARK, Calif. , Aug. 27, 2015 /PRNewswire/ ... company in the emerging field of regenerative medicine, today ... two investor conferences in the month of September.  ... Officer, will present at Rodman & Renshaw,s 17th Annual ... 10:25am ET/7:25am PT at the St. Regis Hotel in ...
(Date:8/27/2015)... YORK , August 27, 2015 ... enhancing image processing functions in the human vision system, announced ... point guard Chris Paul to develop ... players who want to improve their real-life on-court performance. ... the court, whether it is shooting a ball or blocking ...
(Date:8/27/2015)... PARK, N.C. , Aug. 27, 2015 /PRNewswire/ ... the decision by FedEx, UPS and The US ... certain biological specimens classified as ,select agents, by ... long history of handling these sensitive shipments. ... of global transportation regulations, trained and certified personnel ...
(Date:8/26/2015)... - iCo Therapeutics ("iCo" or "the Company") (TSX-V: ICO) ... quarter ended June 30, 2015. Amounts, unless specified ... under International Financial Reporting Standards ("IFRS"). ... Oral Amp B program, rapidly advancing towards the ... Rae , President & CEO of iCo Therapeutics. "We ...
Breaking Biology Technology:Asterias Biotherapeutics to Present at Upcoming Investor Conferences 2Eight-Time All-Star Chris Paul and GlassesOff Partner to Develop Innovative Mobile App Designed to Improve On-Court Performance 2Eight-Time All-Star Chris Paul and GlassesOff Partner to Develop Innovative Mobile App Designed to Improve On-Court Performance 3Marken Ensures Safe Transportation Of Select Agents And Toxins 2iCo Therapeutics Announces Second Quarter 2015 Financial Results 2iCo Therapeutics Announces Second Quarter 2015 Financial Results 3
... is the industry standard microarray image analysis ... imaging and analysis tools, visualizations, automation capabilities, ... is included with every GenePix scanner, and ... scanners and all types of arrays. A ...
... is the ideal instrument for budget-conscious labs that ... applications. Get Applied Biosystems proven PCR ... lab space without sacrificing results. Enhance ... Technology You Can Afford The Applied ...
... synthesis with a wide variety of purity levels, ... needs. Purity: IG(>50%), >70%, >80% ... Sequence Length: Up to 120 residues ... phosphorylation, D-amino acids, MAPs, KLH/BSA conjugation, and much ...
... The AquaMax DW4 liquid handling system from ... washing all in one instrument. The system ... dispensing and plate washing96-, 384- and 1536-welland ... washing. AquaMax DW4 has been optimized to ...
Biology Products: