Navigation Links
Avian flu becoming more resistant to antiviral drugs, says University of Colorado study
Date:1/7/2009

A new University of Colorado at Boulder study shows the resistance of the avian flu virus to a major class of antiviral drugs is increasing through positive evolutionary selection, with researchers documenting the trend in more than 30 percent of the samples tested.

The avian flu, an Influenza A subtype dubbed H5N1, is evolving a resistance to a group of antiviral drugs known as adamantanes, one of two classes of antiviral drugs used to prevent and treat flu symptoms, said CU-Boulder doctoral student Andrew Hill, lead study author. The rise of resistance to adamantanes -- which include the nonprescription drugs amantadine and rimantadane -- appears to be linked to Chinese farmers adding the drugs to chicken feed as a flu preventative, according to a 2008 paper by researchers from China Agricultural University, said Hill.

In contrast, resistance of the avian flu virus to the second, newer class of antiviral drugs that includes oseltamivir -- a prescription drug marketed under the brand name Tamiflu -- is present, but is not yet prevalent or under positive genetic selection, said Hill of CU-Boulder's ecology and evolutionary biology department. The CU findings should help health administrators around the world plan for the possibility of an avian flu pandemic.

The CU-Boulder study is the first to show H5N1 drug resistance to adamantanes arose through novel genetic mutations rather than an exchange of RNA segments within cells, a process known as re-assortment, said Hill. The research on the mutations, combined with molecular evolution tests and a geographic visualization technique using Google Earth, "provides a framework for analysis of globally distributed data to monitor the evolution of drug resistance," said Hill.

The CU-Boulder-led study appears online in the journal Infection, Genetics and Evolution. Co-authors included CU-Boulder Associate Professor Robert Guralnick, recent CU-Boulder graduate Meredith Wils
'/>"/>

Contact: Andrew Hill
andrew.hill@colorado.edu
303-735-0441
University of Colorado at Boulder
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Protein tubules free avian flu virus from immune recognition
2. Genetic evidence for avian influenza movement from Asia to North America via wild birds
3. Avian flu threat: New approach needed
4. New research refutes myth of pure Scandinavian race
5. Solving an avian scourge could also provide benefits to human health
6. Avian origins: new analysis confirms ancient beginnings
7. MIT finds key to avian flu in humans
8. Smiths Detection to launch a portable diagnostic system for foot-and-mouth disease and avian flu
9. New field-deployable biosensor detects avian influenza virus in minutes instead of days
10. Scientists demonstrate feasibility of preventing malaria parasite from becoming sexually mature
11. Mountain summits in the Alps becoming increasingly similar
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Avian flu becoming more resistant to antiviral drugs, says University of Colorado study
(Date:4/15/2014)... in visualizing the movement within plants of a ... drought. The achievement will allow researchers to conduct ... plants respond to drought and other environmental stresses ... carbon dioxide, or CO2, concentration., A paper describing ... of the scientific journal eLife and ...
(Date:4/15/2014)... Texas The global experts who study the deadliest ... and Thomas G. Ksiazek, professors at the University of ... the 6th annual International Symposium on Filoviruses. The filoviruses ... 50 to 90 percent of people infected. The current ... caused more than 100 deaths so far. , ...
(Date:4/15/2014)... University dental researchers have found a less invasive ... the mouth to study how the mouth,s natural ... isolating some specialized immune cells (white blood cells ... diseases in the mouthor reject foreign tissues, such ... more about treating and preventing such health issues ...
Breaking Biology News(10 mins):Biologists develop nanosensors to visualize movements and distribution of plant hormone 2International research group recognizes UTMB experts 2International research group recognizes UTMB experts 3New method isolates immune cells for researchers to study how they ward off oral diseases 2
... Calif.) Michael Gazzaniga, professor of psychology at UC ... the Study of the Mind, has received the Humboldt ... "Professor Gazzaniga is a true pioneer in reaching ... the relationship between mind and brain," said UCSB Chancellor ...
... up in Brooklyn, NY, UC Riverside,s Jerome Schultz ... peer into a microscope to examine slides of tissues his ... that early interest in science evolved into an illustrious career ... that the American Institute of Chemical Engineers ( AIChE ), ...
... study finds that genes significantly affect variation in voter ... vote and participate in the political system. The ... T. Dawes (of UC San Diego) and psychologist Laura ... the May issue of the American Political Science ...
Cached Biology News:Neuroscientist Michael Gazzaniga awarded Humboldt Prize 2UC Riverside bioengineer receives high honor from chemical engineers 2UC Riverside bioengineer receives high honor from chemical engineers 3UC Riverside bioengineer receives high honor from chemical engineers 4Why do people vote? Genetic variation in political participation 2
(Date:1/15/2014)... 2014 The Microcompetition with Foreign DNA ... disease. One of these latent viruses is the Epstein ... rheumatoid arthritis (RA). Rheumatoid arthritis (RA) is a chronic ... by the theory, a study found that RA patients ... (1). , What is Microcompetition? , Dr. Hanan ...
(Date:1/15/2014)... Sunnyvale, CA (PRWEB) January 15, 2014 ... of high throughput research solutions, today announced that ... companies, has received delivery of Freeslate’s CM ... form screening. , Lupin, headquartered in Mumbai, ... quality, affordable generic and branded formulations and Active ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 Date: Friday, ... p.m. , Location: Warrington Country Club, 1360 Almshouse Road, ... Foundation, the only national nonprofit organization solely dedicated to ... quality of life for those affected worldwide, will host ... Warrington Country Club in Warrington, Pa. , Each ...
(Date:1/14/2014)... , Jan. 14, 2014  3D Communications, a leading provider ... major scientific, regulatory, business, and media events in ... , today announced its former associate Virginia Cox , ... office. Virginia Cox re-joins ... Commissioner for the Office of External Affairs at the U.S. ...
Breaking Biology Technology:Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2Former FDA Associate Commissioner Returns To 3D Communications 2
... Mass., Dec. 20, 2010 A pediatrician, nurses, and ... be on-site at Berlin Elementary School on Monday, December ... no charge to the student,s family. Magellan Biosciences has ... portable LeadCare II analyzers, which provide three-minute blood-lead results ...
... A pipefitter knows how to make an exact cut on a ... cut on a carbon nanotube, with a diameter 1/50,000th the thickness ... in the British journal Proceedings of the Royal Society A ... first time how single-walled carbon nanotubes are cut, a finding that ...
... 17 /PRNewswire-FirstCall/ - YM BioSciences Inc. (NYSE Amex: ... its previously announced public offering of 25,000,000 common shares ... of US $37,650,000. In connection with the offering, the ... purchase up to 3,750,000 additional common shares to cover ...
Cached Biology Technology:Whitney M. Young, Jr. Health Services and Magellan Biosciences Partner to Provide Three-Minute LeadCare II Blood-Lead Screenings to Berlin Elementary Students 2Whitney M. Young, Jr. Health Services and Magellan Biosciences Partner to Provide Three-Minute LeadCare II Blood-Lead Screenings to Berlin Elementary Students 3Whitney M. Young, Jr. Health Services and Magellan Biosciences Partner to Provide Three-Minute LeadCare II Blood-Lead Screenings to Berlin Elementary Students 4Whitney M. Young, Jr. Health Services and Magellan Biosciences Partner to Provide Three-Minute LeadCare II Blood-Lead Screenings to Berlin Elementary Students 5How do you cut a nanotube? Lots of compression 2YM BioSciences Closes Public Offering of Common Shares 2YM BioSciences Closes Public Offering of Common Shares 3
... to the maintenance of appropriate levels ... important and diverse as those involved ... stress response, antigen presentation, modulation of ... cell cycle regulation, transcription, and signalling ...
... protein identification Service includes 1. Scanning ... spots 3. High-sensitive tryptic in-gel digestion ... samples for MALDI-MS 5. Acquisition of ... MALDI-MS (Bruker ultraflex TOF/TOF) 6. Acquisition ...
Each Yeast-GFP clone represents an individual S. cerevisiae strain containing an open reading frame with a C-terminal Aequorea Victoria GFP (S65T) fusion tag....
... is a new product number, created ... If showing no availability yet, please ... (R4276) or contact customer service for ... surface, easy grip) Mfr ...
Biology Products: