Navigation Links
Avian flu becoming more resistant to antiviral drugs, says University of Colorado study
Date:1/7/2009

A new University of Colorado at Boulder study shows the resistance of the avian flu virus to a major class of antiviral drugs is increasing through positive evolutionary selection, with researchers documenting the trend in more than 30 percent of the samples tested.

The avian flu, an Influenza A subtype dubbed H5N1, is evolving a resistance to a group of antiviral drugs known as adamantanes, one of two classes of antiviral drugs used to prevent and treat flu symptoms, said CU-Boulder doctoral student Andrew Hill, lead study author. The rise of resistance to adamantanes -- which include the nonprescription drugs amantadine and rimantadane -- appears to be linked to Chinese farmers adding the drugs to chicken feed as a flu preventative, according to a 2008 paper by researchers from China Agricultural University, said Hill.

In contrast, resistance of the avian flu virus to the second, newer class of antiviral drugs that includes oseltamivir -- a prescription drug marketed under the brand name Tamiflu -- is present, but is not yet prevalent or under positive genetic selection, said Hill of CU-Boulder's ecology and evolutionary biology department. The CU findings should help health administrators around the world plan for the possibility of an avian flu pandemic.

The CU-Boulder study is the first to show H5N1 drug resistance to adamantanes arose through novel genetic mutations rather than an exchange of RNA segments within cells, a process known as re-assortment, said Hill. The research on the mutations, combined with molecular evolution tests and a geographic visualization technique using Google Earth, "provides a framework for analysis of globally distributed data to monitor the evolution of drug resistance," said Hill.

The CU-Boulder-led study appears online in the journal Infection, Genetics and Evolution. Co-authors included CU-Boulder Associate Professor Robert Guralnick, recent CU-Boulder graduate Meredith Wils
'/>"/>

Contact: Andrew Hill
andrew.hill@colorado.edu
303-735-0441
University of Colorado at Boulder
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Protein tubules free avian flu virus from immune recognition
2. Genetic evidence for avian influenza movement from Asia to North America via wild birds
3. Avian flu threat: New approach needed
4. New research refutes myth of pure Scandinavian race
5. Solving an avian scourge could also provide benefits to human health
6. Avian origins: new analysis confirms ancient beginnings
7. MIT finds key to avian flu in humans
8. Smiths Detection to launch a portable diagnostic system for foot-and-mouth disease and avian flu
9. New field-deployable biosensor detects avian influenza virus in minutes instead of days
10. Scientists demonstrate feasibility of preventing malaria parasite from becoming sexually mature
11. Mountain summits in the Alps becoming increasingly similar
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Avian flu becoming more resistant to antiviral drugs, says University of Colorado study
(Date:11/21/2014)... , November 18, 2014 According ... Market by Systems (Video, RFID, Access Control, Intrusion Detection, ... Hotels, Banks, Government), Component Service Geography - Global Forecasts ... Market is projected to be around $25 Billion in ... 2020, growing at a CAGR of 8.69%. ...
(Date:11/18/2014)...  The Secure Identity & Biometrics Association (SIBA) ... the formation of The Airport Entry and Exit ... and Biometric Entry and Exit Solutions Framework for ... from BORDERPOL, the international non-profit organization that works ... regarding border security, traveler and migration systems. ...
(Date:11/12/2014)... 2014 Crossmatch™, a leading provider of biometric ... fingerprint readers have been deployed throughout Montparnasse Pasteleria, ... Mexico . The bakery chain implemented the Crossmatch ... caused by employees clocking in for each other. ... Montparnasse relied on paper timecards and a mechanical time ...
Breaking Biology News(10 mins):Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 3Montparnasse Pasteleria Achieves Time and Attendance Transparency with Crossmatch U.are.U Fingerprint Readers 2
... University of Pennsylvania researchers has revealed that a number of ... to represent three different species are all members of ... led other scientists to label them as separate species in ... the study found. "Because of the vagaries of ...
... CAMBRIDGE, Mass. -- By tracking the previously unknown movements ... are shedding new light on how the immune system ... Central to the immune response is the activity ... in the body,s lymph nodes upon detection of a ...
... August 9, 2013 Felle competitie en ... en efficiënter de beste kandidaten te matchen. Voor bedrijven ... moderne arbeidsmarkt komt CRMATCH met een geavanceerde oplossing gebaseerd ... recruiter worstelt met alsmaar grotere en complexere hoeveelheden gegevens. ...
Cached Biology News:Fresh analysis of dinosaur skulls by penn researchers finds 3 species are 1 2Fresh analysis of dinosaur skulls by penn researchers finds 3 species are 1 3Helper cells aptly named in battle with invading pathogens 2Recruiters matchen het efficiëntst met CRMATCH en ELISE 2
(Date:12/17/2014)... Washington, USA (PRWEB) December 16, 2014 ... Baum, manager at Philipps- Universität Marburg’s Department of ... and photonics, in the newly released SPIE ... “And never be too shy to ask questions.” ... (science, technology, engineering, and mathematics) occupations ranging from ...
(Date:12/17/2014)... 17, 2014 This report is ... Tubing industry. For an overview analysis, the report ... industry chain structure, industry overview, policy analysis, and ... industry has witnessed rapid development with key ... acquisitions. This report mentions quartz tubing upstream raw ...
(Date:12/17/2014)... AUSTIN, Texas , Dec. 16, 2014  Vermillion, ... company focused on gynecologic disease, today announced the next ... into a premier bio-analytics solutions provider with the naming ... to President and Chief Executive Officer, while current Chairman ... will continue to serve as Chairman. These changes are ...
(Date:12/17/2014)... LEXINGTON, Mass. , Dec. 17, 2014   ... a biopharmaceutical company developing therapeutic products for rare disorders, ... Healthcare Conference being held in San Francisco, ... , President and Chief Executive Officer, will present on ... p.m. EST).  The presentation will be webcast live and ...
Breaking Biology Technology:Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 2Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 32020 Quartz Tubing Market: Global Development & Forecasts Analysis Now at DeepResearchReports.com 2Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 2Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 3Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 4
... , ... assay • LEADseeker • SPA Imaging Beads, ... present in high levels in the pituitary and are processed into ... and β-endorphin. The various melanocyte stimulating hormones are known to activate ...
... , ... kinase assay • LEADseeker • chemiluminescence , , ... least 500 kinase and phosphatase enzymes exist, their activities having ... cascade in disease pathways such as inflammation and cancer, so ...
... , ... workspace • base set • differential expression analysis • principal components ... , ... advanced statistics on samples from a study on human ovarian cancer. ...
Cached Biology Technology:The development of a melanocortin MC4 receptor binding assay using the LEADseeker Multimodality Imaging System 2The development of a melanocortin MC4 receptor binding assay using the LEADseeker Multimodality Imaging System 3The development of a melanocortin MC4 receptor binding assay using the LEADseeker Multimodality Imaging System 4The development of a melanocortin MC4 receptor binding assay using the LEADseeker Multimodality Imaging System 5Performance of the AMARA HitHunter Chemiluminescence Kinase Assay with the LEADseeker Multimodality Imaging System 2Performance of the AMARA HitHunter Chemiluminescence Kinase Assay with the LEADseeker Multimodality Imaging System 3Performance of the AMARA HitHunter Chemiluminescence Kinase Assay with the LEADseeker Multimodality Imaging System 4Extended data analysis using DeCyder EDA 2Extended data analysis using DeCyder EDA 3Extended data analysis using DeCyder EDA 4Extended data analysis using DeCyder EDA 5Extended data analysis using DeCyder EDA 6Extended data analysis using DeCyder EDA 7Extended data analysis using DeCyder EDA 8Extended data analysis using DeCyder EDA 9Extended data analysis using DeCyder EDA 10
... sequence alignment, 3D structure visualization, phylogenetic tree ... in a single application. ... Uniprot, sort and filter them in real-time ... it, rapidly searching, filtering and sorting ...
...
Request Info...
...
Biology Products: