Navigation Links
Autism may be linked to abnormal immune system characteristics and novel protein fragment
Date:1/3/2012

nown growth factor for nerves, and studies imply that it plays a role in T-cell immune responses as well.

To study the autism-related effects of this protein fragment on postnatal neurodevelopment and behavior, Dr. Tan and his team inserted the human DNA sequence coding for the sAPP-α fragment into the genome of a mouse model for autism. While the studies are ongoing, the researchers documented the protein fragment's effects on the immune system of the test mice.

"We used molecular biology and immunohistochemistry techniques to characterize T-cell development in the thymus and also function in the spleen of the test animals," Dr. Tan said. "Then we compared transgenic mice to their wild-type littermates."

The researchers found that increased levels of sAPP-α in the transgenic mice led to increased cytotoxic T-cell numbers. The investigators also discovered subsequent impairment in the recall function of memory T-cells in the test mice, suggesting that the adaptive immune response is negatively affected in the presence of high levels of the protein fragment.

"Our work suggests that the negative effects of elevated sAPP-α on the adaptive immune system is a novel mechanism underlying certain forms of autism," concluded Dr. Tan, who holds the Silver Chair in Developmental Neurobiology. "The findings also add support to the role of sAPP-α in the T-cell response."


'/>"/>

Contact: Anne DeLotto Baier
abaier@health.usf.edu
813-974-3303
University of South Florida (USF Health)
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Neurons grown from skin cells may hold clues to autism
2. Diagnoses of autism spectrum disorders vary widely across clinics
3. UMMS researchers identify epigenetic signatures of autism
4. New findings validate the accuracy of autism diagnosis in children with Down syndrome
5. Study finds promising drug treatment for improving language, social function in people with autism
6. Children with autism benefit from early, intensive therapy
7. Study finds pregnancy and birth environment may affect development of autism in twins
8. Weatherstone Fellows publish research as Autism Speaks announces 2011 Weatherstone Fellows
9. Research reveals effectiveness of seizure treatments for children with autism
10. Therapies to improve biochemical functions hold promise as treatments for autism
11. Women who start prenatal vitamins early are less likely to have children with autism
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Autism may be linked to abnormal immune system characteristics and novel protein fragment
(Date:8/28/2014)... FASEB MARC (Maximizing Access to Research Careers) Program ... Genetics Society of America,s 27th Annual Mouse Molecular ... 2014 in Pacific Grove, California. These awards ... post doctorates and scientists from underrepresented groups into ... to encourage the participation of young scientists at ...
(Date:8/28/2014)... (Maximizing Access to Research Careers) Program has announced ... of Sports Medicine,s Conference on Integrative Physiology of ... These awards are meant to promote the ... underrepresented groups into the mainstream of the basic ... young scientists at the American College of Sports ...
(Date:8/28/2014)... in German . ... with the help of sophisticated assembly lines. Mobile assembly carriers, ... part of these assembly lines. In the case of a ... stages arranged in a precise spatial and chronological sequence, resulting ... , The creation of such an assembly line at molecular ...
Breaking Biology News(10 mins):Nanoscale assembly line 2Nanoscale assembly line 3
... the nervous system may thrive by disrupting cell function ... and spread to other cells. Princeton University researchers ... of the herpes virus indirectly take control of a ... energy supply, communication with other cells, and self-destruction response ...
... SAN FRANCISCO -- Researchers looking into the value ... after an eight-week program, study participants demonstrated improved ... and increased strength and endurance. The study, ... Medical Center in Indianapolis, Indiana University-Purdue University Indianapolis ...
... gas the ultimate fuel for stars is lurking ... Braun has found.,This is the first accurate measurement of this ... the Big Bang the Universe,s matter was almost entirely hydrogen ... generated galaxies, stars and planets and the process is ...
Cached Biology News:To spread, nervous system viruses sabotage cell, hijack transportation 2To spread, nervous system viruses sabotage cell, hijack transportation 3To spread, nervous system viruses sabotage cell, hijack transportation 4Study: In-patient, out-patient stroke rehab might benefit from yoga 2There's more star-stuff out there but it's not dark matter 2
(Date:8/28/2014)...   SunTrust Robinson Humphrey (STRH) today ... its equity research team in biotechnology and oilfield ... equity research demonstrates our commitment to providing our ... their investment decision making," said Biff Woodruff ... to make significant investments in differentiated content at ...
(Date:8/28/2014)... August 28, 2014 A new ... the world is available from Strategic Consulting, Inc., ... “ Industrial Microbiology Market Review, Fourth Edition: Global ... ” (IMMR—4) tracks and compares microbiology test volumes, ... America, Europe and Asia, and forecasts future volumes ...
(Date:8/27/2014)... Utah (PRWEB) August 27, 2014 Varian ... will expand its current Salt Lake City manufacturing facility ... outside of Utah to ultimately create 1,000 new full ... years. , “Utah is home to hardworking people ... can be credited with Varian’s success in the manufacturing ...
(Date:8/27/2014)... 27, 2014   MSC , a healthcare performance ... announced the appointment of Mary Beth Loesch ... years of experience preparing companies for rapid growth and ... Vice President of Corporate Development and Healthcare. In that ... , as well as corporate strategy and marketing. Previously, ...
Breaking Biology Technology:SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 2SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 32 Billion Industrial Microbiology Tests Conducted for Product Quality and Safety Worldwide 22 Billion Industrial Microbiology Tests Conducted for Product Quality and Safety Worldwide 3Varian Medical Systems Groundbreaking on Facility Expansion Triggers Influx of New Jobs to Salt Lake 2Varian Medical Systems Groundbreaking on Facility Expansion Triggers Influx of New Jobs to Salt Lake 3MSC names Mary Beth Loesch President and CEO 2
... M. Adams and R. Deadman , ... , GE Healthcare offers a range ... A combination of these kits with the Genesis Freedom™ Robotic Sample Processor (RSP) from ... ...
... Key words: cAMP • ... • assay miniaturization , ... the largest family of transmembrane receptors and are responsible for the transduction ... marketed drugs are active at this receptor family; however, these drugs exhibit ...
... , ... Measurement of receptor internalization using the pH-sensitive cyanine dye, ... this dye that shows greater relative fluorescence intensity when maximally ... enhanced dye, CypHer5E, is a red-excited, pH-sensitive fluorogenic dye that ...
Cached Biology Technology:Automation of TempliPhi and GenomiPhi DNA Amplification Kits on the Genesis Freedom Robotic Sample Processor 2Automation of TempliPhi and GenomiPhi DNA Amplification Kits on the Genesis Freedom Robotic Sample Processor 3Development of a sensitive enzyme fragment complementation assay for cyclic adenosine 3', 5' monophosphate and its validation for pharmacological screening at G protein-coupled receptors 2Development of a sensitive enzyme fragment complementation assay for cyclic adenosine 3', 5' monophosphate and its validation for pharmacological screening at G protein-coupled receptors 3Development of a sensitive enzyme fragment complementation assay for cyclic adenosine 3', 5' monophosphate and its validation for pharmacological screening at G protein-coupled receptors 4Development of a sensitive enzyme fragment complementation assay for cyclic adenosine 3', 5' monophosphate and its validation for pharmacological screening at G protein-coupled receptors 5Development of a sensitive enzyme fragment complementation assay for cyclic adenosine 3', 5' monophosphate and its validation for pharmacological screening at G protein-coupled receptors 6The use of CypHer5E and the IN Cell Analyzer 1000 for live-cell receptor internalization studies 2The use of CypHer5E and the IN Cell Analyzer 1000 for live-cell receptor internalization studies 3The use of CypHer5E and the IN Cell Analyzer 1000 for live-cell receptor internalization studies 4The use of CypHer5E and the IN Cell Analyzer 1000 for live-cell receptor internalization studies 5The use of CypHer5E and the IN Cell Analyzer 1000 for live-cell receptor internalization studies 6