Navigation Links
Autism may be linked to abnormal immune system characteristics and novel protein fragment
Date:1/3/2012

nown growth factor for nerves, and studies imply that it plays a role in T-cell immune responses as well.

To study the autism-related effects of this protein fragment on postnatal neurodevelopment and behavior, Dr. Tan and his team inserted the human DNA sequence coding for the sAPP-α fragment into the genome of a mouse model for autism. While the studies are ongoing, the researchers documented the protein fragment's effects on the immune system of the test mice.

"We used molecular biology and immunohistochemistry techniques to characterize T-cell development in the thymus and also function in the spleen of the test animals," Dr. Tan said. "Then we compared transgenic mice to their wild-type littermates."

The researchers found that increased levels of sAPP-α in the transgenic mice led to increased cytotoxic T-cell numbers. The investigators also discovered subsequent impairment in the recall function of memory T-cells in the test mice, suggesting that the adaptive immune response is negatively affected in the presence of high levels of the protein fragment.

"Our work suggests that the negative effects of elevated sAPP-α on the adaptive immune system is a novel mechanism underlying certain forms of autism," concluded Dr. Tan, who holds the Silver Chair in Developmental Neurobiology. "The findings also add support to the role of sAPP-α in the T-cell response."


'/>"/>

Contact: Anne DeLotto Baier
abaier@health.usf.edu
813-974-3303
University of South Florida (USF Health)
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Neurons grown from skin cells may hold clues to autism
2. Diagnoses of autism spectrum disorders vary widely across clinics
3. UMMS researchers identify epigenetic signatures of autism
4. New findings validate the accuracy of autism diagnosis in children with Down syndrome
5. Study finds promising drug treatment for improving language, social function in people with autism
6. Children with autism benefit from early, intensive therapy
7. Study finds pregnancy and birth environment may affect development of autism in twins
8. Weatherstone Fellows publish research as Autism Speaks announces 2011 Weatherstone Fellows
9. Research reveals effectiveness of seizure treatments for children with autism
10. Therapies to improve biochemical functions hold promise as treatments for autism
11. Women who start prenatal vitamins early are less likely to have children with autism
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Autism may be linked to abnormal immune system characteristics and novel protein fragment
(Date:8/24/2015)... South Africa , August 24, 2015 ... Germany ,s largest biometrics manufacturer DERMALOG and its ... with the "2015 African Biometrics Company of the Year Award". ... Nigeria .   -Cross reference: ... http://www.presseportal.de/nr/8896 - On Thursday evening, in ...
(Date:8/20/2015)... ., Aug. 20, 2015 NXT-ID, Inc. (NASDAQ: ... authentication company focused on the growing mobile commerce market ... has joined The Smart Card Alliance and the EMV ... Alliance and the Smart Card Alliance Latin America (SCALA) ... industry peers and thought leaders promoting adoption of smart ...
(Date:8/17/2015)... Conn. , Aug. 17, 2015  NXT-ID, Inc. ... biometric authentication company focused on the growing mobile commerce ... its new sales campaign for Q4 2015. The new ... marketing team consisting of Amplitude Marketing Group ( http://amplitudemarketing.com/ ... Marketing Group is a leader in retail driven marketing ...
Breaking Biology News(10 mins):Frost & Sullivan Honors DERMALOG with Biometrics Prize for Achievements in Africa 2Frost & Sullivan Honors DERMALOG with Biometrics Prize for Achievements in Africa 3NXT-ID, Inc. Joins Smart Card Alliance and EMV Migration Forum 2NXT-ID, Inc. Joins Smart Card Alliance and EMV Migration Forum 3NXT-ID, Inc. Joins Smart Card Alliance and EMV Migration Forum 4NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 2NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 3
... The Federation of American Societies for Experimental ... the Science Research Conference (SRC): Gastrointestinal Tract XV: ... conference on Histone Deacetylases, Sirtuins, and Reversible Acetylation ... unique scientific conference where the biological functions of ...
... of Iowa prepared a patient to inhale a panic-inducing dose ... breathing in the mixture, she cried for help, overwhelmed by ... woman in her 40s known as SM, has an extremely ... to the amygdala, an almond-shaped area in the brain long ...
... MD The Federation of American Societies for ... for the Science Research Conference (SRC): Genetic Recombination ... Research Conference on Genetic Recombination & Genome Rearrangements ... representing all leading model systems in the study ...
Cached Biology News:Human brain is divided on fear and panic 2Human brain is divided on fear and panic 3
(Date:9/3/2015)... ... September 03, 2015 , ... Michigan-based technology ... wearable early 2016. , The device, called the Halo H1, is a ... electrical sensing technology. These sensors track trending interstitial fluid levels in the body, ...
(Date:9/2/2015)... 2, 2015 Research and Markets ... of Jain PharmaBiotech,s new report "Nanobiotechnology ... offering. An increasing use ... industries is anticipated. Nanotechnology will be applied ... from formulations for optimal delivery to diagnostic ...
(Date:9/2/2015)... -- Research and Markets ( ... PharmaBiotech,s new report "Biochips and Microarrays - ... This report is an analysis of ... report starts with a description of technologies as ... array comparative genomic hybridization (CGH), copy number variation ...
(Date:9/2/2015)... DUBLIN , Sep. 02, 2015 ... announced the addition of Jain PharmaBiotech,s new report ... their offering. The markets for gene therapy ... approved gene therapy product and it is marketed in ... markets are estimated for the years 2014-2024. The estimates ...
Breaking Biology Technology:Technology Startup Halo Wearables to Unveil Non-Invasive Hydration Monitoring Device Early 2016 2Global Nanobiotechnology Applications, Markets and Companies Report 2015-2024 2Global Nanobiotechnology Applications, Markets and Companies Report 2015-2024 3Global Biochips and Microarrays Technologies, Markets and Companies Report 2015 with Market Size in 2014 and Projected Value for the Years 2019 and 2024 2Global Gene Therapy Market Study 2015-2024 - Technologies, Markets and Companies Analysis 2
... Ability to Elicit Long-Lasting Tumor Protection In Vivo; Lead ... ... Cancer and/or HIV -, SAN DIEGO, CA, Sept. 24 ... vivo results of its lead therapeutic vaccine candidate for the ...
... availability of ... bone fracture screening, TORONTO, ... in health and wellness solutions, announced,they are developing components for ... assessment. In conjunction with top researchers at Toronto,s University ...
... BIRMINGHAM, Ala., Sept. 24 BioCryst,Pharmaceuticals, Inc. (Nasdaq: ... at the,UBS 2007 Global Life Sciences Conference in ... for Tuesday, September 25, 2007 at 2:00 p.m. ... http://www.biocryst.com . The,presentation will be archived for ...
Cached Biology Technology:Nventa announces publication of HspE7 data 2Nventa announces publication of HspE7 data 3Nventa announces publication of HspE7 data 4Nventa announces publication of HspE7 data 5Cooler Solutions and Leading Research Hospital to Design Revolutionary Osteoporosis Diagnosis Device 2BioCryst to Present at UBS 2007 Global Life Sciences Conference 2BioCryst to Present at UBS 2007 Global Life Sciences Conference 3
...
... protein western blot (WtPAN) is ... specific protein expression in plant ... is included in each blot ... comparison between different western blots. ...
... suitable for use with RNA. ... with 0.1% diethylpyrocarbonate (DEPC) and ... DEPC.DNase/RNase-Free Distilled WaterDistilled Water is ... molecular biology applications. It is ...
The S. cerevisiae Hansen strains are the parental yeast strains from which the deletions were derived....
Biology Products: