Navigation Links
Autism may be linked to abnormal immune system characteristics and novel protein fragment
Date:1/3/2012

Tampa, FL (Jan 3, 2012) Immune system abnormalities that mimic those seen with autism spectrum disorders have been linked to the amyloid precursor protein (APP), reports a research team from the University of South Florida's Department of Psychiatry and the Silver Child Development Center.

The study, conducted with mouse models of autism, suggests that elevated levels of an APP fragment circulating in the blood could explain the aberrations in immune cell populations and function both observed in some autism patients. The findings were recently published online in the Journal of the Federation of American Societies for Experimental Biology.

The USF researchers concluded that the protein fragment might be both a biomarker for autism and a new research target for understanding the physiology of the disorder.

"Autism affects one in 110 children in the United States today," said research team leader Jun Tan, MD, PhD, professor of psychiatry and the Robert A. Silver Chair, Rashid Laboratory for Developmental Neurobiology at USF's Silver Child Development Center. "While there are reports of abnormal T-cell numbers and function in some persons affected with autism, no specific cause has been identified. The disorder is diagnosed by behavioral observation and to date no associated biomarkers have been identified."

"Not only are there no associated biomarkers, but the prognosis for autism is poor and the costs associated with care are climbing," said Francisco Fernandez, MD, department chair and head of the Silver Center. "The work of Dr. Tan and his team is a start that may lead to earlier diagnosis and more effective treatments."

The amyloid precursor protein is typically the focus of research related to Alzheimer's disease. However, recent scientific reports have identified elevated levels of the particular protein fragment, called, sAPP-α, in the blood of autistic children. The fragment is a well-k
'/>"/>

Contact: Anne DeLotto Baier
abaier@health.usf.edu
813-974-3303
University of South Florida (USF Health)
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Neurons grown from skin cells may hold clues to autism
2. Diagnoses of autism spectrum disorders vary widely across clinics
3. UMMS researchers identify epigenetic signatures of autism
4. New findings validate the accuracy of autism diagnosis in children with Down syndrome
5. Study finds promising drug treatment for improving language, social function in people with autism
6. Children with autism benefit from early, intensive therapy
7. Study finds pregnancy and birth environment may affect development of autism in twins
8. Weatherstone Fellows publish research as Autism Speaks announces 2011 Weatherstone Fellows
9. Research reveals effectiveness of seizure treatments for children with autism
10. Therapies to improve biochemical functions hold promise as treatments for autism
11. Women who start prenatal vitamins early are less likely to have children with autism
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Autism may be linked to abnormal immune system characteristics and novel protein fragment
(Date:8/6/2015)... Germany , August 6, 2015 ... Instruments (SMI) shows the world,s first Eye ... on Epson,s Moverio BT-200 see-through head mounted display and ... solution, unprecedented quality and efficiency is brought to personalized ... For the first time, professionals and researchers can integrate ...
(Date:8/4/2015)... 04, 2015 ... announced the addition of the "Digital ... Service), Sub-Segment (Computer Forensics, Network Forensics, Mobile ... Service, Vertical and Region - Global Forecast ... By Component (Hardware, Software, and ...
(Date:7/31/2015)... julho de 2015 A 10 a. ... realizada pela BGI de 22-25 de outubro de 2015, em ... A conferência está celebrando seu 10 o. aniversário este ... tornou uma das reuniões mais influentes do mundo no ... dinâmicos, entusiastas e prazerosos. A ICG-10 ...
Breaking Biology News(10 mins):SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 2SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 3Digital Forensics Market - The Market Represents a Compound Annual Growth Rate (CAGR) of 11.3% From 2015 to 2020 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 3
... both bring a combination of individual scientific skills, ... together, these offer the opportunity to build a ... will address the urgent need for bringing new ... discovery, antibiotics and other antimicrobial agents have saved ...
... public health concern in Africa and a potential biological ... Due to its virulent nature, and because no ... have had to work under the most stringent biocontainment ... and hampering the ability of scientists to develop countermeasures. ...
... genes involved in Lupus, a devastating autoimmune disease, in ... In an international genetic study of more than ... Lupus (systemic lupus erythematosus or SLE) and mutations in ... scientists from Imperial College London and institutions in the ...
Cached Biology News:Unique fungal collection could hold key to future antibiotics 2Unique fungal collection could hold key to future antibiotics 3Ebola virus disarmed by excising a single gene 2Ebola virus disarmed by excising a single gene 3Genes linked with lupus are revealed, giving hope for new treatments 2Genes linked with lupus are revealed, giving hope for new treatments 3
(Date:9/1/2015)... September 1, 2015 Shire plc (LSE: ... Sara Mathew to its Board of Directors as a ... Audit, Compliance & Risk Committee of the Shire Board. Both ... Sara previously served as Chairman, President and Chief Executive ... 2013. During her 12-year tenure at D&B, she helped drive ...
(Date:8/31/2015)... ... 31, 2015 , ... In recent years, biodegradable plastics have ... carbon footprints and compostability. These properties can help in limiting the degradation of ... of applications, the market for biodegradable plastics can be broadly segmented into packaging, ...
(Date:8/31/2015)... Research and Markets ( http://www.researchandmarkets.com/research/k6lcp2/mexico_biomedical ) has ... Market - Growth, Trends & Forecasts (2014-2020)" report ... Biomedical Sensors market is estimated at $0.20 billion by ... 2014-2020 The near future will bring biomedical ... each individual. These sensors can be set to trigger ...
(Date:8/31/2015)...  For people with Down syndrome, news from ... company, located in the Science + Technology Park at ... therapies yet for people with Down syndrome and other chromosome ... syndrome and Edwards syndrome aneuploidies in human cell cultures, ... Elixirgen plans to develop this technology into a treatment ...
Breaking Biology Technology:Shire Appoints Sara Mathew to Board of Directors 2Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 2Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 3Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 4Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 5Mexico Biomedical Sensors Market Report 2015-2020 2New Down syndrome therapy discovered 2
... Blindness in the UK(1) Though ... Factors Remains Low, WALTON OAKS, England, October 9 ... of the eye disease glaucoma. It,is estimated that there are ... at risk of losing their sight due to undiagnosed glaucoma(2),despite ...
... to Pathwork Following FDA ... Clearance and $20M Fundraising Round, SUNNYVALE, Calif., Oct. ... announced today the,appointment of two key positions within the company,s ... as Vice,President of US Sales. These professionals bring over 20 ...
... battle with heart disease that included numerous medications, trips to the emergency ... in the Intensive Care Unit at an Ohio hospital. Both sides of ... transplant. , ... TUCSON, Ariz. (Business Wire EON) October 8, 2008 ...
Cached Biology Technology:World Sight Day - Britons at Risk of Losing Their Sight by Not Having Regular Eye Tests 2World Sight Day - Britons at Risk of Losing Their Sight by Not Having Regular Eye Tests 3World Sight Day - Britons at Risk of Losing Their Sight by Not Having Regular Eye Tests 4World Sight Day - Britons at Risk of Losing Their Sight by Not Having Regular Eye Tests 5Pathwork Diagnostics Announces Key Additions to Management Team 2 "Put Down the BBQ Ribs, We've Found You a Donor Heart," Nurse Tells Patient : Ohio Father near Death Gets Second Chance at Life with CardioWest™ temporary Total Artificial Heart 2
... of the mitochondrial transmembrane potential ... intracellular events that occur following ... Apoptosis Detection Kit utilizes a ... as a mitochondrial activity marker. ...
The PDS-1000 He Hepta system includes the PDS-1000 He biolistic system and the Hepta adaptor....
... BioLogic LP system, 220-240 V, is ... fraction collection. The system includes the ... kit with MV-6 injection valve, proportioning ... cell, tubing and fittings kit, column ...
... been developed for affinity capture of ... of ProteinChip chemical surfaces allow differential ... unique biochemical properties. Each chip has ... comparison, and the chips are color-coded ...
Biology Products: