Navigation Links
Are there rearrangement hot spots in the human genome?
Date:11/9/2007

The debate over the validity of genomic rearrangement hotspots has its most recent addition in a new theory put forth by researchers at the University of California San Diego. The study, published on November 9 in PLoS Computational Biology, holds that there are indeed rearrangement hotspots in the human genome.

Doctors Max Alekseyev and Pavel Pevzner developed a theory for analyzing complex rearrangements (including transpositions) which demonstrates that even if transpositions were a dominant evolutionary force, there are still rearrangement hotspots in mammalian genomes.

In 1970 the random breakage model (RBM) was proposed by Susumo Ohno, and later formalized by Nadeau and Taylor in 1984. This model postulates that rearrangements are random, and thus there are no rearrangement hotspots in mammalian genomes. Biologists largely embraced the model as it held such predictive powers.

However, in 2003 the model was refuted by Pevzner and Tesler, who suggested an alternative fragile breakage model (FBM) of chromosome evolution. FBM implies that the human genome is a mosaic of solid regions with low propensity for rearrangements and fragile regions where rearrangement hotspots reside. The rebuttal of RBM resulted in a rebuttal of the rebuttal, and a scientific divide was begun.

Most recent studies support the existence of rearrangement hotspots, but some researchers still uphold the RBM model. This study represents a major advance in the debate.


'/>"/>

Contact: Mary Kohut
Press@plos.org
415-568-3460
Public Library of Science
Source:Eurekalert

Page: 1

Related biology news :

1. Computational actinide chemistry: Are we there yet?
2. Hydrothermal vents: Hot spots of microbial diversity
3. Hot spots the key to controlling European carp in Australia
4. Gene regulation, not just genes, is what sets humans apart
5. Antioxidant overload may underlie a heritable human disease
6. Facial attraction -- choice of sexual partner shaped the human face
7. Humans fostering forest-destroying disease
8. SRMs track fire retardants in humans and environment
9. St. Jude influenza survey uncovers key differences between bird flu and human flu
10. Human derived stem cells can repair rat hearts damaged by heart attack
11. Influence of sex and handedness on brain is similar in capuchin monkeys and humans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/31/2014)... that emits over a wide part of the electromagnetic ... being built in Lund, Sweden. The MAX IV facility ... putting together its component parts in a storage - ... just a few hundred metres. Nevertheless, if these various ... of experiments that require source brightness and transverse coherence ...
(Date:10/31/2014)... the war against Ebola one important hurdle has just ... at the University of North Carolina at Chapel Hill ... mice that can be infected with Ebola and display ... published in the current issue of Science , ... vaccines, which are desperately needed to curb the worldwide ...
(Date:10/31/2014)... , Oct. 30, 2014  HITLAB SM , ... to announce its inaugural HITLAB Innovators Summit SM ... Low Library. HITLAB will partner with the Clinton ... Blueprint Health, ProtoHack, Columbia Business School Alumni Club ... Columbia Industrial Engineering and Operations Research, bringing together ...
Breaking Biology News(10 mins):A new generation of storage -- ring 2Improved mouse model will accelerate research on potential Ebola vaccines, treatments 2HITLAB Announces Inaugural HITLAB Innovators Summit 2HITLAB Announces Inaugural HITLAB Innovators Summit 3
... can cause congenital heart defects has been identified by a ... discovery could lead to new treatments for those affected by ... Princeton researchers focused on identifying and studying the gene in ... with other groups studying the genetics of mice and people. ...
... Parascript, LLC, the image analysis and pattern recognition ... Xpert was awarded best performance for forensic signature ... in Handwriting Recognition (ICFHR2010) in Kolkata, India, held ... seven participants representing a total of 10 offline ...
... insects and pathogens continue to become established in US forests ... a study published in the December 2010 issue of ... Juliann E. Aukema of the National Center for Ecological Analysis ... are being newly detected in US forests at a rate ...
Cached Biology News:Scientists find gene linked to congenital heart defect 2Scientists find gene linked to congenital heart defect 3Scientists find gene linked to congenital heart defect 4Parascript SignatureXpert Wins Forensic Signature Verification Competition 2Forest pests accumulating despite regulations 2
(Date:10/31/2014)... Arlington, VA (PRWEB) October 31, 2014 ... safety and sustainability consultancy, announced today that Dr. ... a Principal Consultant and will work closely with ... Clewell will also continue to serve at The ... Research Triangle Park, North Carolina, where he is ...
(Date:10/30/2014)... Investor-Edge has initiated coverage on ... Medivation Inc. (NASDAQ: MDVN ), Pharmacyclics Inc. ... MKT: SYN), and Ironwood Pharmaceuticals Inc. (NASDAQ: IRWD). Free ... http://investor-edge.com/register . On Wednesday, October 29, ... the Dow Jones Industrial Average declined 0.18%, to finish ...
(Date:10/30/2014)... MA (PRWEB) October 30, 2014 ... and collaboration provider, offers Office 365 end users ... into a complete phone system by adding voice ... 365 (O365) includes Lync Online, a communication tool ... Lync calls. With hosted voice, O365 becomes a ...
(Date:10/30/2014)... (PRWEB) October 30, 2014 Avure Technologies celebrates ... 525L, the newest member of its fleet of high volume ... reaching an anniversary as we return to PackExpo this year, ... ago in Las Vegas,” said Jeff Williams, CEO at Avure. ... and we’re pleased to be meeting the challenges of market ...
Breaking Biology Technology:Internationally recognized health scientist Dr. Harvey Clewell renews association with ENVIRON 2Internationally recognized health scientist Dr. Harvey Clewell renews association with ENVIRON 3Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 2Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 3Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 4Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 5SoundConnect Launches Voice Enablement and Hybrid Audio Conferencing for Office 365 2SoundConnect Launches Voice Enablement and Hybrid Audio Conferencing for Office 365 3In High Demand: New High Pressure Processing (HPP) System with Maximum Throughput Drives Strong Sales 2In High Demand: New High Pressure Processing (HPP) System with Maximum Throughput Drives Strong Sales 3
... Signalife, Inc. (Amex:,SGN) and Athletes for Life Foundation ... heart monitoring and screening at the Pontotoc,Technology Center ... Bowl champion, and a founder of the Athletes ... to participate in a children,s health,education program sponsored ...
... highly efficient and fast PCR amplification ... in a ... Biosystems, Inc., a leading,developer of state-of-the-art PCR devices and Cell-based ... at the San,Diego Convention Center that it has successfully completed ...
... New York City, WASHINGTON, NEW YORK, and ... Life Science Advisors, the EBD Group and FasterCures,today ... new,partnering meeting designed to promote funding of non-profit ... partnering between,those groups and biopharmaceutical companies. The inaugural ...
Cached Biology Technology:Signalife Announces AFL Joins NIH Education Program 2Signalife Announces AFL Joins NIH Education Program 3Ahram Biosystems Completes Development of a Palm-Size Portable PCR Device 2Partnering for Philanthropy Conference Launched to Unite Innovative Non-profit Research Organizations with Philanthropists and Industry 2Partnering for Philanthropy Conference Launched to Unite Innovative Non-profit Research Organizations with Philanthropists and Industry 3
... Versatile state of the Art ... flask to dual 38,000 L fermentation. ... scale to production. Aseptic operation ... Batch, Fed-Batch, and Continuous Modes. ...
Competitors to lower non-specific signal...
... Each vial contains 200 g of lyophilized ... sequence (C-terminal amino acids 380-402; GLTPSAWEASSLRSSRHSGLSHF. ... antigen for production of Cayman's EP1 receptor ... be used in conjunction with this antibody ...
Immunogen: VDAC3 Protein Storage: -20 C, Avoid Freeze/Thaw Cycles...
Biology Products: