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Antiepileptic drug use while pregnant impacts early child development
Date:7/17/2013

s, sentence skills, and autistic traits compared to unexposed children.

Further analysis determined that AED-exposed children had increased risk of birth defects compared to children not exposed to the drugs in utero. Importantly, no increased risk of developmental delays was found in children born to women with epilepsy who did not use AED during pregnancy; children of fathers with epilepsy generally scored within the normal ranges for early childhood development.

"Our studya unique large-scale, population-based study on early developmental outcomes in offspring of parents with epilepsyconfirms that children exposed to anti-seizure medications in the womb had lower scores for key developmental areas than children not exposed to AEDs," concludes Dr. Veiby. "Exposure to valproate, lamotrigine, carbamazepine or multiple anti-seizure medications was linked to adverse developmental outcomes."

The authors stress the importance of optimal seizure control during pregnancy that balances possible adverse effects on the baby's brain development. They suggest future research examine the effects of specific AEDs on fetal development, and whether these effects continue from early childhood into school-age and adulthood.


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Contact: Dawn Peters
sciencenewsroom@wiley.com
781-388-8408
Wiley
Source:Eurekalert

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