Navigation Links
Antiepileptic drug use while pregnant impacts early child development
Date:7/17/2013

Children whose mothers took antiepileptic drugs (AEDs) while pregnant are at increased risk of early development issues, according to a new study published in Epilepsia, a journal published by Wiley on behalf of the International League Against Epilepsy (ILAE). Results of the study suggest that children exposed to AEDs in the womb were at risk for difficulties with motor development, language skills, social skills, and autistic traits compared to children whose mothers did not take anti-seizure medications.

Medical evidence suggests that epilepsy is fairly common in women of childbearing years, with the use of AEDs during pregnancy ranging from 0.2% to 0.5%. Studies have shown that children whose mothers have epilepsy are at increased risk of birth defects (congenital malformations)mainly thought to be caused by use of older generation AEDs during pregnancy. However, there is less understanding of AED effects on cognition during development, and there is a need for more evidence regarding long-term outcomes of children exposed to anti-seizure medication in utero.

A research team, led by Dr. Gyri Veiby from Haukeland University Hospital in Bergen, Norway, studied children from the Norwegian Mother and Child Cohort Study. From 1999 through 2008, researchers recruited mothers at 13-17 weeks of pregnancy; those mothers subsequently reported motor development, language skills, social skills and autistic traits of their children at 18 months (61,351 children) and 36 months (44,147 children). Risk of adverse outcomes was determined in children according to epilepsy in the mother or father, and with or without AED exposure in the womb.

Results show that 333 children were exposed to AEDs in the womb. At 18 months of age, the children exposed to AEDs in utero had increased risk of abnormal gross motor skills and autistic traits. Analysis of AED-exposed children at 36 months revealed an increase of abnormal scores for gross motor skills, sentence skills, and autistic traits compared to unexposed children.

Further analysis determined that AED-exposed children had increased risk of birth defects compared to children not exposed to the drugs in utero. Importantly, no increased risk of developmental delays was found in children born to women with epilepsy who did not use AED during pregnancy; children of fathers with epilepsy generally scored within the normal ranges for early childhood development.

"Our studya unique large-scale, population-based study on early developmental outcomes in offspring of parents with epilepsyconfirms that children exposed to anti-seizure medications in the womb had lower scores for key developmental areas than children not exposed to AEDs," concludes Dr. Veiby. "Exposure to valproate, lamotrigine, carbamazepine or multiple anti-seizure medications was linked to adverse developmental outcomes."

The authors stress the importance of optimal seizure control during pregnancy that balances possible adverse effects on the baby's brain development. They suggest future research examine the effects of specific AEDs on fetal development, and whether these effects continue from early childhood into school-age and adulthood.


'/>"/>

Contact: Dawn Peters
sciencenewsroom@wiley.com
781-388-8408
Wiley
Source:Eurekalert

Related biology news :

1. Eating junk food while pregnant may make your child a junk food addict
2. Libertarian paternalism and school lunches: Guiding healthier behavior while preserving choices
3. Protein filmed while unfolding at atomic resolution
4. Music with dinner: Whales sing during foraging season, not just while breeding
5. Multi-tasking whales sing while feeding, not just breeding
6. New process doubles production of alternative fuel while slashing costs
7. Ultrasound idea: Prototype NIST/CU bioreactor evaluates engineered tissue while creating it
8. Pregnant women with high celiac disease antibodies are at risk for low birth weight babies
9. Study reveals risk factors for blood clots in pregnant and postnatal women
10. Progesterone may be why pregnant women are more vulnerable to certain infections
11. Few pregnant women treated for sexually transmitted infections
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/9/2016)... This BCC Research report provides an overview ... Sequencing (RNA Seq) market for the years 2015, 2016 ... reagents, data analysis, and services. Use this ... market such as RNA-Sequencing tools and reagents, RNA-Sequencing data ... each segment and forecast their market growth, future trends ...
(Date:3/8/2016)... N.C. , March 8, 2016   ... sensor technology, today announced it has secured $11M ... by GII Tech, a new venture fund being ... with additional participation from existing investors TDF Ventures ... the funds to continue its triple-digit growth and ...
(Date:3/3/2016)... SOTO, Kansas , March 3, 2016 ... Oncimmune,s Early CDT®-Lung, a blood test to aid ... cancer Early CDT®-Lung test to its clients ... Early CDT®-Lung test to its clients which include ... a leader in early cancer detection, today announced a ...
Breaking Biology News(10 mins):
(Date:4/27/2016)... British Virgin Islands (PRWEB) , ... April 27, ... ... Holding Company Ltd. (d/b/a Biohaven) is pleased to announce the appointment of John Tilton ... he was an Executive Director and one of the founding commercial leaders responsible ...
(Date:4/27/2016)... ... April 27, 2016 , ... Global Stem Cells Group ... Ross is the founder of GSCG affiliate Kimera Labs in Miami. , In 2004, ... hematopoietic stem cell transplantation for hematologic disorders and the suppression of graft vs. host ...
(Date:4/26/2016)... ... April 27, 2016 , ... ... Rothgerber Christie LLP as an associate in the firm’s Intellectual Property practice group. ... mechanical and electromechanical patent applications. He has an electrical engineering and computer engineering ...
(Date:4/26/2016)... ... ... Mr. Palmer created the RPO business for Ceridian and lead the Public ... contract in the U.S. intelligence community with The SI (a Lockheed Martin divestiture). , ... of Accolo. “We are growing and his experience guiding our expansion is unparalleled. ...
Breaking Biology Technology: