Navigation Links
Antidepressants need new nerve cells to be effective, UT Southwestern researchers find
Date:8/27/2008

w nerves to grow in the dentate gyrus.

They genetically engineered mice to lack TrkB specifically in the stem cells that give rise to new neurons, then gave them antidepressants for several weeks or allowed them to run on wheels. When the mice were tested for depressive behavior, the tests revealed that neither the antidepressants nor the exercise had helped them, and the animals also had not grown new nerve cells in the dentate gyrus.

"At least in mice, this result directly links antidepressants and voluntary exercise with TrkB-mediated creation of nerve cells," Dr. Parada said.

The results also showed that antidepressants required TrkB to stimulate the growth of new nerve cells.

Matching the timeframe for medicated patients to feel less depressed, it takes several weeks for new nerve cells to grow, Dr. Parada said. This parallel effect, he said, may mean that antidepressants need to stimulate growth of new cells in the dentate gyrus in order to achieve their full effect.

"We can get biochemical, physiological, behavioral and anatomical results in animal models," Dr. Parada said. "These all resonate with the human condition, so perhaps you have a physiological relevancy.

"There could be a way to stimulate growth of nerve cells to fight depression, for example."


'/>"/>

Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

Page: 1 2

Related biology news :

1. N.Y. research team discovers how antidepressants and cocaine interact with brain cell targets
2. Compound that helps rice grow reduces nerve, vascular damage from diabetes
3. UT Southwestern researchers create molecule that nudges nerve stem cells to mature
4. Engineer develops detergent to promote peripheral nerve healing
5. Tumor-targeting viral therapy slows neuroblastoma, malignant peripheral nerve sheath tumors
6. Salk scientists identify key nerve navigation pathway
7. Team of scientists develops non-invasive method to track nerve-cell development in live human brain
8. West Nile virus spread through nerve cells linked to serious complication
9. Targeting nerve growth factor may cure liver cancer
10. Specific brain protein required for nerve cell connections to form and function
11. Senescence in liver cells is found by CSHL scientists to help limit acute tissue damage
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Antidepressants need new nerve cells to be effective, UT Southwestern researchers find
(Date:10/29/2014)... in the living world compete with members of ... how much they invest into their competitive ability. ... get access to high-quality resources, while others seem ... the lower-quality resources that are left over for ... and human societies seems to fluctuate considerably over ...
(Date:10/29/2014)... study on a large cohort of kidney cancer patients ... the disease -- and reveals an apparent link between ... particularly in Romania. , The research, by an international ... Genome Quebec Innovation Centre in Montreal, underscores the importance ... The compound, found in plants of the Aristolochia genus, ...
(Date:10/28/2014)... North America, Europe and China have published a paper ... Sciences that reveals important details about key transitions ... From strange and exotic algae, mosses, ferns, trees and ... and vegetables we eat and the ornamental plants adorning ... a billion years of history., "Our study generated DNA ...
Breaking Biology News(10 mins):Evolution of competitiveness 2Evolution of competitiveness 3Study sheds light on genetic architecture of kidney cancer 2Study sheds light on genetic architecture of kidney cancer 3New study uses DNA sequences to look back in time at key events in plant evolution 2New study uses DNA sequences to look back in time at key events in plant evolution 3
... ability to pay attention to relevant information while ignoring ... to focus and filter out "noise," we could not ... attention in the brain, the cellular mechanisms responsible for ... now., In a study appearing in the journal ...
... Some of the top scientists in the nation, ... members, will make presentations at a University of Louisville-hosted ... Symposium: Anatomical and Functional Modularity of the Cerebral Cortex," ... Conference Center, 200 Abraham Flexner Way. Admission is free, ...
... Kuala Lumpur, Malaysia, St. Louis, MO and Cold Spring Harbor, NY-- ... Shell, that regulates yield of the oil palm tree. The fruit ... one-half of the supply of edible vegetable oil worldwide, and provide ... discovery, the product of a multiyear effort to provide a high-quality ...
Cached Biology News:Neuroscience symposium bringing top scientists to Louisville, Aug. 1-2 2Full genome map of oil palm indicates a way to raise yields and protect rainforest 2Full genome map of oil palm indicates a way to raise yields and protect rainforest 3
(Date:10/30/2014)... INDIANAPOLIS , Oct. 30, 2014 A ... Battelle Technology Partnership Practice, takes an in-depth look at ... innovation outputs that have resulted over two different time ... also provides a view of future opportunities for investment ... Indiana report shows gains in innovation ...
(Date:10/27/2014)... Carolina (PRWEB) October 27, 2014 Ryan ... earlier this month to sit down with Bryan Hamilton, the ... RPG Solutions to discuss talent in the Research Triangle region ... topics that were highlighted at the roundtable include the ... Triangle, the significance of work/life balance and the unique role ...
(Date:10/27/2014)... , Oct. 27, 2014 Kalorama Information ... recent Ebola concern in the United States ... virus.  The healthcare market researcher said the FDA,s Emergency Use ... vitro diagnostic tests for the detection of the Ebola ... proved useful.  Kalorama routinely assess the IVD industry and ...
(Date:10/27/2014)... The report “Smart Highway Market ... Communication, Monitoring), and by Display (Variable Message Signs, ... the global market into various sub-segments with in-depth ... the drivers and restraints for this market with ... 75 market tables and 37 figures spread through ...
Breaking Biology Technology:New report shows Indiana's gains in life sciences innovation capital outpace the nation 2New report shows Indiana's gains in life sciences innovation capital outpace the nation 3New report shows Indiana's gains in life sciences innovation capital outpace the nation 4New report shows Indiana's gains in life sciences innovation capital outpace the nation 5Personify's Ryan Carfley Talks Recruiting with Triangle Business Journal, RPG Solutions 2Personify's Ryan Carfley Talks Recruiting with Triangle Business Journal, RPG Solutions 3Kalorama: PCR The Go-to Test in Ebola Fight 2Kalorama: PCR The Go-to Test in Ebola Fight 3Smart Highway Market by Technology, and Display Expected to Reach $27.992.0 Million by 2019- New Report by MarketsandMarkets 2Smart Highway Market by Technology, and Display Expected to Reach $27.992.0 Million by 2019- New Report by MarketsandMarkets 3Smart Highway Market by Technology, and Display Expected to Reach $27.992.0 Million by 2019- New Report by MarketsandMarkets 4
... expressing green fluorescent protein (GFP) in their retina cells ... video cameras, creating a real time computer record of ... the open access journal BMC Biotechnology , will ... and aging. , John Tower led a team of ...
... for Equipment and Service Excellence at the 54th Annual ... , IRVINE, Calif., Dec. 16 Masimo ... CO-Oximetry and Measure-Through-Motion and Low-Perfusion pulse oximetry, announced that ... notification system, Masimo Patient SafetyNet, was featured in a ...
... , - BiomarkerCenter of Excellence Established in ... 16 /PRNewswire-FirstCall/ -- Covance Inc. (NYSE: ... that it has purchased a minority equity stake in Caprion Proteomics, ... further enhance its biomarker service offerings to clients. , ...
Cached Biology Technology:AARC Presentation Cites Masimo Patient SafetyNet as Key Factor in 'Improving Patient Outcomes and Reducing Costs' in Post-Acute Care Facilities 2AARC Presentation Cites Masimo Patient SafetyNet as Key Factor in 'Improving Patient Outcomes and Reducing Costs' in Post-Acute Care Facilities 3AARC Presentation Cites Masimo Patient SafetyNet as Key Factor in 'Improving Patient Outcomes and Reducing Costs' in Post-Acute Care Facilities 4AARC Presentation Cites Masimo Patient SafetyNet as Key Factor in 'Improving Patient Outcomes and Reducing Costs' in Post-Acute Care Facilities 5Covance Purchases Equity Stake in Caprion Proteomics 2Covance Purchases Equity Stake in Caprion Proteomics 3Covance Purchases Equity Stake in Caprion Proteomics 4Covance Purchases Equity Stake in Caprion Proteomics 5
...
Request Info...
Purified Mouse anti-Hu LAT (pY226) Storage Temperature: Refrigerate(2 to 8C)...
Molecular Biology grade. Ideally suited for DNA and RNA separation and recovery. High gel strength. Gelling temp. 36C. Melting temp. 88C. EEO: 0.05-0.13 Resolution 0.2-40 kb; Rnase/Dnase: none detec...
Biology Products: