Navigation Links
Antidepressants need new nerve cells to be effective, UT Southwestern researchers find
Date:8/27/2008

DALLAS Aug. 28, 2008 Researchers at UT Southwestern Medical Center have discovered in mice that the brain must create new nerve cells for either exercise or antidepressants to reduce depression-like behavior.

In addition, the researchers found that antidepressants and exercise use the same biochemical pathway to exert their effects.

These results might help explain some unknown mechanisms of antidepressants and provide a new direction for developing drugs to treat depression, said Dr. Luis Parada, chairman of developmental biology and senior author of a study in the Aug. 14 issue of the journal Neuron.

In animals, it was already known that long-term treatment with antidepressants causes new nerve cells to be generated in a part of the brain called the dentate gyrus. Exercise, which can also relieve the symptoms of depression, stimulates the generation of new nerve cells in the same area.

"We would never claim that what we study in mice directly relates to how antidepressants work in humans, but there are interesting features in parallel," Dr. Parada said. "The study unifies different observations that point to the brain's dentate gyrus region and to creation of nerve cells as being important in depression."

Antidepressants act very quickly to increase levels of natural compounds, called neurotransmitters, which nerve cells use to communicate. It takes several weeks to several months, however, for the patients who respond to such treatments to feel less depressed. Dr. Parada said this implies that some other long-term mechanism is also at work.

The current study was designed to test several phenomena that have long been observed in animal studies but have not been studied together to see if they are linked, Dr. Parada said.

The researchers focused on a molecule called TrkB, or Track-B, which is found on the surface of nerve cells and responds to several growth factors to cause ne
'/>"/>

Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

0

GOOD

Page: 1 2

Related biology news :

1. N.Y. research team discovers how antidepressants and cocaine interact with brain cell targets
2. Compound that helps rice grow reduces nerve, vascular damage from diabetes
3. UT Southwestern researchers create molecule that nudges nerve stem cells to mature
4. Engineer develops detergent to promote peripheral nerve healing
5. Tumor-targeting viral therapy slows neuroblastoma, malignant peripheral nerve sheath tumors
6. Salk scientists identify key nerve navigation pathway
7. Team of scientists develops non-invasive method to track nerve-cell development in live human brain
8. West Nile virus spread through nerve cells linked to serious complication
9. Targeting nerve growth factor may cure liver cancer
10. Specific brain protein required for nerve cell connections to form and function
11. Senescence in liver cells is found by CSHL scientists to help limit acute tissue damage
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Antidepressants need new nerve cells to be effective, UT Southwestern researchers find
(Date:5/22/2013)... drastically reduces the time and effort needed to ... biotechnology, scientists are reporting. Published in the journal ... the way for more rapid development of designer ... activities. , Keith Shearwin and colleagues explain that ... material DNA into a bacterium,s genome is critical ...
(Date:5/22/2013)... pneumophila bacteria is responsible for legionellosis, an infectious ... infect us, this pathogen has developed a complex method ... our cells, thus avoiding these acting against the infectious ... centre, CIC bioGUNE, in which teams from the National ... National Supercomputation Centre in Barcelona (BSC) have also participated, ...
(Date:5/22/2013)... the biodiversity of pollinating insects and wild plants have ... , Researchers led by the University of Leeds and ... evidence of dramatic reductions in the diversity of species ... and 1980s. , But the picture brightened markedly after ... losses among bees, hoverflies and wild plants. ...
Breaking Biology News(10 mins):Mechanism discovered which aids Legionella to camouflage itself in the organism 2Encouraging signs for bee biodiversity 2Encouraging signs for bee biodiversity 3
... everywhere, and every day, with learning as the goal. ... better productivity and potentially more profit. In classrooms, better ... connect more with patients. So, doing coaching right would ... been a major topic of research at Case Western ...
... Physicians caring for patients with sepsis may soon have a ... Research led by Dr. Karel Tyml and his colleagues at ... have found that vitamin C can not only prevent the ... is caused by a bacterial infection that can begin anywhere ...
... The most widely adopted measure for assessing the state of ... nearly half the ecosystems where it was applied. The ... scientists, and is reported in this week,s issue of the ... like flipping a coin; half the time you get the ...
Cached Biology News:Coaching with compassion can 'light up' human thoughts 2Coaching with compassion can 'light up' human thoughts 3Coaching with compassion can 'light up' human thoughts 4Vitamin C: A potential life-saving treatment for sepsis 2Widely adopted indicator of fisheries health questioned 2Widely adopted indicator of fisheries health questioned 3Widely adopted indicator of fisheries health questioned 4
(Date:5/22/2013)... 2013 Express Diagnostics Int’l, Inc. ... are pleased to announce a sponsorship agreement with ... New Zealand distributor of DrugCheck® onsite testing devices, manufactured ... in the Austin 400 May 17-19 in Austin, Texas. ... that involves each car of the Erebus Motorsport team ...
(Date:5/22/2013)... A recent study from researchers in ... find that those who took probiotics were able to run ... study showed that in extreme heat conditions, probiotics were able ... acne treatment explains what this new discovery means ... their skin condition. , While researchers tote the benefits ...
(Date:5/21/2013)... First patients dosed with PSX1002, ... designed using Prosonix, particle engineering platform Prosonix, ... inhaled Respiratory Medicines by Design , has initiated ... assess its effect on lung function and the safety ... to severe chronic obstructive pulmonary disease (COPD). The first ...
(Date:5/21/2013)... (PRWEB) May 21, 2013 Custom ... to reporting eLearning solution using Tin Can API ... dashboard tool. CLD is a leading developer of ... medical device companies worldwide. , Tin Can ... that helps learners and trainers more accurately measure ...
Breaking Biology Technology:Australian Distributor of Express Diagnostics Signs Sponsorship Agreement with V8 Supercar Team 2Adult Acne Treatment, Probiotic Action Shares Insight on New Findings Between Probiotics and Heat Tolerance, and What It Means for Acne Sufferers 2Prosonix Initiates Phase 2 Clinical Study with PSX1002 in Patients with Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD) 2Prosonix Initiates Phase 2 Clinical Study with PSX1002 in Patients with Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD) 3Prosonix Initiates Phase 2 Clinical Study with PSX1002 in Patients with Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD) 4CLD Integrates Tin CAN API with its eLearning Solutions and Launches its Excelerometer Tracking Statement Dashboard 2CLD Integrates Tin CAN API with its eLearning Solutions and Launches its Excelerometer Tracking Statement Dashboard 3
... into the Cisco Open Platform for Safety and Security; ... ... Employees, and Citizens, MORGANTOWN, W.Va., April 1, 2008 ... it,has partnered with Cisco on the newly launched Cisco Open ...
... HILTON HEAD ISLAND, S.C., April 1 Dr. Roger ... and founder and,chairman of the not-for-profit public charity CureHIV.us, ... community, including funding,initiatives such as the Grand Challenges in ... clinical studies of a new drug and treatment,method, LiSAVIOR., ...
... Revenue and Positive ... for Three Consecutive Quarters, PRINCETON, N.J., April 1 ... company, today,announced record growth in revenues for 2007. The company ... generated positive EBITDA for,the third consecutive quarter. Laureate achieved other ...
Cached Biology Technology:Augusta Systems Technologies Integrated into Cisco's Newly Launched Safety and Security Platform 2Augusta Systems Technologies Integrated into Cisco's Newly Launched Safety and Security Platform 3Cure HIV Reaches Out to Foundation Community to Fund LiSAVIOR 2Laureate Pharma Reports Record Growth for 2007 2Laureate Pharma Reports Record Growth for 2007 3
... Error-free cloning of BAC (100+kb), fosmid ... Greater insert stability than any othe BAC ... for high yields and easy recombinant DNA ... or transcription-free (pSMART VC) vectors for the ...
Trop-2 Purified Anti-Human clone 162-46, Isotype Mouse IgG 1 , 100 µg Consult technical datasheet for details....
... BAC (100+kb), fosmid (40kb), and large plasmid ... any othe BAC vector. On command 20-50 ... easy recombinant DNA purification. Available with blue-white ... vectors for the highest insert stability. Kits ...
... Adapted to Sf-900 II ... isolated from Spodoptera frugiperda ... cells (1). The Sf21 ... serum-free suspension culture in ...
Biology Products: