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Antibiotic-resistant typhoid likely to spread despite drug control program
Date:12/9/2013

but resistance is rising. Withdrawing or restricting the use of this class of antibiotics is one approach to try and combat the spread of resistance. However, the results of this study suggest that we need to think beyond this , as antibiotic resistance will likely continue to rise even if these strategies are implemented."

Dr Jimmy Whitworth, Head of International Activities at the Wellcome Trust, said: "These important findings from researchers in Vietnam are very worrying. If confirmed, one of our main strategies for controlling drug-resistance in typhoid will be ineffective. We will need to concentrate on developing more effective and affordable vaccines, and improving water supplies and sanitation, a Herculean task for low and middle income countries."

There are an estimated 21 million cases of typhoid fever around the world each year. If left untreated, it's estimated that up to one in five with the disease will die and of those who survive, some will have permanent physical or mental disabilities. According to a World Health Organization report, 90% of the world's typhoid deaths occur in Asia and the disease persists mainly in children under five years.

Typhoid infects the gut and bloodstream, causing fever that can reach temperatures of 39-40 C and constipation or diarrhoea. The disease can be associated with other characteristics including, rose-coloured spots on the chest, confusion and perforation of the gut.


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Contact: Jen Middleton
j.middleton@wellcome.ac.uk
44-207-611-7262
Wellcome Trust
Source:Eurekalert

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