Navigation Links
Antibiotic-resistant typhoid likely to spread despite drug control program
Date:12/9/2013

Restricting the use of antibiotics is unlikely to stop the spread of drug resistance in typhoid fever, according to a study funded by the Wellcome Trust and published in the journal eLife.

The findings reveal that antibiotic-resistant strains of Salmonella Typhi bacteria can out-compete drug sensitive strains when grown in the laboratory, even in the absence of antibiotics.

Typhoid fever is transmitted by consuming food or drink that is contaminated with Salmonella Typhi bacteria and the disease is linked to poor sanitation and limited access to clean drinking water. The disease can be treated but there is widespread drug resistance to common antibiotics and resistance to the recommended, more specialised antibiotic therapy for typhoid fever is increasing.

Researchers at the Oxford University Clinical Research Unit, Wellcome Trust Vietnam Research Programme, created twelve laboratory strains of Salmonella Typhi bacteria with one or more genetic mutations that confer resistance to the recommended antibiotic therapy for typhoid fever, fluoroquinolone. Typically, when bacteria develop antibiotic resistance it comes at a cost and when the drug is absent, they are usually weaker and less able to compete for food and resources than strains that are not resistant.

Dr Maciej Boni, a Sir Henry Dale Fellow funded jointly by the Wellcome Trust and Royal Society at the Oxford University Clinical Research Unit in Vietnam, who co-led the study, said: "When we grew different strains of Salmonella Typhi in the lab, we found that half of the antibiotic resistant strains had a growth advantage over their parent strain, even in the absence of antibiotic, enabling them to predominate in the population."

Dr Stephen Baker, also a Sir Henry Dale Fellow in the Oxford University Clinical Research Unit, said: "Currently, the control of typhoid across Asia and Africa relies on treatment with fluoroquinolones
'/>"/>

Contact: Jen Middleton
j.middleton@wellcome.ac.uk
44-207-611-7262
Wellcome Trust
Source:Eurekalert

Page: 1 2

Related biology news :

1. Antibiotic-resistant pathogens persist in antibiotic-free pigs
2. New study shows how copper restricts the spread of global antibiotic-resistant infections
3. Scientists notch a win in war against antibiotic-resistant bacteria
4. Lack of energy an enemy to antibiotic-resistant microbes
5. Researchers track antibiotic-resistant strains of Salmonella from farm to fork
6. Costs for changing pollution criteria in Florida waters likely to exceed EPA estimates
7. Evidence shows that anti-depressants likely do more harm than good, researchers find
8. Nearly one-tenth of hemispheres mammals unlikely to outrun climate change
9. Girls mathematics performance more likely to suffer than boys as a result of mathematics anxiety
10. Research warns Asia unlikely to achieve climate, poverty goals unless womens rights are recognized
11. Southern elephant seals likely detect prey bioluminescence for foraging
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2015)... NXT-ID, Inc. (NASDAQ: NXTD ... company focused on the growing mobile commerce market, announced ... DISTRIBUTED METHOD AND SYSTEM TO IMPROVE COLLABORATIVE ... establishes NXT-ID,s position in the emerging "Internet of Things" ... for multiple devices to collaborate with one another to ...
(Date:2/5/2015)... PARK, North Carolina , 5. Februar ... 35. Jahr als spezialisiertes Logistikunternehmen und hat ... als einzige klinische Logistikfirma (Clinical Logistics Organization ... Kernbotschaft der neuen Kampagne lautet First ... Lieferungen. Foto: http://photos.prnewswire.com/prnh/20150205/173753 ...
(Date:2/5/2015)... 2015   Marvin Test Solutions , ... test solutions for military, aerospace, and manufacturing ... TS-323 GENASYS Test Platform to ... is a high-performance PXI-based system designed to ... require performance functional testing. GENASYS features a ...
Breaking Biology News(10 mins):NXT-ID Patents Collaborative Services to Enable the "Internet of Things" 2NXT-ID Patents Collaborative Services to Enable the "Internet of Things" 3Marken startet Kampagne mit Patienten im Mittelpunkt 2Marken startet Kampagne mit Patienten im Mittelpunkt 3Marvin Test Solutions' GENASYS Platform Advances Mission-Critical Aerospace Production Test 2Marvin Test Solutions' GENASYS Platform Advances Mission-Critical Aerospace Production Test 3Marvin Test Solutions' GENASYS Platform Advances Mission-Critical Aerospace Production Test 4
... 1, 2012)For eastern Pacific populations of leatherback turtles, the ... that climate change could exacerbate existing threats and nearly ... hatchlings in nests buried at hotter, drier beaches are ... according to a new study in the journal ...
... When people have similar injuries, why do some end up ... The first longitudinal brain imaging study to track participants with ... all in their heads - quite literally. A ... chronic pain develops the more two sections of the brain ...
... Like detectives seeking footprints and other clues on a ... tracks of important players in the body,s molecular landscape. ... Jolla Institute for Allergy & Immunology, has done just ... of inflammation-producing immune cells. The finding provides powerful, ...
Cached Biology News:Rising heat at the beach threatens largest sea turtles, climate change models show 2Rising heat at the beach threatens largest sea turtles, climate change models show 3Why chronic pain is all in your head 2La Jolla Institute scientist discovers key step in immune system-fueled inflammation 2La Jolla Institute scientist discovers key step in immune system-fueled inflammation 3La Jolla Institute scientist discovers key step in immune system-fueled inflammation 4
(Date:3/4/2015)... -- In an article published and posted online today, ... review the clinical aspects of diseases caused by 5 ... article, "Clinical Management of Potential Bioterrorism-Related Conditions," was published ... New England Journal of Medicine . ... Tom Inglesby—review the clinical management of conditions resulting from ...
(Date:3/4/2015)... , Mar. 04, 2015 Research and ... the addition of Jain PharmaBiotech,s new report ... their offering. This report follows ... characteristic that can be objectively measured and evaluated ... processes as well as pharmacological responses to a ...
(Date:3/4/2015)... Proove Biosciences , a commercial ... to announce the launch of their CME-accredited course ... of Pain”. , The continuing medical education program ... year. The focus of the program is to ... treatments, integrate appropriate pain management techniques, and incorporate ...
(Date:3/4/2015)... San Jose, California (PRWEB) March 04, 2015 ... Chain Reaction (PCR) represents one of the fastest growing ... among cell biologists in subcellular visualization is driving growth ... The need for deeper understanding of gene expressions will ... reagents market. Expanding applications in fields ranging from pharma, ...
Breaking Biology Technology:Latest Clinical Information On Bioterrorism Threats 2Global Biomarkers Report 2014-2024 - Technologies, Markets and Companies 2Global Biomarkers Report 2014-2024 - Technologies, Markets and Companies 3Proove Biosciences Launches CME Accredited Program with Medscape 2Proove Biosciences Launches CME Accredited Program with Medscape 3Focus on Quantifying Nucleic Acid Molecules Spurs Growth in the qPCR & dPCR Instrumentation Market, According to a New Report by Global Industry Analysts, Inc. 2Focus on Quantifying Nucleic Acid Molecules Spurs Growth in the qPCR & dPCR Instrumentation Market, According to a New Report by Global Industry Analysts, Inc. 3Focus on Quantifying Nucleic Acid Molecules Spurs Growth in the qPCR & dPCR Instrumentation Market, According to a New Report by Global Industry Analysts, Inc. 4
... UK,s National Physical Laboratory (NPL) is working to provide more ... nanotechnology which could lead to much more accurate devices ... Nobel Prize in 1986. It uses a nano-sized probe to ... finger reading Braille on an extremely small scale. The technique ...
... 20 Deloitte today released the 2010 Technology Fast ... media, telecommunications, life sciences and clean technology companies in ... fiscal year revenue growth from 2005 to 2009.  For ... on the Technology Fast 500™ than any other single ...
... Iowa, Oct. 20 Bio-Research Products announced today ... offerings a lower cost, industrial grade for application ... Dr. Bryce Cunningham, President, said that "there has ... and pharmaceutical markets which has prompted us to ...
Cached Biology Technology:Measuring the electrical properties of nano-crystals 2Deloitte Announces 2010 Technology Fast 500™ Rankings 2Deloitte Announces 2010 Technology Fast 500™ Rankings 3Deloitte Announces 2010 Technology Fast 500™ Rankings 4Bio-Research Products Introduces New Grade of Chloroperoxidase Enzyme for Industrial Applications 2
... that it uses a deep-UV deuterium bulb, which ... with a shutter (controlled via a TTL signal ... DH-2000 Deuterium Tungsten Halogen Light Source combines ... light sources in a single optical path. The ...
... pump is a dedicated cuff pump for small ... replaces manual inflation and can be used for ... mouse and rat; from single up to multi-channel ... pump has adjustable cut-off pressure in 50 mmHg ...
... depleted sera are specifically depleted of a ... the depleted protein, the alternative and classical ... therefore ideal for the detection and quantitation ... have been used to assess complement activation ...
... of light production by luciferase-cDNA transfected cell ... technique in the development of reporter gene ... as an indicator for the transcription of ... enzyme is due to advantages such as ...
Biology Products: