Navigation Links
Antibiotic-resistant typhoid likely to spread despite drug control program
Date:12/9/2013

Restricting the use of antibiotics is unlikely to stop the spread of drug resistance in typhoid fever, according to a study funded by the Wellcome Trust and published in the journal eLife.

The findings reveal that antibiotic-resistant strains of Salmonella Typhi bacteria can out-compete drug sensitive strains when grown in the laboratory, even in the absence of antibiotics.

Typhoid fever is transmitted by consuming food or drink that is contaminated with Salmonella Typhi bacteria and the disease is linked to poor sanitation and limited access to clean drinking water. The disease can be treated but there is widespread drug resistance to common antibiotics and resistance to the recommended, more specialised antibiotic therapy for typhoid fever is increasing.

Researchers at the Oxford University Clinical Research Unit, Wellcome Trust Vietnam Research Programme, created twelve laboratory strains of Salmonella Typhi bacteria with one or more genetic mutations that confer resistance to the recommended antibiotic therapy for typhoid fever, fluoroquinolone. Typically, when bacteria develop antibiotic resistance it comes at a cost and when the drug is absent, they are usually weaker and less able to compete for food and resources than strains that are not resistant.

Dr Maciej Boni, a Sir Henry Dale Fellow funded jointly by the Wellcome Trust and Royal Society at the Oxford University Clinical Research Unit in Vietnam, who co-led the study, said: "When we grew different strains of Salmonella Typhi in the lab, we found that half of the antibiotic resistant strains had a growth advantage over their parent strain, even in the absence of antibiotic, enabling them to predominate in the population."

Dr Stephen Baker, also a Sir Henry Dale Fellow in the Oxford University Clinical Research Unit, said: "Currently, the control of typhoid across Asia and Africa relies on treatment with fluoroquinolones
'/>"/>

Contact: Jen Middleton
j.middleton@wellcome.ac.uk
44-207-611-7262
Wellcome Trust
Source:Eurekalert

Page: 1 2

Related biology news :

1. Antibiotic-resistant pathogens persist in antibiotic-free pigs
2. New study shows how copper restricts the spread of global antibiotic-resistant infections
3. Scientists notch a win in war against antibiotic-resistant bacteria
4. Lack of energy an enemy to antibiotic-resistant microbes
5. Researchers track antibiotic-resistant strains of Salmonella from farm to fork
6. Costs for changing pollution criteria in Florida waters likely to exceed EPA estimates
7. Evidence shows that anti-depressants likely do more harm than good, researchers find
8. Nearly one-tenth of hemispheres mammals unlikely to outrun climate change
9. Girls mathematics performance more likely to suffer than boys as a result of mathematics anxiety
10. Research warns Asia unlikely to achieve climate, poverty goals unless womens rights are recognized
11. Southern elephant seals likely detect prey bioluminescence for foraging
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/16/2014)... wages war on the human body. Battles are ... In pancreatic cancer, this stalemate—known as tumor dormancy—can ... malignant, a phenomena that is poorly understood. ... laboratory of Salvatore Torquato, a Professor of Chemistry ... surrounding tumor dormancy and the switch to a ...
(Date:10/16/2014)... new synthesis of recent research findings to inform their ... two states. , The Ecology and Management of ... Synthesis of the Relevant Biophysical Science and Implications for ... the U.S. Forest Service,s Pacific Northwest Research Station, is ... a synthesis of the large body of scientific information ...
(Date:10/16/2014)... Although monocultures can be cultivated efficiently, they are ... water caused by monoculture cultivation is becoming increasingly ... principal crop form and are regarded as the ... production – quite wrongfully, finds Bernhard Schmid, an ... advocates a novel form of agriculture and forestry. ...
Breaking Biology News(10 mins):Modeling tumor dormancy 2New report synthesizes best available science on management of moist mixed-conifer forests 2Plant communities produce greater yield than monocultures 2Plant communities produce greater yield than monocultures 3
... detailed analysis of ancient and modern DNA to show ... modern European beavers is due largely to human hunting., ... researcher Professor Michi Hofreiter, provides important new insights into ... Crucially, it shows the European beaver has been strongly ...
... and East Malling Research have identified a new way of ... on the UK,s valuable cherry and plum crops. Brown ... attacks stone fruit as well as causing blossom ... the use of fungicide treatments, but in some cases these ...
... are discussed, University of Washington researchers have found that ... reflect sunlight and curb the effects of global warming ... and supported by strict reductions in greenhouse gas (GHG) ... in IOP Publishing,s journal Environmental Research Letters , ...
Cached Biology News:Researchers shed new light on the genetic history of the European beaver 2Researchers warn against abrupt stop to geoengineering method 2
(Date:10/22/2014)... 22, 2014 Research and Markets ... "Global DNA Diagnostics Market (Product types, Application, Technology, ... Trends, Company Profiles, Demand, Insights, Analysis, Research, Report, ... report to their offering. This ... techniques, end users and Geography) Global Size, Industry ...
(Date:10/22/2014)... Involution Studios , a healthcare ... new infographic, Understanding Ebola . The goal ... easy to follow informative tool for anyone wanting to ... and prevention. , "As the news has spread in ... outbreak represents not only a healthcare crisis with global ...
(Date:10/22/2014)... October 22, 2014 According to ... by Service Type (Consulting, Integration, Deployment & Support), ... Deployment Model (Public, Private, Others (Hybrid & Community)) ... defines and segments the Cloud Professional Services Market ... forecasting of revenues. It also identifies the drivers ...
(Date:10/22/2014)... and HONG KONG , Oct. 22, ... therapeutics enterprise, announced today that rare disease expert ... vice president, research. Dr. McKew brings more than two ... positions at the National Institutes of Health, Wyeth Research ... Wyeth). Dr. McKew will lead aTyr,s efforts to expand and ...
Breaking Biology Technology:Global DNA Diagnostics Market (Product types, Application, Technology, End User and Geography) - Forecast to 2020 2Global DNA Diagnostics Market (Product types, Application, Technology, End User and Geography) - Forecast to 2020 3Involution Studios' Ebola Infographic Provides Key Disease Information and Statistics at a Glance 2Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 2Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 3Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 4Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 5aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 2aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 3
... Milwaukee and perhaps throughout Wisconsin will be asked to ... Milwaukee moves toward completion of its wireless Internet installation. ... a contract with Midwest Fiber Networks, LLC ... five goals that are key to bridging the digital ...
... doesn't mince words when it comes to broadband connectivity. , ... columnist for WTN Media , moving from dial-up Internet service ... stagecoach. Why bother when there is a Mercedes Benz ... is an issue most communities are faced with, and in Carlini's ...
... I want any old time. Lyrics from I'm Free ... this old Rolling Stones standard from the Sixties as a ... services targeted at Boomers with bloated bank balances (regretably only ... at helping people achieve their retirement dreams, it also aptly ...
Cached Biology Technology:Businesses could bridge digital divide in Milwaukee with used computers 2Businesses could bridge digital divide in Milwaukee with used computers 3Carlini beats drum for high-speed broadband 2Can a talent market work inside organizations? 2Can a talent market work inside organizations? 3Can a talent market work inside organizations? 4Can a talent market work inside organizations? 5Can a talent market work inside organizations? 6
G-Protein Coupled Receptor Assay, For 500 assays. SPA. Category: Drug Screening & Cellular Assays, Assays ....
... 9 oligodeoxynucleotides are random ... at the 5' end ... Fluor dyes and they ... microarray spot morphology, hybridization ...
EDTA, disodium salt, 1 kg. Ethylene diaminetetraacetic acid.Dihydrate. Assay: 99.0-101.0%, nuclease-free.Risks: 36, 37, 38 ; Safety Precautions: 22, 36, 37. Category: Nucleotides & Enzymes & Biochemi...
Mycoplasma tested...
Biology Products: