Navigation Links
Ant guts could pave the way for better drugs
Date:3/25/2008

Scientists have discovered two key proteins that guide one of the two groups of pathogenic bacteria to make their hardy outer shells -- their defense against the world.

The work, they said, could allow researchers to create new antibiotics against gram-negative bacteria, like E. coli and salmonella, that would destroy these bacteria by disabling the mechanism that produces their protective coating.

"A long-term goal is to find inhibitors of these proteins we have discovered," said Natividad Ruiz, a research molecular biologist at Princeton University and the lead author on the paper describing the work. "Small molecule inhibitors could become antibiotics that subvert the outer membrane."

The research, conducted by Ruiz, Thomas Silhavy, Princeton's Warner-Lambert Parke-Davis Professor of Molecular Biology, and others from Harvard University, is described in the online edition of the April 8 Proceedings of the National Academy of Sciences.

The team discovered the proteins through an extended process of elimination. The scientists looked at microbes in the guts of carpenter ants. The bacteria, which have lived there for millions of years -- passed on over many generations -- have lost many of the traits necessary for survival in the outer world. As a result, their collection of genes, known as a genome, is far smaller and simpler than the genome of E. coli.

Scientists sequenced the genome of the model bacterium E. coli 11 years ago, yet they still do not understand the functions of about 40 percent of the thousands of proteins produced by those genes, according to Ruiz. Proteins are the workhorses of cells, directing and producing the creation of many key cell structures and functions.

In contrast, the genome of the bacteria found in the ant gut, Blochmannia floridanus, contains the instructions for only 583 proteins. Since the bacteria are closely related, nearly all of Blochmannia's genes -- 564 -- are foun
'/>"/>

Contact: Kitta MacPherson
kittamac@princeton.edu
609-258-5729
Princeton University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Newly created cancer stem cells could aid breast cancer research
2. Obesity and lack of exercise could enhance the risk of pancreatic cancer
3. Finding that 1-in-a-billion that could lead to disease
4. 60 second test could help early diagnosis of common brain diseases
5. Auto immune response creates barrier to fertility; could be a step in speciation
6. Paracetamol, one of most used analgesics, could slow down bone growth
7. Drug could improve pregnancy outcomes in wider range of women with insulin resistance
8. Thousands of starving children could be restored to health with peanut butter program
9. Nanotech could make solar energy as easy and cheap as growing grass
10. CO2 emissions could violate EPA ocean-quality standards within decades
11. MIT model could improve some drugs effectiveness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/12/2015)... -- IriTech, a leading iris based identity management technology ... Design Network, announced today that the Chief Minister ... MK2120U device during a launching event of Andhra Pradesh ... The iris scanner is manufactured by U.S. based ... India through its Indian partner, Biometronic Technology, ...
(Date:3/12/2015)... 2015 WHEN:Tuesday, March 17, 2015 at 11:00 ... . SPEAKERS: , Frost & Sullivan Measurement & ... Biometric companies must plan for ... different markets and industries. This is especially true ... Join Frost & Sullivan,s upcoming ...
(Date:3/10/2015)... , March 10, 2015  Continuing its 167-year ... Unexpected, Hammacher Schlemmer introduces The Eye Scanning Password ... before granting access to secure websites or sensitive data. ... verify travelers at international borders, the device has a ... pattern points of the iris, converting them into an ...
Breaking Biology News(10 mins):Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 2Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 3Biometrics Key to Future Growth in Healthcare, Retail and Financial Markets 2Biometrics Key to Future Growth in Healthcare, Retail and Financial Markets 3Hammacher Schlemmer Introduces The Eye Scanning Password Authenticator 2
... University of North Carolina at Chapel Hill School of ... developed and experimentally tested a technique to predict new ... a computational method that compares how similar the structures ... binding partners -- known as ligands -- of disease ...
... WI, NOVEMBER 4, 2009 -- The world,s greatest wines are ... and something called the "terroir" -- a term often defined as ... discuss terroir with an emphasis on soil science in a symposium ... Environment" will be presented in two parts at the 2009 Annual ...
... LLEIDA, SPAINIn a research report published in a recent ... Sim Alegre examined the effects of covering orchard floors ... light distribution, orchard temperature, and profitability. The experiments were ... before commercial harvest in orchards of ,Mondial Gala, apples. ...
Cached Biology News:Study points to new uses, unexpected side effects of already existing drugs 2Great wines come from great soils 2Reflective film can boost profits for apple growers 2
(Date:3/27/2015)... 2015 Working in collaboration with the ... London , Richmond Pharmacology is the first centre ... study for an investigational RNAi therapeutic being developed for the ... nerves and heart. Read press release ... Based at St Georges University of London ...
(Date:3/26/2015)... -- Roka Bioscience, Inc. (NASDAQ: ROKA ), a ... solutions for the detection of foodborne pathogens, today ... and full year ended December 31, 2014. ... quarter ended December 31, 2014 was $1.4 million ... 2013 and $1.5 million for the third quarter ...
(Date:3/26/2015)... March 26, 2015  BioNano Genomics, Inc., the leader ... Salyer as chief commercial officer. Salyer has more ... sales teams in life sciences. At BioNano, Salyer will ... a genome-mapping platform to assemble a comprehensive view of ... To date, 32 institutions located in the ...
(Date:3/26/2015)... ReliantHeart, Inc., an innovative supplier of advanced ... precision transit-time flow measurement solutions, are collaborating on a ... of the HeartAssist5® Left Ventricular Assist Device ... mobility and peace of mind. , The Transonic ... draw 1/6th of the power required by earlier flow ...
Breaking Biology Technology:Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 2Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 3Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 4Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 5Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 6Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 7BioNano Genomics Appoints Terry Salyer as Chief Commercial Officer 2BioNano Genomics Appoints Terry Salyer as Chief Commercial Officer 3LVAD patients to have greater mobility and peace of mind through Transonic and ReliantHeart’s True Flow collaboration for the HeartAssist5® 2LVAD patients to have greater mobility and peace of mind through Transonic and ReliantHeart’s True Flow collaboration for the HeartAssist5® 3
... Focus on Drug Development for Neurological ConditionsBROOMFIELD, Colo., ... delivering breakthrough therapies in central nervous system (CNS) ... Inc., a drug development company. The new ... of proprietary small molecule drugs for acute and ...
... Career and Technical Education (NRCCTE), funded by the Office of Vocational ... a report that focuses on the question: What Will Be the ... that centered on three questions: , , ... secondary and postsecondary instruction be articulated? , ...
... Expert Platforms for Translational Research , COLUMBIA, S.C., April ... Board: CLXS), a leading developer of semantic search and ... research portal www.BiomedExperts.com has blown ... surpass 150,000 by the end of April. The ...
Cached Biology Technology:Accera, Inc. Launches Neuera Pharmaceuticals, Inc. 2Accera, Inc. Launches Neuera Pharmaceuticals, Inc. 3What Will Be the Impact of Programs of Study? 2Collexis BiomedExperts Fast Approaching 150,000 Registered Users 2Collexis BiomedExperts Fast Approaching 150,000 Registered Users 3Collexis BiomedExperts Fast Approaching 150,000 Registered Users 4
Aspergillus (IgG) Ab EIA Sample Size: 100 l...
Taq DNA Polymerase (cloned), 250 units. Category: Nucleotides & Enzymes & Biochemicals, Modifying Enzymes, Polymerases....
... Reduce bench time to just 15 ... from the paralles that can be drawn between ... older idea of instant foods. Instant meals ... in freeze-dried format and are reconstituted by adding ...
APO(a) EIA Sample Size: 25 l...
Biology Products: