Navigation Links
Analytical trick accelerates protein studies
Date:2/24/2013

MADISON Researchers at the University of Wisconsin-Madison have found a new way to accelerate a workhorse instrument that identifies proteins. The high-speed technique could help diagnose cancer sooner and point to new drugs for treating a wide range of conditions.

Proteins are essential building blocks of biology, used in muscle, brain, blood and hormones. If the genes are the blueprints, the proteins patterned on them are the hammers and tongs of life.

Proteins are not only numerous humans have more than a 100,000 varieties but each one has a complex structure that determines its exact function in the biological realm. Just as tissue from cats and kangaroos can be distinguished by studying the individual "letters" of their genetic codes, protein A can be distinguished from protein B by looking at the amino-acid subunits that compose all proteins.

The fastest way to count and identify proteins is to use a mass spectrometer, a precise instrument that measures chemical compounds by mass. "Mass spec is an essential part of modern biology, and most people use it to look at variations in proteins," says Joshua Coon, a professor of chemistry and biomolecular chemistry.

Because mass spectrometers are expensive, and proteins are both numerous and ubiquitous, chemists have recently learned to double up their samples so they can, for example, compare normal tissue to diseased tissue in a single run.

Knowing how the proteins change when good tissue goes bad suggests what has gone wrong.

Now, Coon has doubled-down on the doubling-up process with a technique that has the potential to run as many as 20 samples at once. The new process, described in the journal Nature Methods, has already gone to work, says Alexander Hebert, a graduate student who was first author on the new publication.

"Working with John Denu at the Wisconsin Institute for Discovery, we are looking at mice that lived with or wit
'/>"/>

Contact: Joshua Coon
jcoon@chem.wisc.edu
608-263-1718
University of Wisconsin-Madison
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UCSB scientists report new beginning in split-brain research, using new analytical tools
2. Natures phenomena might teach Virginia Tech engineers new tricks
3. Scientists trick iron-eating bacteria into breathing electrons instead
4. Global economic pressures trickle down to local landscape change, altering disease risk
5. 30 minutes of daily exercise does the trick
6. Rice agriculture accelerates global warming, new research finds
7. Antibacterial proteins molecular workings revealed
8. Nano-machines for bionic proteins
9. Bridges experimental and bioinformatics perspectives to delineate protein-DNA interactions
10. Discovering cell surface proteins behavior
11. Newly identified natural protein blocks HIV, other deadly viruses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... MA A study published online in the ... a novel approach to preventing cervical cancer based on ... cancer after removal of a discrete population of cells ... a study that looked at squamocolumnar junction cells, or ... and have been implicated as the origins of cervical ...
(Date:7/25/2014)... professor of biomedical engineering at the University of ... engineering and artificial organ development., "Introduction to Tissue ... to entering into the field of artificial organ ... biomedical engineering at UH, served as a series ... there are other published books on the subject ...
(Date:7/25/2014)... has opened the way for the development of new lines ... annual barley production is second only to wheat with 7-8 ... most important diseases of barley. , Senior Research Scientist Dr ... growths on the cell walls of barley plants that block ... research, by the ARC Centre of Excellence in Plant Cell ...
Breaking Biology News(10 mins):Clearing cells to prevent cervical cancer 2University of Houston researcher publishes textbook on tissue engineering 2New hope for powdery mildew resistant barley 2
... from the atmosphere are unlikely to offer an economically feasible ... to a report issued by the American Physical Society and ... not kid ourselves that we can pour all the carbon ... it out later at little cost," said Socolow, a professor ...
... scientists have discovered how two closely related proteins guide ... and repelling these axons as they navigate the most ... make remarkably precise connections. The discovery, reported April ... proteins belonging to the "semaphorin" family of guidance cues ...
... of Botany (KIB), part of the Chinese Academy of ... Natural Products and Bioprospecting (NPAB). As a ... in the SpringerOpen portfolio, available on www.springerlink.com . ... Science (CLoS), a collection comprising more than 90 English-language ...
Cached Biology News:Report: Direct removal of carbon dioxide from air likely not viable 2Johns Hopkins scientists reveal nerve cells' navigation system 2Johns Hopkins scientists reveal nerve cells' navigation system 3New SpringerOpen journal from the Chinese Academy of Sciences 2
(Date:7/24/2014)... July 24, 2014 Gain recognition ... Supply Chain of the biotech industry. Nominations are ... Awards, brought to you by the Bio ... of supply chain management professionals for the past ... stakeholders of the Biotech industry – Manufacturers, Service ...
(Date:7/24/2014)... MENLO PARK, Calif. , July 24, 2014 ... biotechnology company in the emerging field of regenerative ... live webcast of a presentation to investors on ... 1:30 p.m. PDT.  The presentation will include an ... pipeline. To access the webcast, visit http://www.ustream.tv/channel/asterias-biotherapeutics ...
(Date:7/24/2014)... equipment, trained personnel, and detection dogs to safeguard ... A revolutionary new electronic chip with nano-sized chemical ... easier. , The groundbreaking nanotechnology-inspired sensor, devised by ... School of Chemistry and Center for Nanoscience and ... picks up the scent of explosives molecules better ...
(Date:7/24/2014)... Yet, scientists are making progress in devising suitable ... approach relies on quantum dotsa kind of artificial ... A new study demonstrates that changing the coupling ... electrical impulses can help better control them. This ... as quantum information units, which would produce faster ...
Breaking Biology Technology:Call for Submission: BSMA’s Supply Chain Management Innovation Awards 2Call for Submission: BSMA’s Supply Chain Management Innovation Awards 3Asterias Biotherapeutics Announces Live Investor Webcast 2Asterias Biotherapeutics Announces Live Investor Webcast 3Asterias Biotherapeutics Announces Live Investor Webcast 4Nano-sized chip 'sniffs out' explosives far better than trained dogs 2
... a largely unseen battle now raging in the workplace. It ... are managers who covet the traditional employment deal money, ... commitment to playing the organizational game by traditional rules, e.g., ... unquestioning willingness to do whatever the business requires. Only Type ...
... University of Wisconsin-Madison leads the nation in the number ... in 2006. UW-Madison's total this year is up to ... ,The foundation bestows the awards on young researchers in ... biology, neuroscience and physics. Sloan Fellowships carry a two-year, ...
... Defense Agency, an information security consulting firm headquartered here ... been chosen to challenge eight student teams in an ... complexity and sophistication, so it's essential to support collegiate ... of cyber defenders," said Sami Saydjari, president and founder ...
Cached Biology Technology:Who will win the battle to redefine the workplace? 2Who will win the battle to redefine the workplace? 3Who will win the battle to redefine the workplace? 4Who will win the battle to redefine the workplace? 5UW-Madison has 7 Sloan research fellows, top in nation 2