Navigation Links
An important discovery in breast cancer by IRCM researchers
Date:4/15/2013

Montral, April 15, 2013 A team of researchers at the IRCM, led by Dr. Jean-Franois Ct, made an important discovery in breast cancer, which will published online this week by the scientific journal Proceedings of the National Academy of Sciences (PNAS). The Montral scientists identified the DOCK1 protein as a potential target to reduce the progression of metastases in patients suffering from breast cancer, the most common type of cancer in women.

Dr. Ct's laboratory is interested in metastasis, which is the spread of cancer from an organ (or part of an organ) to another. Nearly 90 per cent of cancer patient deaths are attributable to metastasis, thus explaining the importance of understanding the underlying cellular and molecular mechanisms of this harmful process.

"Despite important breakthroughs in breast cancer treatment, few mechanisms are known to explain the spread of metastases," says Dr. Ct, Director of the Cytoskeletal Organization and Cell Migration research unit at the IRCM. "We are looking to identify the proteins that regulate the metastatic process so that new agents can be developed and combined with current treatments."

Two major breast cancer subtypes, HER2+ and Basal, have a tendency to be metastatic and recurrent, and are ultimately associated to a poor survival rate. Research at the IRCM was conducted on the HER2+ type (Human Epidermal growth factor Receptor 2), which represents approximately 25 per cent of breast cancer cases. HER2 positive tumours tend to develop and spread more quickly than other types of tumours.

"By studying a genetic mouse model with HER2+ breast cancer, we identified the protein DOCK1 as an important regulator of metastasis," explains Mlanie Laurin, doctoral student in Dr. Ct's laboratory and first author of the study. "When we eliminated this protein in mice, our results showed a significant decrease in lung metastases. We also discovered that the DOCK1 protein contributes to the growth of tumours."

"To show the correlation between the expression of DOCK1 and breast cancer prognosis, we performed an analysis of several databases of patient genic," adds Dr. Benjamin Haibe-Kains, researcher at the IRCM who collaborated with Dr. Ct's team. "We did indeed discover that high levels of DOCK1 in HER2+ or Basal breast cancer patients are associated with a lower prognosis, or recurrence of the disease."

"Our work defined a new molecule required for the progression of breast cancer to the metastatic stage and allowed us to identify new markers that could become potential targets to stop the progression of metastases," concludes Dr. Ct. "We also showed that a chemical inhibitor of the DOCK1 protein, developed by Dr. Yoshinori Fukui, our collaborator in Japan, can stop the migration of cancerous cells. These results could eventually lead to the development of drugs that would limit the progression of metastatic breast cancer and could thereby improve patient prognosis."

"We are proud to fund this research," comments Melody Enguix, Scientific Communication Advisor at the Canadian Cancer Society. "The findings are another important step toward understanding how we can stop metastases, which are the cause of most breast cancer deaths."


'/>"/>

Contact: Julie Langelier
julie.langelier@ircm.qc.ca
514-987-5555
Institut de recherches cliniques de Montreal
Source:Eurekalert

Related biology news :

1. Improved Authentication and Confidentiality Protection. ICAP Patent Brokerage Announces for Auction Important Patents in Data Encryption and Document Security
2. Misperception of weight is an important barrier to weight loss
3. Zip code as important as genetic code in childhood obesity
4. Geneticist develops tool to identify genes important in disease, tailoring individual treatment
5. Overweight? New research explains how proper sleep is important for healthy weight
6. Wildfire and an example of its important link to the ecosystem
7. University of Miami-led study finds winds played important role in keeping oil away from S. Fla.
8. Large, medically important class of proteins starts to yield its secrets
9. It must be important but what does it do? The strange case of UCP2
10. Reciprocity an important component of prosocial behavior
11. New research: Soluble corn fiber plays important role in gut health and calcium absorption
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/7/2016)...  Syngrafii Inc. and San Antonio Credit Union ... integrating Syngrafii,s patented LongPen™ eSignature "Wet" solution into ... result in greater convenience for SACU members and ... existing document workflow and compliance requirements. ... Highlights: ...
(Date:6/2/2016)... The Department of Transport Management (DOTM) ... million US Dollar project, for the , Supply ... Enrolment, and IT Infrastructure , to ... implementation of Identity Management Solutions. Numerous renowned international vendors participated ... was selected for the most compliant and innovative ...
(Date:6/2/2016)... LONDON , June 2, 2016 ... Systems, Manned Platforms, Unmanned Systems, Physical Infrastructure, Support & ... intelligence provider visiongain offers comprehensive analysis of ... that this market will generate revenues of $17.98 billion ... Systems acquired DVTEL Inc, a leader in software and ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Houston ... with the Cy-Fair Sports Association to serve as ... the agreement, Houston Methodist Willowbrook will provide sponsorship ... and connectivity with association coaches, volunteers, athletes and ... with the Cy-Fair Sports Association and to bring ...
(Date:6/23/2016)... 23, 2016  The Biodesign Challenge (BDC), a university ... to harness living systems and biotechnology, announced its winning ... New York City . ... showcased projects at MoMA,s Celeste Bartos Theater during the ... MoMA,s senior curator of architecture and design, and ...
(Date:6/23/2016)... ... 2016 , ... STACS DNA Inc., the sample tracking software company, today announced ... has joined STACS DNA as a Field Application Specialist. , “I am thrilled ... COO of STACS DNA. “In further expanding our capacity as a scientific integrator, Hays ...
(Date:6/23/2016)... , June 23, 2016  Blueprint Bio, a company ... to the medical community, has closed its Series A ... Nunez . "We have received a commitment ... capital we need to meet our current goals," stated ... us the runway to complete validation on the current ...
Breaking Biology Technology: