Navigation Links
An important discovery in breast cancer by IRCM researchers
Date:4/15/2013

Montral, April 15, 2013 A team of researchers at the IRCM, led by Dr. Jean-Franois Ct, made an important discovery in breast cancer, which will published online this week by the scientific journal Proceedings of the National Academy of Sciences (PNAS). The Montral scientists identified the DOCK1 protein as a potential target to reduce the progression of metastases in patients suffering from breast cancer, the most common type of cancer in women.

Dr. Ct's laboratory is interested in metastasis, which is the spread of cancer from an organ (or part of an organ) to another. Nearly 90 per cent of cancer patient deaths are attributable to metastasis, thus explaining the importance of understanding the underlying cellular and molecular mechanisms of this harmful process.

"Despite important breakthroughs in breast cancer treatment, few mechanisms are known to explain the spread of metastases," says Dr. Ct, Director of the Cytoskeletal Organization and Cell Migration research unit at the IRCM. "We are looking to identify the proteins that regulate the metastatic process so that new agents can be developed and combined with current treatments."

Two major breast cancer subtypes, HER2+ and Basal, have a tendency to be metastatic and recurrent, and are ultimately associated to a poor survival rate. Research at the IRCM was conducted on the HER2+ type (Human Epidermal growth factor Receptor 2), which represents approximately 25 per cent of breast cancer cases. HER2 positive tumours tend to develop and spread more quickly than other types of tumours.

"By studying a genetic mouse model with HER2+ breast cancer, we identified the protein DOCK1 as an important regulator of metastasis," explains Mlanie Laurin, doctoral student in Dr. Ct's laboratory and first author of the study. "When we eliminated this protein in mice, our results showed a significant decrease in lung metastases. We also discovered that the DOCK1 protein contribute
'/>"/>

Contact: Julie Langelier
julie.langelier@ircm.qc.ca
514-987-5555
Institut de recherches cliniques de Montreal
Source:Eurekalert

Page: 1 2

Related biology news :

1. Improved Authentication and Confidentiality Protection. ICAP Patent Brokerage Announces for Auction Important Patents in Data Encryption and Document Security
2. Misperception of weight is an important barrier to weight loss
3. Zip code as important as genetic code in childhood obesity
4. Geneticist develops tool to identify genes important in disease, tailoring individual treatment
5. Overweight? New research explains how proper sleep is important for healthy weight
6. Wildfire and an example of its important link to the ecosystem
7. University of Miami-led study finds winds played important role in keeping oil away from S. Fla.
8. Large, medically important class of proteins starts to yield its secrets
9. It must be important but what does it do? The strange case of UCP2
10. Reciprocity an important component of prosocial behavior
11. New research: Soluble corn fiber plays important role in gut health and calcium absorption
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... who studied 100 twin pairs have identified a gene mutation ... than six hours of sleep per night. The genetic ... of sleep deprivation. , Results show that a participant with ... an average nightly sleep duration of only five hours, which ... who slept for about six hours and five minutes per ...
(Date:7/31/2014)... completed a 20-year study that looks at the ... times of the year. It finds that burning ... has no measurable negative consequences for the prairie ... The study was conducted by Gene Towne, research ... chief, and Joseph Craine, research assistant professor, both ...
(Date:7/31/2014)... of animal models against the highly infectious and virulent ... disease that kills approximately 30,000 Americans annually. The research ... Immunity . , In the study, the vaccine ... toxins produced by C. difficile , as well ... that mimics the human disease, after only two immunizations. ...
Breaking Biology News(10 mins):Study of twins discovers gene mutation linked to short sleep duration 2Study finds benefits to burning Flint Hills prairie in fall and winter 2Study finds benefits to burning Flint Hills prairie in fall and winter 3C. difficile vaccine proves safe, 100 percent effective in animal models 2
... PalmSecure(TM) Biometric Authentication, Self-Service Check In, Credit Card Scanning ... for Physician PracticesCHICAGO and SUNNYVALE, Calif., April 7 ... ) and Fujitsu , a leading ... today unveiled the Allscripts Patient Kiosk ...
... Company,Limited, a global provider of fingerprint recognition software and ... Fingerprint,Scanner. , FS90 uses a ... a very small form factor. Its size is 57(L) ... one half of Futronic FS80 USB2.0 Fingerprint Scanner but,can ...
... -- Which is a better strategy, specializing in ... more profitable than organic farming? Is it less ... of Wisconsin,s College of Agriculture and Life Sciences ... Wisconsin Integrated Cropping Systems Trial (WICST) in 1990. ...
Cached Biology News:Allscripts Integrates Electronic Health Records with Innovative Patient Kiosk 2Allscripts Integrates Electronic Health Records with Innovative Patient Kiosk 3Allscripts Integrates Electronic Health Records with Innovative Patient Kiosk 4Allscripts Integrates Electronic Health Records with Innovative Patient Kiosk 5Allscripts Integrates Electronic Health Records with Innovative Patient Kiosk 6Allscripts Integrates Electronic Health Records with Innovative Patient Kiosk 7Futronic Launches FS90 USB2.0 Mini Fingerprint Scanner 2
(Date:8/1/2014)... Once a decision has been made ... will discuss how to define your tolerance for lowest ... Allen, Senior Director of Facilities Integration at Fluor Industrial ... Industrial Services, and special guest Carrier Li, Director in ... as they provide an examination of the Conceptual Design ...
(Date:7/31/2014)... (PRWEB) July 31, 2014 Food ... are increasingly searching for food alternatives that offer ... benefits. The food ingredient market has numerous players ... such as Vital Force Technology (VFT). VFT ... than 4,000 energetic patterns, all tested to produce ...
(Date:7/31/2014)... British mathematician (1912-1954), is famous for a number of ... In 1936 he published a paper, which laid the ... of a computer algorithm. He next played a pivotal ... which cracked the German military codes, enabling the Allies ... in the late 1940,s he turned his attention to ...
(Date:7/31/2014)... , July 31, 2014 ... Market Research "Quantum Dots Market - Global Industry Analysis, ... the market was valued at USD 88.5 million in ... by 2023, growing at a CAGR of 53.8% from ... Dots Market Report at  http://www.transparencymarketresearch.com/quantum-dots.html Increasing ...
Breaking Biology Technology:Defining Low Cost in Your Solution for Future Facilities, New Webinar for Pharma, Biotech, Medical Device and Healthcare Companies, Hosted by Xtalks 2Functional Ingredient Manufacturer – Vital Force Technology Infuses Raw Materials & Ingredients with Subtle Energy Formula 2A mathematical theory proposed by Alan Turing in 1952 can explain the formation of fingers 2A mathematical theory proposed by Alan Turing in 1952 can explain the formation of fingers 3Global Quantum Dots Market is Expected to Reach USD 8,246.8 Million in 2023: Transparency Market Research 2Global Quantum Dots Market is Expected to Reach USD 8,246.8 Million in 2023: Transparency Market Research 3Global Quantum Dots Market is Expected to Reach USD 8,246.8 Million in 2023: Transparency Market Research 4
... China, March 11 /Xinhua-PRNewswire-FirstCall/ -- China,Bionanometer Industries ... the bionanometer industry has formally signed an ... China Guangzhou,LGLY Advertising LTD., Guangzhou LGLY ... It was,founded in December 1997 and is ...
... March 11 ChanTest, the leading provider of,ion ... customers,will feature the latest in its expanding line ... Toxicology conference March 17-20, in Seattle, Washington.,New FDA ... Channel,Panel(TM) and Brain Channel Panel(TM), which ChanTest designed ...
... The Project on Emerging Nanotechnologies (PEN) and National ... premiere event for the television series Nanotechnology: The ... The eventby invitation onlywill include remarks by U.S. ... Congressional Nanotechnology Caucus. , The series three programs ...
Cached Biology Technology:CBIU Signs Agreement with LGLY Advertising LTD 2ChanTest to Highlight Expanded Ion Channel Testing Services for Preclinical Safety at ToxExpo, Including the World's Largest Catalog of Validated Ion Channels, Booth 2504 2New nanotechnology television series does 'sweat the small stuff' 2
For use with SSP products or any application requiring agarose gel separation • Multiple formats available to meet various throughput needs • Includes replacement parts for each un...
...
Request Info...
Human RUNX2/CBFA1 MAb (Clone 232902)...
Biology Products: