Navigation Links
American College of Medical Genetics responds to new FDA labeling decision for warfarin
Date:8/23/2007

BETHESDA, MD August 23, 2007 On August 16, the Food and Drug Administration approved new labeling information for the blood-thinner warfarin, sold under the brand name Coumadin. The new label suggests that one can prescribe higher or lower doses that may be safer for patients with variations in two genes, CYP2C9 or VKORC1. These variations can be learned through genetic testing, which may be a useful tool in determining appropriate dosing levels for individual patients and lower risks of bleeding complications.

The FDA labeling change for warfarin is the next step in the pathway toward incorporating genetics into the care of patients who need anticoagulation. The FDA has said that physicians should be aware of the role of genetics in warfarin dosing, but now the hard part is doing the necessary groundwork to determine how best to use genetic testing to improve care, said Marc S. Williams, MD, FACMG, ACMG Board Member and a co-chair of the expert group on Pharmacogenetic Testing of CYP2C9 and VKORC1 Alleles for Warfarin Use. This group is completing a report on the use of pharmacogenomic testing for warfarin and is based on a rapid-ACCE (Analytic validity, Clinical validity, Clinical utility and Ethical, legal and social implications) Review on Genetic Testing and Warfarin Dosing.

Available online at www.acmg.net, this 74-page report is the most thorough review of the scientific and clinical evidence surrounding the use of genetic testing to guide dosing of warfarin and was undertaken by a multidisciplinary group convened in 2006 of clinical pharmacologists, doctors of pharmacy, clinical geneticists, physicians with expertise in the use of warfarin, pharmacoeconomists, and experts in evidence-based medicine. The purpose of the rapid-ACCE review was to provide an independent, systematic review of the evidence and to develop recommendations based on this evidence. The review indicated that the test itself is as accurate as most genetic tests and that there is strong evidence to support the relationship between the genetic variant(s) and the final dose of warfarin in patients. Further, The report states that there are situations in which one should perform genetic tests when prescribing warfarin. In particular, it states in the conclusion that CYP2C9 and VKORC1 genotypes can reasonably be used as part of diagnostic efforts to determine the cause of an unusually low maintenance dose of warfarin or an unusually high INR (the test used to monitor warfarin) during standard dosing, said Michael S. Watson, PhD, FACMG, Executive Director of the American College of Medical Genetics who commissioned the study in 2006 with funding provided by the American College of Medical Genetics Foundation. However, the ACCE review and the work group noted that there are still significant gaps in our knowledge of the clinical utility and the balance between harm, benefit and cost. Resolving this is necessary before genetic testing becomes the standard of care for all patients undergoing anticoagulation with warfarin. There are also insufficient data about the impact of this testing on adverse events.

In response to the need for more information on implementing genetic testing into warfarin dosing, the American College of Medical Genetics will release a position statement in fall 2007 in the journal Genetics in Medicine which will provide the details of how the experts interpreted the evidence as to the use of these genetic tests to inform warfarin dosing.

With 30 million Americans on warfarin and 2 million or more adverse side effects reported annually, the potential for genetic testing to minimize pain and suffering is tremendous. Genetics will continue to play an ever-increasing role in the prevention, diagnosis and treatment of disease, said Joe Leigh Simpson, MD, FACMG, President of the American College of Medical Genetics.


'/>"/>
Contact: Kathy Beal
kbeal@acmg.net
301-238-4582
American College of Medical Genetics
Source:Eurekalert

Related biology news :

1. First North American Encapsulated Islet Transplant without Long-term Immune Suppression into a Patient with Type 1 Diabetes
2. Health costs soar as 60 million Americans classed as obese
3. Discovery of an American salamander where it shouldnt be: Korea
4. DNA traces evolution of extinct sabertooths and the American cheetah-like cat
5. North & South American researchers find architectural abnormalities in T. cruzi ribosome
6. T-rays: New imaging technology spotlighted by American Chemical Society
7. New peptide antibiotic isolated from American oyster
8. Computers to save unique type of American red squirrel
9. Alcoholism, smoking and genetics among Plains American Indians
10. Gene variation increases SIDS risk in African Americans
11. Americans support free access to research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2016)... 31, 2016   ... the "Company") LegacyXChange is excited to release ... soon to be launched online site for trading 100% ... ) will also provide potential shareholders a sense of ... to an industry that is notorious for fraud. The ...
(Date:3/22/2016)... 22, 2016 According ... Market for Consumer Industry by Type (Image, Motion, ... (Communication & IT, Entertainment, Home Appliances, & ... to 2022", published by MarketsandMarkets, the market ... reach USD 26.76 Billion by 2022, at ...
(Date:3/17/2016)... 17, 2016 ABI Research, the leader ... global biometrics market will reach more than $30 ... from 2015. Consumer electronics, particularly smartphones, continue to ... anticipated to reach two billion shipments by 2021 ... Pavlakis , Research Analyst at ABI Research. "Surveillance ...
Breaking Biology News(10 mins):
(Date:4/29/2016)... 29, 2016 According to ... Research "Separation Systems for Commercial Biotechnology Market - ... Forecast 2015 - 2023", the separation systems for ... Mn in 2014 and is projected to expand ... 2023 to reach US$ 19,227.8 Mn in 2023. ...
(Date:4/29/2016)... ... April 29, 2016 , ... Intelligent Implant Systems announced today that ... 510(k) for sale in the United States. These components expand the capabilities of ... With one-level sales beginning in October of 2015, the company has seen significant sales ...
(Date:4/28/2016)... , April 28, 2016 ... company reports the Company,s CEO  was featured in ... Accelerators Enter When VCs Fear To Tread: ... Leader magazine is an essential business ... everything from emerging biotechs to Big Pharmas. Their ...
(Date:4/28/2016)... York, NY (PRWEB) , ... April 28, 2016 ... ... QuickSTAT has made significant investments in recruiting top industry experts, and expanding its ... Platform, which provides industry-leading tools for clients to manage their clinical trial projects. ...
Breaking Biology Technology: