Navigation Links
Alzheimer's disease therapeutic prevents long-term damage from TBI in pre-clinical studies
Date:3/15/2009

WASHINGTON, D.C. A class of Alzheimer's disease drugs currently studied in clinical trials appears to reduce damage caused by traumatic brain injury in animals, researchers at Georgetown University Medical Center report in an upcoming advance online publication of Nature Medicine.

They say the results suggest that this class of drugs could potentially do something no other drug has been able to do-- prevent the long-term and continuing damage that often follows a serious injury to the brain.

That is because the agents, known as gamma secretase inhibitors, are designed to prevent build-up of amyloid, a toxic peptide found in the brain. This peptide clogs the brains of Alzheimer's patients but it is has also been found in people who have died from traumatic brain injury, says the study's lead author, neuroscientist Mark Burns, PhD, an assistant professor at GUMC.

"No one knows why it occurs, but abnormal amounts of amyloid plaque have been found during an autopsy in about a third of brain injury victims, some of whom were children who would ordinarily never have had these deposits," says Burns. "Remarkably, these deposits may occur in less than one day after injury."

There is another connection between traumatic brain injury and Alzheimer's disease, he says it is known that people who suffered a brain injury had a 400 percent increased risk of developing the disorder.

"But up until now, these were just interesting observations," Burns says. "In this study we show that the same pathways activated chronically in Alzheimer's disease are activated acutely in traumatic brain injury and that they appear to play a very important role in secondary injury."

Severe brain injury usually produces an immediate "necrotic" death of nerve cells, but this damage is often followed by a secondary wave of injury that can last weeks, months, and even years, Burns says. This damage comes from apoptosis, which is a differ
'/>"/>

Contact: Karen Mallet
km463@georgetown.edu
215-514-9751
Georgetown University Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Paradigm shift in Alzheimerss research: new treatments
2. Iron is involved in prion disease-associated neuronal demise
3. Seeing stem cells helps in fight against peripheral arterial disease
4. Metastatic bone disease patients can walk in Lazarus footsteps
5. Pitt researchers describe molecular 2-step leading to protein clumps of Huntingtons disease
6. Stem cell breakthrough gives new hope to sufferers of muscle-wasting diseases
7. Computer superpower strengthens attempts to combat common diseases
8. Cats eye diseases genetically linked to diseases in humans
9. New discovery paves the way for new diagnosis of serious lung disease
10. Addiction: Insights from Parkinsons disease
11. Portable kit may 1 day detect plant disease before disastrous outbreak
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/10/2015)... , August 10, 2015 The latest ... offers comprehensive analysis of the global border security market ... revenues of $16.4bn in 2015. Now: Border security ... an example of the business critical issue you need to ... visiongain ,s objective analysis of how this will impact ...
(Date:8/6/2015)... , Aug. 6, 2015 Synaptics Inc. ... human interface solutions, today announced collaboration with Microsoft ... Windows 10. Microsoft leveraged Synaptics, deep expertise in ... system. Through stringent testing, Synaptics, ... certified with Microsoft,s Precision TouchPad (PTP) specification empowering ...
(Date:8/5/2015)... 2015 The biosensors market is proving highly ... into newer sectors, and development of devices resulting in ... has seen the entry of multiple participants each year ... (Photo - http://photos.prnewswire.com/prnh/20150805/255570 ) ... the Global Biosensors Market ( http://www.frost.com/nee9 ), finds ...
Breaking Biology News(10 mins):Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 2Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 3Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 4Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 5Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 6Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 7Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 8Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 9Synaptics Chosen for Human Interface Co-Development on Windows 10 2Innovative Biosensors Incite Use in Non-Traditional Applications 2Innovative Biosensors Incite Use in Non-Traditional Applications 3Innovative Biosensors Incite Use in Non-Traditional Applications 4
... Inc.,(OTC Bulletin Board: INVI), a leading global supplier ... received an order for the,Company,s SharpEye(TM) system from ... manufacturer. The SharpEye product provides analysis of functional,and ... in the manufacturing,process, and the system will be ...
... produced to help people absorb more calcium. Researchers ... the calcium intake of humans who ate the carrot and ... was done in collaboration with Baylor College of Medicine, means ... diseases as osteoporosis. If you eat a serving ...
... some of the genetic secrets that enable pine ... disease, uncovering critical new information about forests natural ... this genetic analysis will allow forest stewardship programs ... that could in time repel insects such as ...
Cached Biology News:Integral Vision, Inc. Announces SharpEye(TM) Order From New Customer 2Got carrots? Vegetables may have bone to pick as calcium providers 2UBC discovery unlocks tree genetics, gives new hope for pine beetle defense 2
(Date:8/27/2015)... ... 27, 2015 , ... Capital Edge Consulting , a nationwide consulting firm ... announce their ranking as one of the top 5000 companies listed on the ... the nation. , “It is truly an honor to be recognized as one of ...
(Date:8/27/2015)... /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ("Biorem" or "the Company") today ... 30, 2015. Biorem,s complete second quarter financial statements and MD&A have ... ,000,s except earnings per shareThree-months ended , Six -months endedJune 30 ... 2015 , 2014 Revenue , 4,709 , ... profit , 1,656 , 56 , ...
(Date:8/27/2015)... N.C. , Aug. 27, 2015 ... decision by FedEx, UPS and The US Postal ... biological specimens classified as ,select agents, by the ... history of handling these sensitive shipments. ... global transportation regulations, trained and certified personnel to ...
(Date:8/26/2015)... ... August 26, 2015 , ... ... its investment in the development and manufacture of highly valued cardiac markers used ... scientific team's extensive expertise with protein chemistry has led to the development and ...
Breaking Biology Technology:Capital Edge Consulting Makes Inc. 5000 List of America’s Fastest-Growing Private Companies 2Capital Edge Consulting Makes Inc. 5000 List of America’s Fastest-Growing Private Companies 3BIOREM Reports $718,000 Net Earnings for the Second Quarter 2BIOREM Reports $718,000 Net Earnings for the Second Quarter 3Marken Ensures Safe Transportation Of Select Agents And Toxins 2Lee Biosolutions Announces Increased Investment in the Development and Manufacturing of Biomarkers Used in Early Detection Of Heart Disease 2
... , NEW BRUNSWICK, N.J., Nov. 16 Senesco Technologies, ... today announced that, on November 16, 2009, Bruce C. Galton ... of directors. In addition, Mr. Galton resigned from his ... pursue other interests. Mr. Galton and the Company currently ...
... , ARMSTRONG, Iowa, Nov. 16 Art,s Way Manufacturing, ... Art,s Way Scientific, Inc. - Buildings For Science - will ... nursery and finisher operations. The complex will be used to ... production. Research projects will include trials on nutrition, physiology and ...
... 16 Palatin Technologies, Inc. (NYSE Amex: PTN ) today ... reported a net loss of $37,000, or $(0.00) per basic and ... a net loss of $4.3 million, or $(0.05) per basic and ... in the quarter ended September 30, 2009 were $3.7 million, compared ...
Cached Biology Technology:Senesco Technologies, Inc. Announces Management Change 2Senesco Technologies, Inc. Announces Management Change 3Art's Way Manufacturing Announces Contract for Modular Swine Facility for the University of Georgia 2Art's Way Manufacturing Announces Contract for Modular Swine Facility for the University of Georgia 3Palatin Technologies, Inc. Reports First Quarter Fiscal Year 2010 Results; Teleconference and Webcast to be held on November 16, 2009 2Palatin Technologies, Inc. Reports First Quarter Fiscal Year 2010 Results; Teleconference and Webcast to be held on November 16, 2009 3Palatin Technologies, Inc. Reports First Quarter Fiscal Year 2010 Results; Teleconference and Webcast to be held on November 16, 2009 4Palatin Technologies, Inc. Reports First Quarter Fiscal Year 2010 Results; Teleconference and Webcast to be held on November 16, 2009 5Palatin Technologies, Inc. Reports First Quarter Fiscal Year 2010 Results; Teleconference and Webcast to be held on November 16, 2009 6
Mycoplasma tested...
...
... kit contains the basic components required for ... natural and recombinant rat Thymus Chemokine-1 in ... contains sufficient materials to run ELISAs on ... following conditions are met: The ...
Blimp-1 (H-150)...
Biology Products: