Navigation Links
Altered gene protects some African-Americans from coronary artery disease
Date:1/27/2011

future assist physicians in risk-stratifying those without inherited protection so they could be monitored more closely for early signs and symptoms of disease.

The findings are set to appear in the Journal of Human Genetics online Jan. 27.

Becker, a professor at both the Johns Hopkins University School of Medicine and Hopkins' Bloomberg School of Public Health, and a team that included researchers at Duke and Emory universities, also say their results, based on blood analysis from 548 black men and women in the Baltimore region and confirmed in several hundred more in the Atlanta and Durham, N.C., regions, help explain why earlier studies found potentially dangerous genetic connections to this type of heart disease in Caucasians, Hispanics and Asians, but failed to find a negative tie-in to the disease in blacks.

Earlier studies, says Becker, had involved genome-wide reviews in multiracial populations and taken "a needle in the haystack approach" to finding that one change in a string of some 58,000 base pairs, in a chromosomal region known as 9p21. That region, which includes CDKN2B, is associated with higher rates of coronary disease in non-blacks.

The team's latest analysis was successful, she believes, because it had a large and sufficiently broadly based black volunteer population. The study group comprised men and women between the ages of 26 and 60. Investigators also focused on the 9p21 region and a subsection of genetic material within called ANRIL that overlaps and is closely held to CDKN2B, but away from the deleterious genetic variant found earlier.

Johns Hopkins cardiologist Brian Kral, M.D., M.P.H., says the abundance of activity in this particular region of the genome, including CDK2NB and ANRIL, suggests that everyday replication of this zone could play a more fundamental, underlying role in the progression of coronary artery disease in all races.

Kral, an assistant professor a
'/>"/>

Contact: David March
dmarch1@jhmi.edu
410-955-1534
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Most river flows across the US are altered by land and water management
2. 1st census shows life in planet ocean is richer, more connected, more altered than expected
3. New data on the regulation of a protein that is altered in all cancers
4. Altered gene can increase risk of schizophrenia
5. Effectiveness of progesterone in reducing preterm births may be altered by genetic predisposition
6. Scientists unlock possible aging secret in genetically altered fruit fly
7. Afla-Guard also protects corn crops
8. Scientists discover how neuroglobin protects against Alzheimers
9. 2009 H1N1 vaccine protects against 1918 influenza virus
10. Suspended animation protects against lethal hypothermia, study shows
11. Experimental treatment protects monkeys from lethal Ebola virus post-exposure
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2015)... -- According to a new market ... Technology, Material (Optical Prism, Piezoelectric, Capacitive & Adhesives), ... & Geography - Global Forecast to 2014 - ... expected to reach $14,500.07 Million by 2020, at ... 76 market Tables and 109 Figures spread through ...
(Date:6/25/2015)... , June 25, 2015  TAKE Solutions Ltd., a ... by the United States Patent and Trademark Office (USPTO) ... process leverages TAKE Solutions, Clinical Accelerators to reduce the ... (when compared to standardization without the accelerators), thus reducing ... At the heart of the patented ...
(Date:6/24/2015)... 24, 2015 This report provides market analysis ... six years. It contains an analysis of the drivers, ... their impact from the short, medium, and long term ... industry, market, and technology trends that currently, prevail in ... concerned authorities to efficiently manage the increasing marine traffic ...
Breaking Biology News(10 mins):Fingerprint Sensors Market Worth $14,500.07 Million by 2020 2Fingerprint Sensors Market Worth $14,500.07 Million by 2020 3Fingerprint Sensors Market Worth $14,500.07 Million by 2020 4TAKE Solutions Awarded Patent By USPTO 2Automatic Identification System Market by Class, by Platform, by Application and by Geography - Global Forecasts & Analysis to 2014 - 2020 2
... that are linked with the onset of Barrett,s oesophagus (BE), ... have been identified for the first time. The discovery of ... develop screening tests for people at high risk of developing ... that there may be genetic causes for BE as well ...
... Sunday, September 9, 2012 A new paper published online ... the second most common type of lung cancer may one ... other lung cancer patients. Squamous cell lung cancer ... cancer, ranking second only to lung adenocarcinoma in the number ...
... 7, 2012 The University of Illinois at ... teams joining the NASA Astrobiology Institute (NAI) to study the ... approximately $8 million. Nigel Goldenfeld, Swanlund Professor of ... Institute for Genomic Biology (IGB), will serve as the principal ...
Cached Biology News:Researchers find first evidence for a genetic cause for Barrett's oesophagus 2Researchers find first evidence for a genetic cause for Barrett's oesophagus 3New potential targets discovered for treating squamous cell lung cancers 2New potential targets discovered for treating squamous cell lung cancers 3University of Illinois at Urbana-Champaign awarded 5-year grant from NASA 2University of Illinois at Urbana-Champaign awarded 5-year grant from NASA 3
(Date:6/30/2015)... ... 2015 , ... Students and faculty from Beijing City University ... “Integrative Biotechnology,” an applied biotechnology course team-taught by faculty members from both institutions. ... from both universities and is taught on both continents. , “Our alliance with ...
(Date:6/30/2015)... June 30, 2015  Today, Americord Registry, one of the ... Andrew Horne , a partner at Kirkland & Ellis LLP, ... Logo - http://photos.prnewswire.com/prnh/20150630/226958LOGO   "We are ... Board," says Martin Smithmyer , CEO of Americord. "He ... career that will assist Americord,s growth and vision." ...
(Date:6/30/2015)... ... June 30, 2015 , ... Matrix Marketing Group, LLC , ... hired Gem Swartz to head up its account management department as vice president of ... and Amanda bring senior account management and delivery expertise to the growing Matrix Marketing ...
(Date:6/30/2015)... IL (PRWEB) , ... June 30, 2015 , ... ... effective August 14. She has accepted the position of vice president of instruction ... August 17. , “I greatly appreciated the opportunity to lead SIUE during ...
Breaking Biology Technology:Rivier University and Beijing City University Academic and Cultural Exchanges Begin 2Americord Registry Announces Andrew Horne as Advisory Board Member 2Matrix Marketing Group Expands Client Services Team 2SIUE’s Furst-Bowe Accepts VP of Instruction at CVTC 2SIUE’s Furst-Bowe Accepts VP of Instruction at CVTC 3
... Heritage has recently,overcome patent claims held by a competitor ... and databases that allow families around,the world to match ... the,use of surnames and Y-chromosomes to establish a family ... rendered a formal opinion,stating that the relevant claims are ...
... of advanced neuromodulation products designed to accelerate recovery from central ... largest provider of inpatient rehabilitative healthcare services, will expand the ... NESS L300™ Foot Drop System to 88 rehabilitation hospitals nationwide. ... ...
... OSAKA, Japan, July 30 /PRNewswire/ - Cytochroma and,Mitsubishi ... have signed a license agreement under which Cytochroma ... Asia, including Japan, to develop,and commercialize CTA018, Cytochroma,s ... development in Canada for the treatment of secondary,hyperparathyroidism ...
Cached Biology Technology:DNA Heritage Success in Patent Battle Helps Keep Genealogy DNA Test Prices Low 2 Bioness Announces NESS H200 and L300 Systems to Be Available at 88 HealthSouth Hospitals Nationwide 2 Bioness Announces NESS H200 and L300 Systems to Be Available at 88 HealthSouth Hospitals Nationwide 3Cytochroma and Mitsubishi Tanabe form partnership for chronic kidney disease therapies in U.S. and Asia 2Cytochroma and Mitsubishi Tanabe form partnership for chronic kidney disease therapies in U.S. and Asia 3Cytochroma and Mitsubishi Tanabe form partnership for chronic kidney disease therapies in U.S. and Asia 4
... The CopyControl™ vector can be induced prior ... vectors provide the stability of single-copy BACs ... or other cloning vectors. The kits provide ... reagents, insert size screening system) necessary to ...
... EPICENTREs patented MasterAmp™ 10X PCR ... performance and allows improved sensitivity and ... templates. Using MasterAmp™ PCR Enhancer in ... of DNA melting, increases enzyme?s thermal ...
... Streptavidin-AP Systems provide rapid, precise localization ... in frozen or paraffin-embedded tissue, cytospins ... also facilitate double or triple labeleing ... simultaneously with primary antibodies of different ...
... Biotin Streptavidin-HRP Systems provide rapid, precise ... antigens in frozen or paraffin-embedded tissue, ... systems also facilitate double or triple ... performed simultaneously with primary antibodies of ...
Biology Products: