Navigation Links
Altered gene protects some African-Americans from coronary artery disease
Date:1/27/2011

future assist physicians in risk-stratifying those without inherited protection so they could be monitored more closely for early signs and symptoms of disease.

The findings are set to appear in the Journal of Human Genetics online Jan. 27.

Becker, a professor at both the Johns Hopkins University School of Medicine and Hopkins' Bloomberg School of Public Health, and a team that included researchers at Duke and Emory universities, also say their results, based on blood analysis from 548 black men and women in the Baltimore region and confirmed in several hundred more in the Atlanta and Durham, N.C., regions, help explain why earlier studies found potentially dangerous genetic connections to this type of heart disease in Caucasians, Hispanics and Asians, but failed to find a negative tie-in to the disease in blacks.

Earlier studies, says Becker, had involved genome-wide reviews in multiracial populations and taken "a needle in the haystack approach" to finding that one change in a string of some 58,000 base pairs, in a chromosomal region known as 9p21. That region, which includes CDKN2B, is associated with higher rates of coronary disease in non-blacks.

The team's latest analysis was successful, she believes, because it had a large and sufficiently broadly based black volunteer population. The study group comprised men and women between the ages of 26 and 60. Investigators also focused on the 9p21 region and a subsection of genetic material within called ANRIL that overlaps and is closely held to CDKN2B, but away from the deleterious genetic variant found earlier.

Johns Hopkins cardiologist Brian Kral, M.D., M.P.H., says the abundance of activity in this particular region of the genome, including CDK2NB and ANRIL, suggests that everyday replication of this zone could play a more fundamental, underlying role in the progression of coronary artery disease in all races.

Kral, an assistant professor a
'/>"/>

Contact: David March
dmarch1@jhmi.edu
410-955-1534
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Most river flows across the US are altered by land and water management
2. 1st census shows life in planet ocean is richer, more connected, more altered than expected
3. New data on the regulation of a protein that is altered in all cancers
4. Altered gene can increase risk of schizophrenia
5. Effectiveness of progesterone in reducing preterm births may be altered by genetic predisposition
6. Scientists unlock possible aging secret in genetically altered fruit fly
7. Afla-Guard also protects corn crops
8. Scientists discover how neuroglobin protects against Alzheimers
9. 2009 H1N1 vaccine protects against 1918 influenza virus
10. Suspended animation protects against lethal hypothermia, study shows
11. Experimental treatment protects monkeys from lethal Ebola virus post-exposure
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... of the Santa Ana Wildfire Threat Index a ... the powerful, hot, dry Santa Ana wind, which can ... introduced Sept. 17 by the U.S. Forest Service, in ... , The index includes four classification levels ranging from ... fire agencies and other emergency responders, the media and ...
(Date:9/17/2014)... as an EC-FP5 four-year project, delivering its first release ... successful participations in several EC projects, as a part ... project (EU BON), to increase the general awareness of ... the general dissemination of the Fauna Europaea results, the ... its novel e-Publishing tools to prepare data papers for ...
(Date:9/17/2014)... shopping bags and their environmental impact recently scored a ... statewide ban on the bags, and Governor Jerry Brown ... industry is not yielding without a fight, according to ... the weekly newsmagazine of the American Chemical Society. , ... the anti-bag campaign logged its first small victory in ...
Breaking Biology News(10 mins):UCLA scientists play key role in developing new Santa Ana Wildfire Threat Index 2Contributions on Fauna Europaea: Data papers as innovative model on expert involvement 2
... of Adelaide researchers have taken a step forward in ... finding that a genetic mutation leads to a reduction ... among the top four types of intellectual disability linked ... families, including many large Australian families, have been discovered ...
... N.Y. ─ Stingrays swim through water with such ease ... University are studying how their movements could be used ... The vehicles could allow researchers to more efficiently ... also serve during clean up or rescue efforts. ...
... the walls of plant cells, to bind and protect the ... lignin is a major challenge for those who would extract ... biofuels. As part of their search for economic ways to ... (JBEI) have characterized the enzymatic activity of a rain forest ...
Cached Biology News:Gene linked to common intellectual disability 2Stingray movement could inspire the next generation of submarines 2Lignin-feasting microbe holds promise for biofuels 2
(Date:9/17/2014)... , Sept. 17, 2014 Intarcia ... quantitative data from a study of the cost and ... the 50 th Annual Meeting of the European ... poster session today, Christian Frois , Ph.D., of ... a series of planned Intarcia-sponsored, retrospective studies to characterize ...
(Date:9/17/2014)... , Sept. 17, 2014 /PRNewswire/ - SQI Diagnostics Inc. ... develops and commercializes proprietary technologies and products for advanced ... been approved for trading in the United ... is expected to commence on September 17, 2014 on ... continue to trade on the TSX Venture Exchange under ...
(Date:9/17/2014)... LAKE FOREST, California , 17 de ... BB: CYRX) ("la compañía"), principal proveedor mundial ... industria de las ciencias de la vida, ... una compañía de logística global con sede ... a su base de clientes Europa en ...
(Date:9/17/2014)... , September 17, 2014 ... of action from a truly novel class ... MGB Biopharma, a biopharmaceutical company developing ... today that it has secured £4.0m ($6.4m) ... antibacterial, MGB-BP-3, against a range of Gram-positive ...
Breaking Biology Technology:Intarcia Reveals New Insights At EASD Meeting Characterizing The Burden Of Poor Control And Non-Adherence To Anti-Diabetic Therapies 2Intarcia Reveals New Insights At EASD Meeting Characterizing The Burden Of Poor Control And Non-Adherence To Anti-Diabetic Therapies 3Intarcia Reveals New Insights At EASD Meeting Characterizing The Burden Of Poor Control And Non-Adherence To Anti-Diabetic Therapies 4Intarcia Reveals New Insights At EASD Meeting Characterizing The Burden Of Poor Control And Non-Adherence To Anti-Diabetic Therapies 5SQI Diagnostics to begin Trading on the OTCQX Marketplace in the United States 2SQI Diagnostics to begin Trading on the OTCQX Marketplace in the United States 3Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 2Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 3Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 4Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 5MGB Biopharma Secures £4.0m ($6.4m) to Advance its Novel Lead Antibacterial, MGB-BP-3, into Clinical Development 2MGB Biopharma Secures £4.0m ($6.4m) to Advance its Novel Lead Antibacterial, MGB-BP-3, into Clinical Development 3MGB Biopharma Secures £4.0m ($6.4m) to Advance its Novel Lead Antibacterial, MGB-BP-3, into Clinical Development 4MGB Biopharma Secures £4.0m ($6.4m) to Advance its Novel Lead Antibacterial, MGB-BP-3, into Clinical Development 5MGB Biopharma Secures £4.0m ($6.4m) to Advance its Novel Lead Antibacterial, MGB-BP-3, into Clinical Development 6MGB Biopharma Secures £4.0m ($6.4m) to Advance its Novel Lead Antibacterial, MGB-BP-3, into Clinical Development 7
... , ,MILWAUKEE,WI. Merge eFilm a ... signed a new $15 million unsecured line of credit ... a Milwaukee-based firm. , ,The firms previous $5 million ... drawn, was set to expire in December 2005. The ...
... UW-Madison professor Raj Veeramani and Menasha Corp. research ... of innovation in todays economy at the first ... in northeast Wisconsin. , ,The WIN Foundation is ... which is the independent, non-profit science and technology ...
... issued in November by a Washington, DC, think tank ... projects currently underway in Madison could raise that score, ... who works within the Department of Administration (DOA) ... into that agency, also said the Center for ...
Cached Biology Technology:WIN Northeast Wisconsin Chapter Launched for Regions Entrepreneurs 2Wisconsin to Get Serious about E-Government 2Wisconsin to Get Serious about E-Government 3Wisconsin to Get Serious about E-Government 4
Troponin I (22B11)...
Immulon 4 HBX 1x12 Strip, flat bottom; high binding extra surface with special resin and irradiation, offers maximum protein uptake....
...
... Enterokinase (rEK) is a highly purified preparation ... a serine protease which recognizes the identical ... and has similar enzymatic activity. Novagen&'s enzyme ... and purified to yield the highest activity ...
Biology Products: