Navigation Links
After decades of research, scientists unlock how insulin interacts with cells
Date:1/9/2013

."

The magnitude of the challenge is, in part, evidenced by the diversity of the team required to overcome it. Weiss partnered with Associate Professor Mike Lawrence, of the Walter and Eliza Hall Institute of Medical Research in Melbourne, Australia, to lead the project. They, in turn, engaged scientists from the University of Chicago, the University of York in the United Kingdom, and the Institute of Organic Chemistry and Biochemistry in Prague in the Czech Republic.

The scientists recognized that cells absorb sugar from food as energy for the body, yet glucose can't penetrate a cell's membrane without help from insulin, a hormone secreted from endocrine cells in the pancreas. To absorb the sugar, most cells have insulin "receptors" that bind the hormone as it flows through the bloodstream.

The researchers tested structural models using molecular-genetic methods to insert probes that, in turn, are activated by ultra-violet light into the receptor. The procedure creates highly detailed, three-dimensional imageswhich provided critical answers for Weiss, Lawrence and their colleagues.

"Both insulin and its receptor undergo rearrangement as they interact," Lawrence said. "A piece of insulin folds out and key pieces within the receptor move to engage the insulin hormone. You might call it a 'molecular handshake.'"

Understanding the bonding mechanics offers possible advances in how diabetes is treated, now usually with daily, multiple insulin injections. The discovery, Weiss said, suggests that targeting small molecules "to the signaling clefts" of the receptor may allow for alternatives to injections, as well as fewer doses per day.

Diabetes patients develop high blood sugar from inadequate insulin production, imperfect cellular to insulin, or both. The disease can cause wide-ranging complications, from heart disease, stroke and high blood pressure to blindness and kidney problems.

Diabetes affects nearly
'/>"/>

Contact: Jessica Studeny
jessica.studeny@case.edu
216-368-4692
Case Western Reserve University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Cognitive deficits from concussions still present after 2 months
2. Ups and downs of biodiversity after mass extinction
3. Research pinpoints key gene for regenerating cells after heart attack
4. UofL scientist uncovers how airway cells regenerate after chlorine gas injury
5. Leukemia patients remain in remission more than 2 years after engineered T cell therapy
6. Microbial missing link discovered after man impales hand on tree branch
7. After 121 years, identification of grave robber fossil solves a paleontological enigma
8. New injectable gels toughen up after entering the body
9. Neurons made from stem cells drive brain activity after transplantation in laboratory model
10. Bone marrow stem cells do not improve short-term recovery after heart attack
11. After long-ago mass extinction, global warming hindered species recovery
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/20/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... growing mobile commerce market, announces its biometric payment technology, ... featured in 2015 "I Want That" International CES Special, ... the DIY Network.   DIY,s "I Want ... site of the 2015 International CES for a firsthand ...
(Date:3/19/2015)... March 19, 2015  NXT-ID, Inc. (NASDAQ: NXTD ... on the growing mobile commerce market, announces its biometric payment ... clip that aired this week on Washington DC,s ... In a segment "The Next Great Thing", host ... way to pay, and ,a really big breakthrough in mobile ...
(Date:3/17/2015)... Minn. , March 17, 2015 ... technology company specializing in clinical study management systems, ... be in attendance at ARENA,s Outsourcing in Clinical ... NC.  This event provides an excellent forum for ... easy-to-use, flexible and affordable software-as-a-service (SaaS) eClinical technology ...
Breaking Biology News(10 mins):NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 2NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 3NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 2NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 3Connect With MedNet Solutions At Outsourcing In Clinical Trials Southeast 2
... BERKELEY, CA -- A link between the immune system ... themselves of obsolete or toxic parts may one day ... other deadly infectious diseases. Scientists with the U.S. Department ... have discovered proteins residing in both systems that point ...
... A study in the Sept. 21 on-line edition ... interaction of a critical molecule involved in cell death ... blocking this molecule, called Cyclophilin D (CypD), and development ... for the prevention and treatment of Alzheimer,s disease, according ...
... It seems that our brain can correct speech errors in ... Niels Schiller and Lesya Ganushchak, NWO researchers in Leiden, made ... errors. This research can contribute to improvements in the treatment ... language. Our brain is fairly good at preventing ...
Cached Biology News:Proteomics study yields clues as to how tuberculosis might be thwarting the immune system 2Proteomics study yields clues as to how tuberculosis might be thwarting the immune system 3Mitochondria could be a target for therapeutic strategy for Alzheimer's disease patients 2Brain recognizes verbal 'oh dear' wave 2
(Date:3/29/2015)...  Caris Life Sciences® today announced the presentation ... the company,s panomic, comprehensive tumor profiling service, found ... and difficult to treat gynecological cancers may inform ... improve patient outcomes. These studies were presented today ... Gynecologic Oncology (SGO) 2015 Annual Meeting on Women,s ...
(Date:3/29/2015)... Texas , March 29, 2015 /PRNewswire/ ... presentation of important study data showing the ... in 1,599 gynecologic cancer samples. Using Caris ... profiling service, researchers identified expression of programmed ... cancers independent of histology while its ligand ...
(Date:3/27/2015)... March 27, 2015 Earlier this year, ... promotion of hair regrowth in adult men and women ... or Norwood Hamilton classifications of IIa-V and Fitzpatrick Classification ... plagued by products that over-promise and under-deliver, FDA Clearance ... faith and confidence among more than 80 million men ...
(Date:3/27/2015)... , 27. März 2015  Peter ... in Biomedical Science für seine bahnbrechende Arbeit ... zwischen Zellkompartimenten transportiert werden, sowie für die ... zur Reaktion auf Stress nutzen, der mit ... Walter ist Professor für Biochemie an der ...
Breaking Biology Technology:Caris Molecular Intelligence Facilitates Comparison of Biomarker Profiles to Inform Targeted Treatment Strategies in Distinct Gynecological Cancers 2Caris Molecular Intelligence Facilitates Comparison of Biomarker Profiles to Inform Targeted Treatment Strategies in Distinct Gynecological Cancers 3Caris Molecular Intelligence Facilitates Comparison of Biomarker Profiles to Inform Targeted Treatment Strategies in Distinct Gynecological Cancers 4Caris Life Sciences' Multiplatform Tumor Profiling Technology Identifies Expression of PD-1 and PD-L1 in Gynecologic Malignancies 2Caris Life Sciences' Multiplatform Tumor Profiling Technology Identifies Expression of PD-1 and PD-L1 in Gynecologic Malignancies 3Caris Life Sciences' Multiplatform Tumor Profiling Technology Identifies Expression of PD-1 and PD-L1 in Gynecologic Malignancies 4Dr. Robert Leonard Applauds FDA Clearance of Capillus272Pro™ Hair Loss Laser Cap 2Deutschstämmiger Zellbiologe Peter Walter gewinnt den Vilcek Prize in Biomedical Science 2015 2Deutschstämmiger Zellbiologe Peter Walter gewinnt den Vilcek Prize in Biomedical Science 2015 3Deutschstämmiger Zellbiologe Peter Walter gewinnt den Vilcek Prize in Biomedical Science 2015 4
... Pa., Sept. 23 Environmental,Tectonics Corporation,s (Amex: ... announced the sale and placement of two BARA-MED(R) ... The,Shoreline Facility was established in Corpus Christi, Texas, ... care medical center in the region. The,facility offers ...
... Premacure to Initiate Phase II Trial for IPLEX(TM) ... UPPSALA, Sweden, Sept. 23 ,Insmed Inc. (Nasdaq CM: ... and Premacure AB, a biopharmaceutical company,dedicated to the ... due to premature birth, today noted the presentation ...
... Vein Recognition Device Helps BayCare Accurately,Identify Patients, ... Patient Privacy, SUNNYVALE, Calif., Sept. 23 ... leading supplier of innovative computer products,including hard ... announced that BayCare Health System, the largest ...
Cached Biology Technology:Environmental Tectonics Corporation Announces a Multiple Sale for Monoplace Hyperbaric Chambers 2Environmental Tectonics Corporation Announces a Multiple Sale for Monoplace Hyperbaric Chambers 3Insmed and Premacure Cite Study Results Demonstrating Potential Effectiveness of IPLEX(TM) in Preventing Blindness in Premature Infants 2Insmed and Premacure Cite Study Results Demonstrating Potential Effectiveness of IPLEX(TM) in Preventing Blindness in Premature Infants 3Insmed and Premacure Cite Study Results Demonstrating Potential Effectiveness of IPLEX(TM) in Preventing Blindness in Premature Infants 4Insmed and Premacure Cite Study Results Demonstrating Potential Effectiveness of IPLEX(TM) in Preventing Blindness in Premature Infants 5Fujitsu PalmSecure and HT Systems' PatientSecure Selected by BayCare Health System to Protect Patient Confidentiality and Prevent Medical Identity Theft 2Fujitsu PalmSecure and HT Systems' PatientSecure Selected by BayCare Health System to Protect Patient Confidentiality and Prevent Medical Identity Theft 3Fujitsu PalmSecure and HT Systems' PatientSecure Selected by BayCare Health System to Protect Patient Confidentiality and Prevent Medical Identity Theft 4Fujitsu PalmSecure and HT Systems' PatientSecure Selected by BayCare Health System to Protect Patient Confidentiality and Prevent Medical Identity Theft 5
... is a new product number, created ... If showing no availability yet, please ... (Z71,487-9) or contact customer service for ... 100 mm, No. of sidearm 4 ...
... pYD1 Yeast Display Vector is specifically designed ... the surface of Saccharomyces cerevisiae. Displayed proteins ... interact with known or putative ligands. pYD1 ... consists of two domains Aga1 and Aga2 ...
Packaging: 6 bottles for 1 l ready-to-use-solution ID clarifier: ready-to-use solution ...
... Polyclonal Antibody against Aph-1a (Aph-1aL,S ... The gamma secretase is a multiprotein ... and Pen-2; all four proteins are ... gamma secretase complex catalyzes cleavage of ...
Biology Products: