Navigation Links
African-American study identifies 4 genetic variants associated with blood pressure
Date:9/10/2013

Case Western Reserve University is part of a landmark study that has discovered four novel gene variations which are associated with blood pressure. The 19-site meta-analysis, involving nearly 30,000 African-Americans, also found that the set of genetic mutations are also associated with blood pressure across other populations.

Epidemiology and biostatistics professor Xiaofeng Zhu, PhD, is co-senior author of the paper, which appears in The American Journal of Human Genetics. The Continental Origins and Genetic Epidemiology Network (COGENT) consortium conducted the research, which is the largest genome-wide association study of blood pressure in individuals of African ancestry. Most gene discovery studies to date have been performed using individuals of European ancestry. Previous genome-wide association studies using samples from individuals of African descent failed to detect any replicable genes associated with blood pressure.

"In addition to their disproportionate suffering, hypertension occurs earlier in life for African-Americans compared to individuals of other ancestries," Zhu explained. "Therefore, it is important to study this population to better understand genetic susceptibility to hypertension."

Zhu and his colleagues also confirmed that previous findings regarding other genes whose presence correlates with increased hypertension risk.

"Although it is unknown how the genes regulate blood pressure," Zhu added, "our findings contribute to better understanding of blood pressure pathways that can lead to future development of drug target for hypertension and may guide therapy for clinical care."

Experts estimate genetic make-up accounts for roughly 40-50 percent of individuals' susceptibility to hypertension. Other factors associated with the disease include lifestyle, diet, and obesity. Compared to Americans of European-ancestry, African-Americans' increased hypertension prevalence contributes t
'/>"/>

Contact: Jessica Studeny
Jessica.studeny@case.edu
216-368-4692
Case Western Reserve University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Vigorous physical activity linked to lower incidence of obesity in young African-American women
2. Body mass index of low income African-Americans linked to proximity of fast food restaurants
3. African-American, Caucasian women should take identical vitamin D doses
4. Cancer risk for African-American women with benign breast disease factors Wayne State finds
5. Abuse during childhood linked to uterine fibroids in African-American women
6. Abuse during childhood linked to adult-onset asthma in African-American women
7. Levels of hepatitis C virus higher among African-Americans and males
8. Therapy slows onset and progression of Lou Gehrigs disease, study finds
9. Cytos Biotechnology Presents Additional Results From Phase 2a Study of CYT003 for the Treatment of Allergic Asthma
10. LSUHSC researchers develop new system to better study behavior, cell function
11. 400-year study finds Northeast forests resilient, changing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... York University is paving the way for a ... and military troops exposed to poisonous chemicalsparticularly those ... article in the current issue of the journal ... organophosphates, which are compounds commonly used in pesticides ... by NYU School of Engineering Associate Professor of ...
(Date:7/30/2014)... A deep-sea octopus protected and tended her eggs until ... published July 30, 2014 in the open-access journal ... Aquarium Research Institute and colleagues. , Octopuses typically have ... females protect and take care of their fertilized eggs ... eggs for 1 to 3 months, but little is ...
(Date:7/30/2014)... Everybody knows the shortest distance between two points is ... that sperm have been taking the familiar axiom to ... usually thought to be intense, with each racing for ... in some species, sperm form cooperative groups that allow ... , A new study, conducted by Heidi Fisher, ...
Breaking Biology News(10 mins):Engineering a protein to prevent brain damage from toxic agents 2Deep-sea octopus has longest-known egg-brooding period 2When cooperation counts 2When cooperation counts 3
... Researchers from Michigan State University,s departments of Electrical ... new wearable sensor network to assess a person,s physical ... engineering professor Subir Biswas, participants will wear three small, ... lower leg that during any physical activity will ...
... Research (SFBR) in San Antonio have found a gene ... in the blood as a result of a high-cholesterol ... developed at SFBR that has normal blood levels of ... low-cholesterol diet, but extremely elevated levels of LDL cholesterol ...
... Animal flocks, be it honeybees, fish, ants or birds, ... decisions at a moment,s notice, a phenomenon which has ... today, Wednesday 15 September, in New Journal of ... German Physical Society), uses a particle model to explain ...
Cached Biology News:Wearable sensor technology to measure physical activity 2Scientists find gene for high cholesterol in blood 2Understanding behavioral patterns: Why bird flocks move in unison 2
(Date:7/30/2014)... Yuma Regional Cancer Center Officially Opens ... comprehensive cancer care to Yuma, Arizona. , The ... has officially opened. A Mayo Clinic Care Network ... as open, semi-private and private infusion rooms, oncology ... Center, hematology, rehabilitation center, a pain management program ...
(Date:7/30/2014)... 30, 2014  Dyadic International, Inc. ("Dyadic") (OTCQX: ... and proprietary technologies are used to discover, develop, ... the bioenergy, bio-based chemical, biopharmaceutical and industrial enzyme ... Dubinski as Vice President and Chief Financial Officer. ... and information technology operations for Dyadic and will ...
(Date:7/30/2014)... , July 30, 2014   Epic Sciences, ... and develops novel diagnostics to personalize and advance the ... of Gregory T. Lucier as chairman of ... and CEO of Life Technologies (formerly Invitrogen). Mr. Lucier ... Epic commercializes its circulating rare cell analysis platform with ...
(Date:7/30/2014)... July 30, 2014  RXi Pharmaceuticals Corporation ... company focused on discovering, developing and commercializing ... using RNA-targeted technologies, today announced that their ... for the reduction of recurrence of hypertrophic ... been initiated. Logo - ...
Breaking Biology Technology:Sate-of-the-Art Yuma Regional Cancer Center Officially Opens 2Thomas Dubinski joins Dyadic as Chief Financial Officer 2Thomas Dubinski joins Dyadic as Chief Financial Officer 3Thomas Dubinski joins Dyadic as Chief Financial Officer 4Epic Sciences Appoints Greg Lucier as Chairman of the Board of Directors 2Epic Sciences Appoints Greg Lucier as Chairman of the Board of Directors 3RXi Pharmaceuticals Expands Clinical Program with Initiation of Third Phase 2a Study with RXI-109 for Treatment of Hypertrophic Scars 2RXi Pharmaceuticals Expands Clinical Program with Initiation of Third Phase 2a Study with RXI-109 for Treatment of Hypertrophic Scars 3RXi Pharmaceuticals Expands Clinical Program with Initiation of Third Phase 2a Study with RXI-109 for Treatment of Hypertrophic Scars 4RXi Pharmaceuticals Expands Clinical Program with Initiation of Third Phase 2a Study with RXI-109 for Treatment of Hypertrophic Scars 5
... SAN DIEGO , June 2 Neurocrine Biosciences, Inc. (Nasdaq: ... Executive Officer of Neurocrine Biosciences, will be presenting at the Jefferies 2010 Global ... in New York . , ... The live presentation for the Jefferies conference takes place on Wednesday, June ...
... International ... ... 2010 -- The International Food Information Council (IFIC) 2010 “ Consumer Perceptions of Food ... consider its potential benefits for reducing the impact of food and food production on ...
... Repligen Corporation (Nasdaq: RGEN ) announced today that it will ... Wednesday, June 9th, 2010 , before the market opens.  The Company President ... conference call and webcast on the same day at 10:00 a.m. EDT ... Company. , , , ...
Cached Biology Technology:Neurocrine Biosciences to Present at the Jefferies 2010 Global Life Sciences Conference and the 9th Annual Needham Healthcare Conference 2Interest in Environment & Sustainability Prevails in Food Technology Survey 2Interest in Environment & Sustainability Prevails in Food Technology Survey 3Interest in Environment & Sustainability Prevails in Food Technology Survey 4Interest in Environment & Sustainability Prevails in Food Technology Survey 5Repligen Announces Conference Call of Fourth Quarter and Fiscal Year 2010 Financial Results 2Repligen Announces Conference Call of Fourth Quarter and Fiscal Year 2010 Financial Results 3