Navigation Links
African-American study identifies 4 genetic variants associated with blood pressure
Date:9/10/2013

Case Western Reserve University is part of a landmark study that has discovered four novel gene variations which are associated with blood pressure. The 19-site meta-analysis, involving nearly 30,000 African-Americans, also found that the set of genetic mutations are also associated with blood pressure across other populations.

Epidemiology and biostatistics professor Xiaofeng Zhu, PhD, is co-senior author of the paper, which appears in The American Journal of Human Genetics. The Continental Origins and Genetic Epidemiology Network (COGENT) consortium conducted the research, which is the largest genome-wide association study of blood pressure in individuals of African ancestry. Most gene discovery studies to date have been performed using individuals of European ancestry. Previous genome-wide association studies using samples from individuals of African descent failed to detect any replicable genes associated with blood pressure.

"In addition to their disproportionate suffering, hypertension occurs earlier in life for African-Americans compared to individuals of other ancestries," Zhu explained. "Therefore, it is important to study this population to better understand genetic susceptibility to hypertension."

Zhu and his colleagues also confirmed that previous findings regarding other genes whose presence correlates with increased hypertension risk.

"Although it is unknown how the genes regulate blood pressure," Zhu added, "our findings contribute to better understanding of blood pressure pathways that can lead to future development of drug target for hypertension and may guide therapy for clinical care."

Experts estimate genetic make-up accounts for roughly 40-50 percent of individuals' susceptibility to hypertension. Other factors associated with the disease include lifestyle, diet, and obesity. Compared to Americans of European-ancestry, African-Americans' increased hypertension prevalence contributes t
'/>"/>

Contact: Jessica Studeny
Jessica.studeny@case.edu
216-368-4692
Case Western Reserve University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Vigorous physical activity linked to lower incidence of obesity in young African-American women
2. Body mass index of low income African-Americans linked to proximity of fast food restaurants
3. African-American, Caucasian women should take identical vitamin D doses
4. Cancer risk for African-American women with benign breast disease factors Wayne State finds
5. Abuse during childhood linked to uterine fibroids in African-American women
6. Abuse during childhood linked to adult-onset asthma in African-American women
7. Levels of hepatitis C virus higher among African-Americans and males
8. Therapy slows onset and progression of Lou Gehrigs disease, study finds
9. Cytos Biotechnology Presents Additional Results From Phase 2a Study of CYT003 for the Treatment of Allergic Asthma
10. LSUHSC researchers develop new system to better study behavior, cell function
11. 400-year study finds Northeast forests resilient, changing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/21/2014)... Calif., July 21, 2014 Dysfunction in dopamine ... 2,000 genes in the brain,s prefrontal cortex and ... neuropsychiatric disorders, such as schizophrenia, according to UC ... activity in brain cells that receive this neurotransmitter ... can affect a variety of behavioral and physiological ...
(Date:7/21/2014)... University of California, Riverside Bourns College of Engineering students have ... a backyard grill reduces by 70 percent the level of ... thick steel carbon plate with an insulated handle can be ... the grill to allow the plate to slide in and ... who could sell new grills with the plate already installed. ...
(Date:7/21/2014)... see an innovation and think, "Of course! Why didn,t ... thoughts of our own invention, sparking ideas and building ... the International Space Station Program Science Office,s new 15-book ... have going on in orbit, their mental wheels may ... encourage investigators to propose new research and potentially make ...
Breaking Biology News(10 mins):UCI researchers find epigenetic tie to neuropsychiatric disorders 2Catching grease to cut grill pollution 2International Space Station researcher guides aim to maximize science 2International Space Station researcher guides aim to maximize science 3International Space Station researcher guides aim to maximize science 4
... program,s 50th anniversary celebrations, Clemson,s bioengineering department ... at the 2013 Clemson Biomaterials Symposium, Biomaterials-What,s ... Biomaterials research is an interdisciplinary science, ... materials science, with deep roots at Clemson ...
... physicists from the University of York, has shed important ... out at the nanoscale, provide valuable new information for ... from the threats of acidification and rising water temperatures., ... - skeletons which build up over time into vast ...
... the smallest bat barely reaches a gram. Nevertheless, the two ... the ability to use echolocation - a biological sonar - ... of toothed whales and bats share surprisingly many similarities - ... extremely in size. Echolocation systems are one of Nature,s ...
Cached Biology News:Clemson hosting biomaterials symposium 2Physicists provide new insights into coral skeleton formation 2Bats and whales behave in surprisingly similar ways 2Bats and whales behave in surprisingly similar ways 3
(Date:7/21/2014)... July 21, 2014 Lawrence ... Investment Board (WIB) and Las Positas College (LPC) ... technical education and hands-on training for veterans, officials ... Program at Las Positas is designed to ... for engineering technician careers, and establishes a pipeline ...
(Date:7/21/2014)... (July 21, 2014) The yield so far is ... developed a low-energy, solution-based mineral substitution process to make ... use in electronics and alternative energy devices. , A ... of the July 21 issue of the journal ... research in the inorganic and nuclear chemistry fields. The ...
(Date:7/20/2014)... the process releases radioactive krypton and xenon gases. Naturally ... gas radon. A new porous material called CC3 effectively ... Nature Materials shows how: by breathing enough ... , The CC3 material could be helpful in removing ... air in buildings and also in recycling useful elements ...
(Date:7/18/2014)... LANSING, Mich. , July 18, 2014  Neogen ... Stephen Snyder , Neogen,s chief operating officer and ... said he will work as a consultant going forward ... Snyder has been in this position since ... be fulfilled by James Herbert , who has ...
Breaking Biology Technology:Engineering Program Established for Veterans 2Engineering Program Established for Veterans 3Oregon chemists eye improved thin films with metal substitution 2A noble gas cage 2A noble gas cage 3
... mortality faced by patients at ... national average, EL SEGUNDO, Calif., July 7 ... those diagnosed with chronic,kidney failure and disease (CKD), significantly ... by both the Clinical,Performance Measures Report published in 2006 ...
... Takes Over From Bernard Barataud, EVRY, France, July ... new president to head the laboratory created in 1990 ... succeeds Bernard,Barataud, who has decided to hand over the ... then between 1999 and 2008., Yves Champey is ...
... July 3 Bioheart, Inc.,(Nasdaq: BHRT ) ... development,of autologous (patient-derived) cell therapies and devices for ... announced that its Board,of Directors appointed Howard J. ... Technology Officer, to serve as Chief Executive,Officer effective ...
Cached Biology Technology:Superior Patient Clinical Outcomes Confirms DaVita's Leadership Position on Quality Dialysis Care 2Superior Patient Clinical Outcomes Confirms DaVita's Leadership Position on Quality Dialysis Care 3A New President at the Head of the Genethon Laboratory 2Bioheart, Inc., Board Appoints Howard J. Leonhardt Chief Executive Officer 2Bioheart, Inc., Board Appoints Howard J. Leonhardt Chief Executive Officer 3
MMP-1/8 (H-300)...
Gastric Carcinoma Marker [BY-1 (3H11)]...
Mouse VEGF R1/Flt-1 Phycoerythrin MAb (Clone 141522) Keywords: Receptor Tyrosine Kinase, RTK, VEGFR1, VEGF Receptor 1 Protein Family: Receptor Tyrosine Kinases, VEGF/PDGF Family...
Mouse VEGF R1/Flt-1 Allophycocyanin MAb (Clone 141522) Keywords: Receptor Tyrosine Kinase, RTK, VEGFR1, VEGF Receptor 1 Protein Family: Receptor Tyrosine Kinases, VEGF/PDGF Family...
Biology Products: