Navigation Links
Adverse effects of phthalates on ovarian response to IVF
Date:7/8/2013

London, 8 July 2013: Phthalates are among a group of industrial chemicals shown in some studies to have adverse effects on reproductive health and development, particularly in the male. As such, they have been collectively defined as "endocrine disruptors", and proposed as one of several possible environmental exposures responsible for a decline in fertility. They are classified in two groups - high molecular weight phthalates are used in the production of plastics, while low molecular weight phthalates are frequently used in the manufacture of cosmetics.(1) Human studies increasingly report associations of phthalates with various adverse reproductive outcomes, including altered semen quantity and quality. Their effect, however, has been less well studied in women, and, despite widespread human exposure to phthalates, little is known about the effects of low-level, daily exposures to phthalates on ovarian function - and hence on women's reproductive health.

A new study reported at this year's annual meeting of ESHRE by Dr Irene Souter of Massachusetts General Hospital and Harvard Medical School in Boston, USA, now suggests that exposure to phthalates - as measured by levels of phthalate metabolites in urine - is associated with reduced fertility when defined as a response to IVF treatment. " Our data support the hypothesis that exposure to specific phthalates might lead to adverse female reproductive outcomes," said Dr Souter.

The study followed the progress of 231 women (in 325 fresh treatment cycles) scheduled for IVF at the Massachusetts General Hospital between 2004 and 2012; urine samples were taken at the start of and throughout treatment and analysed for metabolites of four primary phthalates.

The association of levels of urinary metabolites was then explored with three markers of response to IVF: the number of eggs produced following ovarian stimulation, embryo development, and implantation failure.

Results first showed that urinary phthalates were detected in almost all the women, reflecting the widespread level of exposure. Results also showed:

  • The odds of implantation failure increased with each rising quartile of two of the urinary phthalate metabolites. For example, for DEHP (used in vinyl plastic products) the odds of implantation failure in the highest quartile Q4) was twice that of the lowest (Q1).
  • There was also an escalating decrease of 4.17% (Q2), 6.19% (Q3) and 11.4% (Q4) in the number of oocytes retrieved with each DEHP phthalate quartile when compared with Q1 (the lowest reference quartile).

The results thus showed that urinary concentrations of some commonly used phthalates were "dose-dependently" associated with a lower yield of IVF oocytes, and an increased risk of implantation failure. However, the results did not detect any association between levels of urinary phthalates and rates of fertilisation or embryo development.

Commenting, Dr Souter believes the results "support the hypothesis" that phthalates are widespread in the environment and may well have an adverse effect on female fertility, particularly when tested in the model of IVF.

"We are all primarily exposed to phthalates through inhalation and ingestion," she explained. "It is extremely difficult if not impossible to avoid exposure to phthalates, since they are in so many products." However, she added, exposure can be reduced by the following:

  • Limit the use of personal care products with fragrances in them (including many of the modern baby care products and air fresheners).
  • Limit use of plastic food storage containers and plastic wraps (certainly do not heat food in them).
  • Read the labels and avoid children's toys made of plastics (vinyl) that contain phthalates.


'/>"/>

Contact: Christine Bauquis
christine@eshre.eu
32-499-258-046
European Society of Human Reproduction and Embryology
Source:Eurekalert

Related biology news :

1. BPA linked to potential adverse effects on heart and kidneys
2. Carbon dioxide from water pollution, as well as air pollution, may adversely impact oceans
3. Diet could combat adverse side-effects of quinine
4. La Jolla Institute discovery could lead to new way to screen drugs for adverse reactions
5. Time is of the essence for reducing the long-term effects of iron deficiency
6. Patients use OTC NSAIDs even when they have a high risk of serious side effects
7. Hidden effects of climate change may threaten eelgrass meadows
8. Fish oil may stall effects of junk food on brain
9. Study examines effects of genetic variants for infants with neonatal abstinence syndrome
10. Olympic Coast Sanctuary report is first step in addressing effects of climate change
11. Symposium highlights epigenetic effects of milk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/2/2016)... 2016  BioMEMS devices deployed in hospitals ... medical screening and diagnostic applications, such as ... that facilitate and assure continuous monitoring without ... being bolstered through new opportunities offered by ... coupled with wireless connectivity and low power ...
(Date:2/2/2016)... 2016 Technology Enhancements Accelerate Growth of X-ray Imaging ... digital and computed radiography markets in Thailand ... Indonesia (TIM). It provides an in-depth ... well as regional market drivers and restraints. The study ... and market attractiveness, both for digital and computed radiography. ...
(Date:2/1/2016)... Canada , February 1, 2016 ... technological advancements to drive global touchfree intuitive gesture control ... --> Rising sales of consumer electronics coupled ... gesture control market size through ... consumer electronics coupled with new technological advancements to drive ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... Florida , February 11, 2016 ... and Promote Genetic Understanding to Support Research and Discovery ... GenomeAsia 100K, today announced an ambitious plan to sequence 100,000 ... South Asian countries and at least 7 of North and ... In the first phase, the project will focus on ...
(Date:2/11/2016)... Feb. 11, 2016  Bioethics International, a not-for-profit organization focused ... developed, marketed and made accessible to patients around the world, ... had named the publication of the Good Pharma Scorecard ... is also featured as one of BMJ Open ,s ... year that are most frequently read. Ed Sucksmith ...
(Date:2/11/2016)... , Feb. 11, 2016  Dovetail Genomics™ LLC today ... beta program for a planned metagenomic genome assembly service. ... company,s metagenomic genome assembly method in a talk on ... Biology & Technology conference in Orlando, Fla. ... highly complex datasets is difficult. Using its proprietary ...
(Date:2/11/2016)... ... 2016 , ... Global Stem Cells Group, a ... Stem Cells Network (GSCN) to distribute exosome injection and other biological products to ... Rica, Dominican Republic, Colombia, Argentina, Nicaragua, Panama, El Salvador, Venezuela, Peru, Ecuador, Paraguay, ...
Breaking Biology Technology: