Navigation Links
'Activating' RNA takes DNA on a loop through time and space
Date:2/17/2013

tivating ncRNAs.

Mutations in the MED12 protein are a marker for FG syndrome (also know as OpitzKaveggia syndrome), a rare genetic disorder that leads to abnormalities throughout the body and varying degrees of physical and neurological problems. "This clearly shows how activating ncRNAs can influence disease development, an idea that has been gaining evidence in the scientific literature," Shiekhattar said. To confirm that ncRNA-a works with Mediator to form a loop in DNA, the researchers used a technique called chromosome conformation capture (3C) to gain a better understanding of the three-dimensional structure of chromosomes. Their results show how Mediator gets a foothold of sorts on the portion of DNA that encodes the ncRNA-a, and twists the DNA to form a loop.

"The looping mechanism serves to physically bring together a distant enhancer element with the start site of the targeted gene, allowing Mediator to recruit the proteins responsible for reading the gene to the location," Shiekhattar said. "It is at least one answer to how these classical enhancer elements function while being physically distant from their target genes."


'/>"/>

Contact: Greg Lester
glester@wistar.org
215-898-3934
The Wistar Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UC research takes a new approach to identifying food deserts
2. Building healthy bones takes guts
3. REACH news: European ombudsman takes up PETA complaint
4. Global Companion Diagnostic Market Worth $19.3 billion by 2023: What it Takes to Become a Major Companion Diagnostic Player
5. It takes two to tangle: Wistar scientists further unravel telomere biology
6. NSF interdisciplinary program takes on critical national research priorities
7. University of Leicester takes delivery of unique eye imaging equipment
8. ONR-funded research takes flight in Popular Science article
9. Barley takes a leaf out of reindeers book in the land of the midnight sun
10. Why do people choke when the stakes are high?
11. Explosive breakthrough in research on molecular recognition
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... , Dec. 18, 2014 Research and ... the addition of the "iPhone 5S Fingerprint ... Report" report to their offering. ... the acquisition of AuthenTec in July 2012, Apple ... 5S. It is currently the only device of ...
(Date:12/19/2014)... and Markets ( http://www.researchandmarkets.com/research/86ncd6/micro_market ) has announced ... America Perimeter Security Systems Market" report to their ... The North American perimeter security market is estimated ... to 2019. Although the U.S. market holds a larger ... is expected to grow at a higher CAGR of ...
(Date:12/19/2014)... VIEW, Calif. , Dec. 18, 2014  23andMe, ... publication of a study that pinpoints fine-scale differences in ... United States . Since immigrants first ... the United States has served as a ... illuminates how American history and the ongoing mixing of ...
Breaking Biology News(10 mins):iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 323andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4
... around the world are faced with two daunting tasks—maintaining ... as possible. In the years following the terrorist attacks ... in the U.S. but around the world. Most officials ... concern, yet many security measures end up detaining passengers, ...
... centers of men and women,s brains works is different, ... journal Biology of Sex Differences . Men have ... but women are better at discriminating between colors. ... sex hormone (androgen) receptors throughout cerebral cortex, especially in ...
... 1. No Nutritional or Safety Differences Between Organic and ... in nutritional value or risk for bacterial contamination between ... being published in Annals of Internal Medicine , ... (ACP). While the consumption of organic fruits and vegetables ...
Cached Biology News:Securiport: Biometric Scanning is Gold Standard in Airport Security 2The eyes have it: Men do see things differently to women 2Annals of Internal Medicine tip sheet for Sept. 4, 2012 2Annals of Internal Medicine tip sheet for Sept. 4, 2012 3Annals of Internal Medicine tip sheet for Sept. 4, 2012 4
(Date:12/19/2014)... (PRWEB) December 19, 2014 Bioject ... developer and manufacturer of needle-free injection technology, today ... with Immunomic Therapeutics, Inc. (“ITI”) for ITI to ... with its LAMP™ vaccine platform. , In ... exclusive Worldwide license to the Biojector®-2000 that triggers ...
(Date:12/19/2014)... Lawrence, MA (PRWEB) December 19, 2014 ... flow MRLAFMQ test for the Detection of Aflatoxin M1 ... test to receive independent third party validation. The peer ... Science Unit of the Institute for Agricultural and Fisheries ... Francis Group. , Aflatoxin B1, the most toxic ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one ... of Nick Maroulis, Pharm.D. to the newly created position ... In this position, Dr. Maroulis will continue to manage ... of our multi-site pharmacies as the company expands. Dr. ... that time he has served in many different capacities ...
(Date:12/19/2014)... , Dec. 19, 2014 Naurex Inc., ... novel drugs for diseases of the central nervous system, ... and chief executive officer, will present at the 33 ... presentation will take place at 3:00 p.m. PST on ... in San Francisco, Calif. ...
Breaking Biology Technology:Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 2Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 3Charm Sciences Achieves Independent Validation of First 15 Minute Quantitative Screening Method for Aflatoxin M1 2BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Naurex to Present at 33rd Annual J.P. Morgan Healthcare Conference 2
... , July 8 Calithera ... the completion of a Series A financing totaling ... U.S. Venture Partners, Advanced Technology Ventures, Delphi Ventures and ... capital will be used to support the company,s pioneering ...
... VANCOUVER , July 7 /PRNewswire-FirstCall/ - Dragon Pharmaceutical ... that based on the receipt of preliminary proxies, the Company ... and Plan of Merger ("Merger") by and among Dragon, Chief ... Limited, and Mr. Yanlin Han . The Merger must ...
... , , ... replacement for petroleum oil more than doubles rubber,s stretchability and reduces its environmental impact ... Ford,s biomaterial researchers are ... as deflector shields and baffles, radiator deflector shields, cupholder inserts and floor mats , ...
Cached Biology Technology:Calithera Biosciences Closes $40 Million in Series A Financing 2Calithera Biosciences Closes $40 Million in Series A Financing 3Calithera Biosciences Closes $40 Million in Series A Financing 4Dragon Pharma announces receipt of preliminary proxies to approve merger 2Dragon Pharma announces receipt of preliminary proxies to approve merger 3Ford Pioneers Patent-Pending Use of Eco-Friendly Soy Oil in Rubber Automotive Parts 2Ford Pioneers Patent-Pending Use of Eco-Friendly Soy Oil in Rubber Automotive Parts 3Ford Pioneers Patent-Pending Use of Eco-Friendly Soy Oil in Rubber Automotive Parts 4
... Genomics Solution is a comprehensive suite ... visualization specifically designed to reliably extract ... high-dimensional genomic studies containing thousands of ... memory efficient and will analyze large ...
...
...
Hepatocyte Differentiation Environment...
Biology Products: