Navigation Links
'Activating' RNA takes DNA on a loop through time and space
Date:2/17/2013

Long segments of RNA encoded in our DNA but not translated into proteinare key to physically manipulating DNA in order to activate certain genes, say researchers at The Wistar Institute. These non-coding RNA-activators (ncRNA-a) have a crucial role in turning genes on and off during early embryonic development, researchers say, and have also been connected with diseases, including some cancers, in adults.

In an online article of the journal Nature, a team of scientists led by Wistar's Ramin Shiekhattar, Ph.D., detail the mechanism by which long non-coding RNA-activators promote gene expression. They show how these RNA molecules help proteins in the cell to create a loop of DNA in order to open up genes for transcription. Their experiments have also described how particular ncRNA-a molecules are related to FG syndrome, a genetic disease linked to severe neurological and physical deficits. "These ncRNA-activators can activate specific genes by working with large protein complexes, filling in a big piece of the puzzle," said Shiekhattar, Herbert Kean, M.D., Family Professor and senior author of the study. "Our DNA encodes thousands of these ncRNA-activators, each with a role in timing the expression of a specific gene. As we learn more about non-coding RNA, I believe we will have a profoundly better understanding of how our genes function."

Their findings also provide a plausible mechanism of how locations along chromosomes, classically known as "enhancer" elements, can influence the expression ("reading") of genes located 5,000 to 100,000 base pairs ("letters") of DNA away. According to their findings, ncRNA-a molecules bind to large protein complexes to form a loop of DNA, which then opens up the gene to the molecular machinery that transcribes DNA. "There is an abundance of evidence to indicate that enhancers are critical components of transcription during embryonic development and disease process," Shiekhattar said.

"Non-c
'/>"/>

Contact: Greg Lester
glester@wistar.org
215-898-3934
The Wistar Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UC research takes a new approach to identifying food deserts
2. Building healthy bones takes guts
3. REACH news: European ombudsman takes up PETA complaint
4. Global Companion Diagnostic Market Worth $19.3 billion by 2023: What it Takes to Become a Major Companion Diagnostic Player
5. It takes two to tangle: Wistar scientists further unravel telomere biology
6. NSF interdisciplinary program takes on critical national research priorities
7. University of Leicester takes delivery of unique eye imaging equipment
8. ONR-funded research takes flight in Popular Science article
9. Barley takes a leaf out of reindeers book in the land of the midnight sun
10. Why do people choke when the stakes are high?
11. Explosive breakthrough in research on molecular recognition
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... MA A study published online in the ... a novel approach to preventing cervical cancer based on ... cancer after removal of a discrete population of cells ... a study that looked at squamocolumnar junction cells, or ... and have been implicated as the origins of cervical ...
(Date:7/25/2014)... professor of biomedical engineering at the University of ... engineering and artificial organ development., "Introduction to Tissue ... to entering into the field of artificial organ ... biomedical engineering at UH, served as a series ... there are other published books on the subject ...
(Date:7/25/2014)... has opened the way for the development of new lines ... annual barley production is second only to wheat with 7-8 ... most important diseases of barley. , Senior Research Scientist Dr ... growths on the cell walls of barley plants that block ... research, by the ARC Centre of Excellence in Plant Cell ...
Breaking Biology News(10 mins):Clearing cells to prevent cervical cancer 2University of Houston researcher publishes textbook on tissue engineering 2New hope for powdery mildew resistant barley 2
... from the atmosphere are unlikely to offer an economically feasible ... to a report issued by the American Physical Society and ... not kid ourselves that we can pour all the carbon ... it out later at little cost," said Socolow, a professor ...
... scientists have discovered how two closely related proteins guide ... and repelling these axons as they navigate the most ... make remarkably precise connections. The discovery, reported April ... proteins belonging to the "semaphorin" family of guidance cues ...
... of Botany (KIB), part of the Chinese Academy of ... Natural Products and Bioprospecting (NPAB). As a ... in the SpringerOpen portfolio, available on www.springerlink.com . ... Science (CLoS), a collection comprising more than 90 English-language ...
Cached Biology News:Report: Direct removal of carbon dioxide from air likely not viable 2Johns Hopkins scientists reveal nerve cells' navigation system 2Johns Hopkins scientists reveal nerve cells' navigation system 3New SpringerOpen journal from the Chinese Academy of Sciences 2
(Date:7/24/2014)... July 24, 2014 Gain recognition ... Supply Chain of the biotech industry. Nominations are ... Awards, brought to you by the Bio ... of supply chain management professionals for the past ... stakeholders of the Biotech industry – Manufacturers, Service ...
(Date:7/24/2014)... MENLO PARK, Calif. , July 24, 2014 ... biotechnology company in the emerging field of regenerative ... live webcast of a presentation to investors on ... 1:30 p.m. PDT.  The presentation will include an ... pipeline. To access the webcast, visit http://www.ustream.tv/channel/asterias-biotherapeutics ...
(Date:7/24/2014)... equipment, trained personnel, and detection dogs to safeguard ... A revolutionary new electronic chip with nano-sized chemical ... easier. , The groundbreaking nanotechnology-inspired sensor, devised by ... School of Chemistry and Center for Nanoscience and ... picks up the scent of explosives molecules better ...
(Date:7/24/2014)... Yet, scientists are making progress in devising suitable ... approach relies on quantum dotsa kind of artificial ... A new study demonstrates that changing the coupling ... electrical impulses can help better control them. This ... as quantum information units, which would produce faster ...
Breaking Biology Technology:Call for Submission: BSMA’s Supply Chain Management Innovation Awards 2Call for Submission: BSMA’s Supply Chain Management Innovation Awards 3Asterias Biotherapeutics Announces Live Investor Webcast 2Asterias Biotherapeutics Announces Live Investor Webcast 3Asterias Biotherapeutics Announces Live Investor Webcast 4Nano-sized chip 'sniffs out' explosives far better than trained dogs 2
... a largely unseen battle now raging in the workplace. It ... are managers who covet the traditional employment deal money, ... commitment to playing the organizational game by traditional rules, e.g., ... unquestioning willingness to do whatever the business requires. Only Type ...
... University of Wisconsin-Madison leads the nation in the number ... in 2006. UW-Madison's total this year is up to ... ,The foundation bestows the awards on young researchers in ... biology, neuroscience and physics. Sloan Fellowships carry a two-year, ...
... Defense Agency, an information security consulting firm headquartered here ... been chosen to challenge eight student teams in an ... complexity and sophistication, so it's essential to support collegiate ... of cyber defenders," said Sami Saydjari, president and founder ...
Cached Biology Technology:Who will win the battle to redefine the workplace? 2Who will win the battle to redefine the workplace? 3Who will win the battle to redefine the workplace? 4Who will win the battle to redefine the workplace? 5UW-Madison has 7 Sloan research fellows, top in nation 2