Navigation Links
Accelerated search for active agents to treat Alzheimer's and Parkinson's
Date:2/24/2012

Professor Erich Wanker of the Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch and of the Excellence Cluster Neurocure is to receive EUR 675 000 in funding from the Helmholtz Association over the next two years. The grant shall be used to accelerate the search for active agents to treat diseases that are caused by protein misfolding. These include Alzheimer's and Parkinson's. The grant amount will be matched by the MDC, a member institution of the Helmholtz Association, which means that the total funding for the research project will be EUR 1.35 million.

The grant shall be used to develop a standardized screening platform for the identification of active agents that can be utilized by the pharmaceutical industry. The project is intended to result in the establishment of a spin-off company. The key element will be a system to identify active agents that impact protein aggregates that are toxic for brain cells. Protein aggregation plays a significant role in common neurological diseases such as Alzheimer's and Parkinson's or the rare Huntington's disease. In the pathogenesis of these diseases, a misfolding of specific proteins occurs in the brain cells, leading to an aggregation of harmful structures that cannot be disposed of. This increasingly leads to degeneration of the brain cells in the affected individuals and subsequently depending on the protein and the disease to memory loss, movement disorders, psychosis and dementia. Altogether, about 40 diseases can be attributed to protein misfolding, including diabetes mellitus.

The research group of Professor Wanker has been studying protein misfolding for over ten years and has developed innovative concepts and methods to test active agents for their capacity to intervene in protein misfolding processes. One of the group's discoveries is that epigallocatechin-3-gallate (EGCG), a green tea extract, binds to toxic misfolded products and modulates these into nontoxic structures.


'/>"/>
Contact: Barbara Bachtler
bachtler@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related biology news :

1. Concordia research accelerated
2. Accelerated lab evolution of biomolecules could yield new generation of medicines
3. Study finds link between chronic depression and accelerated immune cell aging
4. New year, new vitamin C discovery: It cures mice with accelerated aging disease
5. Geological cycle causes biodiversity booms and busts every 60 million years, research suggests
6. UC Santa Barbara researchers new study may lead to MRIs on a nanoscale
7. Research examines environmental triggers altering gene function in CFS patients
8. Researchers discover how vitamin D inhibits inflammation
9. Study finds college students willing to donate genetic material to biobanks for research
10. Purdue researchers reveal role of protein mutation in Parkinsons disease
11. Engineering, geoscience faculty help lead $3 million NSF Delta research collaboration
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/16/2014)... how the bowel lining develops and, in the process, ... , The researchers produced evidence that stem cells are ... a feature of the bowel lining, and believe these ... controversial finding as scientists are still divided on the ... Chin Wee Tan and Professor Tony Burgess from the ...
(Date:10/15/2014)... WASHINGTON, N.Y. , Oct. 15, 2014 /PRNewswire/ ... technology solutions for home and community-based care, today ... benefits of implementing Sandata,s Santrax® Electronic Visit Verification™ ... Care Services is a home health company founded ... Texas . The ...
(Date:10/15/2014)... pneumonia in female mice to an enzyme activated by ... more resistant to respiratory infections than males. Now, an ... to bacterial pneumonia in female mice is linked to ... show that this enzyme is ultimately activated by the ... team, lead by Professor Lester Kobzik at the Harvard ...
Breaking Biology News(10 mins):Cryptic clues drive new theory of bowel cancer development 2Sandata Announces Case Study with Quality Care Services, Inc. 2
... ecological sustainability of biofuels and the impact of their ... will take place on Friday, Dec. 5, in Panama ... Forests: Trends, Implications and Emerging Alternatives, is sponsored by ... Program in Native Species Reforestation, both joint programs of ...
... "Waterproof" versions of popular varieties of rice, which can ... farmers, fields with flying colors. Several of these varieties are ... certification agencies in Bangladesh and India, where farmers suffer major ... tons of rice per year. This is enough rice to ...
... Department of Plant Biology and Biotechnology at the ... been granted the Danisco Award 2008. She received ... secondary metabolites, which are biologically active substances in, ... has focused on biosynthetic pathways, regulation and transport ...
Cached Biology News:Conference to explore sustainability of biofuels 2From genes to farmers' fields 2From genes to farmers' fields 3The Danisco Award 2008 goes to D.Sc. Barbara Ann Halkier from Faculty of Life Sciences, Copenhagen 2
(Date:10/20/2014)... 2014 Mapp Biopharmaceutical,s valiant effort to ... to fight the Ebola outbreak will make the ... production of pharmaceuticals can be, according to Kalorama ... while some may be taken aback by the ... industry knowledge are well aware of the complex ...
(Date:10/20/2014)... 20, 2014 , A major ... and the delivery of care has revealed changing trends ... inequalities in the provision of healthcare services across the ... by United European Gastroenterology (UEG), have been announced today ... awareness of the burden of GI disorders across ...
(Date:10/20/2014)... Rochelle, Virginia (PRWEB) October 20, 2014 ... of NDA Partners LLC, announced today that Ellen ... and legal support for the pharmaceutical industry, has ... and manager of its legal services practice. ... reports and expert witness and testimony, to top ...
(Date:10/19/2014)... -- NextCODE Health, which enables clinicians and researchers to use ... announced the launch of its new genomic data analysis and ... Society of Human Genetics (ASHG) annual meeting in ... apply for free beta access, visit www.nextcode.com . A ... viewed here . The Exchange: ...
Breaking Biology Technology:Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 2Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 3Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 2Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 3Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 4Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 5NDA Partners Appoints Ellen Teplitzky, JD as Director of its Legal Services Practice 2The NextCODE Exchange: The first global, real-time system for sharing full-resolution genomic data 2The NextCODE Exchange: The first global, real-time system for sharing full-resolution genomic data 3
... and to Complete Current Phase 3 Trial of Naturlose(R) ... June 23 Spherix Incorporated (Nasdaq: SPEX ... a provider of technical and regulatory consulting services to ... it has received its first full-scale production batch of ...
... Sciences Holdings, Inc. (OTC Bulletin Board: ADLS), today announced ... once-a-day, oral antibiotic Restanza(TM) (cethromycin), showed that a 14-day ... an inhaled lethal dose of anthrax. All of the ... (the human equivalent dose of 300 mg) of Restanza ...
... VIENNA, Austria, June 23 MIG ... Venture Capital & Private Equity Award,competition, hosted by the industry ... between the,German venture fund and the Austrian biotechnology company as ... Biologicals. , Last Tuesday MIG Fonds ...
Cached Biology Technology:Spherix Announces Full-Scale Production of Pharmaceutical Tagatose 2Spherix Announces Full-Scale Production of Pharmaceutical Tagatose 3Spherix Announces Full-Scale Production of Pharmaceutical Tagatose 4Advanced Life Sciences' Restanza(TM) Shows 100% Survival In Confirmatory Anthrax Study 2Advanced Life Sciences' Restanza(TM) Shows 100% Survival In Confirmatory Anthrax Study 3AFFiRiS AG: 1st Place in Venture Capital & Private Equity Awards for MIG Fonds and AFFiRiS 2AFFiRiS AG: 1st Place in Venture Capital & Private Equity Awards for MIG Fonds and AFFiRiS 3
... Trap is specifically designed for efficient ... as DMSO and DMF in the ... refrigeration system set at -5 o ... DMSO, while completely eliminating the risk ...
Thermo Forma provides an array of accessory Racks for the Cryo/CryoPlus 16" Diameter storage system. To maximise inventory capacity a Jumbo Arrowhead configuration is recommended. You may choose betw...
... combine high durability and capacity with unequalled ... mechanism prevents vibration, allowing the unit to ... other part, from the large rubber block ... aluminum platform is designed to last through ...
The Holten Horizontal series of laminar airflow work benches offers comfort and ease of use....
Biology Products: