Navigation Links
Accelerated search for active agents to treat Alzheimer's and Parkinson's
Date:2/24/2012

Professor Erich Wanker of the Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch and of the Excellence Cluster Neurocure is to receive EUR 675 000 in funding from the Helmholtz Association over the next two years. The grant shall be used to accelerate the search for active agents to treat diseases that are caused by protein misfolding. These include Alzheimer's and Parkinson's. The grant amount will be matched by the MDC, a member institution of the Helmholtz Association, which means that the total funding for the research project will be EUR 1.35 million.

The grant shall be used to develop a standardized screening platform for the identification of active agents that can be utilized by the pharmaceutical industry. The project is intended to result in the establishment of a spin-off company. The key element will be a system to identify active agents that impact protein aggregates that are toxic for brain cells. Protein aggregation plays a significant role in common neurological diseases such as Alzheimer's and Parkinson's or the rare Huntington's disease. In the pathogenesis of these diseases, a misfolding of specific proteins occurs in the brain cells, leading to an aggregation of harmful structures that cannot be disposed of. This increasingly leads to degeneration of the brain cells in the affected individuals and subsequently depending on the protein and the disease to memory loss, movement disorders, psychosis and dementia. Altogether, about 40 diseases can be attributed to protein misfolding, including diabetes mellitus.

The research group of Professor Wanker has been studying protein misfolding for over ten years and has developed innovative concepts and methods to test active agents for their capacity to intervene in protein misfolding processes. One of the group's discoveries is that epigallocatechin-3-gallate (EGCG), a green tea extract, binds to toxic misfolded products and modulates these into nontoxic structures.


'/>"/>
Contact: Barbara Bachtler
bachtler@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related biology news :

1. Concordia research accelerated
2. Accelerated lab evolution of biomolecules could yield new generation of medicines
3. Study finds link between chronic depression and accelerated immune cell aging
4. New year, new vitamin C discovery: It cures mice with accelerated aging disease
5. Geological cycle causes biodiversity booms and busts every 60 million years, research suggests
6. UC Santa Barbara researchers new study may lead to MRIs on a nanoscale
7. Research examines environmental triggers altering gene function in CFS patients
8. Researchers discover how vitamin D inhibits inflammation
9. Study finds college students willing to donate genetic material to biobanks for research
10. Purdue researchers reveal role of protein mutation in Parkinsons disease
11. Engineering, geoscience faculty help lead $3 million NSF Delta research collaboration
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... Ongoing deforestation and fragmentation of forests in the ... remnant forests, contributing to rapid and widespread forest ... of researchers., The findings show that forests in ... severe droughts coupled with forest fires lead to ... said Jennifer Balch, assistant professor of geography, Penn ...
(Date:4/17/2014)... University researchers have detected new early-warning signs of the ... could have far-reaching implications for the diagnosis and treatment ... 25 million Americans. , "We had not expected to ... early stages," said Ann Elsner, professor and associate dean ... of the study. "We set out to study the ...
(Date:4/17/2014)... led by the Australian National University (ANU), have ... and deep-sea temperature variability over the past 5.3 ... understand the climate surrounding ice ages over the ... the relationship between carbon dioxide levels, global temperatures ... University of Southampton (UoS) and the National Oceanography ...
Breaking Biology News(10 mins):Drought and fire in the Amazon lead to sharp increases in forest tree mortality 2Drought and fire in the Amazon lead to sharp increases in forest tree mortality 3New technique detects microscopic diabetes-related eye damage 2New technique detects microscopic diabetes-related eye damage 3Ancient sea-levels give new clues on ice ages 2
... A majority of adults in California are obese or overweight, and ... a new study from the UCLA Center for Health Policy Research. ... other as well as to heart disease increased significantly in ... 26 percent between 2001 and 2007. The "epidemic" ...
... associate professor of neurobiology and anatomy at The University ... one of 17 researchers to win a 2010 National ... scientists who propose revolutionary, high-impact approaches to major challenges ... proposing a new way to study how the brain ...
... LANSING, Mich. Girls eating a high-fat diet during puberty, ... be at a greater risk of developing breast cancer later ... implications that a high-fat diet may have detrimental effects ... new cancer prevention efforts. The findings come from ...
Cached Biology News:Obesity, diabetes epidemics continue to grow in California, UCLA study finds 2Obesity, diabetes epidemics continue to grow in California, UCLA study finds 3UTHealth neuroscientist wins prominent NIH Director's Pioneer Award 2High-fat diet during puberty linked to breast cancer risk later in life 2
(Date:1/15/2014)... January 15, 2014 This webinar will ... and clinical safety assessment in biosimilars. , Regulatory frameworks ... biosimilar drug development, however the complex nature of biopharmaceuticals ... safety and efficacy extremely challenging. Based on the specific ...
(Date:1/15/2014)... 2014 Two champions of science, technology, ... of an annual competition for middle and high school ... innovative STEM study. The competition presents students with real-world ... Engineering Aptitude, Mathematics, and Sciences is a program ...
(Date:1/15/2014)... Arizona (PRWEB) January 15, 2014 2013 ... for Scottsdale’s Brain State Technologies®. They saw continued independent ... Medical Center who were awarded a $1 million grant ... published in “Brain and Behavior” a peer reviewed journal, ...
(Date:1/15/2014)... Jan. 15, 2014 TaiGen Biotechnology Company, Limited ("TaiGen") ... with R-Pharm, a leading Russian pharmaceutical company, to develop ... Russian Federation , Turkey ... (CIS). Nemonoxacin is a novel antibiotic for the treatment of ...
Breaking Biology Technology:Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4
... Berkeley -- Scientists who dream of shrinking computers to ... building block for both processor and memory, yet setting ... has been a challenge. , Now, University of California, ... a single atom, moving one step closer to quantum ...
... Sept. 13 Halozyme Therapeutics,Inc. (Nasdaq: HALO ), ... extracellular matrix, today announced,that Jonathan Lim, MD, Halozyme,s President ... Global Life Sciences Conference to be held at,the Grand ... 2007 at 9:00,a.m. Eastern time (6:00 a.m. Pacific time). ...
... 13 Cadence Pharmaceuticals,Inc. (Nasdaq: CADX ... and commercializing proprietary product candidates principally,for use ... Malvina Laudicina has,joined Cadence,s management team as ... will lead the regulatory and quality assurance,activities ...
Cached Biology Technology:Physicists pin down spin of surface atoms 2Physicists pin down spin of surface atoms 3Halozyme Therapeutics to Present at UBS 2007 Global Life Sciences Conference 2Cadence Pharmaceuticals Names Malvina Laudicina Vice President of Regulatory Affairs and Quality Assurance 2Cadence Pharmaceuticals Names Malvina Laudicina Vice President of Regulatory Affairs and Quality Assurance 3