Navigation Links
Abuse of painkillers can predispose adolescents to lifelong addiction
Date:9/10/2008

No child aspires to a lifetime of addiction. But their brains might. In new research to appear online in the journal Neuropsychopharmacology this week, Rockefeller University researchers reveal that adolescent brains exposed to the painkiller Oxycontin can sustain lifelong and permanent changes in their reward system changes that increase the drug's euphoric properties and make such adolescents more vulnerable to the drug's effects later in adulthood.

The research, led by Mary Jeanne Kreek, head of the Laboratory of the Biology of Addictive Diseases, is the first to directly compare levels of the chemical dopamine in adolescent and adult mice in response to increasing doses of the painkiller. Kreek, first author Yong Zhang, a research associate in the lab, and their colleagues found that adolescent mice self-administered Oxycontin less frequently than adults, suggesting that adolescents were more sensitive to its rewarding effects. These adolescent mice, when re-exposed to a low dose of the drug as adults, also had significantly higher dopamine levels in the brain's reward center compared to adult mice newly exposed to the drug.

"Together, these results suggest that adolescents who abuse prescription pain killers may be tuning their brain to a lifelong battle with opiate addiction if they re-exposed themselves to the drug as adults," says Kreek. "The neurobiological changes seem to sensitize the brain to the drug's powerfully rewarding properties."

During adolescence, the brain undergoes marked changes. For example, the brain's reward pathway increases production of dopamine receptors until mid-adolescence and then either production declines or numbers of receptors decline. By abusing Oxycontin during this developmental period, adolescents may inadvertently trick the brain to keep more of those receptors than it really needs. If these receptors stick around and the adolescent is re-exposed to the drug as an adult, the rush
'/>"/>

Contact: Thania Benios
tbenios@rockefeller.edu
212-327-7146
Rockefeller University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Surviving the revolution, easier than withstanding human use and abuse
2. Study finds possible connection between marijuana abuse and stroke or heart attacks
3. A research of the UGR shows the genetic predisposition to develop alcohol abuse
4. Are some men predisposed to pedophilia?
5. Risks and benefits of antipsychotics in children and adolescents
6. Learning how to say no to alcohol advertising and peer pressure works for inner-city adolescents
7. Cocaine: How addiction develops
8. Large-scale investment catapults CAMHs mental illness and addiction research forward
9. Erasing drug-associated memories may stop drug addiction relapses
10. Corals addiction to junk food
11. Hungry mothers risk addiction in their adult children
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/7/2015)... 2015 Research and ... of the "Capacitive Fingerprint Sensors Patent Landscape" ... this date, fingerprint sensing technology is the most ... are well developed. This patent landscape focuses on ... The domain of capacitive fingerprint sensors is closely ...
(Date:7/2/2015)... -- Research and Markets( http://www.researchandmarkets.com/research/jvft55/next_generation ) ... Biometrics Market by Application, Technology, Function & Geography - ... The next generation biometrics market is expected ... of 17.9% between 2015 and 2020 Travel ... Safran SA ( France ), ...
(Date:6/29/2015)... 24, 2015 Research and ... "Latin America Biomedical Sensors Market - Growth, Trends ... The Latin America Biomedical Sensors market is estimated ... 2.04% over the period 2014-2020 The near ... the genetic formulation of each individual. These sensors can ...
Breaking Biology News(10 mins):Worldwide Capacitive Fingerprint Sensors Patent Landscape Market Report 2015-2020 - Main IP Holders include Seiko Epson, AuthenTec, Sony and STMicroelectronics 2Next Generation Biometrics Market 2015 - Global Forecast to 2020 with Safran, NEC, 3M Cogent, Fujitsu & Suprema Dominating the $24 Billion Market 2Next Generation Biometrics Market 2015 - Global Forecast to 2020 with Safran, NEC, 3M Cogent, Fujitsu & Suprema Dominating the $24 Billion Market 3Latin America Biomedical Sensors Market Report 2015-2020 2
... (Feb. 6, 2014) Declines in the underlying brain skills ... In fact, this cognitive decline is a fact of life ... the cognitive health of older adults are critically important for ... activity and cognitive training are among the efforts aimed at ...
... at Rice University and the University of Texas Medical ... sensitive and efficient test for the diarrheal disease cryptosporidiosis ... Results from the diagnostic developed by the lab of ... strip that resembles a pregnancy test. Lines on the ...
... have for the first time sequenced an ancient RNA genome ... old - pushing its origin back at least 2,000 years and ... to its spread., Researchers at the University of Warwick have detected ... in a 750-year-old barley grain found at a site near the ...
Cached Biology News:Nutritional supplement improves cognitive performance in older adults, study finds 2Nutritional supplement improves cognitive performance in older adults, study finds 3Quick test finds signs of diarrheal disease 2Quick test finds signs of diarrheal disease 3RNA sequencing of 750-year-old barley virus sheds new light on the Crusades 2RNA sequencing of 750-year-old barley virus sheds new light on the Crusades 3
(Date:7/29/2015)... -- US-Australian drug discovery company, Novogen Limited (ASX: NRT; ... to progressing its ground-breaking technology platforms to Phase 1 ... the Company delivers the best value for shareholders. ... said the Company currently had an extensive program of ... and academic partnerships and initiatives, and he was working ...
(Date:7/29/2015)... ... July 29, 2015 , ... G-CON Manufacturing, Inc., the leading ... 2nd generation cell therapy POD® design. The 2nd generation portfolio not only delivers ... new POD® design. , “G-CON first offered our miniPOD CT product line ...
(Date:7/29/2015)...  Pfenex Inc. (NYSE MKT: PFNX) announced today that ... on Thursday, August 13, 2015, before the open of ... host a conference call to discuss the financial results ... the financial results and business update will be publicly ... 1-866-376-8058 (US) or 1-412-542-4131 (international) and reference Pfenex to ...
(Date:7/29/2015)... ... 2015 , ... Finding gooey or crusty material in the corner of your ... considerable number of terms in popular use to describe it, ophthalmologists call it “gound” ... mucus, blood cells, skin cells and dust, but until now there has been virtually ...
Breaking Biology Technology:Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 2Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 3Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 4Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 5Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 6Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 7Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 8Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 9Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 10G-CON Manufacturing Launches Their 2nd Generation Cell Therapy Cleanroom POD® 2G-CON Manufacturing Launches Their 2nd Generation Cell Therapy Cleanroom POD® 3Pfenex To Report Second Quarter 2015 Results and Provide Business Update on Thursday, August 13, 2015 2What Are ‘Eye Crusties’ Made Of? uBiome Invites Citizen Scientists to Find Out 2What Are ‘Eye Crusties’ Made Of? uBiome Invites Citizen Scientists to Find Out 3What Are ‘Eye Crusties’ Made Of? uBiome Invites Citizen Scientists to Find Out 4
... May 22 SuperGen, Inc.,(Nasdaq: SUPG ... discovery, rapid,development and commercialization of therapies for ... Michael Molkentin, C.P.A.,Chief Financial Officer and Corporate ... President of Drug Discovery Operations, are scheduled,to ...
... PHILLIPSBURG, N.J., May 22 Celldex,Therapeutics (a wholly-owned ... that its lead product,candidate, CDX-110, being developed for ... subject of an oral presentation at the 44th,Annual ... (ASCO). The,ASCO meeting will be held at McCormick ...
... AMSTERDAM, The Netherlands, May 22 Amsterdam,Molecular ... field of human gene,therapy, today announced that ... in Rome, Italy, to their advanced small ... of Duchenne,muscular dystrophy (DMD). The combination with ...
Cached Biology Technology:SuperGen to Present at FBR Capital Markets 12th Annual Spring Investor Conference on May 29, 2008 2AVANT Immunotherapeutics Announces Oral Presentation of CDX-110 at ASCO Annual Meeting 2AVANT Immunotherapeutics Announces Oral Presentation of CDX-110 at ASCO Annual Meeting 3AMT Accesses Technology for Treatment of Duchenne Muscular Dystrophy 2AMT Accesses Technology for Treatment of Duchenne Muscular Dystrophy 3
Special grade: for molecular biology Density: 1.000 g/mL (20 C)...
Mol wt: average mol wt12,360.96 Da by calculation...
... Grace's medium were developed in several laboratories ... of these modifications were developed by Dr. ... derived from the cabbage looper,Tricoplusia ni. This ... The medium when properly supplemented has been ...
... clear polystyrene with frosted labeling surfaces, ... cell counting. 100% integrity tested. Linkage: ... product number, created to easily match ... availability yet, please order under the ...
Biology Products: