Navigation Links
Abuse of painkillers can predispose adolescents to lifelong addiction
Date:9/10/2008

No child aspires to a lifetime of addiction. But their brains might. In new research to appear online in the journal Neuropsychopharmacology this week, Rockefeller University researchers reveal that adolescent brains exposed to the painkiller Oxycontin can sustain lifelong and permanent changes in their reward system changes that increase the drug's euphoric properties and make such adolescents more vulnerable to the drug's effects later in adulthood.

The research, led by Mary Jeanne Kreek, head of the Laboratory of the Biology of Addictive Diseases, is the first to directly compare levels of the chemical dopamine in adolescent and adult mice in response to increasing doses of the painkiller. Kreek, first author Yong Zhang, a research associate in the lab, and their colleagues found that adolescent mice self-administered Oxycontin less frequently than adults, suggesting that adolescents were more sensitive to its rewarding effects. These adolescent mice, when re-exposed to a low dose of the drug as adults, also had significantly higher dopamine levels in the brain's reward center compared to adult mice newly exposed to the drug.

"Together, these results suggest that adolescents who abuse prescription pain killers may be tuning their brain to a lifelong battle with opiate addiction if they re-exposed themselves to the drug as adults," says Kreek. "The neurobiological changes seem to sensitize the brain to the drug's powerfully rewarding properties."

During adolescence, the brain undergoes marked changes. For example, the brain's reward pathway increases production of dopamine receptors until mid-adolescence and then either production declines or numbers of receptors decline. By abusing Oxycontin during this developmental period, adolescents may inadvertently trick the brain to keep more of those receptors than it really needs. If these receptors stick around and the adolescent is re-exposed to the drug as an adult, the rush
'/>"/>

Contact: Thania Benios
tbenios@rockefeller.edu
212-327-7146
Rockefeller University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Surviving the revolution, easier than withstanding human use and abuse
2. Study finds possible connection between marijuana abuse and stroke or heart attacks
3. A research of the UGR shows the genetic predisposition to develop alcohol abuse
4. Are some men predisposed to pedophilia?
5. Risks and benefits of antipsychotics in children and adolescents
6. Learning how to say no to alcohol advertising and peer pressure works for inner-city adolescents
7. Cocaine: How addiction develops
8. Large-scale investment catapults CAMHs mental illness and addiction research forward
9. Erasing drug-associated memories may stop drug addiction relapses
10. Corals addiction to junk food
11. Hungry mothers risk addiction in their adult children
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/14/2015)... YORK , May 14, 2015 /PRNewswire/ ... in identity verification and online remote proctoring, ... a software-as-a-service (SaaS) company and creator of ... customers of the two companies will benefit ... in Canvas. As a fully ...
(Date:5/11/2015)... 11, 2015 Curemark LLC, a privately held ... a new Phase III double blind, randomized, placebo-controlled clinical ... CM-AT, on all children ages 3-8 with Autism. Previously, ... III double blinded clinical trial for CM-AT in children ... the digestive enzyme chymotrypsin. This new trial will help ...
(Date:5/7/2015)... Sweden , May 7, 2015 ... touch fingerprint sensors, FPC1022 and FPC1035, FPC,s smallest ... and FPC1035 are mainly considered for integration on ... size gives smartphone OEMs increased possibilities to integrate ... The decreased size also improves possibilities for module ...
Breaking Biology News(10 mins):Verificient and Instructure Announce Alliance Partnership to Provide Online Proctoring for K-12 and Higher Education Institutions 2Curemark, LLC, Launches New Phase III Trial in Expanded Population of Children with Autism 2FPC Introduces its Smallest Touch Fingerprint Sensors to Date 2
... rates are concentrated in the northern part of the ... according to a report in Cancer Epidemiology, Biomarkers ... for Cancer Research. Ahmedin Jemal, D.V.M., Ph.D., vice ... said the decrease in death rates ranged from about ...
... global cooling and warming over the past few million ... they do today, according to a new study by ... The researchers, who analyzed California gray whale ( Eschrichtius ... 120,000 years, also found evidence to support the idea ...
... Move over, boy bands of Americathere,s a new ... Middle School in San Diego, California, entered The Christopher ... (STEM) program that challenges middle-school students to identify a ... Taking a cue from the popular group the Backstreet ...
Cached Biology News:Southern US states lag in reducing death rates from colorectal cancer 2Gray whales likely survived the Ice Ages by changing their diets 2Gray whales likely survived the Ice Ages by changing their diets 3Gray whales likely survived the Ice Ages by changing their diets 4Gray whales likely survived the Ice Ages by changing their diets 5Middle-school students educate community on proper computer posture 2
(Date:5/26/2015)... Kalifornien und HILDEN, Deutschland, May 26, 2015 ... Insight ®   ermöglicht ... die Erstellung dazugehöriger Berichte; Vorstellung auf den ... QIAGEN N.V. (NASDAQ: QGEN ; ... Markteinführung von QIAGEN Clinical Insight ® ...
(Date:5/26/2015)... RICHMOND, Calif. , May 26, 2015  Sangamo BioSciences, ... Lanphier , Sangamo,s president and CEO, will provide an update ... programs and an overview of the company,s business strategy at ... 2015 Global Healthcare Conference. The conference is being held in ... presentation will be webcast live and may be accessed via ...
(Date:5/26/2015)... May 26, 2015  Alere Inc. (NYSE: ALR ) ... failure to timely file its Quarterly Report on Form 10-Q ... 10-Q"), it has received a notice from the New York ... compliance with the NYSE,s continued listing requirements under the timely ... Company Manual. The reason for the delay ...
(Date:5/26/2015)... 26, 2015 Global Stem Cells ... plans for the company’s first cellular and regenerative medicine ... a full day, hands-on stem cell training class Oct. ... Garcia Gimenez, M.D., President of Therapeutic Confrontations (CONFTERA) in ... increasing interest in regenerative medicine and recent advances in ...
Breaking Biology Technology:QIAGEN bringt klinische Bioinformatik-Plattform für Next Generation Sequencing-Anwendungen auf den Markt 2QIAGEN bringt klinische Bioinformatik-Plattform für Next Generation Sequencing-Anwendungen auf den Markt 3QIAGEN bringt klinische Bioinformatik-Plattform für Next Generation Sequencing-Anwendungen auf den Markt 4QIAGEN bringt klinische Bioinformatik-Plattform für Next Generation Sequencing-Anwendungen auf den Markt 5QIAGEN bringt klinische Bioinformatik-Plattform für Next Generation Sequencing-Anwendungen auf den Markt 6Sangamo BioSciences Announces Presentation At The Jefferies 2015 Global Healthcare Conference 2Stem Cell Training, Inc. Announces First European Symposium on Cellular and Regenerative Medicine 2Stem Cell Training, Inc. Announces First European Symposium on Cellular and Regenerative Medicine 3
... members help guide non-profit on path to cure ... Project, a Minnesota,non-profit organization created to expedite the ... attracted two well-known experts to its,Board of Directors: ... (Logo: http://www.newscom.com/cgi-bin/prnh/20071214/CLF057LOGO-b ), Steven D. ...
... 16 Celator Pharmaceuticals today,announced that John Bennett, ... the BIO Business Forum during the Biotechnology Industry,Organization ... will,provide a corporate overview and an update on ... on Wednesday, June 18,2008 at 3:30 PDT in ...
... NovaVision today announced,the appointment of Rudy Mazzocchi as ... is responsible for leveraging the company,s novel,technology to ... patients with,impaired vision have access to NovaVision(R) Vision ... expertise bringing new medical technologies,and devices to market ...
Cached Biology Technology:Spring Point Project Names New Members to Board of Directors 2NovaVision Appoints Medical Technology Veteran Rudy Mazzocchi as Chief Executive Officer 2NovaVision Appoints Medical Technology Veteran Rudy Mazzocchi as Chief Executive Officer 3
Extra Large bottle for hybridization 300 x 70mm...
Request Info...
... is TWO ROTORS in ONE! Now, you ... can spin both 1.5 - 2.0 ml ... design provides excellent chemical resistance and can ... fully compatible with common decontamination methods, including ...
... compatible with hood installations. ... system for 384-well plates, ... prepares large quantities of ... Wellpro also performs plate ...
Biology Products: