Navigation Links
AACR news: Six2 homeoprotein allows breast cancer cells to detach and metastasize
Date:4/9/2013

In results presented at the AACR Annual Meeting 2013, researchers from the University of Colorado Cancer Center show that the Six2 homeoprotein, while not involved in primary tumor growth, allows cells to detach from substrate and survive their transition through the bloodstream to faraway sites of metastasis.

"Here we show for the first time that Six2 causes breast cancer progression. It's this metastasis, especially to the lung, that can eventually be deadly and so perhaps even more so than affecting the size of the primary tumor, we are especially excited to present this new information about metastasis," says first author Chu-An Wang, PhD, postdoc in the lab of CU Cancer Center investigator Heide Ford, PhD, the paper's senior author.

The Six2 gene codes for a transcription factor that regulates cell growth needed in developing kidney tissues, but then silenced in the healthy, adult body. Some breast cancer cells have discovered a way to reactivate this Six2 gene, which allows them to survive detachment from their tissue of origin and the programmed cell death known as anoikis that makes most wandering cells self-destruct.

Wang and colleagues knocked down Six2 expression in breast cancer cells and showed that the cells' ability to metastasize in mouse models was much reduced. Interestingly, Six2 knockdown did nothing for the cells' ability to grow at the site of origin. Corroborating the claim of Six2's role in metastasis is its correlation with poor prognosis in human breast cancer tissues of 1881 samples examined from the GOBO database, the breast cancer tissues higher in Six2 were simply more aggressively metastatic.

"We're now working to discover Six2's target genes," Wang says. "For example, we hypothesize an effect on the expression of E-Cadherin, whose loss has been implicated in the metastatic potential of many cancers."


'/>"/>

Contact: Garth Sundem
garth.sundem@ucdenver.edu
805-559-2023
University of Colorado Denver
Source:Eurekalert

Page: 1

Related biology news :

1. AACR news: Paragazole excels in preclinical models of triple-negative breast cancer
2. REACH news: European ombudsman takes up PETA complaint
3. Good news: Fewer maternal and child deaths
4. More accurate, sensitive DNA test allows early identification of fungus causing WNS
5. Novel storage mechanism allows command, control of memory
6. A Spanish breakthrough allows the electroporation of cell cultures for less than 1 Euro
7. Long menopause allows killer whales to care for adult sons
8. How the cell swallows
9. Robot vision: Muscle-like action allows camera to mimic human eye movement
10. Not-so-precious: Stripping gold from AFM probes allows better measurement of picoscale forces
11. New technique allows simulation of noncrystalline materials
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/19/2017)... Jan. 19, 2017 Sensory Inc ... and security for consumer electronics, and i ... systems and cybersecurity solutions, today announced a global ... financial institutions worldwide to bolster security of data ... secure user authentication platforms they offer, innerCore now ...
(Date:1/18/2017)... 2017 MedNet Solutions , an ... entire spectrum of clinical research, is proud to ... for the organization in terms of corporate growth, ... products and services. The company,s exceptional achievements can ... iMedNet ™ – ...
(Date:1/12/2017)... , Jan. 12, 2017  Trovagene, Inc. (NASDAQ: ... (ctDNA) technologies, today announced that it has signed agreements ... and the Middle East ... milestone marks the first wave of international distribution agreements ... and blood samples. The initial partners will ...
Breaking Biology News(10 mins):
(Date:1/19/2017)... Research and Markets has announced the addition ... Type, Application - Global Opportunity Analysis and Industry Forecast, 2014-2022" ... ... is projected to reach $15,737 million by 2022 from $6,521 in ... Omic technologies segment accounted for more than half ...
(Date:1/19/2017)... and HOUSTON , Jan. 19, ... today announced the formation of its Medical/Clinical Advisory ... and industry veterans who enhance the range and ... accelerates development of its novel prenatal diagnostic tests.  ... clinical and strategic guidance for the company,s product ...
(Date:1/19/2017)... DUBLIN , Jan 19, 2017 Research and ... has announced the addition ... - Material, Application - Forecast to 2025" report to ... The report provides a detailed analysis on current ... Market forecasts till 2025, using estimated market values as the base numbers ...
(Date:1/19/2017)... , ... January 19, 2017 , ... ... product vigilance software to leading biopharmaceutical and medical device manufacturers and regulators, is ... fully 21 CFR Part 11-compliant email client designed to provide product vigilance departments ...
Breaking Biology Technology: