Navigation Links
AACR news: Six2 homeoprotein allows breast cancer cells to detach and metastasize
Date:4/9/2013

In results presented at the AACR Annual Meeting 2013, researchers from the University of Colorado Cancer Center show that the Six2 homeoprotein, while not involved in primary tumor growth, allows cells to detach from substrate and survive their transition through the bloodstream to faraway sites of metastasis.

"Here we show for the first time that Six2 causes breast cancer progression. It's this metastasis, especially to the lung, that can eventually be deadly and so perhaps even more so than affecting the size of the primary tumor, we are especially excited to present this new information about metastasis," says first author Chu-An Wang, PhD, postdoc in the lab of CU Cancer Center investigator Heide Ford, PhD, the paper's senior author.

The Six2 gene codes for a transcription factor that regulates cell growth needed in developing kidney tissues, but then silenced in the healthy, adult body. Some breast cancer cells have discovered a way to reactivate this Six2 gene, which allows them to survive detachment from their tissue of origin and the programmed cell death known as anoikis that makes most wandering cells self-destruct.

Wang and colleagues knocked down Six2 expression in breast cancer cells and showed that the cells' ability to metastasize in mouse models was much reduced. Interestingly, Six2 knockdown did nothing for the cells' ability to grow at the site of origin. Corroborating the claim of Six2's role in metastasis is its correlation with poor prognosis in human breast cancer tissues of 1881 samples examined from the GOBO database, the breast cancer tissues higher in Six2 were simply more aggressively metastatic.

"We're now working to discover Six2's target genes," Wang says. "For example, we hypothesize an effect on the expression of E-Cadherin, whose loss has been implicated in the metastatic potential of many cancers."


'/>"/>

Contact: Garth Sundem
garth.sundem@ucdenver.edu
805-559-2023
University of Colorado Denver
Source:Eurekalert

Page: 1

Related biology news :

1. AACR news: Paragazole excels in preclinical models of triple-negative breast cancer
2. REACH news: European ombudsman takes up PETA complaint
3. Good news: Fewer maternal and child deaths
4. More accurate, sensitive DNA test allows early identification of fungus causing WNS
5. Novel storage mechanism allows command, control of memory
6. A Spanish breakthrough allows the electroporation of cell cultures for less than 1 Euro
7. Long menopause allows killer whales to care for adult sons
8. How the cell swallows
9. Robot vision: Muscle-like action allows camera to mimic human eye movement
10. Not-so-precious: Stripping gold from AFM probes allows better measurement of picoscale forces
11. New technique allows simulation of noncrystalline materials
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/16/2014)... Our ability to store memories improves during childhood, ... its connections with prefrontal and parietal cortices. New ... brain regions develop at this crucial time. Eventually, ... emerge in the transition into and during adolescence ... , Located deep in the middle of the ...
(Date:4/16/2014)... group composed of Dr. Martin Prechtl, Leo Heim and ... Chemistry has discovered a new method of generating hydrogen ... liquids is of particular interest when it comes to ... "Selective and mild hydrogen production using water and formaldehyde", ... Communications . , Among other applications, the new approach ...
(Date:4/15/2014)... community is creating a tropical home away from home ... the attention of scientists. David W. Taylor (University of ... a close look at the fresh crops in the ... gives new meaning to a phrase that food lovers ... kitchen. , "Culinary preferences tell us a good deal ...
Breaking Biology News(10 mins):How kids' brain structures grow as memory develops 2The human food connection: A new study reveals more about our relationship to food 2The human food connection: A new study reveals more about our relationship to food 3
... Doctors may soon be able to diagnose lung cancer ... Institute of Standards and Technology (NIST), where scientists have ... tomography (CT) scans and to lessen the amount of ... For years, radiologists have determined the size of ...
... Bacteria in the ocean can harvest light energy from ... novel finding by a team of scientists in Sweden and ... open access journal PLoS Biology . "It was ... sea that could harvest the energy from sunlight for growth," ...
... Baltimore, MDDouglas E. Koshland, staff scientist at Carnegie,s ... members of the National Academy of Sciences (NAS) for ... NAS is one of the highest honors given to ... will be inducted into the academy next April during ...
Cached Biology News:To improve lung cancer diagnosis, good medicine is a polymer pill 2Rhodopsin phototrophy promotes bacterial survival 2Carnegie's Doug Koshland elected to National Academy of Sciences 2
(Date:1/15/2014)... 2014 The Microcompetition with Foreign DNA ... disease. One of these latent viruses is the Epstein ... rheumatoid arthritis (RA). Rheumatoid arthritis (RA) is a chronic ... by the theory, a study found that RA patients ... (1). , What is Microcompetition? , Dr. Hanan ...
(Date:1/15/2014)... Sunnyvale, CA (PRWEB) January 15, 2014 ... of high throughput research solutions, today announced that ... companies, has received delivery of Freeslate’s CM ... form screening. , Lupin, headquartered in Mumbai, ... quality, affordable generic and branded formulations and Active ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 Date: Friday, ... p.m. , Location: Warrington Country Club, 1360 Almshouse Road, ... Foundation, the only national nonprofit organization solely dedicated to ... quality of life for those affected worldwide, will host ... Warrington Country Club in Warrington, Pa. , Each ...
(Date:1/14/2014)... , Jan. 14, 2014  3D Communications, a leading provider ... major scientific, regulatory, business, and media events in ... , today announced its former associate Virginia Cox , ... office. Virginia Cox re-joins ... Commissioner for the Office of External Affairs at the U.S. ...
Breaking Biology Technology:Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2Former FDA Associate Commissioner Returns To 3D Communications 2
... , INDIANAPOLIS , ... and manufacturing companies continued to expand in 2009, despite challenges ... in the economy, the prospect of healthcare reform and other ... announced, and service line extensions were added by companies such ...
... , New kinase array designed for ... VANCOUVER , Feb. 10 /PRNewswire/ - ... novel Protein Kinase Microarray with 200 recombinant human protein ... applications for drug target counter screening, to identify novel ...
... ... users to search the most sought after jobs in the industry anytime, anywhere. ... (PRWEB) -- MedReps.com gives members ... on the web. But in a competitive market like medical sales, job seekers need every ...
Cached Biology Technology:Indiana Biopharmaceutical Service Providers Maintain Steady Growth Despite Industry Challenges 2Indiana Biopharmaceutical Service Providers Maintain Steady Growth Despite Industry Challenges 3Indiana Biopharmaceutical Service Providers Maintain Steady Growth Despite Industry Challenges 4Kinexus Announces the Launch of a New Protein Kinase Microarray 2With the MedReps.com iPhone App, the Medical Sales Job Search Goes Mobile 2
... coli containing a clone of the human Topoisomerase ... II alters the topological state of nucleic acids ... transient break which generates a separate DNA helix ... DNA passage mechanism, the enzyme can relax negatively ...
RNase-Free DNase 50 l...
supplied with 10x reaction buffer...
... RNase H degrades, as an endoribonuclease, ... DNA hybrids of natural origin, e.g. ... synthetic complexes, e.g. poly(A) x poly(dT). ... and 3-OH termini. Nearly no activity ...
Biology Products: