Navigation Links
A surprising new function for small RNAs in evolution

It has long been known that certain proteins, known as transcription factors, directly control the way in which information is read from DNA. As a result, it is widely believed that changes in genes encoding such proteins underlie the mechanisms responsible for evolutionary adaptation. The idea that small RNA molecules, so-called microRNAs, may play an important part in evolutionary changes to animals' appearance is completely new. An international team of researchers, including Christian Schltterer and Alistair McGregor from the Institute of Population Genetics of the University of Veterinary Medicine, Vienna (Vetmeduni Vienna), has now published a study that describes such an evolutionary mechanism.

Small and large bald patches

Insect bodies are generally covered with a large number of microscopic hairs. This is the case for the legs of many closely related species of the fruit fly genus Drosophila, although the animals have a bald patch on the second pair of legs, intriguingly known as the naked valley. Previous work had shown that the size of this patch is regulated by the gene ultrabithorax (Ubx) and that it differs between species. However, the work at the Vetmeduni Vienna showed that similar differences are shown by individuals from different populations of Drosophila melanogaster.

Their search for the genetic basis of the variation led the researchers to a segment of fruit fly DNA that contained four genes. Three of these genes were known to encode proteins with no role in the development of the hairs. The fourth gene, known as miR-92a, encodes a microRNA. Previous experiments had shown that an increase in activity of the miR-92a gene was associated with a loss of hairs from the animals' wings. By overexpressing the gene in the legs of the fruit flies, the scientists were able to cause hair loss on the animals' legs.

Schltterer is naturally excited by the findings. "This is the first experiment to show that natural variation in the expression of a microRNA can lead to a change in the appearance of an organism. MicroRNAs can fine-tune the level at which genes are expressed, so evolutionary changes in the production of microRNA would be an elegant way to cause morphological changes."


Contact: Christian Schlötterer
University of Veterinary Medicine -- Vienna

Related biology news :

1. Surprising findings on hydrogen production in green algae
2. Scientists find surprising new influence on cancer genes
3. Computer modeling reveals how surprisingly potent hepatitis C drug works
4. New look at cell membrane reveals surprising organization
5. Climate changes effects on temperate rain forests surprisingly complex
6. Surprising teaching tool in K-12 science education -- Zebrafish research
7. Despite their thick skins, alligators and crocodiles are surprisingly touchy
8. Surprising demographic shifts in endangered monkey population challenge conservation expectations
9. Nuclear weapons surprising contribution to climate science
10. Seabirds study shows plastic pollution reaching surprising levels off coast of Pacific Northwest
11. First-of-its-kind study reveals surprising ecological effects of earthquake and tsunami
Post Your Comments:
(Date:11/17/2015)... Paris from 17 th until 19 th ... from 17 th until 19 th November 2015.   ... the first combined scanner in the world which scans both ... two different scanners were required: one for passports and one ... same surface. This innovation is an ideal solution for electronic ...
(Date:11/17/2015)... 2015  Vigilant Solutions announces today that Mr. ... Directors. --> --> ... the partnership at TPG Capital, one of the largest ... Billion in revenue.  He founded and led TPG,s Operating ... companies, from 1997 to 2013.  In his first role, ...
(Date:11/16/2015)... 2015  Synaptics Inc. (NASDAQ: SYNA ), ... announced expansion of its TDDI product portfolio with ... and display driver integration (TDDI) solutions designed to ... TDDI products add to the previously-announced TD4300 ... resolution), and TD4322 (FHD resolution) solutions. All four ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... , Nov. 24, 2015  Clintrax Global, Inc., a worldwide ... Carolina , today announced that the company has set a ... a 391% quarter on quarter growth posted for Q3 of 2014 ... and Mexico , with the establishment of ... December 2015. --> United Kingdom and ...
(Date:11/24/2015)... November 24, 2015 SHPG ) announced today ... the Piper Jaffray 27 th Annual Healthcare Conference in ... 2015, at 8:30 a.m. EST (1:30 p.m. GMT). --> ... Officer, will participate in the Piper Jaffray 27 th Annual ... on Tuesday, December 1, 2015, at 8:30 a.m. EST (1:30 p.m. ...
(Date:11/24/2015)... Nov. 24, 2015  Twist Bioscience, a company ... Leproust, Ph.D., Twist Bioscience chief executive officer, will ... on December 1, 2015 at 3:10 p.m. Eastern ... City. --> --> ... Twist Bioscience is on Twitter. Sign up to ...
(Date:11/24/2015)... QC , Nov. 24, 2015 /CNW Telbec/ - ProMetic ... "Corporation") announced today that Mr. Pierre Laurin , President ... corporate presentation at the upcoming Piper Jaffray 27 th ... Palace Hotel, on December 1-2, 2015. st ... available for one-on-one meetings throughout the day. The presentation will ...
Breaking Biology Technology: