Navigation Links
A study on cell migration provides insights into the movement of cancer cells
Date:11/21/2013

Jordi Casanova, head of the "Morphogenesis in Drosophila" lab at IRB Barcelona and CSIC research professor, and Galle Lebreton, postdoctoral fellow in the same group, have published a study performed using Drosophila melanogaster in the Journal of Cell Science. This work reveals that in a multiple movement, a single cell can act as the leader and can drag the rest with it. The scientists have studied the tracheal development of Drosophila in vivo and describe the morphological characteristics of the leading cell and provide molecular details about how it drives the movement.

"Cancer researchers are keen to know how cells are organized to achieve migration and to form new capillaries to feed an expanding cancerous tumor," explains Galle Lebreton, first author of the article. "Our study gives new data about how angiogenesis might arise," comments the French scientist at IRB Barcelona. Angiogenesis or the formation of new blood vessels is a critical process in the context of cancer because it is one of the steps that mark the transformation of a benign tumour into a malignant one. The formation of new blood vessels involves the synchronized movements of groups of cells. In this regard, understanding how these groups work will open up new research lines on angiogenesis.

Over seven hours, the scientists tracked a group of seven cells that form one of the tracheal branches of the fly Drosophila melanogaster in its first hours of development. The leading cell is the only one that has receptors for the growth factor FGF. The FGF signal stimulates a cascade of reactions in this cell in order to generate sufficient energy and to turn it into the promoter of motility.

"This is a novel piece of work because we monitored the entire process in vivo and because it is the first time we have seen, in an experimental context, that a single cell can lead this multiple migration," says Casanova.

It is important
'/>"/>

Contact: Sònia Armengou
armengou@irbbarcelona.org
34-934-037-255
Institute for Research in Biomedicine (IRB Barcelona)
Source:Eurekalert  

Page: 1 2

Related biology news :

1. UT Dallas study: Initial success for new tinnitus treatment
2. Connections in the brains of young children strengthen during sleep, CU-Boulder study finds
3. Women prescribed combination HRT should use caution when taking apigenin supplement, MU study finds
4. Dartmouth-led study shows diet alone can be significant source of arsenic
5. Shadehouses with photoselective nets featured in study of growing conditions
6. Study to identify functions of hypothetical genes in 2 infectious disease pathogens
7. Bone marrow mononuclear stem cells show no new gains in heart function says TIME study
8. Drexel study: Consumers order a less unhealthy meal when the menu has nutritional labeling
9. Body mass index may predict heart disease risk for type-2 diabetic patients new study finds
10. Study shows wind turbines killed 600,000 bats last year
11. Clinical ovarian cancers display extensive genetic heterogeneity, study suggests multiple treatment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A study on cell migration provides insights into the movement of cancer cells
(Date:10/31/2014)... good for attracting species, but it may not be enough ... study has found. , The researchers surveyed two types of ... abundance of two insects that interact with them. They found ... and black walnut, they didn,t find a corresponding abundance of ... the walnuts and black cherries and a type of wasp ...
(Date:10/31/2014)... 30, 2014  HITLAB SM , a healthcare ... its inaugural HITLAB Innovators Summit SM on ... HITLAB will partner with the Clinton Foundation,s Health ... ProtoHack, Columbia Business School Alumni Club of ... Engineering and Operations Research, bringing together leaders in ...
(Date:10/30/2014)... 2014—Oligonucleotide-based therapeutics present unique challenges when it comes ... developmental harm. New consensus guidelines for toxicity testing ... biological characteristics of these novel biopharmaceuticals are presented ... journal from Mary Ann Liebert, Inc. publishers ... Nucleic Acid Therapeutics website until November ...
Breaking Biology News(10 mins):Green spaces don't ensure biodiversity in urban areas 2HITLAB Announces Inaugural HITLAB Innovators Summit 2HITLAB Announces Inaugural HITLAB Innovators Summit 3New guidelines for reproductive & developmental toxicity testing of oligonucleotide drugs 2
... Institute of Nanoscience have discovered how to use the ... a chip. Based on this, they built a transport ... individually. To demonstrate this, the Delft researchers sorted the ... the University of Florida has called the Delft discovery ...
... working at the University of Bristol has found a ... food poisoning. Their work is reported in Nature Medicine. ... shown that one particular antibiotic ? fosfomycin ?can treat ... laboratory conditions. , Because it was not effective in ...
... Wegener Institute for Polar and Marine Research observed ... began in Ny-Ålesund on Svalbard. Monitoring instruments displayed ... found. Aerosols from eastern Europe have been transported ... large-scale weather situation. , Usually the air ...
Cached Biology News:Biological motors sort molecules one by one on a chip 2Record air pollution above the Arctic 2
(Date:10/31/2014)... (PRWEB) October 30, 2014 Two ... America were hosted by Charm Sciences at its ... their week in the US, the participants discussed ... control, hygiene management, and process verification, and received ... , This was the first visit to the ...
(Date:10/31/2014)... October 31, 2014 Following the successful ... free learning webinar to introduce its new product and ... and biostatisticians. , Launched in September, Formedix On Demand ... of clinical trial automation tools. For the first time, ... browser. And by introducing Formations – a revolutionary new ...
(Date:10/31/2014)... The report "Dairy Alternative (Beverage) Market ... Sweetened, Unsweetened), Channel (Supermarket, Health Store, Pharmacy, Convenience ... to 2018," defines and segments the dairy alternative ... revenue and volume for plant-based dairy alternative beverages. ... $14 Billion by 2018 with the Asia-Pacific region ...
(Date:10/31/2014)... ENVIRON , an international ... that Dr. Harvey Clewell III has rejoined the ... closely with senior professionals in ENVIRON’s Health Sciences ... at The Hamner Institutes for Health Sciences (The ... he is Director, Center for Human Health Assessment. ...
Breaking Biology Technology:Charm Sciences Hosts Executives from Latin America for Dairy Safety Executive Seminar 2Formedix to Introduce "Revolutionary" Clinical Trial Automation Software with Learning Webinar 2Dairy Alternative Beverage Market Projected to Reach $14 Billion by 2018 - Report by MarketsandMarkets 2Dairy Alternative Beverage Market Projected to Reach $14 Billion by 2018 - Report by MarketsandMarkets 3Dairy Alternative Beverage Market Projected to Reach $14 Billion by 2018 - Report by MarketsandMarkets 4Internationally recognized health scientist Dr. Harvey Clewell renews association with ENVIRON 2Internationally recognized health scientist Dr. Harvey Clewell renews association with ENVIRON 3
... ST PETER PORT, Guernsey and LONDON, July 6 ... to Drive Novel Antibiotics Platform Addressing,Areas of Major Unmet Need, ... Celtic Pharma Holdings Advisors LLP ("CPHA"), the advisor ... ("CP2"), today announces its,investment in a majority shareholding in Novacta ...
... NEW BRUNSWICK, N.J., July 3 Johnson & Johnson (NYSE: ... its tender offer for all outstanding shares of common stock of ... (Eastern time) on July 2, 2009. The offer was conducted ... Merger Sub, Inc. , , The depositary for the tender ...
... , PHOENIX, July 2 As many as ... with an eating disorder because they,re ashamed to admit they ... Eating and Anxiety Disorders . Healthcare professionals, family members ... in males that may signify an eating disorder. Therefore, effective ...
Cached Biology Technology:Celtic Pharma Holdings Announces Investment in Novacta Biosystems Limited 2Celtic Pharma Holdings Announces Investment in Novacta Biosystems Limited 3Celtic Pharma Holdings Announces Investment in Novacta Biosystems Limited 4Celtic Pharma Holdings Announces Investment in Novacta Biosystems Limited 5Johnson & Johnson Completes Initial Tender Offer for Cougar Biotechnology 2Johnson & Johnson Completes Initial Tender Offer for Cougar Biotechnology 3Johnson & Johnson Completes Initial Tender Offer for Cougar Biotechnology 4Remuda Ranch Programs for Eating and Anxiety Disorders Reports Need for Increasing Awareness of Eating Disorders in Males 2