Navigation Links
A study on cell migration provides insights into the movement of cancer cells
Date:11/21/2013

Jordi Casanova, head of the "Morphogenesis in Drosophila" lab at IRB Barcelona and CSIC research professor, and Galle Lebreton, postdoctoral fellow in the same group, have published a study performed using Drosophila melanogaster in the Journal of Cell Science. This work reveals that in a multiple movement, a single cell can act as the leader and can drag the rest with it. The scientists have studied the tracheal development of Drosophila in vivo and describe the morphological characteristics of the leading cell and provide molecular details about how it drives the movement.

"Cancer researchers are keen to know how cells are organized to achieve migration and to form new capillaries to feed an expanding cancerous tumor," explains Galle Lebreton, first author of the article. "Our study gives new data about how angiogenesis might arise," comments the French scientist at IRB Barcelona. Angiogenesis or the formation of new blood vessels is a critical process in the context of cancer because it is one of the steps that mark the transformation of a benign tumour into a malignant one. The formation of new blood vessels involves the synchronized movements of groups of cells. In this regard, understanding how these groups work will open up new research lines on angiogenesis.

Over seven hours, the scientists tracked a group of seven cells that form one of the tracheal branches of the fly Drosophila melanogaster in its first hours of development. The leading cell is the only one that has receptors for the growth factor FGF. The FGF signal stimulates a cascade of reactions in this cell in order to generate sufficient energy and to turn it into the promoter of motility.

"This is a novel piece of work because we monitored the entire process in vivo and because it is the first time we have seen, in an experimental context, that a single cell can lead this multiple migration," says Casanova.

It is important to note that the development of trachea in the Drosophila fly is similar to that of bronchia in humans. Consequently, this development is also of biomedical interest in order to unravel the basic processes involved in the formation of new tissue.


'/>"/>

Contact: Sònia Armengou
armengou@irbbarcelona.org
34-934-037-255
Institute for Research in Biomedicine (IRB Barcelona)
Source:Eurekalert  

Related biology news :

1. UT Dallas study: Initial success for new tinnitus treatment
2. Connections in the brains of young children strengthen during sleep, CU-Boulder study finds
3. Women prescribed combination HRT should use caution when taking apigenin supplement, MU study finds
4. Dartmouth-led study shows diet alone can be significant source of arsenic
5. Shadehouses with photoselective nets featured in study of growing conditions
6. Study to identify functions of hypothetical genes in 2 infectious disease pathogens
7. Bone marrow mononuclear stem cells show no new gains in heart function says TIME study
8. Drexel study: Consumers order a less unhealthy meal when the menu has nutritional labeling
9. Body mass index may predict heart disease risk for type-2 diabetic patients new study finds
10. Study shows wind turbines killed 600,000 bats last year
11. Clinical ovarian cancers display extensive genetic heterogeneity, study suggests multiple treatment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A study on cell migration provides insights into the movement of cancer cells
(Date:11/29/2016)... BioDirection, a privately held medical device company developing novel ... concussion and other traumatic brain injury (TBI), announced today ... the U.S. Food and Drug Administration (FDA) to review ... meeting company representatives reviewed plans for clinical development of ... a planned pilot trial. "We are ...
(Date:11/24/2016)... 2016 Cercacor today introduced Ember TM ... non-invasively measure hemoglobin, Oxygen Content, Oxygen Saturation, ... Rate in approximately 30 seconds. Smaller than a smartphone, ... access to key data about their bodies to help ... Hemoglobin carries oxygen to muscles. When ...
(Date:11/19/2016)... Securus Technologies, a leading provider of civil ... corrections and monitoring, announced today that it has offered ... an independent technology judge determine who has the largest ... telephone calling platform, and the best customer service. ... of what we do – which clearly is not ...
Breaking Biology News(10 mins):
(Date:12/2/2016)... More than $4.3 million was raised last night ... ). The gala was held at the American Museum of ... and honored Alan Alda and P. ... medicine and the public understanding of science. Since the first ... has raised $40 million for the Laboratory,s research and education ...
(Date:12/2/2016)... ... , ... ACEA Biosciences, Inc. announced today that it will be presenting updated ... World Conference on Lung Cancer 2016, taking place in Vienna, Austria December 3rd-8th. ... for AC0010 in patients with advanced non-small cell lung cancer harboring the EGFR T790M ...
(Date:12/2/2016)... ... December 01, 2016 , ... DrugDev believes the only ... a beautiful technology experience. All three tenets were on display at the 2nd Annual ... from over 40 sponsor, CRO and site organizations to discuss innovation and the future ...
(Date:12/2/2016)... The immunohistochemistry (IHC) market is projected ... of 7.3% during the forecast period of 2016 to 2021 dominated ... accounted for the largest share of immunohistochemistry (IHC) market, by end ... , , ... market spread across 225 pages, profiling 10 companies and supported with ...
Breaking Biology Technology: