Navigation Links
A study on cell migration provides insights into the movement of cancer cells
Date:11/21/2013

Jordi Casanova, head of the "Morphogenesis in Drosophila" lab at IRB Barcelona and CSIC research professor, and Galle Lebreton, postdoctoral fellow in the same group, have published a study performed using Drosophila melanogaster in the Journal of Cell Science. This work reveals that in a multiple movement, a single cell can act as the leader and can drag the rest with it. The scientists have studied the tracheal development of Drosophila in vivo and describe the morphological characteristics of the leading cell and provide molecular details about how it drives the movement.

"Cancer researchers are keen to know how cells are organized to achieve migration and to form new capillaries to feed an expanding cancerous tumor," explains Galle Lebreton, first author of the article. "Our study gives new data about how angiogenesis might arise," comments the French scientist at IRB Barcelona. Angiogenesis or the formation of new blood vessels is a critical process in the context of cancer because it is one of the steps that mark the transformation of a benign tumour into a malignant one. The formation of new blood vessels involves the synchronized movements of groups of cells. In this regard, understanding how these groups work will open up new research lines on angiogenesis.

Over seven hours, the scientists tracked a group of seven cells that form one of the tracheal branches of the fly Drosophila melanogaster in its first hours of development. The leading cell is the only one that has receptors for the growth factor FGF. The FGF signal stimulates a cascade of reactions in this cell in order to generate sufficient energy and to turn it into the promoter of motility.

"This is a novel piece of work because we monitored the entire process in vivo and because it is the first time we have seen, in an experimental context, that a single cell can lead this multiple migration," says Casanova.

It is important
'/>"/>

Contact: Sònia Armengou
armengou@irbbarcelona.org
34-934-037-255
Institute for Research in Biomedicine (IRB Barcelona)
Source:Eurekalert  

Page: 1 2

Related biology news :

1. UT Dallas study: Initial success for new tinnitus treatment
2. Connections in the brains of young children strengthen during sleep, CU-Boulder study finds
3. Women prescribed combination HRT should use caution when taking apigenin supplement, MU study finds
4. Dartmouth-led study shows diet alone can be significant source of arsenic
5. Shadehouses with photoselective nets featured in study of growing conditions
6. Study to identify functions of hypothetical genes in 2 infectious disease pathogens
7. Bone marrow mononuclear stem cells show no new gains in heart function says TIME study
8. Drexel study: Consumers order a less unhealthy meal when the menu has nutritional labeling
9. Body mass index may predict heart disease risk for type-2 diabetic patients new study finds
10. Study shows wind turbines killed 600,000 bats last year
11. Clinical ovarian cancers display extensive genetic heterogeneity, study suggests multiple treatment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A study on cell migration provides insights into the movement of cancer cells
(Date:8/11/2015)... August 11, 2015 Today, ZUK announced its ... as well as expected revenues in 2015 that relate to sales ... revenue guidance of approximately 2,200 MSEK for 2015. Jörgen ... prominent smartphone manufacturer in China ... selected FPC1 155 for Z1 ...
(Date:8/6/2015)... Germany , August 6, 2015 ... (SMI) shows the world,s first Eye Tracking ... Epson,s Moverio BT-200 see-through head mounted display and on ... unprecedented quality and efficiency is brought to personalized visualization ... the first time, professionals and researchers can integrate gaze, ...
(Date:8/5/2015)... , Aug. 5, 2015 The biosensors market ... in applications, penetration into newer sectors, and development of ... global biosensors space has seen the entry of multiple ... so far. (Photo - http://photos.prnewswire.com/prnh/20150805/255570 ) ... Analysis of the Global Biosensors Market ( ...
Breaking Biology News(10 mins):FPC's Touch Fingerprint Sensor FPC1155 in ZUK's Smartphone Z1 2SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 2SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 3Innovative Biosensors Incite Use in Non-Traditional Applications 2Innovative Biosensors Incite Use in Non-Traditional Applications 3Innovative Biosensors Incite Use in Non-Traditional Applications 4
... is available in Spanish . , Adolescents of ... and regular physical activity present increased levels of insulin and ... appetite control and energy expenditure. This was the conclusion drawn ... of the University of Granada . Further, after thorough ...
... of diabetes risk than does BMI. This is the ... the German Institute for Nutritional Research in Potsdam-Rehbrcke, in ... (Dtsch Arztebl Int 2010; 107[26]: 470-6). Current guidelines ... overweight should be based on the determination of the ...
... Minimally invasive surgery is increasingly common and effective for ... which use slender, handheld tools inserted into the body ... the most important factor determining the success of the ... Polytechnic Institute has won a $2.3 million federal grant ...
Cached Biology News:Children in good shape have better appetite control and energy expenditure 2Designing touch-sensitive virtual reality tools to train and test tomorrow's surgeons 2Designing touch-sensitive virtual reality tools to train and test tomorrow's surgeons 3
(Date:8/31/2015)... 31, 2015 LabStyle Innovations Corp. (OTCQB: ... today announced it recently closed a round of ... used to support the global rollout and initial ... cloud-based, diabetes management solution that includes novel software ... glucose monitoring device, and for working capital purposes. ...
(Date:8/31/2015)... (PRWEB) , ... August 31, 2015 , ... There’s a ... Minerva is the first commercially available new FDA approved system in the last ... rate of 92%, the high Amenorrhea (zero bleeding) rate of 66%, the high Patient ...
(Date:8/28/2015)... -- According to a new market research ... Thawing Equipment, Alarms), by Biospecimen (Human Tissue, Stem Cells, ... - Global Forecast to 2020", published by MarketsandMarkets, the ... Million by 2020 from USD 2,150.48 Million in 2015, ... 2020. Browse 74 Tables and 95 ...
(Date:8/28/2015)... ... August 28, 2015 , ... Riordan-McKenna Institute ... announced today that the use of sterile, dehydrated amniotic tissue AlphaPATCH™ developed by ... otherwise non-healing surgical knee wound. , The case involved a 78-year-old male, who ...
Breaking Biology Technology:LabStyle Innovations Closes $2.5 Million Funding to Support Global Rollout of Dario Diabetes Management Solution 2LabStyle Innovations Closes $2.5 Million Funding to Support Global Rollout of Dario Diabetes Management Solution 3LabStyle Innovations Closes $2.5 Million Funding to Support Global Rollout of Dario Diabetes Management Solution 4U.S. FDA Approves Minerva Endometrial Ablation System 2U.S. FDA Approves Minerva Endometrial Ablation System 3Biopreservation Market Worth 3,731.03 Million USD by 2020 2Biopreservation Market Worth 3,731.03 Million USD by 2020 3Biopreservation Market Worth 3,731.03 Million USD by 2020 4Biopreservation Market Worth 3,731.03 Million USD by 2020 5Dallas-Fort Worth Stem Cell Researchers Use Amniotic Tissue To Successfully Treat Non-Healing Surgical Wound 2Dallas-Fort Worth Stem Cell Researchers Use Amniotic Tissue To Successfully Treat Non-Healing Surgical Wound 3Dallas-Fort Worth Stem Cell Researchers Use Amniotic Tissue To Successfully Treat Non-Healing Surgical Wound 4
... Something that was always taken for granted was the quality ... Sprint commercials, they emphasized that "you can hear a pin ... infrastructure. , ,The old Bell system also had very ... from analog to digital lines with digital repeaters (amplifiers) that ...
... multi-national corporations have decided to lease space in the ... and Eaton Corp. will have sales offices in ... management for Irgens Development Partners, LLC . , ... a global manufacturer of automotive systems, plans to open a ...
... Wis. - In what many in state government consider ... for the consolidation of computer servers in state government, but ... according to State CIO Matt Miszewski. , ,The revised timetable ... large agencies, the Department of Corrections and the ...
Cached Biology Technology:Is traditional voice quality an oxymoron with today's cellular, VoIP? 2Is traditional voice quality an oxymoron with today's cellular, VoIP? 3State alters schedule for server consolidation 2State alters schedule for server consolidation 3State alters schedule for server consolidation 4