Navigation Links
A study on cell migration provides insights into the movement of cancer cells
Date:11/21/2013

Jordi Casanova, head of the "Morphogenesis in Drosophila" lab at IRB Barcelona and CSIC research professor, and Galle Lebreton, postdoctoral fellow in the same group, have published a study performed using Drosophila melanogaster in the Journal of Cell Science. This work reveals that in a multiple movement, a single cell can act as the leader and can drag the rest with it. The scientists have studied the tracheal development of Drosophila in vivo and describe the morphological characteristics of the leading cell and provide molecular details about how it drives the movement.

"Cancer researchers are keen to know how cells are organized to achieve migration and to form new capillaries to feed an expanding cancerous tumor," explains Galle Lebreton, first author of the article. "Our study gives new data about how angiogenesis might arise," comments the French scientist at IRB Barcelona. Angiogenesis or the formation of new blood vessels is a critical process in the context of cancer because it is one of the steps that mark the transformation of a benign tumour into a malignant one. The formation of new blood vessels involves the synchronized movements of groups of cells. In this regard, understanding how these groups work will open up new research lines on angiogenesis.

Over seven hours, the scientists tracked a group of seven cells that form one of the tracheal branches of the fly Drosophila melanogaster in its first hours of development. The leading cell is the only one that has receptors for the growth factor FGF. The FGF signal stimulates a cascade of reactions in this cell in order to generate sufficient energy and to turn it into the promoter of motility.

"This is a novel piece of work because we monitored the entire process in vivo and because it is the first time we have seen, in an experimental context, that a single cell can lead this multiple migration," says Casanova.

It is important to note that the development of trachea in the Drosophila fly is similar to that of bronchia in humans. Consequently, this development is also of biomedical interest in order to unravel the basic processes involved in the formation of new tissue.


'/>"/>

Contact: Sònia Armengou
armengou@irbbarcelona.org
34-934-037-255
Institute for Research in Biomedicine (IRB Barcelona)
Source:Eurekalert  

Related biology news :

1. UT Dallas study: Initial success for new tinnitus treatment
2. Connections in the brains of young children strengthen during sleep, CU-Boulder study finds
3. Women prescribed combination HRT should use caution when taking apigenin supplement, MU study finds
4. Dartmouth-led study shows diet alone can be significant source of arsenic
5. Shadehouses with photoselective nets featured in study of growing conditions
6. Study to identify functions of hypothetical genes in 2 infectious disease pathogens
7. Bone marrow mononuclear stem cells show no new gains in heart function says TIME study
8. Drexel study: Consumers order a less unhealthy meal when the menu has nutritional labeling
9. Body mass index may predict heart disease risk for type-2 diabetic patients new study finds
10. Study shows wind turbines killed 600,000 bats last year
11. Clinical ovarian cancers display extensive genetic heterogeneity, study suggests multiple treatment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A study on cell migration provides insights into the movement of cancer cells
(Date:4/24/2017)... 24, 2017 Janice Kephart , ... Identity Strategy Partners, LLP (IdSP) , today issues ... President Trump,s March 6, 2017 Executive Order: ... vetting can be instilled with greater confidence, enabling ... all refugee applications are suspended by until at ...
(Date:4/18/2017)... -- Socionext Inc., a global expert in SoC-based imaging and computing solutions, ... which features the company,s hybrid codec technology. A demonstration utilizing TeraFaces ... will be showcased during the upcoming Medtec Japan at Tokyo Big ... Las Vegas Convention Center April 24-27. ... Click here for an image of ...
(Date:4/13/2017)... 2017 UBM,s Advanced Design and Manufacturing event ... emerging and evolving technology through its 3D Printing and ... alongside the expo portion of the event and feature ... focused on trending topics within 3D printing and smart ... event will take place June 13-15, 2017 at the Jacob ...
Breaking Biology News(10 mins):
(Date:6/22/2017)... ... June 22, 2017 , ... Ovation ... infertility as a disease, bringing new hope for prospective parents who are challenged ... meeting to back the World Health Organization’s designation in hopes of changing the ...
(Date:6/22/2017)... , ... June 22, 2017 , ... ... announced the release of Limfinity® version 6.5, a content-packed update to the Limfinity® ... to gain a larger and more diverse base of customers among labs and ...
(Date:6/20/2017)... Iowa (PRWEB) , ... June 20, 2017 , ... ... chance to immediately determine the adulterants which pose the most likely threat to ... - 28 of this year. , IFT's annual food expo attracts over ...
(Date:6/20/2017)... ... June 20, 2017 , ... ... therapeutics from millions-diverse immune repertoires, announces launch of its new Surge(TM) Discovery ... Johnson, PhD, CEO of GigaGen, will present on Surge at the conference. , ...
Breaking Biology Technology: