Navigation Links
A study by the MUHC and McGill University opens a new door to understanding cancer
Date:8/13/2007

Montreal, 9 August 2007 - An in-depth understanding of the mechanisms that trigger cancer cell growth is vital to the development of more targeted treatments for the disease. An article published in the August 3 issue of Molecular Cell provides a key to these mechanisms that may prove crucial in the future. The paper is co-authored by Dr Morag Park, Director of the MUHC Molecular Oncology Group, and Dr Kalle Gehring, Head of the Nuclear Magnetic Resonnance Laboratory of the McGill University Biochemistry Department.

To understand cancer, it is necessary to first understand how the molecules interact, explains Dr. Park, who is also a Professor of oncology and biochemistry at McGill University. In that study we have clarified the structure of some of the proteins involved and their connections, which allows us to understand the consequences of these interactions. This is, in fact, a feat that merits close attention, because it means that researchers can now see elements smaller than a millionth of a millimetre!

In a cells interior, the function of the ubiquitin molecule is to clean house. It attaches itself to proteins that must disappear and triggers their degradation; in doing so, it allows a number of mechanisms to be minutely controlled. This new study reveals that ubiquitin also promotes interactions between proteins known as Cb-b. In a healthy patient, Cb-b is activated when a growth factor attaches itself to the surface of a cell, its role being to mitigate the cell proliferation and growth mechanisms induced by the factor. However, in some cancer patients this mitigation mechanism does not appear to function, partly because the ubiquitin does not attach itself correctly to the cell surface and to Cb-b. As a result, the effects of the growth factor become much more pronounced, which results in an unrestrained proliferation of cells that can become a cancer.

In the long term, this may serve as a basis for us to find ways to inter
'/>"/>

Contact: Isabelle Kling
isabelle.kling@muhc.mcgill.ca
514-934-1934
McGill University Health Centre
Source:Eurekalert

Page: 1 2

Related biology news :

1. Bioartificial kidney under study at MCG
2. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
3. W.M. Keck Foundation funds study of friendly microbes
4. Yellowstone microbes fueled by hydrogen, according to U. of Colorado study
5. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
6. UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims
7. Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible
8. Study Links Ebola Outbreaks To Animal Carcasses
9. Genome-wide mouse study yields link to human leukemia
10. Breakthrough Microarray-based Technology for the Study of Cancer
11. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2014)... Mothers give a newborn baby a gift of ... system. But antibiotics, used to fend off infection, ... leaving already-vulnerable premature babies more susceptible to dangerous ... neonatology researchers at The Children,s Hospital of Philadelphia ... revealing how gut microbes play a crucial role ...
(Date:4/18/2014)... scientists have used techniques like X-ray crystallography and nuclear ... the atomic structure of molecules, but such efforts have ... large quantities of a specific molecule and often in ... it all but impossible to peer into the structure ... problems may soon be a thing of the past. ...
(Date:4/18/2014)... soon as they,re planted may be good news for a ... the wild, a plant whose seeds sprouted at the first ... just an insurance policy against late frosts or unexpected dry ... too: Plants whose seeds put off sprouting until conditions ... a team of researchers working at the National Evolutionary Synthesis ...
Breaking Biology News(10 mins):Study of gut microbes, antibiotics: Clues to improving immunity in premature infants 2MRI, on a molecular scale 2MRI, on a molecular scale 3Plants with dormant seeds give rise to more species 2
... of evolution of the two key characteristics that preceded flight: ... hulking meat-eating dinosaurs had to shrink in size and grow ... "We were really surprised to discover that the key ... of Paraves," said Mr Puttick of Bristol,s School of Earth ...
... have independently discovered that a single regulatory protein acts ... of male and female sexual forms (termed gametocytes) of ... biology with important implications for human health. The protein, ... that initiate the development of gametocytes -- the only ...
... , A molecule previously linked to lung injuries in ... role in microbial infections of the lung suffered by ... study led by San Diego State postdoctoral researcher Katrine ... be detected in higher concentrations in CF patients than ...
Cached Biology News:New insights into the origin of birds 2A key protein is discovered as essential for malaria parasite transmission to mosquitos 2A key protein is discovered as essential for malaria parasite transmission to mosquitos 3A key protein is discovered as essential for malaria parasite transmission to mosquitos 4A key protein is discovered as essential for malaria parasite transmission to mosquitos 5Is a 'buttery' molecule behind cystic fibrosis flare-ups? 2Is a 'buttery' molecule behind cystic fibrosis flare-ups? 3
(Date:1/15/2014)... AudioNotch is the internet's leading provider of ... of tinnitus. Patients listen to sound therapy that is ... of weeks to months, their tinnitus volume decreases. , AudioNotch ... Music and Notched White Noise. Now, AudioNotch is pleased to ...
(Date:1/14/2014)... 14, 2014  3D Communications, a leading provider of strategic communications services ... media events in the United States and ... Virginia Cox , JD, is returning to the firm,s ... re-joins 3D after more than two years of service as Associate ...
(Date:1/14/2014)... iLab Solutions, the leader in core facility management software, today ... In this role, Michelle will work with current and potential ... development of iLab products. Her main goal will be to ... scientific community by offering the most advanced, user-friendly, and high-impact ...
(Date:1/14/2014)... (PRWEB) January 13, 2014 Bob Hainsey, ... more than 20 years in the industry, has joined ... . Hainsey will serve as the society’s Science and ... Hainsey join SPIE as our Technology Strategist, further strengthening ...
Breaking Biology Technology:Former FDA Associate Commissioner Returns To 3D Communications 2iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2Photonics R&D Leader Bob Hainsey Joins SPIE Technical Staff 2
... turbine, miniaturized ,car jack, and micro-chainmail demonstrate the ... ultra-precision EFAB manufacturing technology, VAN NUYS, Calif., ... Design & Manufacturing West a set of,highly-miniaturized ,building ... to develop innovative new products. Water-powered,turbines just over ...
... SEATTLE, Dec. 18 Cell Therapeutics, Inc.,(CTI) ... met with and received,feedback from the rapporteur and ... (paclitaxel poliglumex,CT-2103). The feedback supports submission of the ... the first half of 2008 that CTI was ...
... IRIDEX,Corporation (Nasdaq: IRIX ) today announced that ... Chief Financial Officer effective January 2, 2008., ... Vice President,of Finance for NextHop Technologies, Inc., a ... President of Finance and Chief,Financial Officer for InfoGear ...
Cached Biology Technology:Microfabrica Introduces Set of Miniature 'Building Blocks' for Minimally-Invasive Medical Devices 2Microfabrica Introduces Set of Miniature 'Building Blocks' for Minimally-Invasive Medical Devices 3Cell Therapeutics, Inc. (CTI) to Submit Marketing Authorization Application for XYOTAX(TM) for First-line Non-small Cell Lung Cancer Ahead of Schedule 2Cell Therapeutics, Inc. (CTI) to Submit Marketing Authorization Application for XYOTAX(TM) for First-line Non-small Cell Lung Cancer Ahead of Schedule 3Cell Therapeutics, Inc. (CTI) to Submit Marketing Authorization Application for XYOTAX(TM) for First-line Non-small Cell Lung Cancer Ahead of Schedule 4IRIDEX Announces James Mackaness Will Be Chief Financial Officer 2
... GRADE ,5-Bromo-4-chloro-3-indoxyl-beta-D-galactopyranoside C 14 H ... 6 ,M.W.= 408.63 ,Assay: Greater ... in DMF) ,Biological Activity: Blue color ... Analysis: Agrees with theoretical values ,Thin ...
BD IMagnet 1 each...
... A.P. Johnstone and M.W. Turner ... strategies and methods used in the ... of antibodies in immunoassays, the standardisation ... ELISA techniques including amplification systems, enzyme ...
MitoScreen (JC-1) Kit , 100 tests Consult technical datasheet for details....
Biology Products: