Navigation Links
A solution to reducing inflammation
Date:9/20/2012

Research carried out at The University of Manchester has found further evidence that a simple solution, which is already used in IV drips, is an effective treatment for reducing inflammation.

The researchers also identified that hypertonic solution, which is a solution with an elevated concentration of salt, can ease inflammation purely through bathing in it proving the Victorians were right to visit spa towns to "take the waters" for ailments like rheumatoid arthritis.

The research team, led by Dr Pablo Pelegrin, was investigating how cell swelling can control inflammation; the immune system's first response to injury or infection.

They discovered that white blood cells swell in a similar way to how tissue swells around a wound. The team then went on to look at what causes the swelling.

The researchers injected solutions with low ions into mice. They found that these solutions acted as a danger signal, causing cells to swell. The swelling then activates a group of proteins called NLRP3 which then release inflammatory mediators. These activate neighbouring cells to increase inflammation.

However, when a hypertonic solution was administered to the mouse it drew the water out of the cells shrinking them back to their original size. This in turn deactivated the signal for inflammation.

Dr Pelegrin's research provides further evidence for the use of hypertonic fluid therapy for the reduction of inflammation in the brain, a treatment that can reduce the amount of damage caused by illnesses such as stroke and epilepsy. His team has been able to show for the first time why the solution works at a molecular level.

Dr Pelegrin says: "Hypertonic solutions have been used in the treatment of stroke for many years. Clinicians have found that their use not only reduces brain swelling, but also alleviates brain inflammation. However, because there wasn't a molecular target for hypertonic solutions there has been a lot of debate about the clinical effect. Here we have indentified a target for hypertonic solutions by blocking the NLRP3 inflammasome which triggers inflammatory mediators at a molecular level".

The team also looked at the benefits of hypertonic solutions when used outside of the body. They soaked bandages in the solution before using them on the legs of mice. They also tested bathing the inflamed area in a hypertonic solution and in both cases the inflammation was reduced.

It appears the hypertonic solution produces an osmotic gradient through the skin, which explains why hot springs, which have a hypertonic make up, can ease the pain of conditions such as rheumatoid arthritis.

Vincent Compan worked with Dr Pelegrin on this research in the Faculty of Life Sciences. He says: "This research opens up exciting opportunities for the use of hypertonic solution as a treatment for inflammatory illnesses such as arthritis. What we've identified has the potential to be used to help so many patients."

Another aspect of the team's research identified that the signalling process to activate inflammation is one of the oldest evolutionary processes. The researchers found that the same mechanism of cell swelling causes NLRP3 inflammasome activation in fish as well as mammals. This means it is one of oldest responses in the body leading to inflammation.

The research has recently been published in the journal Immunity.


'/>"/>

Contact: Morwenna Grills
Morwenna.Grills@manchester.ac.uk
44-016-127-52111
University of Manchester
Source:Eurekalert

Related biology news :

1. 1 solution to global overfishing found
2. High-resolution atomic imaging of specimens in liquid by TEM using graphene liquid cell
3. Bowman provides strategies to engage public with climate change solutions
4. MedNet Solutions to Demonstrate Its Innovative Suite of eClinical Solutions at the 2012 Bio-IT World Conference & Expo
5. University of Minnesota startup offers game-changing energy solutions that reduce CO2 emissions
6. BioLife Solutions Announces 7th Consecutive Quarter of Record Revenue
7. CDS Monarch Deploys DigitalPersona Strong Authentication Solutions for Secure Access to Electronic Medical Records
8. Scientists find gold-plated fossil solution
9. Validity CTO to Present Natural ID Solutions for Improving Mobile Risk Management and User Experience at NFC Solutions Summit 2012
10. uAttend Time Tracking Solutions Available at TimeClockDeals.com
11. NineSigma Launches NineSights, the Worlds First Open Innovation Social Media Destination for Innovation Seekers and Solution Providers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/8/2019)... (PRWEB) , ... October 07, 2019 , ... The future ... to the genetic level, resulting in people living longer, healthier lives. But it will ... on earth. , Leroy E. Hood, MD, PhD, Chief Strategy Officer and Co-Founder of ...
(Date:10/3/2019)... ... October 02, 2019 , ... Connecticut Innovations (CI), ... support for Connecticut’s innovative, growing companies, today announced that it has closed on ... and winner of the 2018 VentureClash competition. , The outlay ...
(Date:9/30/2019)... Calif. (PRWEB) , ... September ... ... a leading think tank, research, and public interest organization focused on molecular ... Distinguished Student Prize. , The Award recognizes the College graduate or undergraduate ...
Breaking Biology News(10 mins):
(Date:10/3/2019)... Calif. (PRWEB) , ... October 02, 2019 , ... ... business opportunity to investors and venture capital companies in Silicon Valley at a special ... 8:30 pm. The event will be held at the JJ Lake Business Center located ...
(Date:9/30/2019)... THE WOODLANDS, Texas (PRWEB) , ... September 30, ... ... Bridge , the materials science newsletter from Rigaku Corporation , is now ... analysis techniques related to X-ray based materials science, including X-ray diffraction, fluorescence and ...
(Date:9/24/2019)... ... September 24, 2019 , ... Personalized ... training and site qualification for clinical trial sites and physician investigators. The ... potential clinical trial participants. , Clinical trial sites are currently located in San ...
(Date:9/17/2019)... ... 2019 , ... Catalent, a global leader in clinical supply ... Pacific (APAC) will present at the upcoming 3rd Annual Accelerating Clinical Trials in ... Thursday, Sept. 26, at 10:10 a.m., Ms. Delaney will present “Singapore: APAC’s Clinical ...
Breaking Biology Technology: