Navigation Links
A single stem cell mutation triggers fibroid tumors
Date:5/4/2012

CHICAGO --- Fibroid uterine tumors affect an estimated 15 million women in the United States, causing irregular bleeding, anemia, pain and infertility. Despite the high prevalence of the tumors, which occur in 60 percent of women by age 45, the molecular cause has been unknown.

New Northwestern Medicine preclinical research has for the first time identified the molecular trigger of the tumor --- a single stem cell that develops a mutation, starts to grow uncontrollably and activates other cells to join its frenzied expansion.

"It loses its way and goes wild," said Serdar Bulun, M.D., the chair of obstetrics and gynecology at Northwestern University Feinberg School of Medicine and Northwestern Memorial Hospital. "No one knew how these came about before. The stem cells make up only 1 percent of the cells in the tumor, yet they are the essential drivers of its growth."

The paper is published in the journal PLoS ONE. Masanori Ono, M.D., a post-doctoral student in Bulun's lab, is the lead author.

The stem cell initiating the tumor carries a mutation called MED12. Recently, mutations in the MED12 gene have been reported in the majority of uterine fibroid tissues. Once the mutation kicks off the abnormal expansion, the tumors grow in response to steroid hormones, particularly progesterone.

For the study, researchers examined the behavior of human fibroid stem cells when grafted into a mouse, a novel model initiated by Northwestern scientist Takeshi Kurita, a research associate professor of obstetrics and gynecology. The most important characteristic of fibroid stem cells is their ability to generate tumors. Tumors originating from the fibroid stem cell population grew 10 times larger compared to tumors initiated with the main cell population, suggesting a key role of these tumor stem cells is to initiate and sustain tumor growth.

"Understanding how this mutation directs the tumor growth gives us a new dir
'/>"/>

Contact: Marla Paul
Marla-Paul@northwestern.edu
312-503-8928
Northwestern University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Nanobubbles plus chemotherapy equals single-cell cancer targeting
2. Researchers reveal how a single gene mutation leads to uncontrolled obesity
3. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
4. NIST releases first certified reference material for single-wall carbon nanotubes
5. A single cell endoscope
6. Evolution at warp speed: Hatcheries change salmon genetics after a single generation
7. New Columbia engineering technique diagnoses non-periodic arrhythmias in a single heartbeat
8. Smoking a single cigarette may have immediate effect on young adults
9. Single protein, key to ebola virus infection, could aid in drug design
10. Single, key gene discovery could streamline production of biofuels
11. Rapid evolution within single crop-growing season increases insect pest numbers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/30/2014)... 2014 Biological membranes are mainly composed of lipid ... solution ions onto lipid membranes helps clarify functional ... provides a quantitative description of the equilibria between ... and Zbigniew Figaszewski from the University of Bialystok, ... these findings, just published in EPJ E ...
(Date:10/29/2014)... released by unconventional oil and gas production are well ... in the open access journal Environmental Health . ... found. The study is the first to be based ... sites and could be used to supplement official air-quality ... reserves that do not readily flow to the surface. ...
(Date:10/29/2014)... In the largest study of its kind to date, ... genes that heighten the risk for autism. Joseph Buxbaum, ... York City, Mark Daly, Ph.D., Broad Institute of Harvard ... DNA samples from affected children, parents and unrelated people. ... to contribute to the risk for autism spectrum disorder ...
Breaking Biology News(10 mins):Ion adsorption matter in biology 2Air quality and unconventional oil and gas sites 2Air quality and unconventional oil and gas sites 3
... BiOptix announced continued support of the Colorado BioScience ... life sciences showcase event in Colorado to be ... continues to believe in the goals and community that is ... President and CEO of BiOptix.   "As Colorado continues to ...
... become more severe in the Southwest, trees are increasingly ... to middle elevations, University of Arizona researchers report in ... Journal of Geophysical Research Biogeosciences ., Lead author Jeremy ... of geosciences, said: "We know the climate in the ...
... study provides a first-time analysis of the value of forage ... and anchovies. Three kinds of contributions of forage fish were ... fish, and as an important link in the food web ... a total of $16.9 billion, as both direct catch and ...
Cached Biology News:BiOptix Participates in Leading Life Sciences Event BioWest 2012 2Droughts are pushing trees to the limit 2Droughts are pushing trees to the limit 3Droughts are pushing trees to the limit 4Study provides first-time analysis of 3 distinct contributions of forage fish worldwide 2Study provides first-time analysis of 3 distinct contributions of forage fish worldwide 3
(Date:10/30/2014)... October 30, 2014 Investor-Edge has ... (NYSE MKT: ONVO), Medivation Inc. (NASDAQ: MDVN ... Biologics Inc. (NYSE MKT: SYN), and Ironwood Pharmaceuticals Inc. ... be accessed at: http://investor-edge.com/register . On ... 4,549.23, down 0.33%, the Dow Jones Industrial Average declined ...
(Date:10/30/2014)... Global polyvinyl chloride (PVC) demand registered a significant ... especially in North America and Europe. However, the global ... a growing trend. , The largest chunk of the ... segment. In 2013, the key PVC application spheres included ... film. Moreover, the PVC was consumed in the production ...
(Date:10/30/2014)... October 30, 2014 On October ... Medicine Showcase in Chicago, leading applied stem cell ... Dr. Wade McKenna presented talks on New Techniques ... Surgical Applications For Stem Cells. , Dr. Riordan ... and the properties of AlphaGEMS that include: wound ...
(Date:10/30/2014)... 2014 Rancho BioSciences , the ... manually curated public data source TCGA for ... the data is now available for other oncology groups. ... and internal data sources for their Pharma, Government and ... the data that becomes more easily accessible. Rancho ...
Breaking Biology Technology:Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 2Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 3Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 4Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 5Global Polyvinyl Chloride Demand Is on Upward Trend Now, Says Merchant Research & Consulting in Its Topical Study 2Global Polyvinyl Chloride Demand Is on Upward Trend Now, Says Merchant Research & Consulting in Its Topical Study 3Riordan-McKenna Institute Founders, Neil Riordan, PhD and Orthopedic Surgeon, Dr. Wade McKenna Present at the Mid American Regenerative and Cellular Medicine Showcase 2Riordan-McKenna Institute Founders, Neil Riordan, PhD and Orthopedic Surgeon, Dr. Wade McKenna Present at the Mid American Regenerative and Cellular Medicine Showcase 3Riordan-McKenna Institute Founders, Neil Riordan, PhD and Orthopedic Surgeon, Dr. Wade McKenna Present at the Mid American Regenerative and Cellular Medicine Showcase 4Rancho BioSciences Manually Curated TCGA Data Sets Available 2
... Amylin Pharmaceuticals, Inc. (Nasdaq: AMLN ) and ... announced that a supplemental New Drug Application (sNDA) has been ... the expanded use of BYETTA® (exenatide) injection as an add-on ... thiazolidinedione (TZD) in conjunction with diet and exercise for adults ...
... 22, 2010 Novavax, Inc. (Nasdaq: NVAX ... School, led by Dr. Trudy Morrison, published in the ... report indicating that a novel virus-like particle (VLP) vaccine ... a live virus challenge.  This vaccine candidate has been ...
... the University of Santiago de Compostela (USC) have analysed levels ... in Galicia. The results show that 34% of these schools ... Union. Excessive inhalation of radon is associated with lung cancer. ... taken, 34% had radon levels in excess of 400 Bequerels/m3 ...
Cached Biology Technology:Amylin and Lilly Seek Expanded Use of BYETTA® Along with Basal Insulin 2Amylin and Lilly Seek Expanded Use of BYETTA® Along with Basal Insulin 3Amylin and Lilly Seek Expanded Use of BYETTA® Along with Basal Insulin 4Amylin and Lilly Seek Expanded Use of BYETTA® Along with Basal Insulin 5Amylin and Lilly Seek Expanded Use of BYETTA® Along with Basal Insulin 6Amylin and Lilly Seek Expanded Use of BYETTA® Along with Basal Insulin 7NOVAVAX and University of Massachusetts Medical School Publish Preclinical Safety and Efficacy Study of a Respiratory Syncytial Virus (RSV) Virus-like Particle (VLP) Vaccine Candidate 2NOVAVAX and University of Massachusetts Medical School Publish Preclinical Safety and Efficacy Study of a Respiratory Syncytial Virus (RSV) Virus-like Particle (VLP) Vaccine Candidate 3NOVAVAX and University of Massachusetts Medical School Publish Preclinical Safety and Efficacy Study of a Respiratory Syncytial Virus (RSV) Virus-like Particle (VLP) Vaccine Candidate 434 percent of Galician secondary schools exceed maximum recommended radon levels 2
... compact benchtop and stackable multi-function incubator. ... a large display screen to accurately ... circulation inside to evenly distribute temperature ... easily calibrated from the microprocessor controller. ...
... --- a cocktail of 3 siRNAs specifically ... our most popular product. The siTrio reagent ... of your target gene when used under ... and confirmation of optimal transfection with one ...
... with 96 x 0.2 ml reaction module ... applications. It is equipped with an interchangeable ... is compatible with optical modules for real-time ... by algorithm, block, or in-sample probe. It ...
... compact benchtop and stackable multi-function incubator. ... a large display screen to accurately ... circulation inside to evenly distribute temperature ... easily calibrated from the microprocessor controller. ...
Biology Products: