Navigation Links
A single stem cell mutation triggers fibroid tumors
Date:5/4/2012

CHICAGO --- Fibroid uterine tumors affect an estimated 15 million women in the United States, causing irregular bleeding, anemia, pain and infertility. Despite the high prevalence of the tumors, which occur in 60 percent of women by age 45, the molecular cause has been unknown.

New Northwestern Medicine preclinical research has for the first time identified the molecular trigger of the tumor --- a single stem cell that develops a mutation, starts to grow uncontrollably and activates other cells to join its frenzied expansion.

"It loses its way and goes wild," said Serdar Bulun, M.D., the chair of obstetrics and gynecology at Northwestern University Feinberg School of Medicine and Northwestern Memorial Hospital. "No one knew how these came about before. The stem cells make up only 1 percent of the cells in the tumor, yet they are the essential drivers of its growth."

The paper is published in the journal PLoS ONE. Masanori Ono, M.D., a post-doctoral student in Bulun's lab, is the lead author.

The stem cell initiating the tumor carries a mutation called MED12. Recently, mutations in the MED12 gene have been reported in the majority of uterine fibroid tissues. Once the mutation kicks off the abnormal expansion, the tumors grow in response to steroid hormones, particularly progesterone.

For the study, researchers examined the behavior of human fibroid stem cells when grafted into a mouse, a novel model initiated by Northwestern scientist Takeshi Kurita, a research associate professor of obstetrics and gynecology. The most important characteristic of fibroid stem cells is their ability to generate tumors. Tumors originating from the fibroid stem cell population grew 10 times larger compared to tumors initiated with the main cell population, suggesting a key role of these tumor stem cells is to initiate and sustain tumor growth.

"Understanding how this mutation directs the tumor growth gives us a new dir
'/>"/>

Contact: Marla Paul
Marla-Paul@northwestern.edu
312-503-8928
Northwestern University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Nanobubbles plus chemotherapy equals single-cell cancer targeting
2. Researchers reveal how a single gene mutation leads to uncontrolled obesity
3. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
4. NIST releases first certified reference material for single-wall carbon nanotubes
5. A single cell endoscope
6. Evolution at warp speed: Hatcheries change salmon genetics after a single generation
7. New Columbia engineering technique diagnoses non-periodic arrhythmias in a single heartbeat
8. Smoking a single cigarette may have immediate effect on young adults
9. Single protein, key to ebola virus infection, could aid in drug design
10. Single, key gene discovery could streamline production of biofuels
11. Rapid evolution within single crop-growing season increases insect pest numbers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/12/2014)... Fla. , Nov. 12, 2014 Crossmatch™, ... today that its U.are.U ® fingerprint readers have ... chain in Central Mexico . The ... 2014 to eliminate payroll issues caused by employees clocking ... installing the U.are.U fingerprint readers, Montparnasse relied on paper ...
(Date:11/10/2014)... store shelves in early 2010, and people have used ... can be tossed into a washing machine without ever ... convenience, though, has come with risks for young children. ... Hospital found that from 2012 through 2013, U.S. poison ... 6 years of age swallowing, inhaling, or otherwise being ...
(Date:11/7/2014)... , Nov. 7, 2014  In conjunction with the ... Police Departments, The Community Foundation of the Verdugos has ... DNA JUSTICE PROJECT," a $250,000 initiative to keep the ... phase. In its first six months of existence, the Lab ... evidence support for local law enforcement. "Because our ...
Breaking Biology News(10 mins):Montparnasse Pasteleria Achieves Time and Attendance Transparency with Crossmatch U.are.U Fingerprint Readers 2Study finds laundry detergent pods, serious poisoning risk for children 2Community Foundation Of The Verdugos Unveils Campaign To Fund Glendale-Burbank DNA Justice Project 2
... , Aug. 20, 2013 Based on its ... market, Frost & Sullivan presents TATAA Biocenter with ... Customer Value Leadership. TATAA Biocenter offers an end-to-end ... quantitative reverse transcription polymerase chain reaction (qRT-PCR) to ...
... Fla. , Aug. 19, 2013 /PRNewswire-iReach/ -- Jade Holding Group, ... plastic surgery and wellness centers, has just announced that Dr. ... Month for August. (Photo: http://photos.prnewswire.com/prnh/20130819/MN65951 ) ... medical career in 1970 as an undergraduate at the University of ...
... of tiny microorganismshundreds to thousands of species of bacteria ... to a healthy existence. The gastrointestinal (GI) tractand the ... highest diversity of bacterial species. But how do these ... constantly in flux due to foods and fluids moving ...
Cached Biology News:Frost & Sullivan Recognizes TATAA Biocenter's Complete, Best-in-Class Services for Analyzing Genetic Material 2Frost & Sullivan Recognizes TATAA Biocenter's Complete, Best-in-Class Services for Analyzing Genetic Material 3Frost & Sullivan Recognizes TATAA Biocenter's Complete, Best-in-Class Services for Analyzing Genetic Material 4Frost & Sullivan Recognizes TATAA Biocenter's Complete, Best-in-Class Services for Analyzing Genetic Material 5Dr. Paul J. Reilly, MD, FAAFP, is Named Strax Rejuvenation's Doctor of the Month for August 2Dr. Paul J. Reilly, MD, FAAFP, is Named Strax Rejuvenation's Doctor of the Month for August 3A home for the microbiome 2A home for the microbiome 3A home for the microbiome 4
(Date:11/26/2014)... , Nov. 26, 2014 The ... results from a survey of European physicians at ... on Innovation and Biological Therapies" at the Spanish ... event, hosted by EuropaBio and the Spanish Bioindustry ... of Health, physicians from Spanish oncology and rheumatology ...
(Date:11/26/2014)... 25, 2014 SonaCare Medical, a ... (HIFU) devices, recently participated in the American Urology ... 360° .” Key opinion leaders in urology presented ... to small renal masses while attendees had the ... technologies in hands-on labs. Attendees at the Los ...
(Date:11/26/2014)... 25, 2014 Miles Holder, formerly of ... Graphel Carbon Products team as Sales/Marketing Manager. Mr. Holder ... customer service for the graphite industry. , “We are ... team,” stated Dave Trinkley, VP of Market and Product ... of experience in the graphite industry, along with his ...
(Date:11/26/2014)... , Nov. 25, 2014 Bio-Techne Corporation (NASDAQ: ... appointed Robert Gavin to serve in a ... Protein Platforms Division.  Mr. Gavin will be responsible for ... which includes the ProteinSimple business acquired in July 2014 ... San Jose, California -based ProteinSimple develops and ...
Breaking Biology Technology:ASBM Presents European Physicians Survey at Spanish Ministry of Health 2SonaCare Medical Supports American Urology Association’s Small Renal Mass 360° Summit 2SonaCare Medical Supports American Urology Association’s Small Renal Mass 360° Summit 3Miles Holder Joins Graphel Corporation as Sales/Marketing Manager 2Bio?Techne Announces Appointment Of Robert Gavin As Leader Of New Protein Platforms Division 2Bio?Techne Announces Appointment Of Robert Gavin As Leader Of New Protein Platforms Division 3
... $15 million in 2008 on target; Potential label ... expansion could further drive sales, ... MTA: CTIC) reported financial results for the quarter,ended June 30, ... $20,000 for the second quarter of 2007 due primarily to ...
... Mass., Aug. 15 ETEX Corporation, an ... launched an innovative,orthobiologic, EquivaBone(TM). EquivaBone(TM) is a ... with new bone during the healing process., ... Brian Ennis, President and CEO of ETEX ...
... The U.S. hospital,marketplace is multifaceted and ... this challenging marketplace, pharmaceutical and biotechnology,sales people ... to effectively represent their brands. Hospital,formulary decisions ... professionals,focused on efficacy and safety but also ...
Cached Biology Technology:Cell Therapeutics, Inc.'s Second Quarter 2008 Financial Results 2Cell Therapeutics, Inc.'s Second Quarter 2008 Financial Results 3Cell Therapeutics, Inc.'s Second Quarter 2008 Financial Results 4Cell Therapeutics, Inc.'s Second Quarter 2008 Financial Results 5Cell Therapeutics, Inc.'s Second Quarter 2008 Financial Results 6Cell Therapeutics, Inc.'s Second Quarter 2008 Financial Results 7ETEX Launches Innovative Osteoinductive Orthobiologic, EquivaBone(TM) 2U.S. Hospital Sales Opportunities Maximized Through Functional Optimization 2
... media are rigid macroporous hydrophilic media. The ... at moderate pressures, while the macroporous beads ... hydrophilic matrix reduces nonspecific binding. Macro-Prep High ... exchanger with very high flow rates and ...
... collection of phage display libraries, human ... and mouse tissues. All cDNA libraries ... size of cDNA inserts has been ... 1000bp by gel electrophoresis of DNA ...
... is a competitive enzymeimmunoassay (EIA) for the ... rat serum or plasma. Corticosterone is the ... and mice, and in most non-mammalian vertebrates ... mammals produce both corticosterone and cortisol, in ...
Mouse monoclonal [1.F.1] to Yersinia pestis F1 antigen ( Abpromise for all tested applications). Antigen: Purified F1 antigen of Y. pestis vaccine strain EB....
Biology Products: