Navigation Links
A potent suppressor of endometrial cancer is revealed
Date:2/8/2010

he genetic change induced a very rapidly progressing cancer in all mice that carried the mutation. The gene they deleted, called Lkb1, is mutated in many other types of human cancers, and it regulates pathways that are known to contribute to the formation of aggressive cancer cells.

Very few genetic changes act alone to induce cancer. Most cancer cells result from multiple mutations. However, all mice deficient for just Lkb1, exhibited cancerous changes throughout their entire endometrium. "In most mouse cancer models, one creates a tumor prone condition. But additional mutations are usually required for a cell to develop a cancer" says Dr. Castrillon, "What is surprising about the Lkb1 model, is that their entire endometrium becomes malignant. It happens very early and rapidly."

The rapid development of cancer in mice without Lkb1 suggests that this gene or the molecules that its product regulates may be valuable targets for future therapy. The authors show that treating the mice with a drug that blocks a downstream target of the Lkb1 product kills tumor cells, leading to tumor shrinkage and dramatic recovery of the mice. "It is likely that this pathway is very important. We believe that Lkb1 mutations or mutations in other steps in this pathway represent some type of metabolic abnormality that we could take advantage of [for therapeutic intervention]" says Dr. Castrillon.


'/>"/>

Contact: Kristy Kain
kristy.kain@vanderbilt.edu
615-343-1298
The Company of Biologists
Source:Eurekalert

Page: 1 2

Related biology news :

1. Pittsburgh scientists identify human source of stem cells with potential to repair muscle
2. Neuronal conduction of excitation without action potentials based on ceramide production
3. To maximize biofuel potential, researchers look for sorghums sweet spot
4. Joslin researchers uncover potential role of leptin in diabetes
5. Chemistry turns killer gas into potential cure
6. Researchers examine worlds potential to produce biodiesel
7. New inhibitor has potential as cancer drug
8. Potential new therapeutic molecular target to fight cancer
9. WCS study finds potential to double tiger numbers in South Asia
10. Childrens Hospital studying drug with the potential to prevent/delay onset of type 1 diabetes
11. Great potential to improve collection, recycling of Europes electronic waste, says UN report
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/2/2015)... , June 25, 2015 ... addition of the "Next Generation Biometrics Market by ... 2020" report to their offering. The ... Billion by 2020, at a CAGR of 17.9% between ... the leading application for the market. Safran SA ...
(Date:6/30/2015)... 30, 2015 Genisphere announced ... to help further develop Genisphere,s therapeutics capabilities and portfolio. ... having spent much of the last 25 years in ... Bioscience, and Johnson & Johnson. Tom started his career ... Biotech Corporate Finance. He graduated from Dartmouth College with ...
(Date:6/25/2015)... According to a new ... Area), Technology, Material (Optical Prism, Piezoelectric, Capacitive & ... Others) & Geography - Global Forecast to 2014 ... is expected to reach $14,500.07 Million by 2020, ... Browse 76 market Tables and 109 Figures spread ...
Breaking Biology News(10 mins):Next Generation Biometrics Market 2015 - Global Forecast to 2020 with Safran, NEC, 3M Cogent, Fujitsu & Suprema Dominating the $24 Billion Market 2Next Generation Biometrics Market 2015 - Global Forecast to 2020 with Safran, NEC, 3M Cogent, Fujitsu & Suprema Dominating the $24 Billion Market 3Genisphere Appoints New CEO, Thomas Bliss 2Genisphere Appoints New CEO, Thomas Bliss 3Fingerprint Sensors Market Worth $14,500.07 Million by 2020 2Fingerprint Sensors Market Worth $14,500.07 Million by 2020 3Fingerprint Sensors Market Worth $14,500.07 Million by 2020 4
... caused some lethal human epidemics in Central Africa. Research ... from the animal reservoir, which is an any case ... and certain forest antelopes. Results have come from work ... and their partners (1) to shed light on the ...
... at the University of Southern California's Viterbi School ... Ultrasonic Transmission Tomography" (HUTT) system that offers 3D ... those produced by existing commercial X-ray, ultrasound or ... biomedical engineering at the Viterbi School, presented HUTT ...
... Grieg Fry, Ph.D., a scientist from the University of ... the origin and evolution of one of nature's most ... the March issue of the journal Genome Research. , ... Colubroidea, evolved glands for the storage and dispersal of ...
Cached Biology News:Ebola virus: from wildlife to dogs 2Ebola virus: from wildlife to dogs 3Ebola virus: from wildlife to dogs 4A probe, not an echo 2A probe, not an echo 3A probe, not an echo 4Venom doc tracks down snake bioweapons 2
(Date:7/28/2015)... 28, 2015 People with a common form ... significant and sometimes profound improvements in their hearing and ... to a new multicenter study led by specialists at ... described online ahead of print in the journal The Laryngoscope ... clinics in the United States ...
(Date:7/28/2015)... ... July 28, 2015 , ... In ... billion in 2013; while production volume reached close to 1.84 million tonnes in ... a share of 75.5% of the region’s total aluminium hydroxide production; the country’s ...
(Date:7/28/2015)... -- Research and Markets ( http://www.researchandmarkets.com/research/z54c4k/biomedical ) has ... and Freezers Market - Global Industry Analysis, Size, ... report to their offering. ... been segmented based on applications: hospitals, research laboratories, ... others segment includes applications of biomedical refrigerators and ...
(Date:7/28/2015)... 28, 2015 Deerfield Management Company, L.P. today ... L.P., which will invest in groundbreaking advancements in science ... cancer, and orphan diseases. The venture capital fund will ... are developed and improve the way healthcare is delivered ... largest healthcare-focused venture funds in the sector, will donate ...
Breaking Biology Technology:Hybrid Cochlear Implants For Common Form Of Hearing Loss May Benefit Millions 2Hybrid Cochlear Implants For Common Form Of Hearing Loss May Benefit Millions 3EU27 Aluminium Hydroxide Market Analysed and Forecast by BAC Reports in New Research Study Available at MarketPublishers.com 2EU27 Aluminium Hydroxide Market Analysed and Forecast by BAC Reports in New Research Study Available at MarketPublishers.com 3Biomedical Refrigerators and Freezers Market Report - Global Industry Analysis 2015 2Biomedical Refrigerators and Freezers Market Report - Global Industry Analysis 2015 3Deerfield Launches $550 Million Healthcare Venture-Capital Fund 2Deerfield Launches $550 Million Healthcare Venture-Capital Fund 3
... GeneGo, Inc., the leading,provider of databases, software and ... will expand the use of its MetaCore/MetaDrug,Discovery Platform ... Molecular Toxicology majors, and in undergrad honors research,programs. ... and pathway analysis tools needed to analyze complex ...
... /Xinhua-PRNewswire-FirstCall/ -- China Medical,Technologies, Inc. (the ,Company,) ... device company that develops, manufactures and markets ... intensity focused ultrasound,tumor therapy system, today announced ... (the ,Acquisition,) of the entire interest in,Beijing ...
... would, strengthen Elekta,s offering and accelerate the company,s expansion ... ... Elekta AB (publ) (STO: EKTAb),a world leader in clinical solutions ... exclusive negotiations based on,a Letter of Intent to acquire CMS ...
Cached Biology Technology:UC Berkeley Expands Molecular Toxicology Curriculum to Include GeneGo's Platform 2China Medical Technologies Completes Acquisition of BBE 2Elekta Negotiates To Acquire CMS 2Elekta Negotiates To Acquire CMS 3Elekta Negotiates To Acquire CMS 4Elekta Negotiates To Acquire CMS 5
1 unit is sufficient for 1 caspase activity assay....
RABBIT ANTI WARFARIN...
Request Info...
... an agarose-digesting enzyme isolated from Pseudomonas ... bonds in agarose producing carbohydrate molecules ... remaining carbohydrate molecules will not interfere ... with Gelzyme enzyme can be used ...
Biology Products: