Navigation Links
A new treatment option for alcohol dependence: Reduced consumption rather than abstinence
Date:4/11/2013

Philadelphia, PA, April 11, 2013 A potential new treatment for alcoholism called nalmefene is effective and safe for reducing alcohol consumption in alcohol dependent individuals, says a new study published this week in Biological Psychiatry.

Traditionally, abstinence has been regarded as the primary treatment goal for alcohol dependence, and current pharmacological treatments for alcoholism are approved only for relapse prevention. However, relapse rates remain high and a goal of abstinence is unacceptable to many patients. To address these concerns and provide opportunities for improved patient outcomes, new evidence-based treatments are necessary.

"Our new findings may mark a true paradigm shift in the treatment of men and women who suffer from alcohol related disorders. While abstinence should be the best bet, a reduction in consumption may be a valuable alternative for the many patients who cannot attain abstinence or are not (yet) capable of doing so," said Dr. Karl Mann at Central Institute of Mental Health in Germany, who led the research.

Mann and his colleagues conducted a clinical trial to investigate the effectiveness of nalmefene in reducing alcohol consumption. They recruited 604 alcohol-dependent patients, half of whom were randomized to receive nalmefene, while the other half received visually-identical placebo pills. Neither patients nor their doctors knew which treatment they were receiving. Patients were instructed to take one tablet on each day they perceived a risk of drinking alcohol, and were followed by the study investigators for 24 weeks.

What they found is promising. Nalmefene was significantly better than placebo in reducing alcohol consumption and it improved patients' clinical status and liver enzymes. It was also generally well-tolerated, with most side effects characterized as mild or moderate and quickly resolved.

"With nalmefene, we seem to be able to 'block the buzz' which
'/>"/>

Contact: Rhiannon Bugno
Biol.Psych@utsouthwestern.edu
214-648-0880
Elsevier
Source:Eurekalert

Page: 1 2

Related biology news :

1. Stem cells enable personalised treatment for bleeding disorder
2. Breakthrough cancer-killing treatment has no side-effects
3. Measuring ultrasound for better treatment of muscle injuries
4. Vitamin P as a potential approach for the treatment of damaged motor neurons
5. Researchers discover brain cancer treatment using genetic material from bone marrow cells
6. Drug for erectile disorder show promise in the treatment of obesity
7. Beckers Spine Review Releases List of 50 Spine Surgeons & Specialists Researching Biologics for Spine Treatments
8. Discovery could yield treatment for cocaine addicts
9. Novel treatment approach for bladder pain using a herpes simplex virus vector reported
10. Political strife undermines HIV treatment
11. Early antiretroviral treatment reduces viral reservoirs in HIV-infected teens
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/11/2015)... JOSE, Calif. , May 11, 2015 /PRNewswire/ ... developer of human interface solutions, today announced the ... Vice President and Chief Financial Officer, reporting to ... Ali replaces Synaptics, current Chief Financial Officer, ... December 2014. Mr. Ali brings ...
(Date:5/10/2015)... Sweden , May 11, 2015 ... fingerprint sensors FPC1025 and FPC1155 from the distributor World Peace ... of FPC,s distributors in Asia . Deliveries ... sensors will be used by smartphone manufacturers in ... included in the communicated revenue guidance of + 1 000 MSEK ...
(Date:5/6/2015)... TEL AVIV, Israel , May 6, 2015 /PRNewswire/ ... the world,s most established helmet producer, announced today that ... LifeBEAM Smart Helmet, the world,s first bio-sensing cycling helmet ... will be released in two new colors in order ... demand for the product. In addition, LifeBEAM and Lazer ...
Breaking Biology News(10 mins):Synaptics Appoints Wajid Ali as Senior Vice President and Chief Financial Officer 2Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 235 Million 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 3
... CINCINNATIResearchers at the University of Cincinnati (UC) have found ... nervous system, bisphenol A (BPA), could affect a mammal,s ability ... ways that can progress to a potentially fatal infection. ... edition of the Journal of Reproductive Toxicology . ...
... The Canadian Journal of Cardiology has ... fibrillation guidelines. Atrial fibrillation is the most common ... in general, and death. It is, for example, the leading ... seen important changes in the drugs available to treat atrial ...
... SALT LAKE CITY, March 19, 2012Researchers from ... Utah report they have discovered a method to ... translocations quickly, accurately, and inexpensively. A description of ... in this month,s issue of the EMBO Molecular ...
Cached Biology News:BPA could affect reproductive capabilities, cause infection of the uterus 2Beyond the microscope: Identifying specific cancers using molecular analysis 2
(Date:5/22/2015)... 2015 According to a new ... 2D Gel Electrophoresis, Agarose & Polyacrylamide Gel, Capillary Electrophoresis, ... Application & by End User - Global Forecast to ... to reach around $1.98 Billion by 2020 with a ... 2020. Browse 226 ma rket ...
(Date:5/22/2015)... May 22, 2015 Baylor Research Institute (BRI) ... Translational Genomics Research Institute (TGen) in Phoenix, ... on accelerating early detection and treatments for patients with a ... institutions will lead to new clinical trials and access to ... the gap from bench to bedside across Baylor Scott ...
(Date:5/21/2015)... Specialty Pharmacy Times has completed its ... BPA Worldwide as a business publication member. As ... for Specialty Pharmacy Times based on business/distribution, demographics ... member of BPA Worldwide, Specialty Pharmacy Times shows ... the most reliable, unequaled data,” said Chris Hennessy, ...
(Date:5/21/2015)... CA (PRWEB) May 21, 2015 ... has announced a partnership with PicnicHealth, a healthcare ... patients. Participants diagnosed with Inflammatory Bowel Disease (IBD) ... as a complementary uBiome research kit. Both companies ... , For more information on ...
Breaking Biology Technology:Electrophoresis Market Worth $1.98 Billion by 2020 2Electrophoresis Market Worth $1.98 Billion by 2020 3Electrophoresis Market Worth $1.98 Billion by 2020 4Precision Medicine Collaboration to Increase Options for Cancer Patients 2Precision Medicine Collaboration to Increase Options for Cancer Patients 3Precision Medicine Collaboration to Increase Options for Cancer Patients 4Specialty Pharmacy Times Joins BPA Worldwide 2uBiome Partners with PicnicHealth 2uBiome Partners with PicnicHealth 3
... Stevens will host over 100 students and researchers from ... NEMS/MEMS with a focus on Nanomanufacturing. In addition to ... keynote address from Dr. George Hazelrigg, the Deputy Director ... at the US National Science Foundation. The workshop ...
... , July 23 /PRNewswire-Asia-FirstCall/ -- Renhuang,Pharmaceuticals, Inc. (NYSE ... and distributor of botanical products,bio-pharmaceuticals and traditional Chinese medicines ("TCM"), ... by Chinese Academy of,International Trade & Economic Cooperation of Ministry ... , , ...
... MYERS, Fla., July 22 NeoGenomics, Inc. (OTC Bulletin ... quarter 2010 financial results on Thursday, July 29, 2010 . , ... The Company has scheduled a web-cast and conference ... at 11:00 AM EDT .  Interested investors should dial (877) 407-9210 (domestic) ...
Cached Biology Technology:Renhuang Receives AAA(1) Rating from Chinese Academy of International Trade & Economic Cooperation of Ministry of Commerce 2Renhuang Receives AAA(1) Rating from Chinese Academy of International Trade & Economic Cooperation of Ministry of Commerce 3NeoGenomics Schedules its Q2 2010 Earnings Release for July 29, 2010 2NeoGenomics Schedules its Q2 2010 Earnings Release for July 29, 2010 3
... The ProteoSpin CBED Micro Kit provides a ... exchange and desalting of protein samples. The ... Norgens patented protein resin as an ion ... CaCl2,LiCl, CsCl have poor affinities for Norgens ...
... of Total Canine Endostatin. Canine ... Science products include a line of ... and reagents used for multiple research ... kits are ultra-sensitive, quick and dependable ...
... Kit is a very sensitive immunohistochemical tool ... containing both anti-von Willebrand Factor and anti-CD31 ... variety of species. This AP kit provides ... of frozen and paraffin-embedded sections in human ...
... of Eagle's medium have been ... The most widely used modification ... is a modification of Minimum ... contains a higher concentration of ...
Biology Products: