Navigation Links
A new model for organ repair
Date:11/1/2013

Harvard Stem Cell Institute (HSCI) researchers have a new model for how the kidney repairs itself, a model that adds to a growing body of evidence that mature cells are far more plastic than had previously been imagined.

After injury, mature kidney cells dedifferentiate into more primordial versions of themselves, and then differentiate into the cell types needing replacement in the damaged tissue. This finding conflicts with a previously held theory that the kidney has scattered stem cell populations that respond to injury. The research appears online in PNAS Early Edition.

HSCI Kidney Diseases Program Leader Benjamin Humphreys, MD, PhD, a Harvard Medical School assistant professor at Brigham and Women's Hospital, was suspicious of the kidney stem cell repair model because his previous work suggested that all kidney cells have the capacity to divide after injury. He and his colleagues decided to test conventional wisdom by genetically tagging mature kidney cells in mice that do not express stem cell markers; the hypothesis being that the mature cells should do nothing or die after injury. The results showed that not only do these fully differentiated cells multiply, but they can multiply several times as they help to repair the kidney.

"What was really interesting is when we looked at the appearance and expression patterns of these differentiated cells, we found that they expressed the exact same 'stem cell markers' that these other groups claimed to find in their stem cell populations," said Humphreys. "And so, if a differentiated cell is able to express a 'stem cell marker' after injury, then what our work shows is that that's an injury markerit doesn't define a stem cell."

This new interpretation of kidney repair suggests a model by which cells reprogram themselves; similar to the way mature cells can be chemically manipulated to revert to an induced pluripotent state. The research echoes a study published last
'/>"/>

Contact: B. D. Colen
bd_colen@harvard.edu
617-413-1224
Harvard University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Hippocampal and thalamic neuronal metabolism in a putative rat model of schizophrenia
2. Model virus structure shows why theres no cure for common cold
3. Advanced Open Access publishing model
4. Model plant misled scientists about multicellular growth
5. Study explores the role of uncertainty in infectious disease modelling
6. Rensselaer researchers create accurate computer model of RNA tetraloop
7. Model of dangerous bee disease in Jersey provides tool in fight against honeybee infections
8. Researchers develop model of near-optimal genetic code
9. Elevated levels of copper in amyloid plaques associated with neurodegeneration in mouse models of AD
10. Computer model predicts red blood cell flow
11. Mount Sinai researchers develop first successful laboratory model for studying hepatitis C
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2015)...  TAKE Solutions Ltd., a global business technology solutions ... Patent and Trademark Office (USPTO) for its "Method for ... Clinical Accelerators to reduce the time taken to standardize ... without the accelerators), thus reducing time to market. ... the heart of the patented Clinical Data Standardization Process ...
(Date:6/24/2015)... -- Research and Markets( http://www.researchandmarkets.com/research/hhwlfj/huawei_ascend ... "Huawei Ascend Mate 7 Fingerprint Sensor - Reverse ... Huawei,s technological choice for the fingerprint sensor ... and Samsung,s one. The Ascend Mate 7 presents ... a main actor in capacitive sensing human interface ...
(Date:6/23/2015)... N.C. , June 23, 2015   ... today announced the results of a recent study ... accuracy on the wrist during activity. In a ... technology was compared along with the Apple Watch ... accurately measuring heart rate during activity. The study ...
Breaking Biology News(10 mins):TAKE Solutions Awarded Patent By USPTO 2Huawei Ascend Mate 7 Fingerprint Sensor - Reverse Costing Analysis 2Valencell Delivers Breakthrough Heart Rate Accuracy on the Wrist 2Valencell Delivers Breakthrough Heart Rate Accuracy on the Wrist 3
... December 7, 2012 More than 100 academic ... major world-wide initiative: Mathematics of Planet Earth (MPE) ... made by mathematics in tackling global problems, including ... climate change; sustainability; and pandemics. MPE2013 partners will ...
... plant growth patterns are influenced by a variety of ... roots exhibit characteristic behaviours called ,waving, and ,skewing, which ... plants grown on the International Space Station (ISS) ... published in BioMed Central,s open access journal BMC ...
... a biological adaptation that enables them to thrive in the ... on the trait appears to be linked to different genes ... University scientist and colleagues shows. The adaptation is the ... of hemoglobin, the oxygen-carrying protein in red blood cells. Members ...
Cached Biology News:Mathematicians tackle global issues 2Mathematicians tackle global issues 3What happens to plant growth when you remove gravity? 2Different genes behind same adaptation to thin air 2
(Date:6/26/2015)... NEW YORK and MUMBAI, India ... (TCS), (BSE: 532540, NSE: TCS) a leading global IT ... has been designated as a Leader in Worldwide Life ... IDC, in the " IDC MarketScape: Worldwide Life Science ... 2015) report. The report evaluated eight ...
(Date:6/26/2015)... , June 23, 2015 ... the addition of the "Global Cancer Biosimilars ... Market introduction of cancer biosimilar is ... commercialization potential. Chemotherapeutic drugs have dominated the cancer ... have been introduced in past few years. They ...
(Date:6/26/2015)... -- The report "Biolubricants Market by Type ... Chainsaw oils, Mold Release Agents), End Use (Industrial, Commercial ... and Forecasts to 2020" published by MarketsandMarkets, The Biolubricants ... at a CAGR of 6.27% between 2015 and 2020. ...   66 Figures spread through 170 Pages and in-depth ...
(Date:6/25/2015)... Last June, a dedicated global team of Ebola researchers began ... sequencing. Their research, which was written on the research platform ... (Park 2015) , reveals critical information about how ... recent Ebola outbreak. Today Authorea is pleased to ... edit history of the paper are available to the ...
Breaking Biology Technology:TCS Recognized as a Leader in Life Sciences R&D Risk-Based Monitoring by IDC MarketScape 2TCS Recognized as a Leader in Life Sciences R&D Risk-Based Monitoring by IDC MarketScape 3TCS Recognized as a Leader in Life Sciences R&D Risk-Based Monitoring by IDC MarketScape 4Global Cancer Biosimilars Market Opportunity Outlook 2Global Cancer Biosimilars Market Opportunity Outlook 3Biolubricants Market Worth $2,972.13 Million by 2020 2Biolubricants Market Worth $2,972.13 Million by 2020 3Open Science Takes Major Leap Forward 2
... Cerecor Inc. , a biopharmaceutical company focused on the ... activity is in the human nervous system, announced today ... overallotment of its January 2012 Series A preferred stock ... including members of Cerecor,s Board of Directors , ...
... American researchers have shown that prospective magnetic fusion power ... used for the production of weapon-usable materials than nuclear ... The researchers, from Princeton University, found that if nuclear ... there is little risk of fissile materials being produced ...
... N.Y. Jie Lian, assistant professor in the Department ... Institute, has won a prestigious Faculty Early Career Development ... Lian will use the five-year, $500,000 award to further ... in nuclear energy systems. The CAREER Award is given ...
Cached Biology Technology:Cerecor Raises $22 Million Series A Financing 2Fusion presents low proliferation risk, experts conclude 2Rensselaer professor Jie Lian receives NSF CAREER Award 2
... The Neural Stem Cell Expansion Kit - Neurosphere ... neural stem cell expansion as neurospheres in ... specially formulated N-2 Plus Media Supplement, which has ... K.K. et al . (1996) Genes & ...
DNase I (Deoxyribonuclease I) digests single- and double-stranded DNA to oligodeoxyribonucleotides. Ribonuclease activity has been reduced to non-detectable levels....
... E. coli strain containing an overproducing clone ... Reverse Transcriptase catalyzes the polymerization of DNA ... Full-length copies of large mRNAs, >10 kb, ... a much lower RNase H activity than ...
... RQ1 RNase-Free DNase is a preparation ... or double-stranded DNA to produce 3-hydroxyl ... use in applications where maintaining the ... DNase is qualified for use with ...
Biology Products: