Navigation Links
A new model for organ repair
Date:11/1/2013

Harvard Stem Cell Institute (HSCI) researchers have a new model for how the kidney repairs itself, a model that adds to a growing body of evidence that mature cells are far more plastic than had previously been imagined.

After injury, mature kidney cells dedifferentiate into more primordial versions of themselves, and then differentiate into the cell types needing replacement in the damaged tissue. This finding conflicts with a previously held theory that the kidney has scattered stem cell populations that respond to injury. The research appears online in PNAS Early Edition.

HSCI Kidney Diseases Program Leader Benjamin Humphreys, MD, PhD, a Harvard Medical School assistant professor at Brigham and Women's Hospital, was suspicious of the kidney stem cell repair model because his previous work suggested that all kidney cells have the capacity to divide after injury. He and his colleagues decided to test conventional wisdom by genetically tagging mature kidney cells in mice that do not express stem cell markers; the hypothesis being that the mature cells should do nothing or die after injury. The results showed that not only do these fully differentiated cells multiply, but they can multiply several times as they help to repair the kidney.

"What was really interesting is when we looked at the appearance and expression patterns of these differentiated cells, we found that they expressed the exact same 'stem cell markers' that these other groups claimed to find in their stem cell populations," said Humphreys. "And so, if a differentiated cell is able to express a 'stem cell marker' after injury, then what our work shows is that that's an injury markerit doesn't define a stem cell."

This new interpretation of kidney repair suggests a model by which cells reprogram themselves; similar to the way mature cells can be chemically manipulated to revert to an induced pluripotent state. The research echoes a study published last
'/>"/>

Contact: B. D. Colen
bd_colen@harvard.edu
617-413-1224
Harvard University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Hippocampal and thalamic neuronal metabolism in a putative rat model of schizophrenia
2. Model virus structure shows why theres no cure for common cold
3. Advanced Open Access publishing model
4. Model plant misled scientists about multicellular growth
5. Study explores the role of uncertainty in infectious disease modelling
6. Rensselaer researchers create accurate computer model of RNA tetraloop
7. Model of dangerous bee disease in Jersey provides tool in fight against honeybee infections
8. Researchers develop model of near-optimal genetic code
9. Elevated levels of copper in amyloid plaques associated with neurodegeneration in mouse models of AD
10. Computer model predicts red blood cell flow
11. Mount Sinai researchers develop first successful laboratory model for studying hepatitis C
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2015)... , Jan. 30, 2015  It is gratifying ... power and potential for genomic science as a means ... disease prevention and treatment.  I was honored to participate ... government-funded precision medicine program. Since the ... science of genomics—from the first sequenced genome of a ...
(Date:1/22/2015)... 13, 2015  Today, FreeWavz ( www.FreeWavz.com ), the ... campaign on Fundable, https://www.fundable.com/freewavz . FreeWavz will ... capacity to meet customer demand. Logo ... http://photos.prnewswire.com/prnh/20150113/168790 Invented by Dr. ...
(Date:1/22/2015)... POINT ROBERTS, Washington , January 20, 2015 ... technology and tech stocks, releases video from the CES 2015 ... security consultant Apollo Robbins . Apollo shows ... Wocket™ biometric smart wallet, a product of NXT-ID, Inc. (NASDAQ: ...
Breaking Biology News(10 mins):J. Craig Venter, Ph.D., Co-Founder and CEO, Human Longevity, Inc. (HLI) Participates in White House Precision Medicine Event 2FreeWavz Launches on Fundable to Drive Speed-to-Market in 2015 2Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 2Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 3
... San Diego have received New Innovator Awards from the ... translation of cutting-edge science and research to improvements in ... of bioengineering at the UC San Diego Jacobs School ... of medicine at UC San Diego,s School of Medicine, ...
... in German . Scientists at the ... colleagues, have decoded the genome of the Pristionchus pacificus ... In their work, which has been published in the ... from Professor Ralf J. Sommer,s department in Tbingen have ...
... professor at the UC San Diego Jacobs School of Engineering, ... With a new $1.5 million New Innovator Award grant from ... to do just that. , The awards, announced Sept. ... of new investigators who have exceptional creativity and propose bold ...
Cached Biology News:NIH doles out $3M in new innovator awards to 2 UC San Diego faculty 2Insight into the evolution of parasitism 2Insight into the evolution of parasitism 3Generation innovation: Young UC San Diego bioengineer to use NIH grant to fuel tissue engineering 2Generation innovation: Young UC San Diego bioengineer to use NIH grant to fuel tissue engineering 3
(Date:3/2/2015)... 2015 VLP Therapeutics, LLC. ("VLP"), a ... on the research and development of therapeutic and ... upon a novel and proprietary vaccine technology, today ... Grant Award from the Montgomery County Department of ... is awarded to life sciences companies in ...
(Date:3/2/2015)... , March 2, 2015 ... and healthy whole food nutrition products reveal technological ... lifestyle related disorders such as hyperglycemia, obesity, insulin ... concerns.  Nutraceutical and Biotech Companies in focus today ... Nature Foods Ltd. (NYSE: ANFI ), ...
(Date:3/2/2015)... SANTA BARBARA, Calif. , March 2, 2015 ... a biotechnology company developing therapies for autoimmune and ... Trademark Office (USPTO) has issued an important new ... immune system function through the targeting of CLIP. ... the targeted peptide technology underlying VG Life Sciences, ...
(Date:3/2/2015)... Outside GC, the leading provider of on-demand, ... Debbie Casey as a member of the firm, further ... , Debbie has spent over 20 years in ... Care North America in both legal and business capacities. ... with Outside GC’s growing list of healthcare clients, with ...
Breaking Biology Technology:VLP Therapeutics Wins the 2015 Life Sciences Impact Grant Award from the Montgomery County Department of Economic Development 2Clinical Studies & Research Substantiate Claims That Company's Targeted Healthy Nutritional Products Promote Healthy Lipids, Glucose & Insulin Levels 2Clinical Studies & Research Substantiate Claims That Company's Targeted Healthy Nutritional Products Promote Healthy Lipids, Glucose & Insulin Levels 3Clinical Studies & Research Substantiate Claims That Company's Targeted Healthy Nutritional Products Promote Healthy Lipids, Glucose & Insulin Levels 4Clinical Studies & Research Substantiate Claims That Company's Targeted Healthy Nutritional Products Promote Healthy Lipids, Glucose & Insulin Levels 5Clinical Studies & Research Substantiate Claims That Company's Targeted Healthy Nutritional Products Promote Healthy Lipids, Glucose & Insulin Levels 6Clinical Studies & Research Substantiate Claims That Company's Targeted Healthy Nutritional Products Promote Healthy Lipids, Glucose & Insulin Levels 7VG Life Sciences Granted Key Composition Of Matter Patent 2VG Life Sciences Granted Key Composition Of Matter Patent 3Outside GC Expands Healthcare Team 2
... For the first time in Michigan, a,diseased kidney ... through a single incision., "We made several improvements ... type of procedure routinely," says Craig Rogers, M.D., Henry,Ford,s ... last week using the da Vinci Surgical System, which ...
... Provides Comprehensive Clinical Picture, Improves,Patient-Physician Communications, ... Hemophilia A patients who,use Helixate(R) FS, Antihemophilic ... tracking treatment progress in real time,thanks to ... management system recently introduced by CSL Behring. ...
... BOSTON, Aug. 25 Scimitar Equity, LLC ... Bulletin Board: VOQP), entitled,"Creating Value; Turnaround Leverages ... This review is available at website: ... a New Jersey-based biotechnology company,dedicated to becoming ...
Cached Biology Technology:State's First Single Incision Robotic Kidney Removal Performed at Henry Ford Hospital 2CSL Behring's Innovative HeliTrax(SM) System Helps Physicians Manage Hemophilia A Patients 2CSL Behring's Innovative HeliTrax(SM) System Helps Physicians Manage Hemophilia A Patients 3CSL Behring's Innovative HeliTrax(SM) System Helps Physicians Manage Hemophilia A Patients 4VioQuest Pharmaceuticals, Inc Q2/08 Review Issued by Scimitar Equity, LLC 2
... for 15-20 enhancements when used as directed, ... System is designed to amplify the desired signal detected ... evaluating proteins with low expression., Membrane ... blocking the membrane; 1x solution; 250 ml, ...
Applications: Western blotting ...
Ethylene glycol-bis(2-aminoethyl ether)-N,N,N',N'-tetraacetic acid, Molecular Biology Grade...
... esters have moderate chemiluminescence efficiencies and the ... They have the added benefit that they ... to the background signal. This benefit has ... sensitivity immunoassay applications. These compounds can also ...
Biology Products: