Navigation Links
A new avenue to better medicines: Metal-peptide complexes
Date:7/9/2012

Researchers at the RUB and from Berkeley have used metal complexes to modify peptide hormones. In the Journal of the American Chemical Society, they report for the first time on the three-dimensional structure of the resulting metal-peptide compounds. "With this work, we have laid the molecular foundation for the development of better medicines" says Prof. Raphael Stoll from the Faculty of Chemistry and Biochemistry at the Ruhr-University. The team examined hormones that influence the sensation of pain and tumour growth.

Peptide hormones have many functions in the body

Hormones consisting of amino acids, the peptide hormones, convey bodily sensations such as pain and hunger, but also transmit growth signals. One example of this is insulin, which is important for the control of blood sugar levels. In interaction with specific receptors, the G-protein-coupled receptors, peptide hormones transport their messages to the cells. The hormones can be specifically chemically modified so that their effect changes, for example pain tolerance is lowered, or tumour growth inhibited. The German-Californian group of researchers has now found a new way to modify peptide hormones.

Metal complexes react with various peptide hormones

The first time they used a metal complex, namely, a rhodium compound, which reacts with the amino acid tyrosine. The precious metal rhodium is used as a catalyst in the synthesis of highly complex medicinal substances in the research laboratory as well as in industrial plants. Among other things, the researchers analysed the peptide hormone encephalin, which is important for the sensation of pain, and octreotide. The latter is a synthetic derivative of the growth hormone somatostatin, approved as a medicinal substance and already used in the treatment of certain tumours. The reaction with the metal complex was highly selective. Although the hormones consist of hundreds of atoms, the rhodium c
'/>"/>

Contact: Prof. Dr. Nils Metzler-Nolte
nils.metzler-nolte@rub.de
49-234-322-4153
Ruhr-University Bochum
Source:Eurekalert

Page: 1 2

Related biology news :

1. Physics confirms sprinters are performing better than ever before
2. Not-so-precious: Stripping gold from AFM probes allows better measurement of picoscale forces
3. Screening horticultural imports: New models assess plant risk through better analysis
4. Arsenic for better drugs and cleaner crops
5. Better looking birds have more help at home with their chicks
6. Evaluation of microscopy techniques may help scientists to better understand ancient plants
7. New Tool Helps Drug Developers Optimize Their Research and Target Development for Better Results and a Stronger Competitive Edge
8. Better plants for biofuels
9. Better housing conditions for zebrafish could improve research results
10. Bigger gorillas better at attracting mates and raising young
11. Modern hybrid corn makes better use of nitrogen, study shows
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... California, San Diego, have completed the first comprehensive numerical ... uses the pixels in an image as data points ... , The researchers, led by J.S. Chen, the William ... of Engineering at UC San Diego, presented their findings ... conference in Pittsburgh this month. Chen also gave a ...
(Date:9/30/2014)... Health (NIH) awarded Lawrence Livermore National Laboratory (LLNL) ... system that will enable researchers to better understand ... scale. , LLNL,s grant-funded project is part of ... (Brain Research through Advancing Innovative Neurotechnologies) Initiative , ... of the human mind and uncover ways to ...
(Date:9/30/2014)... Fish can live in almost any aquatic environment on ... up many species are pushed to the limit. The ... could prove critical for how different species cope in ... the University of Gothenburg, published in the scientific journal ... Climate change continues apace thanks to increasing levels of ...
Breaking Biology News(10 mins):First comprehensive meshfree numerical simulation of skeletal muscle tissue achieved 2NIH taps lab to develop sophisticated electrode array system to monitor brain act 2NIH taps lab to develop sophisticated electrode array system to monitor brain act 3Shape up quickly -- applies to fish, too! 2
... of modern human behaviour and technological advancement among our ... has taken a step closer to firmly establishing Africa, ... the early development of human behaviour. A new ... Henshilwood, is the first detailed summary of the time ...
... 5, 2012  In a partnership that brings new personalization ... is now enabling its members to transmit body monitoring ... their online trainers. The integration gives FitOrbit trainers access ... activity level and sleep pattern data that helps trainers ...
... Four University of Massachusetts Medical School faculty members ... the American Association for the Advancement of Science (AAAS), ... the journal, Science . They include: ... & physiological systems, who was elected to the section ...
Cached Biology News:Africa's Homo sapiens were the first techies 2BodyMedia & FitOrbit Up the Ante in Personalized Weight Loss 2BodyMedia & FitOrbit Up the Ante in Personalized Weight Loss 3UMass Medical School faculty elected to the American Association for the Advancement of Science 2
(Date:9/30/2014)... Applying a well-known optical phenomenon called thin-film interference, ... demonstrated the ability to "paint" ultra-thin coatings onto ... for making future, flexible electronic devices, creating advanced ... rocket ships and spacecraft with extremely lightweight decorative ... water, it becomes iridescent, revealing a myriad of ...
(Date:9/30/2014)... analog of one of nature,s most efficient light-harvesting ... led by Alejandro Briseno of the University of ... developing long-sought polymer architecture to boost power-conversion efficiency ... devices. , Briseno, with colleagues and graduate ... University and Dresden University of Technology, Germany, report ...
(Date:9/30/2014)... 2014 Report Details Biosimilar drugs ... revenues Do you want to find sales potentials ... predictions for those biological drugs from 2014, helping ... financial data, R&D trends, opportunities and selling prospects. ... to 2024 at overall world market, therapeutic class, ...
(Date:9/30/2014)... Nematicide is a type of chemical ... parasitic roundworms, found in massive quantities virtually everywhere—in ... animals. Nematicides have tended to be broad-spectrum toxicants ... through the soil. A single gram of soil ... more than 10,000 species classified, they are one ...
Breaking Biology Technology:Taking thin films to the extreme 2Blades of grass inspire advance in organic solar cells 2Blades of grass inspire advance in organic solar cells 3Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 2Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 3Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 4Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 5Nematicides Market by Types (Fumigants, Organophosphates, Carbamate and Bio-Nematicides), Applications (Agrochemicals, Industrial, and Others), and Geography (North America, Europe, Asia-Pacific & ROW) - Global Trends & Forecasts to 2019 2
... The Gynecologic Cancer Foundation (GCF) and the Claudia Cohen Research Foundation announce today that ... $50,000 GCF/Claudia Cohen Prize for Outstanding Gynecologic Cancer Researcher.  The prize is being presented ... San Francisco March 14-17, 2010 . , ... ...
... has received a Paragraph IV Notice Letter,from Teva Pharmaceuticals USA, Inc. ("Teva") advising of the filing of an,Abbreviated New Drug Application ("ANDA") for ... ... , , ... ...
... Cylex™, a global life science company that develops and manufactures in vitro diagnostic products based on patented technology, announced today the expansion of ... , ... , , ... ...
Cached Biology Technology:Paul Goodfellow, PhD, Awarded First GCF/Claudia Cohen Prize for Outstanding Gynecologic Cancer Researcher 2Paul Goodfellow, PhD, Awarded First GCF/Claudia Cohen Prize for Outstanding Gynecologic Cancer Researcher 3Paul Goodfellow, PhD, Awarded First GCF/Claudia Cohen Prize for Outstanding Gynecologic Cancer Researcher 4Paul Goodfellow, PhD, Awarded First GCF/Claudia Cohen Prize for Outstanding Gynecologic Cancer Researcher 5Shire Receives INTUNIV (TM) Paragraph IV Notice Letter From Teva Pharmaceuticals 2Shire Receives INTUNIV (TM) Paragraph IV Notice Letter From Teva Pharmaceuticals 3Shire Receives INTUNIV (TM) Paragraph IV Notice Letter From Teva Pharmaceuticals 4Cylex Announces Valuable Personnel Additions 2Cylex Announces Valuable Personnel Additions 3Cylex Announces Valuable Personnel Additions 4Cylex Announces Valuable Personnel Additions 5
Mouse monoclonal [ICRF 44] to Integrin alpha M...
... Finnpipette Focus Long has a ... pipetting from test tubes, bottles, ... long necked vessels. Finnpipette Focus ... you select, it will be ...
... entire pressurized perfusion system for small ... biophysics, electrochemistry, or general liquid-handling research ... as 100 microliters of precious drugs. ... in milliseconds from a single tip. ...
Request Info...
Biology Products: