Navigation Links
A new avenue to better medicines: Metal-peptide complexes
Date:7/9/2012

Researchers at the RUB and from Berkeley have used metal complexes to modify peptide hormones. In the Journal of the American Chemical Society, they report for the first time on the three-dimensional structure of the resulting metal-peptide compounds. "With this work, we have laid the molecular foundation for the development of better medicines" says Prof. Raphael Stoll from the Faculty of Chemistry and Biochemistry at the Ruhr-University. The team examined hormones that influence the sensation of pain and tumour growth.

Peptide hormones have many functions in the body

Hormones consisting of amino acids, the peptide hormones, convey bodily sensations such as pain and hunger, but also transmit growth signals. One example of this is insulin, which is important for the control of blood sugar levels. In interaction with specific receptors, the G-protein-coupled receptors, peptide hormones transport their messages to the cells. The hormones can be specifically chemically modified so that their effect changes, for example pain tolerance is lowered, or tumour growth inhibited. The German-Californian group of researchers has now found a new way to modify peptide hormones.

Metal complexes react with various peptide hormones

The first time they used a metal complex, namely, a rhodium compound, which reacts with the amino acid tyrosine. The precious metal rhodium is used as a catalyst in the synthesis of highly complex medicinal substances in the research laboratory as well as in industrial plants. Among other things, the researchers analysed the peptide hormone encephalin, which is important for the sensation of pain, and octreotide. The latter is a synthetic derivative of the growth hormone somatostatin, approved as a medicinal substance and already used in the treatment of certain tumours. The reaction with the metal complex was highly selective. Although the hormones consist of hundreds of atoms, the rhodium compound was always coordinated by the carbon ring of the tyrosine - the phenol ring.

Structure determined by NMR spectroscopy

The team also clarified the structure of the resulting metal-peptide complexes. "We hope to develop other metal-containing, peptide-like substances by building on these basic studies" says Prof. Dr. Nils-Metzler-Nolte of the Chair of Inorganic Chemistry I. "These could modulate the effect of naturally occurring peptide hormones and, for example, be used as a novel remedy for pain or cancer". For the project, the Californian colleagues made their knowledge of the special reactivity of the rhodium compound available. The researchers in Bochum contributed their experience with metal-peptides, the corresponding receptors and the structural analysis of biological macromolecules. "This again demonstrates that cutting-edge competitive research can only be carried out efficiently within a research association", says Prof. Stoll. The German Research Foundation (SFB 642 and Research Unit 630) and the Research Department for Interfacial Systems Chemistry at RUB supported the work.


'/>"/>
Contact: Prof. Dr. Nils Metzler-Nolte
nils.metzler-nolte@rub.de
49-234-322-4153
Ruhr-University Bochum
Source:Eurekalert

Related biology news :

1. Physics confirms sprinters are performing better than ever before
2. Not-so-precious: Stripping gold from AFM probes allows better measurement of picoscale forces
3. Screening horticultural imports: New models assess plant risk through better analysis
4. Arsenic for better drugs and cleaner crops
5. Better looking birds have more help at home with their chicks
6. Evaluation of microscopy techniques may help scientists to better understand ancient plants
7. New Tool Helps Drug Developers Optimize Their Research and Target Development for Better Results and a Stronger Competitive Edge
8. Better plants for biofuels
9. Better housing conditions for zebrafish could improve research results
10. Bigger gorillas better at attracting mates and raising young
11. Modern hybrid corn makes better use of nitrogen, study shows
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/12/2016)... 2016 WearablesResearch.com , a brand of ... results from the Q1 wave of its quarterly wearables ... consumers, receptivity to a program where they would receive ... insurance company. "We were surprised to see ... Michael LaColla , CEO of Troubadour Research, "primarily because ...
(Date:4/28/2016)... April 28, 2016 First quarter 2016:   ... 966% compared with the first quarter of 2015 The ... 589.1 M (loss: 18.8) and the operating margin was 40% (-13) ... Cash flow from operations was SEK 249.9 M (21.2) ... guidance is unchanged, SEK 7,000-8,500 M. The operating margin ...
(Date:4/15/2016)... CHICAGO , April 15, 2016  A ... companies make more accurate underwriting decisions in a ... offering timely, competitively priced and high-value life insurance ... health screenings. With Force Diagnostics, rapid ... and lifestyle data readings (blood pressure, weight, pulse, ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June 23, 2016   EpiBiome , ... secured $1 million in debt financing from Silicon Valley ... up automation and to advance its drug development efforts, ... new facility. "SVB has been an incredible ... the services a traditional bank would provide," said Dr. ...
(Date:6/23/2016)... , June 23, 2016 Apellis Pharmaceuticals, ... 1 clinical trials of its complement C3 inhibitor, ... and multiple ascending dose studies designed to assess ... of subcutaneous injection in healthy adult volunteers. ... either as a single dose (ranging from 45 ...
(Date:6/23/2016)... CA (PRWEB) , ... June 23, 2016 , ... ... software, is exhibiting at the Pennsylvania Convention Center and will showcase its product’s ... conference. ClinCapture will also be presenting a scientific poster on Disrupting Clinical Trials ...
(Date:6/23/2016)... 2016 ReportsnReports.com adds 2016 ... its pharmaceuticals section with historic and forecast data ... more. Complete report on the Cell ... 15 companies and supported with 261 tables and ... . The Global Cell Culture Media ...
Breaking Biology Technology: