Navigation Links
A nanoscale window to the biological world
Date:12/20/2012

If the key to winning battles is knowing both your enemy and yourself, then scientists are now well on their way toward becoming the Sun Tzus of medicine by taking a giant step toward a priceless advantage the ability to see the soldiers in action on the battlefield.

Investigators at the Virginia Tech Carilion Research Institute have invented a way to directly image biological structures at their most fundamental level and in their natural habitats. The technique is a major advancement toward the ultimate goal of imaging biological processes in action at the atomic level.

"It's sort of like the difference between seeing Han Solo frozen in carbonite and watching him walk around blasting stormtroopers," said Deborah Kelly, an assistant professor at the VTC Research Institute and a lead author on the paper describing the first successful test of the new technique. "Seeing viruses, for example, in action in their natural environment is invaluable."

The technique involves taking two silicon-nitride microchips with windows etched in their centers and pressing them together until only a 150-nanometer space between them remains. The researchers then fill this pocket with a liquid resembling the natural environment of the biological structure to be imaged, creating a microfluidic chamber.

Then, because free-floating structures yield images with poor resolution, the researchers coat the microchip's interior surface with a layer of natural biological tethers, such as antibodies, which naturally grab onto a virus and hold it in place.

In a recent study in Lab on a Chip, Kelly joined Sarah McDonald, also an assistant professor at the VTC Research Institute, to prove that the technique works.

McDonald provided a pure sample of rotavirus double-layered particles for the study.

"What's missing in the field of structural biology right now is dynamics h
'/>"/>

Contact: Paula Byron
paulabyron@vtc.vt.edu
540-526-2027
Virginia Tech
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Nanoscale scaffolds and stem cells show promise in cartilage repair
2. Researchers develop method to grow artificial tissues with embedded nanoscale sensors
3. Engineering research centers awarded $55.5 million to innovate in nanoscale science and engineering
4. New NIH/NHGRI grants to harness nanoscale technologies to cut DNA sequencing costs
5. Salk scientists open new window into how cancers override cellular growth controls
6. Feel-good glass for windows
7. Wireless window sentinel
8. Unraveling biological networks
9. New method for estimating parameters may boost biological models
10. A project to research biological and chemical aspects of microalgae to fuel approach
11. EPA to highlight innovative ways to detect and respond to biological threats
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A nanoscale window to the biological world
(Date:3/10/2015)...  Continuing its 167-year history of offering the Best, ... The Eye Scanning Password Authenticator , a device that ... websites or sensitive data. Employing the same ... the device has a small camera that scans and ... converting them into an encrypted ID that cannot be ...
(Date:3/10/2015)... OXFORD, Conn. , March 10, 2015 /PRNewswire/ ... NXTDW) ("NXT-ID" or the "Company"), a biometric authentication ... reports the company,s Wocket™ smart wallet has been ... 2015" by Rethink Modern. Rethink Modern ... sharing modern and innovative items for your home and lifestyle that ...
(Date:3/3/2015)... FOREST, Calif. , March 3, 2015 ... the leading provider of advanced cryogenic logistics ... markets including immunotherapies, stem cells, cell lines, ... and reproductive medicine, today announced the expansion ... Cancer Research Centers, ("Fred Hutch") Clinical ...
Breaking Biology News(10 mins):Hammacher Schlemmer Introduces The Eye Scanning Password Authenticator 2NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 2NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 3NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 4Cryoport, Inc. Expands Support of Fred Hutchinson Cancer Research Center's Clinical Research Division 2Cryoport, Inc. Expands Support of Fred Hutchinson Cancer Research Center's Clinical Research Division 3
... closer to an effective HIV vaccine. Researchers from ... and the Ragon Institute of MGH, MIT and ... neutralizing antibodies, which block HIV infection. Details are ... PLoS Pathogens . According to author Leo ...
... has designated 2011 the "International Year of Chemistry (IYC)" ... to the world around us. This worldwide initiative is ... Educational, Scientific and Cultural Organization (UNESCO) and the International ... activities conducted by countries, such as the United States, ...
... Six researchers from LSU,s College of Science have been ... for the Advancement of Science, or AAAS, the world,s largest ... ranks LSU among the top 10 percent of universities with ... more than 220 institutions worldwide. LSU ranked second in the ...
Cached Biology News:Researchers report on the early development of anti-HIV neutralizing antibodies 2US launches International Year of Chemistry Feb. 1 with panel of world-renowned chemists 26 LSU College of Science faculty named AAAS Fellows 2
(Date:3/30/2015)... 2015  NuGene International, Inc. ("NuGene") (OTCQB: NUGN), ... Inc. has added another internationally recognized researcher to ... an internationally recognized researcher in bio-inspired materials and ... Peking University, China , Professor ... of North Carolina, Chapel Hill. Following a postdoctoral ...
(Date:3/30/2015)... , March 30, 2015 CASI Pharmaceuticals, ... to the acquisition, development and commercialization of innovative therapeutics ... global market with a commercial focus on ... and Drug Administration (CFDA) has approved the Company,s application ... ovarian clear cell carcinoma (OCCC) patients for its proprietary ...
(Date:3/30/2015)... 30, 2015  Spherix Incorporated (Nasdaq: SPEX ... fostering and monetization of intellectual property, today provided ... 3:13-cv-03494-M and  Spherix v. Uniden , Case No. ... for the Northern District of Texas ... v. Verizon, Case No. 1:14-cv-00721-GBL-TCB, in the ...
(Date:3/30/2015)... , March 30, 2015  Naldemedine, an investigational ... by Shionogi & Co., Ltd., met its primary ... (COMPOSE I) for the treatment of opioid-induced constipation ... receiving opioid therapy. Study results showed that naldemedine ... improved the frequency of spontaneous bowel movement (SBM) ...
Breaking Biology Technology:UCI Professor Zhibin Guan Joins NuGene Advisory Board 2UCI Professor Zhibin Guan Joins NuGene Advisory Board 3CASI Pharmaceuticals Receives Approval From CFDA For Phase 2 Clinical Trial In China With ENMD-2076 For Ovarian Clear Cell Carcinoma 2CASI Pharmaceuticals Receives Approval From CFDA For Phase 2 Clinical Trial In China With ENMD-2076 For Ovarian Clear Cell Carcinoma 3CASI Pharmaceuticals Receives Approval From CFDA For Phase 2 Clinical Trial In China With ENMD-2076 For Ovarian Clear Cell Carcinoma 4CASI Pharmaceuticals Receives Approval From CFDA For Phase 2 Clinical Trial In China With ENMD-2076 For Ovarian Clear Cell Carcinoma 5Spherix Provides Update on Litigation vs. VTech, Uniden and Verizon 2Spherix Provides Update on Litigation vs. VTech, Uniden and Verizon 3Shionogi & Co., Ltd. Announces That Naldemedine Meets Primary Endpoint In A Phase 3 Study For The Treatment Of Opioid-Induced Constipation 2Shionogi & Co., Ltd. Announces That Naldemedine Meets Primary Endpoint In A Phase 3 Study For The Treatment Of Opioid-Induced Constipation 3
... 17 Senetek PLC,(OTC Bulletin Board: SNKTY), a Life ... the science of healthy aging, today,announced that shareholders have ... the Annual General Meeting of Shareholders held on,December 16, ... are pleased with the results of the voting and ...
... Director, Commercial Development;Sam Zeller appointed Senior Director, Regulatory Affairs-- ... Dec. 17 Microbia Precision Engineering, Inc. (Microbia) announced ... and bioproduct commercialization capabilities with the appointments of Gaye ... Zeller as Senior Director of Regulatory Affairs. , ...
... revolutionary Trusted LASIK Surgeons directory service and website at ... for consumers seeking to improve their vision. What sets ... screening process ensuring that only those who are among ... surgery in the United States are listed. Refractive eye ...
Cached Biology Technology:Senetek PLC Announces 2008 Annual General Meeting Voting Results 2Microbia PE Bolsters Senior Management Team; Positions Company for Commercializing Proprietary Bioproducts 2Microbia PE Bolsters Senior Management Team; Positions Company for Commercializing Proprietary Bioproducts 3Hawaii LASIK Eye Surgery Expert Dr. John D. Olkowski Qualifies and Lists with Trusted LASIK Surgeons 2Hawaii LASIK Eye Surgery Expert Dr. John D. Olkowski Qualifies and Lists with Trusted LASIK Surgeons 3Hawaii LASIK Eye Surgery Expert Dr. John D. Olkowski Qualifies and Lists with Trusted LASIK Surgeons 4Hawaii LASIK Eye Surgery Expert Dr. John D. Olkowski Qualifies and Lists with Trusted LASIK Surgeons 5Hawaii LASIK Eye Surgery Expert Dr. John D. Olkowski Qualifies and Lists with Trusted LASIK Surgeons 6Hawaii LASIK Eye Surgery Expert Dr. John D. Olkowski Qualifies and Lists with Trusted LASIK Surgeons 7
Homo sapiens inhibin, beta B (activin AB beta polypeptide) Antigen: Recombinant Protein(142~254aa)...
... cells right in your 35mm dish ... dish Perfusion Chamber has separate openings ... dampen the fluctuations of the liquid ... prevent bubbles from entering the chamber. ...
... Flipper® Racks are ideal for storage and ... These polypropylene racks withstand extreme temperatures, making ... They may also be autoclaved for use ... one side accommodates 0.5ml microcentrifuge tubes, the ...
Functionally tested for consistent G-banding of chromosomes....
Biology Products: