Navigation Links
A mother's salt intake could be key to prenatal kidney development
Date:7/6/2011

Bethesda, Md. (July 6, 2011) A new animal study from Europe has drawn an association between pregnant mothers' sodium intake and their newborn's kidney development. Among the most significant aspects of the study's findings is that either too much or too little salt during pregnancy had an adverse effect on the prenatal development of the offspring's kidneys. The consequence of such disruption can lead to high blood pressure in later years.

These are the conclusions reached in the study, "Both High and Low Maternal Salt Intake in Pregnancy Alters Kidney Development in the Offspring," conducted by Nadezda Koleganova, Grzegorz Piecha, Annett Mller, Monika Weckbach, Peter Schirmacher, and Marie-Luise Gross-Weissmann, Eberhard Ritz and Luis Eduardo Becker, all with the University of Heidelberg in Heidelberg, DE; and Jens Randel Nyengaard of the University of Aarhus, Aarhus, DK. Their study is published in the online edition of the American Journal of Physiology--Renal Physiology.

Background

This research builds upon past studies that recognize that excessive salt intake causes secretion of endogenous cardiotonic steroids such as marinobufagenin (MBG). For the pregnant female, this can be harmful since high concentrations of MBG are correlated to low birth-weight and higher blood pressure in the offspring.

Previous research has also linked high blood pressure with a low nephron number, critical because the nephron is the basic structural and functional unit of the kidney. The nephron eliminates wastes from the body, regulates blood volume and blood pressure, controls levels of electrolytes and metabolites, and regulates blood pH. Its functions are vital to life and are regulated by the endocrine system.

Methodology

Sprague-Dawley rats were fed low, intermediate or high sodium diets during pregnancy and lactation. The litters were standardized to identical size at birth with 1:1 male to female ratio. The offspring were separated from their mothers at four weeks of age and subsequently received the intermediate sodium diet. The animals had free access to water and food and their body weight, food and water consumption were monitored weekly.

The kidney structure was assessed at postnatal weeks 1 and 12, and the expression of proteins known to be involved in kidney development were examined at birth and 1 week of age. Blood pressure was measured by telemetry in male offspring between the ages of two and nine months.

Results

The researchers found that the number of glomeruli (the main structural unit of the kidney) during weeks 1-12 were significantly lower, and the measured blood pressure for males after the fifth month was higher in offspring of mothers on high- or low- compared with intermediate-sodium diet. High salt diet was paralleled by higher concentrations of marinobufagenin in the amniotic fluid and an increase in the expression of both GDNF and its inhibitor, sprouty-1 in the offspring's kidney. The expression of FGF-10, a genetic signal responsible for kidney development, was lower in offspring of mothers on low-sodium diet and the expression of Pax-2 and FGF-2, tissue-specific genes that determine cell lineages, tissue patterning, and cellular proliferation was lower in offspring of mothers on high-sodium diet.

Importance of the Findings

Taken together the above findings indicate that both too low and too high maternal salt intakes retard development of new glomeruli, resulting in a nephron deficit. If the findings in the animals in this study can be extrapolated to humans, both too low and too high salt intake during pregnancy would be a risk factor for hypertension and renal damage in the offspring.

In women, each mother-to-be has specific health issues and conditions that require guidance from a health provider. This study sheds light on the issue of salt intake during pregnancy and draws attention to the possible consequences of consuming too much or too little salt during pregnancy and the impact it may have on the kidney development of an offspring.


'/>"/>

Contact: Donna Krupa
dkrupa@the-aps.org
703-634-7209
American Physiological Society
Source:Eurekalert

Related biology news :

1. New mothers can learn a lot from watching their babies
2. Parenting stress affects new mothers’ postpartum lifestyle
3. Preterm mothers milk contains less antioxidants than mothers completing their gestation
4. Mothers diets have biggest influence on children eating healthy
5. New report suggests why risk for sudden infant death syndrome is greater in babies of mothers who smoke
6. Successful mothers get help from their friends: Dolphin study
7. Discus fish parent young like mammalian mothers
8. Black mothers cite lack of desire as top reasons for not breastfeeding
9. About 94 percent of breastfeeding mothers do not follow a proper diet
10. Giving DHA supplements to breastfeeding mothers
11. HPV vaccination more likely if mothers approve
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/15/2016)... York , March 15, 2016 ... market report published by Transparency Market Research "Digital Door Lock ... and Forecast 2015 - 2023," the global digital door lock ... 731.9 Mn in 2014 and is forecast to grow at ... Growth of micro, small and medium enterprises (MSMEs) across the ...
(Date:3/11/2016)... PUNE, India , March 11, 2016 ... to a new market research report "Image Recognition Market ... by Application (Marketing and Advertising), by Deployment Type (On-Premises ... Global Forecast To 2022", published by MarketsandMarkets, the global ... in 2015 to USD 29.98 Billion by 2020, at ...
(Date:3/9/2016)... BEACH GARDENS, Fla. , March 9, 2016 ... identity management authentication and enrollment solutions, today announced ... DigitalPersona ® Altus multi-factor authentication ... IT and InfoSec managers to step-up security where ... Washington, DC . ...
Breaking Biology News(10 mins):
(Date:5/27/2016)... 27, 2016 At present, the Biotech ... this space know that volatility is what makes this industry ... ActiveWallSt.com: Synta Pharmaceuticals Corp. (NASDAQ: SNTA ), CTI ... LPTN ), and Heat Biologics Inc. (NASDAQ: ... the technical alerts for these stocks at: ...
(Date:5/26/2016)... 2016 Despite the volatility that continues ... space. Today,s pre-market research on ActiveWallSt.com directs the investor community,s ... RDUS ), Cerus Corp. (NASDAQ: CERS ... Five Prime Therapeutics Inc. (NASDAQ: FPRX ). Register ... http://www.activewallst.com/ On Wednesday, shares in ...
(Date:5/25/2016)... (PRWEB) , ... May 25, 2016 , ... Lajollacooks4u has ... and has consistently been rated one of its top attractions. Fortune 500 companies, ... to participate in a unique and intimate team-building experience. , Each event kicks off ...
(Date:5/25/2016)... ... May 25, 2016 , ... The American Medical Informatics Association ... the National Coordinator for Health IT (ONC) outlining a measurement approach to interoperability ... available when and where it was needed. The organization of health informatics professionals ...
Breaking Biology Technology: