Navigation Links
A mother's genes influence her child's aging
Date:8/22/2013

nt at birth.

In ageing research, mitochondria have been scrutinized by researchers for a long time already. The mitochondria in a cell contain thousand of copies of a circular DNA genome. These encode, for instance, proteins that are important for the enzymes of the respiratory chain. Whereas the DNA within the nucleus comes from both parents, the mitochondrial DNA only includes maternal genes, as mitochondria are transmitted to offspring via the oocyte and not via sperm cells. As the numerous DNA molecules within a cell's mitochondria mutate independently from each other, normal and damaged mtDNA molecules are passed to the next generation.

To examine which effects mtDNA damage exerts on offspring, researchers used a mouse model. Mice that inherited mutations of mtDNA from their mother not only died quicker compared to those without inherited defects, but also showed premature ageing effects like reduced body mass or a decrease in male's fertility. Moreover, these rodents were prone to heart muscle disease.

As the researchers discovered, mutations of mtDNA not only can accelerate ageing but also impair development: In mice that, in addition to their inherited defects, accumulated mutations of mtDNA during their lifetime, researchers found disturbances of brain development. They conclude that defects of mtDNA that are inherited and those that are acquired later in life add up and finally reach a critical number.

"Our findings shed light on the ageing process and strongly suggest that the mitochondria play a key role in ageing. They also show that it is important to reduce the number of mutations," says Larsson. However, the question of whether it is possible to affect the degree of mtDNA damage through, for example, lifestyle intervention is yet to be investigated. In the future, the scientists want to investigate whether a reduced number of mutations can actually increase lifespan in model organisms such as fruit flies and mice.
'/>"/>

Contact: Nils-Göran Larsson
larsson@age.mpg.de
49-221-478-89771
Max-Planck-Gesellschaft
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Bright birds make good mothers
2. Offspring of mothers stressed during pregnancy with a passive stress coping style more prone to obesity
3. Female mice exposed to BPA by mothers show unexpected characteristics
4. Privacy a problem for mothers of newborns in neonatal intensive care units, CWRU study finds
5. Nursing gerbils unravel benefit of multiple mothers in collective mammals
6. Grant funded to improve mothers nutrition before pregnancy and impact on baby
7. Infants of overweight mothers grow more slowly
8. Montreal researchers repel mortality in Malian mothers
9. Multiple genes manage how people taste sweeteners
10. Fetal stress disrupts the way genes are transmitted
11. Be happy: Your genes may thank you for it
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... that marine noise can affect animal movement and communication, ... Bristol and Exeter and the cole Pratique des Hautes ... noise stops embryonic development and increases larval mortality in ... Stylocheilus striatus used in this study) usually ... feed on toxic alga but this study, conducted in ...
(Date:7/30/2014)... New York University is paving the way for ... civilians and military troops exposed to poisonous chemicalsparticularly ... An article in the current issue of the ... detoxifying organophosphates, which are compounds commonly used in ... developed by NYU School of Engineering Associate Professor ...
(Date:7/30/2014)... Lewis Carroll,s Through the Looking Glass, collaborators from ... Singapore improved a 35-year-old ecology model to better ... of years. , The new model, called a ... Queen Effect," an evolutionary hypothesis introduced by Lee ... organisms must constantly increase their fitness (or ability ...
Breaking Biology News(10 mins):Boat noise impacts development and survival of sea hares 2Engineering a protein to prevent brain damage from toxic agents 2Classic Lewis Carroll character inspires new ecological model 2Classic Lewis Carroll character inspires new ecological model 3
... G&D, Dr. Guillermo Oliver (St. Jude Childrens ... resolve a century-old debate over the origin of ... the lymphatic vasculature is integral to understanding its ... tissue fluid levels) and disease (lymphedema and spreading ...
... of the scientific journal Science presents research on the ... that ultimately may lead to better diagnosis and treatment ... people every year. It may also bring an ... Giardia lamblia is an intestinal parasite that exists all ...
... Standards and Technology (NIST) today announced 56 ... development projects under the agencys Advanced Technology ... a broad range of technologies, including medical ... electronics, transportation, nanotechnology, energy conservation and automated ...
Cached Biology News:New Swedish research hope for millions of sufferers 2
(Date:7/31/2014)... July 31, 2014 Nearly 20,000 medical professionals ... Annual Meeting & Clinical Lab Expo in ... never-before-seen breakthroughs in diagnostic research and technology that will ... As of Wednesday, July 30, more than ... Meeting & Clinical Lab Expo, with more than 10,000 ...
(Date:7/31/2014)... Researchers at Johns Hopkins have mapped the sound-processing part ... both the proverbial forest and the trees in view. ... views of brain activity within mice, and it enabled ... mice "called" to each other. The results, which represent ... process language, appear online July 31 the journal ...
(Date:7/31/2014)... PORTOLA VALLEY, Calif. , July 31, 2014 /PRNewswire/ ... San Francisco Bay Area , has ... the University of Oxford,s commercialisation company. The potent anti-inflammatory ... David Greaves at the University of Oxford,s Sir ... The company, which has raised over $1.5 million ...
(Date:7/31/2014)... Research and Markets has announced ... report to their offering. ... of the genetic material or genomes of an organism. ... the discovery and development of diagnostic and therapeutic solutions ... Genomics is supported by three major product segments: Instruments, ...
Breaking Biology Technology:Research on Digital Health, Alzheimer's, Ebola Draws Nearly 20,000 Attendees to 2014 AACC Annual Meeting & Clinical Lab Expo 2Research on Digital Health, Alzheimer's, Ebola Draws Nearly 20,000 Attendees to 2014 AACC Annual Meeting & Clinical Lab Expo 3New mapping approach lets scientists zoom in and out as the brain processes sound 2Oxford licenses anti-inflammatory peptides to San Francisco Bay Area start-up 2Oxford licenses anti-inflammatory peptides to San Francisco Bay Area start-up 3Global Genomics Market 2014-2018: Key Vendors are F. Hoffmann-La Roche, Life Technologies, Qiagen and Illumina 2
... the appointment of James Stoppert as President and Chief Executive Officer ... ... EON) September 3, 2008 -- Segetis is the first and ... wide range of industrial chemicals and plastics that are ultimately derived ...
... China, Sept. 3 ,Acesys Pharmatech and Provid Pharmaceuticals ... expertise and project management,capabilities of Provid in the ... structure of Acesys in China., The combined ... of medicinal chemistry for clients in the pharmaceutical ...
... tested new molecular tools for stem cell research to direct ... development programmes. , A collaborative team of scientists from ... (NESCI) have developed two synthetic molecules which can be used ... into other forms of tissue. , Their use ...
Cached Biology Technology: Stoppert Named as President and CEO at Breakthrough Renewable Technology Firm Segetis, Inc 2Acesys and Provid Announce Alliance for Medicinal Chemistry Services 2New stem cell tools to aid drug development 2New stem cell tools to aid drug development 3
... for ambient HPLC. Contains connections and ... two external devices such as RI ... analog output from the 90 detector ... Includes an input for synchronization with ...
... The FDSS6000 System is an imaging ... assay development and high throughput screening ... luminescence modalities., The Hamamatsu light sources ... our companys decades-long experience in photon ...
... and supplies, for 10 chips, provides ... perform standard-sensitivity RNA analysis (nanogram levels) ... automated electrophoresis system. Supplied are 1,250 ... StdSens stain, 20 microliters RNA ladder, ...
... 3-(3,5-Dibromo-4-hydroxy-benzoyl)-2-ethyl-benzofuran-6-sulfonicacid-(4-(thiazol-2-ylsulfamyl)-phenyl)-amide White solid. PROTECT FROM ... cell-permeable sulfanamido-benzbromarone compound that acts as ... inhibitor of PTP1B (IC 50 ... for PTP1B 403 and PTP1B ...
Biology Products: