Navigation Links
A mother's genes influence her child's aging
Date:8/22/2013

As we grow older, not only the function of organs slows down. Also on a cellular level more and more damages occur. One reason is that DNA errors accumulate which cause defective cells. Now a team of researchers lead by Nils-Gran Larsson at the Max Planck Institute for Biology of Ageing in Cologne has shown that ageing is determined not only by the accumulation of DNA damage that occurs during lifetime but also by damage that we acquire from our mothers. In a study on mice, the researchers have shown that mutations of maternally inherited mitochondrial DNA influence the offspring's ageing process starting from birth.

Ageing is a complex process, in the course of which more and more damage accumulates within the bodies' tissues, cells and molecules with serious consequences: Organs lose their function and mortality risk increases. Why some people age faster than others has many reasons that are still unsolved. However, damage that occurs within the mitochondria the cell's powerhouses seems to be of particular importance for ageing.

"The mitochondrion contains its own DNA, the so-called mitochondrial DNA or mtDNA, which changes faster than the DNA in the nucleus, and this has a significant impact on the ageing process," says Nils-Gran Larsson, Director at the Max Planck Institute for Biology of Ageing in Cologne and scientist at the Karolinska Institute in Stockholm. Together with Lars Olson, also a scientist at the Karolinska Institute, he has led the study.

"Many mutations in the mitochondria gradually disable the cell's energy production." Contrary to previous findings, not only mutations that accumulate during lifetime play a role: "Surprisingly, we discovered that our mother's mitochondrial DNA seems to influence our own ageing," says James Stewart, a researcher in Larsson's department. "If mice inherit mtDNA with mutations from their mother, they age more quickly." Thus, some of the mutations that cause ageing are already prese
'/>"/>

Contact: Nils-Göran Larsson
larsson@age.mpg.de
49-221-478-89771
Max-Planck-Gesellschaft
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Bright birds make good mothers
2. Offspring of mothers stressed during pregnancy with a passive stress coping style more prone to obesity
3. Female mice exposed to BPA by mothers show unexpected characteristics
4. Privacy a problem for mothers of newborns in neonatal intensive care units, CWRU study finds
5. Nursing gerbils unravel benefit of multiple mothers in collective mammals
6. Grant funded to improve mothers nutrition before pregnancy and impact on baby
7. Infants of overweight mothers grow more slowly
8. Montreal researchers repel mortality in Malian mothers
9. Multiple genes manage how people taste sweeteners
10. Fetal stress disrupts the way genes are transmitted
11. Be happy: Your genes may thank you for it
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/4/2014)... 2014   Neurotechnology , a provider of ... latest version of its fingerprint matching algorithm has ... evaluation organized by NIST. The MINEX test ... INCITS 378 fingerprint standard template format. MINEX compliance ... in the United States ...
(Date:11/3/2014)... birth weight and preterm birth are linked to increased ... published in the American College of Rheumatology (ACR) journal, ... birth weight and pre-term babies were not at greater ... , According to the ACR, 27 million Americans ... OA. Symptoms of OA range from mild to severe ...
(Date:11/2/2014)... and bump into a biologist . . . , While ... sketch, researchers have taken this premise and applied it to ... in the rising oceans of genomic data. , In this ... studies are publishing at a dizzying rate. The challenge is ... the noise (and there is no shortage of noise). , ...
Breaking Biology News(10 mins):Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 2Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 3Preterm, low birth-weight babies may need new hips in adulthood 2Mutant models 2Mutant models 3Mutant models 4
... achieved dynamic, atomic-scale views of a protein needed to maintain ... work, funded in part by the National Institutes of Health, ... and a variety of other health conditions. Aquaporin proteins ... tissues, but aquaporin zero (AQP0) is found only in the ...
... 2013)Climate changes how species interact with one anotherand not just ... how climate change impacted the world in the ancient past ... in the future, according to a new study published in ... change has occurred repeatedly throughout Earth,s history, but the recent ...
... Children,s Research Hospital scientists have discovered a way to target ... without causing autoimmune problems. Researchers also found evidence that the ... today in the advance online edition of Nature . ... to develop immunotherapies to harness the immune system to fight ...
Cached Biology News:Researchers get close-up view of water pores needed in the eye's lens 2Researchers get close-up view of water pores needed in the eye's lens 3Looking to the past to predict the future of climate change 2Mechanism offers promising new approach for harnessing the immune system to fight cancer 2Mechanism offers promising new approach for harnessing the immune system to fight cancer 3
(Date:11/18/2014)... New Orleans, LA (PRWEB) November 17, 2014 ... developer of build-to-order, open architecture blade-based and rackmount ... new NVIDIA® Tesla® K80 dual-GPU accelerator throughout its ... Utilizing a pair of the company’s latest proprietary ... up to eight discrete NVIDIA Tesla K80 dual-GPU ...
(Date:11/18/2014)... 2014 Athena Signature Series: Turning Cancer ‘Off’ ... Emerson, a professor in the Regulatory Biology Laboratory at the ... discovery points to an “off switch” for drug resistance in ... her local research is making a global impact in the ... then join host Cheryl K. Goodman, CEO of Social Global ...
(Date:11/18/2014)... 18, 2014 American Process Inc. ... formed a partnership with researchers at Georgia Institute ... Technology, and the USDA’s Forest Products Laboratory to ... nanocellulose. Nanocellulose is a rapidly emerging high performance ... project is to replace heavy steel structures within ...
(Date:11/18/2014)... 18, 2014 2014 Deep ... is professional and in-depth report on Polytetrahydrofuran ... information, including its definition, characterization, application, and ... This exploration covers the worldwide business investigation, ... examination covering macroeconomic environment & financial circumstance ...
Breaking Biology Technology:Cirrascale® Expands Multi-GPU Peering Solutions with Support for New NVIDIA Tesla K80 Dual-GPU Accelerators 2Cirrascale® Expands Multi-GPU Peering Solutions with Support for New NVIDIA Tesla K80 Dual-GPU Accelerators 3American Process Inc. Announces Partnership to Develop Ultra-Strong, Lightweight Automotive Components Using Nanotechnology from Nature 2American Process Inc. Announces Partnership to Develop Ultra-Strong, Lightweight Automotive Components Using Nanotechnology from Nature 3PTMEG Market: 2019 Global Polytetrahydrofuran Industry Development Trends & Analysis Now at DeepResearchReports.com 2PTMEG Market: 2019 Global Polytetrahydrofuran Industry Development Trends & Analysis Now at DeepResearchReports.com 3
... in cat litter and other applications. The extraordinary properties of ... its scarcity in the Earth,s crust: only a few mines ... Spain, the world,s biggest exporter of this material. Sepiolite ... to filter and purify wine, but our understanding at the ...
... July 12, 2011 Life Technologies Corporation ... of innovative life science solutions, today introduced ... broad range of Swine Influenza Virus (SIV), a common ... significant weight loss resulting in economic loss to producers. ...
... July 11, 2011 The International Cancer Genome Consortium (ICGC) ... in Kyoto, Japan. The ICGC also announced that it is ... genomic data on more than 25,000 tumors for up to ... importance across the globe. "These new and ...
Cached Biology Technology:Cat litter to become an edible product? 2Life Technologies Introduces First and Only USDA-Approved Real-Time PCR Test to Detect Swine Influenza Virus 2Life Technologies Introduces First and Only USDA-Approved Real-Time PCR Test to Detect Swine Influenza Virus 3ICGC Releases New Genomic Data on Cancer Ahead of Schedule 2ICGC Releases New Genomic Data on Cancer Ahead of Schedule 3ICGC Releases New Genomic Data on Cancer Ahead of Schedule 4ICGC Releases New Genomic Data on Cancer Ahead of Schedule 5
... For use in hybridization incubators ... and GL 45 size PP plug-seal ... seal. Available in three lengths to ... plug-seal caps and O-rings available separately. ...
... efficient extraction of DNA from agarose gels The ... fragments of 150 bp to > 12,000 bp in ... to dissolve the gel slice, followed by adsorption of ... column format. After a wash step, the purified DNA ...
Fujifilm BAS-1800II provides the ideal configuration for a low-cost imager that requires only a small amount of space in the laboratory. The small imager for accurate high-throughput screening...
When added to StemSep T Cell Enrichment cocktail, human TCRab TAC is designed to deplete human TCRab from samples to isolate gd T cells....
Biology Products: